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UniProtKB - P24699 (MYF5_MOUSE)
Protein
Myogenic factor 5
Gene
Myf5
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
1 PublicationGO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: MGI
GO - Biological processi
- camera-type eye development Source: MGI
- cartilage condensation Source: MGI
- embryonic skeletal system morphogenesis Source: MGI
- extracellular matrix organization Source: MGI
- muscle organ development Source: MGI
- muscle organ morphogenesis Source: MGI
- muscle tissue morphogenesis Source: MGI
- ossification Source: MGI
- positive regulation of myoblast differentiation Source: GO_Central
- positive regulation of skeletal muscle fiber development Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of cell-matrix adhesion Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- skeletal muscle cell differentiation Source: MGI
- skeletal muscle tissue development Source: MGI
- somitogenesis Source: MGI
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Differentiation, Myogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-525793, Myogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Myogenic factor 5Short name: Myf-5 |
Gene namesi | Name:Myf5 Synonyms:Myf-5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97252, Myf5 |
VEuPathDBi | HostDB:ENSMUSG00000000435 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127345 | 1 – 255 | Myogenic factor 5Add BLAST | 255 |
Proteomic databases
PaxDbi | P24699 |
PRIDEi | P24699 |
PTM databases
iPTMneti | P24699 |
PhosphoSitePlusi | P24699 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000000435, Expressed in myotome and 114 other tissues |
Genevisiblei | P24699, MM |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 201641, 2 interactors |
STRINGi | 10090.ENSMUSP00000000445 |
Miscellaneous databases
RNActi | P24699, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 83 – 134 | bHLHPROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 226 – 249 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 226 – 246 | Polar residuesSequence analysisAdd BLAST | 21 |
Phylogenomic databases
eggNOGi | KOG3960, Eukaryota |
GeneTreei | ENSGT00950000182959 |
HOGENOMi | CLU_066887_0_0_1 |
InParanoidi | P24699 |
OMAi | MAECNSP |
OrthoDBi | 1471470at2759 |
PhylomeDBi | P24699 |
TreeFami | TF316344 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR022032, Myf5 IPR002546, MyoD_N IPR039704, Myogenic_factor |
PANTHERi | PTHR11534, PTHR11534, 1 hit |
Pfami | View protein in Pfam PF01586, Basic, 1 hit PF00010, HLH, 1 hit PF12232, Myf5, 1 hit |
SMARTi | View protein in SMART SM00520, BASIC, 1 hit SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
P24699-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDMTDGCQFS PSEYFYEGSC IPSPEDEFGD QFEPRVAAFG AHKAELQGSD
60 70 80 90 100
DEEHVRAPTG HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN
110 120 130 140 150
QAFETLKRCT TTNPNQRLPK VEILRNAIRY IESLQELLRE QVENYYSLPG
160 170 180 190 200
QSCSEPTSPT SNCSDGMPEC NSPVWSRKNS SFDSIYCPDV SNACAADKSS
210 220 230 240 250
VSSLDCLSSI VDRITSTEPS ELALQDTASL SPATSANSQP ATPGPSSSRL
IYHVL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56182 mRNA Translation: CAA39643.1 AK044894 mRNA Translation: BAC32132.1 AK083402 mRNA Translation: BAC38902.1 |
CCDSi | CCDS24161.1 |
PIRi | S22825 |
RefSeqi | NP_032682.1, NM_008656.5 XP_006513382.1, XM_006513319.2 |
Genome annotation databases
Ensembli | ENSMUST00000000445; ENSMUSP00000000445; ENSMUSG00000000435 |
GeneIDi | 17877 |
KEGGi | mmu:17877 |
UCSCi | uc007gyz.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56182 mRNA Translation: CAA39643.1 AK044894 mRNA Translation: BAC32132.1 AK083402 mRNA Translation: BAC38902.1 |
CCDSi | CCDS24161.1 |
PIRi | S22825 |
RefSeqi | NP_032682.1, NM_008656.5 XP_006513382.1, XM_006513319.2 |
3D structure databases
AlphaFoldDBi | P24699 |
SMRi | P24699 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201641, 2 interactors |
STRINGi | 10090.ENSMUSP00000000445 |
PTM databases
iPTMneti | P24699 |
PhosphoSitePlusi | P24699 |
Proteomic databases
PaxDbi | P24699 |
PRIDEi | P24699 |
Protocols and materials databases
Antibodypediai | 17297, 467 antibodies from 36 providers |
DNASUi | 17877 |
Genome annotation databases
Ensembli | ENSMUST00000000445; ENSMUSP00000000445; ENSMUSG00000000435 |
GeneIDi | 17877 |
KEGGi | mmu:17877 |
UCSCi | uc007gyz.1, mouse |
Organism-specific databases
CTDi | 4617 |
MGIi | MGI:97252, Myf5 |
VEuPathDBi | HostDB:ENSMUSG00000000435 |
Phylogenomic databases
eggNOGi | KOG3960, Eukaryota |
GeneTreei | ENSGT00950000182959 |
HOGENOMi | CLU_066887_0_0_1 |
InParanoidi | P24699 |
OMAi | MAECNSP |
OrthoDBi | 1471470at2759 |
PhylomeDBi | P24699 |
TreeFami | TF316344 |
Enzyme and pathway databases
Reactomei | R-MMU-525793, Myogenesis |
Miscellaneous databases
BioGRID-ORCSi | 17877, 1 hit in 71 CRISPR screens |
PROi | PR:P24699 |
RNActi | P24699, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000435, Expressed in myotome and 114 other tissues |
Genevisiblei | P24699, MM |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR022032, Myf5 IPR002546, MyoD_N IPR039704, Myogenic_factor |
PANTHERi | PTHR11534, PTHR11534, 1 hit |
Pfami | View protein in Pfam PF01586, Basic, 1 hit PF00010, HLH, 1 hit PF12232, Myf5, 1 hit |
SMARTi | View protein in SMART SM00520, BASIC, 1 hit SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MYF5_MOUSE | |
Accessioni | P24699Primary (citable) accession number: P24699 Secondary accession number(s): Q543W7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot