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Protein

Myogenic factor 5

Gene

Myf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Myogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-375170 CDO in myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenic factor 5
Short name:
Myf-5
Gene namesi
Name:Myf5
Synonyms:Myf-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:97252 Myf5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273451 – 255Myogenic factor 5Add BLAST255

Proteomic databases

PaxDbiP24699
PRIDEiP24699

PTM databases

iPTMnetiP24699
PhosphoSitePlusiP24699

Expressioni

Gene expression databases

BgeeiENSMUSG00000000435 Expressed in 93 organ(s), highest expression level in myotome
CleanExiMM_MYF5
ExpressionAtlasiP24699 baseline and differential
GenevisibleiP24699 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201641, 2 interactors
STRINGi10090.ENSMUSP00000000445

Structurei

3D structure databases

ProteinModelPortaliP24699
SMRiP24699
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 134bHLHPROSITE-ProRule annotationAdd BLAST52

Phylogenomic databases

eggNOGiKOG3960 Eukaryota
ENOG4111SED LUCA
GeneTreeiENSGT00530000063004
HOGENOMiHOG000234800
HOVERGENiHBG006429
InParanoidiP24699
KOiK18484
OMAiSFDSVYC
OrthoDBiEOG091G0GKD
PhylomeDBiP24699
TreeFamiTF316344

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR002546 Basic
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR022032 Myf5
IPR039704 Myogenic_factor
PANTHERiPTHR11534 PTHR11534, 1 hit
PfamiView protein in Pfam
PF01586 Basic, 1 hit
PF00010 HLH, 1 hit
PF12232 Myf5, 1 hit
SMARTiView protein in SMART
SM00520 BASIC, 1 hit
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P24699-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDMTDGCQFS PSEYFYEGSC IPSPEDEFGD QFEPRVAAFG AHKAELQGSD
60 70 80 90 100
DEEHVRAPTG HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN
110 120 130 140 150
QAFETLKRCT TTNPNQRLPK VEILRNAIRY IESLQELLRE QVENYYSLPG
160 170 180 190 200
QSCSEPTSPT SNCSDGMPEC NSPVWSRKNS SFDSIYCPDV SNACAADKSS
210 220 230 240 250
VSSLDCLSSI VDRITSTEPS ELALQDTASL SPATSANSQP ATPGPSSSRL

IYHVL
Length:255
Mass (Da):28,229
Last modified:March 1, 1992 - v1
Checksum:i0BDCBEDF2ABCAEC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56182 mRNA Translation: CAA39643.1
AK044894 mRNA Translation: BAC32132.1
AK083402 mRNA Translation: BAC38902.1
CCDSiCCDS24161.1
PIRiS22825
RefSeqiNP_032682.1, NM_008656.5
XP_006513382.1, XM_006513319.2
UniGeneiMm.4984

Genome annotation databases

EnsembliENSMUST00000000445; ENSMUSP00000000445; ENSMUSG00000000435
GeneIDi17877
KEGGimmu:17877
UCSCiuc007gyz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56182 mRNA Translation: CAA39643.1
AK044894 mRNA Translation: BAC32132.1
AK083402 mRNA Translation: BAC38902.1
CCDSiCCDS24161.1
PIRiS22825
RefSeqiNP_032682.1, NM_008656.5
XP_006513382.1, XM_006513319.2
UniGeneiMm.4984

3D structure databases

ProteinModelPortaliP24699
SMRiP24699
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201641, 2 interactors
STRINGi10090.ENSMUSP00000000445

PTM databases

iPTMnetiP24699
PhosphoSitePlusiP24699

Proteomic databases

PaxDbiP24699
PRIDEiP24699

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000445; ENSMUSP00000000445; ENSMUSG00000000435
GeneIDi17877
KEGGimmu:17877
UCSCiuc007gyz.1 mouse

Organism-specific databases

CTDi4617
MGIiMGI:97252 Myf5

Phylogenomic databases

eggNOGiKOG3960 Eukaryota
ENOG4111SED LUCA
GeneTreeiENSGT00530000063004
HOGENOMiHOG000234800
HOVERGENiHBG006429
InParanoidiP24699
KOiK18484
OMAiSFDSVYC
OrthoDBiEOG091G0GKD
PhylomeDBiP24699
TreeFamiTF316344

Enzyme and pathway databases

ReactomeiR-MMU-375170 CDO in myogenesis

Miscellaneous databases

PROiPR:P24699
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000435 Expressed in 93 organ(s), highest expression level in myotome
CleanExiMM_MYF5
ExpressionAtlasiP24699 baseline and differential
GenevisibleiP24699 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR002546 Basic
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR022032 Myf5
IPR039704 Myogenic_factor
PANTHERiPTHR11534 PTHR11534, 1 hit
PfamiView protein in Pfam
PF01586 Basic, 1 hit
PF00010 HLH, 1 hit
PF12232 Myf5, 1 hit
SMARTiView protein in SMART
SM00520 BASIC, 1 hit
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYF5_MOUSE
AccessioniPrimary (citable) accession number: P24699
Secondary accession number(s): Q543W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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