Myogenic factor 5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage."
    Bowlin K.M., Embree L.J., Garry M.G., Garry D.J., Shi X.
    Differentiation 86:184-191(2013) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein dimerization activity Source: InterPro
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos."
    Yeung F., Chung E., Guess M.G., Bell M.L., Leinwand L.A.
    Nucleic Acids Res 40:7303-7318(2012) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• camera-type eye development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates."
    Sambasivan R., Gayraud-Morel B., Dumas G., Cimper C., Paisant S., Kelly R.G., Kelly R., Tajbakhsh S.
    Dev Cell 16:810-821(2009) [PubMed] [Europe PMC] [Abstract]
• cartilage condensation Source: MGIInferred from mutant phenotypeⁱ
  • "Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6."
    Grass S., Arnold H.H., Braun T.
    Development 122:141-150(1996) [PubMed] [Europe PMC] [Abstract]
• embryonic skeletal system morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Myf-5 revisited: loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice."
    Kaul A., Koster M., Neuhaus H., Braun T.
    Cell 102:17-19(2000) [PubMed] [Europe PMC] [Abstract]
• extracellular matrix organization Source: MGIInferred from mutant phenotypeⁱ
  • "Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo."
    Bajanca F., Luz M., Raymond K., Martins G.G., Sonnenberg A., Tajbakhsh S., Buckingham M., Thorsteinsdottir S.
    Development 133:1635-1644(2006) [PubMed] [Europe PMC] [Abstract]
• muscle organ development Source: MGIInferred from mutant phenotypeⁱ
  • "Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin."
    Wang Y., Schnegelsberg P.N., Dausman J., Jaenisch R.
    Nature 379:823-825(1996) [PubMed] [Europe PMC] [Abstract]
• muscle organ morphogenesis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates."
    Sambasivan R., Gayraud-Morel B., Dumas G., Cimper C., Paisant S., Kelly R.G., Kelly R., Tajbakhsh S.
    Dev Cell 16:810-821(2009) [PubMed] [Europe PMC] [Abstract]
• muscle tissue morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates."
    Sambasivan R., Gayraud-Morel B., Dumas G., Cimper C., Paisant S., Kelly R.G., Kelly R., Tajbakhsh S.
    Dev Cell 16:810-821(2009) [PubMed] [Europe PMC] [Abstract]
• ossification Source: MGIInferred from mutant phenotypeⁱ
  • "Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin."
    Wang Y., Schnegelsberg P.N., Dausman J., Jaenisch R.
    Nature 379:823-825(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of myoblast differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of skeletal muscle fiber development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Xin, an actin binding protein, is expressed within muscle satellite cells and newly regenerated skeletal muscle fibers."
    Hawke T.J., Atkinson D.J., Kanatous S.B., Van der Ven P.F., Goetsch S.C., Garry D.J.
    Am J Physiol Cell Physiol 293:C1636-44(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of cell-matrix adhesion Source: MGIInferred from mutant phenotypeⁱ
  • "Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo."
    Bajanca F., Luz M., Raymond K., Martins G.G., Sonnenberg A., Tajbakhsh S., Buckingham M., Thorsteinsdottir S.
    Development 133:1635-1644(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation."
    Rajan S., Chu Pham Dang H., Djambazian H., Zuzan H., Fedyshyn Y., Ketela T., Moffat J., Hudson T.J., Sladek R.
    Physiol Genomics 44:183-197(2012) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle tissue development Source: MGIInferred from mutant phenotypeⁱ
  • "Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates."
    Sambasivan R., Gayraud-Morel B., Dumas G., Cimper C., Paisant S., Kelly R.G., Kelly R., Tajbakhsh S.
    Dev Cell 16:810-821(2009) [PubMed] [Europe PMC] [Abstract]
• somitogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Myf-5 revisited: loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice."
    Kaul A., Koster M., Neuhaus H., Braun T.
    Cell 102:17-19(2000) [PubMed] [Europe PMC] [Abstract]
  • "Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates."
    Sambasivan R., Gayraud-Morel B., Dumas G., Cimper C., Paisant S., Kelly R.G., Kelly R., Tajbakhsh S.
    Dev Cell 16:810-821(2009) [PubMed] [Europe PMC] [Abstract]
  • "Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6."
    Grass S., Arnold H.H., Braun T.
    Development 122:141-150(1996) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein dimerization activity Source: InterPro

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDMTDGCQFS PSEYFYEGSC IPSPEDEFGD QFEPRVAAFG AHKAELQGSD 
        60         70         80         90        100
DEEHVRAPTG HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN 
       110        120        130        140        150
QAFETLKRCT TTNPNQRLPK VEILRNAIRY IESLQELLRE QVENYYSLPG 
       160        170        180        190        200
QSCSEPTSPT SNCSDGMPEC NSPVWSRKNS SFDSIYCPDV SNACAADKSS 
       210        220        230        240        250
VSSLDCLSSI VDRITSTEPS ELALQDTASL SPATSANSQP ATPGPSSSRL 

IYHVL                                                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot