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Entry version 95 (02 Dec 2020)
Sequence version 2 (26 May 2009)
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Protein

Negative regulator of mitosis

Gene

bimE

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of mitosis in E.nidulans. This protein is part of a regulatory pathway that includes the nimA protein kinase. It is required to prevent premature entry into mitosis. Mutations to this protein both cause cells to enter mitosis and prevent them from leaving mitosis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • molecular adaptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Negative regulator of mitosis
Alternative name(s):
Anaphase-promoting complex subunit 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:bimE
ORF Names:AN2772
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Nidulantes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VI
  • UP000005890 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002158731 – 2067Negative regulator of mitosisAdd BLAST2067

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P24686

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
162425.CADANIAP00010334

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1434 – 1465PC 1Add BLAST32
Repeati1482 – 1520PC 2Add BLAST39
Repeati1532 – 1562PC 3Add BLAST31
Repeati1625 – 1659PC 4Add BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi336 – 347Nuclear localization signalSequence analysisAdd BLAST12

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the APC1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1858, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000746_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24686

Database of Orthologous Groups

More...
OrthoDBi
738153at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024990, Apc1

The PANTHER Classification System

More...
PANTHERi
PTHR12827, PTHR12827, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12859, ANAPC1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P24686-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTVRSLGLH DSSAISFLIA EDLLPAEPSE ELYSWTTSIN NGPNGPVEDE
60 70 80 90 100
LVWTKSCVVW TRAGVIKRVF RLDFEKEDIK YALLTNFAVN NVKRTSDLSS
110 120 130 140 150
LAIPQTTSQQ SNRPSGSESL DGKESRRSST SKHSSRAVVV VLKTQAHIFF
160 170 180 190 200
LEGNSHVVPL PFEVDSVFAT PRGLLFQRKV ADESNTSSYP MVPPNSFMSF
210 220 230 240 250
SQDFCASQFL DYTSGKVQRP SLSTIPAQSP SWKSRPNKRA DLPRVFSLMD
260 270 280 290 300
PHSEMGLVVT NQASRWLHTS LSGRPSGFDV LDPADEIVYV SPRDELAGTF
310 320 330 340 350
RADPKSPLIL VLTVNTITGL YTLWTARYRD NESIPSHRKK KRRDTGGTRS
360 370 380 390 400
KRRSSHFGMA TGTTTPGARP SAGRESFGPR GDNWNASVMS HSQYSTEGRP
410 420 430 440 450
DDDEDDFASK LGQDFGEIGV PSKTSRRVSS MLARADLATS QDRITFSDLV
460 470 480 490 500
TGSQSSTIHP GGLRQSIGAG STRGSFGFNP RSSLPPGAGS IYSTTSSFVD
510 520 530 540 550
PPVDKLLEEL NNESLFEGIE NMDLKESAAG LPEEVFLSKV ESFSSKFSGS
560 570 580 590 600
FLAPSKIKSS KRLKVVTLCP TDYASSHVGE STSMALYLVD QEAKSLTVVN
610 620 630 640 650
IRVESVKKPA KDVVFLKRSK NKATSDERAL LVQASGIQHV SGTLDVCKVV
660 670 680 690 700
DGGLSRIITL SVNDAGATVL HLQMPWNDPI IIELPSKFML HEMDALSSIM
710 720 730 740 750
TVNTSREGSV NRVMADFSMT MTGLDHPAVD GKFDVVDSAK RRHKLQLCME
760 770 780 790 800
PTNPLVRRAF GVCRFALCGY FPDKVADGLL MGWWKTLKWL QEREVCENDL
810 820 830 840 850
EWTALVVTLF AQAIPFIEGD QSGGTTRLTR RKRGLLRSSS GSYVDTESWE
860 870 880 890 900
SMLEQESGSA GVVASWMNTA SWGWVVEQDA EDESTASYGR KPNKEPLSSS
910 920 930 940 950
RSTCRKNTYL LRCATLTREF LRTPQGIAAV GCDGHLRKAL SNSEHSIHTP
960 970 980 990 1000
LCTILVALHL LREEQKLSAC DEEQSHKTLG LLAPVLAQLG GWLGWPSWNW
1010 1020 1030 1040 1050
AEDSYYGSEI ASINRWQFEN TRMAGPDLPA EPLPPPSIFA YLEKAWRGES
1060 1070 1080 1090 1100
CQFWTLLNLV NFDGHPRRGR LWQWCSTLTP RTLALEGFVS EMRHKLSVLE
1110 1120 1130 1140 1150
RIQLLHRWGL TRSVIETFPA GISTPLYEAI IESQTHASTS WSSSFLGLID
1160 1170 1180 1190 1200
RDDLNISSQS STTRPPPPLS LNVSHDAIRD YHQISNSTLD IDAINSFEAS
1210 1220 1230 1240 1250
AEADRFSVTR LIFREDKRFI EAARLLNQSK APAAECHPEP EWTDSDLLEA
1260 1270 1280 1290 1300
QKEVVQLVTL RTLSIPTGRA MLAFSGRLPL LTEKLPIPSF SLQCVMKPSN
1310 1320 1330 1340 1350
VTISADRASF HEEKICWAFF HNGVSTGLAI SKNSKGIDTS WILFNKPQEL
1360 1370 1380 1390 1400
TNRHAGFLLA LGLNGHLRSL AKWVAFKYLT PKHTMTSIGL LLGLSASYLG
1410 1420 1430 1440 1450
TMDTLVTRLL SVHVTRMLPM GAAELNLSPL TQTAGIMGIG LLYCNSQHRR
1460 1470 1480 1490 1500
MSEVMLSEIE NADQEEGSAT NDYLRNEGYR LAAGFALGFI NLGKGKDLKG
1510 1520 1530 1540 1550
MRDMHIVERL LAVAVGTKNV DLAHVLDRAT AGATIALAII FMKTNDETLA
1560 1570 1580 1590 1600
QKVDIPDTTV RFDYVRPDLF LLRTLARHII MWDRIQACDE WFIGSLPEVY
1610 1620 1630 1640 1650
RRRYRLTGVR RLKSNDMPFF NIIAGLCFAL GLRFAGSPDP TVRDILLSYL
1660 1670 1680 1690 1700
DQFIRISRLP APNYDARLAR NSVRHCQDVV ALSLAAVMAG TGDLALFRRL
1710 1720 1730 1740 1750
RSLHGRVDPD TPYGSHMAAH MAIGMLFLGG GSYTLGTSNL AVASLICSLY
1760 1770 1780 1790 1800
PIFPTTVLDN ECHLQAFRHL WVLAAEPRCI VPRDLDSRRP ISMPITVTDS
1810 1820 1830 1840 1850
DGVSGTLTAP CLLPDLNRIA KVEVLSPDYW PLVLDFDSNP GVREKFQQGD
1860 1870 1880 1890 1900
QSIYLRRKAT YNPTGSSFFS STLAGLSSAQ DILPSASTSA SNQGKGLSPS
1910 1920 1930 1940 1950
ALPNVSALLS KESHRFTPKP AAQSIWDWIF QLDSLHGILD AREKELVLPS
1960 1970 1980 1990 2000
SFPARPRPSS TPHDAPWLRQ SAVDSKLLAE SIAQNVIQSA TGRGGNPDEV
2010 2020 2030 2040 2050
RDRLWQLRLL FAWIDAGSSF PSESDEEKRD RQETGSMPSS GHWLRRDYVE
2060
DLRWKIWGVQ ARGSEGS
Length:2,067
Mass (Da):228,577
Last modified:May 26, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7E3CE59C28A60AC
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA51478 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CBF84043 differs from that shown. Reason: Frameshift.Curated
The sequence EAA63206 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1620F → K in EAA63206 (PubMed:16372000).Curated1
Sequence conflicti1620F → K in CBF84043 (PubMed:16372000).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M59705 mRNA Translation: AAA51478.1 Different initiation.
AACD01000049 Genomic DNA Translation: EAA63206.1 Frameshift.
BN001306 Genomic DNA Translation: CBF84043.1 Frameshift.

Protein sequence database of the Protein Information Resource

More...
PIRi
A37879, BWASBE

NCBI Reference Sequences

More...
RefSeqi
XP_660376.1, XM_655284.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAA63206; EAA63206; AN2772.2

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2874447

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ani:AN2772.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59705 mRNA Translation: AAA51478.1 Different initiation.
AACD01000049 Genomic DNA Translation: EAA63206.1 Frameshift.
BN001306 Genomic DNA Translation: CBF84043.1 Frameshift.
PIRiA37879, BWASBE
RefSeqiXP_660376.1, XM_655284.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi162425.CADANIAP00010334

Proteomic databases

PRIDEiP24686

Genome annotation databases

EnsemblFungiiEAA63206; EAA63206; AN2772.2
GeneIDi2874447
KEGGiani:AN2772.2

Phylogenomic databases

eggNOGiKOG1858, Eukaryota
HOGENOMiCLU_000746_0_0_1
InParanoidiP24686
OrthoDBi738153at2759

Family and domain databases

InterProiView protein in InterPro
IPR024990, Apc1
PANTHERiPTHR12827, PTHR12827, 1 hit
PfamiView protein in Pfam
PF12859, ANAPC1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIME_EMENI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24686
Secondary accession number(s): C8VJM8, Q5B9K8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: May 26, 2009
Last modified: December 2, 2020
This is version 95 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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