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Entry version 186 (08 May 2019)
Sequence version 2 (01 Oct 1993)
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Protein

Lactotransferrin

Gene

LTF

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate.
Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity. Antimicrobial properties may include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. The most effective inhibitory activity is seen against E.coli and P.aeruginosa. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Interferes with the lipopolysaccharide (LPS)-stimulated TLR4 signaling, but cannot directly stimulate the TLR4 signaling pathway and subsequent NF-kappa-B activation.
Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.
The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by PMSF and Pefabloc.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=50 µM for Z-Phe-Arg-|-aminomethylcoumarin1 Publication

    pH dependencei

    Optimum pH is 7.5.1 Publication

    Temperature dependencei

    Optimum temperature is 25 degrees Celsius.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi79Iron 1PROSITE-ProRule annotation1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei92PROSITE-ProRule annotation1
    Metal bindingi111Iron 1PROSITE-ProRule annotation1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei136Carbonate 11
    Binding sitei140Carbonate 1PROSITE-ProRule annotation1 Publication1
    Binding sitei142Carbonate 1; via amide nitrogen1
    Binding sitei143Carbonate 1; via amide nitrogen1
    Metal bindingi211Iron 1PROSITE-ProRule annotation1 Publication1
    Metal bindingi272Iron 1PROSITE-ProRule annotation1 Publication1
    Active sitei278NucleophilePROSITE-ProRule annotation1
    Metal bindingi414Iron 2PROSITE-ProRule annotation1 Publication1
    Metal bindingi452Iron 2PROSITE-ProRule annotation1 Publication1
    Binding sitei478Carbonate 21
    Binding sitei482Carbonate 2PROSITE-ProRule annotation1 Publication1
    Binding sitei484Carbonate 2; via amide nitrogen1
    Binding sitei485Carbonate 2; via amide nitrogen1
    Metal bindingi545Iron 2PROSITE-ProRule annotation1 Publication1
    Metal bindingi614Iron 2PROSITE-ProRule annotation1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAntibiotic, Antimicrobial, Hydrolase, Protease, Serine protease
    Biological processImmunity, Ion transport, Iron transport, Osteogenesis, Transport
    LigandIron, Metal-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-BTA-6798695 Neutrophil degranulation
    R-BTA-6799990 Metal sequestration by antimicrobial proteins
    R-BTA-6803157 Antimicrobial peptides

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P24627

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    S60.001

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Lactotransferrin (EC:3.4.21.-)
    Short name:
    Lactoferrin
    Cleaved into the following chain:
    Lactoferricin-B
    Short name:
    Lfcin-B
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:LTF
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

    Organism-specific databases

    Vertebrate Gene Nomenclature Database

    More...
    VGNCi
    VGNC:31077 LTF

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Protein family/group databases

    Allergome; a platform for allergen knowledge

    More...
    Allergomei
    1065 Bos d LF

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2796

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003572620 – 708LactotransferrinAdd BLAST689
    <p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000003572736 – 60Lactoferricin-BAdd BLAST25

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 64PROSITE-ProRule annotation
    Disulfide bondi38 ↔ 55
    Disulfide bondi134 ↔ 217PROSITE-ProRule annotation
    Disulfide bondi176 ↔ 192PROSITE-ProRule annotation
    Disulfide bondi189 ↔ 200PROSITE-ProRule annotation
    Disulfide bondi250 ↔ 264PROSITE-ProRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_000186252N-linked (GlcNAc...) asparagine1
    Disulfide bondi367 ↔ 399PROSITE-ProRule annotation
    Disulfide bondi377 ↔ 390PROSITE-ProRule annotation
    Glycosylationi387N-linked (GlcNAc...) asparagine1
    Disulfide bondi424 ↔ 703PROSITE-ProRule annotation
    Disulfide bondi444 ↔ 666PROSITE-ProRule annotation
    Disulfide bondi476 ↔ 551PROSITE-ProRule annotation
    GlycosylationiCAR_000197495N-linked (GlcNAc...) asparagine1
    Disulfide bondi500 ↔ 694PROSITE-ProRule annotation
    Disulfide bondi510 ↔ 524PROSITE-ProRule annotation
    Disulfide bondi521 ↔ 534PROSITE-ProRule annotation
    GlycosylationiCAR_000198564N-linked (GlcNAc...) asparagine1
    Disulfide bondi592 ↔ 606PROSITE-ProRule annotation
    Disulfide bondi644 ↔ 649PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P24627

    PeptideAtlas

    More...
    PeptideAtlasi
    P24627

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P24627

    PTM databases

    CarbonylDB database of protein carbonylation sites

    More...
    CarbonylDBi
    P24627

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    319

    UniCarbKB; an annotated and curated database of glycan structures

    More...
    UniCarbKBi
    P24627

    Miscellaneous databases

    CutDB - Proteolytic event database

    More...
    PMAP-CutDBi
    P24627

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSBTAG00000001292 Expressed in 9 organ(s), highest expression level in colon

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P24627 baseline and differential

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    Found in a complex with LTF, CLU, EPPIN and SEMG1 (By similarity).

    By similarity

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    P279583EBI-8076910,EBI-6904269From Hepatitis C virus genotype 1a (isolate H).

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    158240, 1 interactor

    Protein interaction database and analysis system

    More...
    IntActi
    P24627, 4 interactors

    Molecular INTeraction database

    More...
    MINTi
    P24627

    STRING: functional protein association networks

    More...
    STRINGi
    9913.ENSBTAP00000001704

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1708
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P24627

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P24627

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 352Transferrin-like 1PROSITE-ProRule annotationAdd BLAST328
    Domaini364 – 693Transferrin-like 2PROSITE-ProRule annotationAdd BLAST330

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the transferrin family.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IEAI Eukaryota
    ENOG410XQ36 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000156055

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000043759

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P24627

    KEGG Orthology (KO)

    More...
    KOi
    K17283

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NKCAFSS

    Database of Orthologous Groups

    More...
    OrthoDBi
    232859at2759

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF324013

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR030684 Lactotransferrin
    IPR016357 Transferrin
    IPR001156 Transferrin-like_dom
    IPR018195 Transferrin_Fe_BS

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00405 Transferrin, 2 hits

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF500683 Lactotransferrin, 1 hit
    PIRSF002549 Transferrin, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00422 TRANSFERRIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00094 TR_FER, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00205 TRANSFERRIN_LIKE_1, 2 hits
    PS00206 TRANSFERRIN_LIKE_2, 2 hits
    PS00207 TRANSFERRIN_LIKE_3, 2 hits
    PS51408 TRANSFERRIN_LIKE_4, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    P24627-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MKLFVPALLS LGALGLCLAA PRKNVRWCTI SQPEWFKCRR WQWRMKKLGA
    60 70 80 90 100
    PSITCVRRAF ALECIRAIAE KKADAVTLDG GMVFEAGRDP YKLRPVAAEI
    110 120 130 140 150
    YGTKESPQTH YYAVAVVKKG SNFQLDQLQG RKSCHTGLGR SAGWIIPMGI
    160 170 180 190 200
    LRPYLSWTES LEPLQGAVAK FFSASCVPCI DRQAYPNLCQ LCKGEGENQC
    210 220 230 240 250
    ACSSREPYFG YSGAFKCLQD GAGDVAFVKE TTVFENLPEK ADRDQYELLC
    260 270 280 290 300
    LNNSRAPVDA FKECHLAQVP SHAVVARSVD GKEDLIWKLL SKAQEKFGKN
    310 320 330 340 350
    KSRSFQLFGS PPGQRDLLFK DSALGFLRIP SKVDSALYLG SRYLTTLKNL
    360 370 380 390 400
    RETAEEVKAR YTRVVWCAVG PEEQKKCQQW SQQSGQNVTC ATASTTDDCI
    410 420 430 440 450
    VLVLKGEADA LNLDGGYIYT AGKCGLVPVL AENRKSSKHS SLDCVLRPTE
    460 470 480 490 500
    GYLAVAVVKK ANEGLTWNSL KDKKSCHTAV DRTAGWNIPM GLIVNQTGSC
    510 520 530 540 550
    AFDEFFSQSC APGADPKSRL CALCAGDDQG LDKCVPNSKE KYYGYTGAFR
    560 570 580 590 600
    CLAEDVGDVA FVKNDTVWEN TNGESTADWA KNLNREDFRL LCLDGTRKPV
    610 620 630 640 650
    TEAQSCHLAV APNHAVVSRS DRAAHVKQVL LHQQALFGKN GKNCPDKFCL
    660 670 680 690 700
    FKSETKNLLF NDNTECLAKL GGRPTYEEYL GTEYVTAIAN LKKCSTSPLL

    EACAFLTR
    Length:708
    Mass (Da):78,056
    Last modified:October 1, 1993 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6FD7FC15D68E93F
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63E → A in AAA21722 (PubMed:8206385).Curated1
    Sequence conflicti66 – 67RA → PG in AAA30617 (PubMed:1718281).Curated2
    Sequence conflicti145I → V in CAA40366 (PubMed:2001696).Curated1
    Sequence conflicti145I → V in AAA21722 (PubMed:8206385).Curated1
    Sequence conflicti145I → V in AAA30610 (PubMed:8206385).Curated1
    Sequence conflicti164 – 165LQ → PP in CAA40366 (PubMed:2001696).Curated2
    Sequence conflicti264C → Y in AAA21722 (PubMed:8206385).Curated1
    Sequence conflicti273A → P in AAA21722 (PubMed:8206385).Curated1
    Sequence conflicti281G → A in AAA21722 (PubMed:8206385).Curated1
    Sequence conflicti291S → R in AAA21722 (PubMed:8206385).Curated1
    Sequence conflicti297F → S in AAA30617 (PubMed:1718281).Curated1
    Sequence conflicti340G → A in CAA40366 (PubMed:2001696).Curated1
    Sequence conflicti418I → V in AAA21722 (PubMed:8206385).Curated1
    Sequence conflicti436S → T in AAA30610 (PubMed:8206385).Curated1
    Sequence conflicti439H → Y in CAA40366 (PubMed:2001696).Curated1
    Sequence conflicti439H → Y in AAA30610 (PubMed:8206385).Curated1
    Sequence conflicti459K → R in AAA21722 (PubMed:8206385).Curated1
    Sequence conflicti514A → R in CAA40366 (PubMed:2001696).Curated1
    Sequence conflicti514A → R in AAA30610 (PubMed:8206385).Curated1
    Sequence conflicti632H → R in BAB03470 (Ref. 5) Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X57084 mRNA Translation: CAA40366.1
    M63502 mRNA Translation: AAA30617.1
    L08604 mRNA Translation: AAA30609.1
    L19993
    , L19982, L19983, L19984, L19985, L19986, L19988, L19989, L19990, L19991, L19992 Genomic DNA Translation: AAA21722.1
    L19981 mRNA Translation: AAA30610.1
    AB046664 mRNA Translation: BAB03470.1
    BC116051 mRNA Translation: AAI16052.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    I45919 TFBOL

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_851341.1, NM_180998.2
    XP_015315141.1, XM_015459655.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSBTAT00000001704; ENSBTAP00000001704; ENSBTAG00000001292

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    280846

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    bta:280846

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X57084 mRNA Translation: CAA40366.1
    M63502 mRNA Translation: AAA30617.1
    L08604 mRNA Translation: AAA30609.1
    L19993
    , L19982, L19983, L19984, L19985, L19986, L19988, L19989, L19990, L19991, L19992 Genomic DNA Translation: AAA21722.1
    L19981 mRNA Translation: AAA30610.1
    AB046664 mRNA Translation: BAB03470.1
    BC116051 mRNA Translation: AAI16052.1
    PIRiI45919 TFBOL
    RefSeqiNP_851341.1, NM_180998.2
    XP_015315141.1, XM_015459655.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1BLFX-ray2.80A20-708[»]
    1LFCNMR-A36-60[»]
    1NKXX-ray1.90A361-708[»]
    1SDXX-ray2.06A361-695[»]
    E700-704[»]
    1Y58NMR-A38-49[»]
    2ALUX-ray2.09A361-708[»]
    2AYSX-ray1.86A361-708[»]
    2B65X-ray1.50A361-705[»]
    2DOJX-ray2.40A361-705[»]
    2DP8X-ray2.50A361-705[»]
    2DQVX-ray2.70A361-705[»]
    2DS9X-ray2.80A361-705[»]
    2DSFX-ray2.80A361-705[»]
    2DVCX-ray3.00A361-705[»]
    2DWAX-ray2.07A361-705[»]
    2DWHX-ray2.80A361-705[»]
    2DWIX-ray2.20A361-705[»]
    2DWJX-ray2.30A361-705[»]
    2DXRX-ray2.85A361-705[»]
    2DXYX-ray2.03A361-705[»]
    2DYXX-ray2.00A361-705[»]
    2E0SX-ray2.15A361-705[»]
    2E1SX-ray2.70A361-705[»]
    2FA7X-ray2.38A361-705[»]
    2G93X-ray1.90A361-705[»]
    2H4IX-ray2.55A361-705[»]
    2HCAX-ray2.80A361-705[»]
    2MD1NMR-A287-303[»]
    2MD2NMR-A287-296[»]
    2MD3NMR-A296-303[»]
    2MD4NMR-A287-298[»]
    2NUVX-ray2.25A361-705[»]
    2NWJX-ray2.25A361-705[»]
    2O1LX-ray1.97A361-705[»]
    2O51X-ray3.00A361-705[»]
    2OCUX-ray2.38A361-705[»]
    2P1SX-ray1.93A361-704[»]
    2PX1X-ray2.50A361-705[»]
    2Q8JX-ray2.71A361-708[»]
    2QJEX-ray2.30A361-708[»]
    2R71X-ray2.07A361-705[»]
    2R9JX-ray2.55A361-705[»]
    2ZMBX-ray2.90A361-705[»]
    3CFLX-ray2.25A361-705[»]
    3CI8X-ray2.40A361-705[»]
    3CRBX-ray2.60A361-705[»]
    3E9XX-ray2.70A361-705[»]
    3IAZX-ray2.00A361-705[»]
    3IB0X-ray1.40A361-705[»]
    3IB1X-ray2.20A361-705[»]
    3IB2X-ray2.29A361-705[»]
    3K0VX-ray1.91A361-705[»]
    3KJ7X-ray1.91A361-705[»]
    3MJNX-ray2.38A361-705[»]
    3O97X-ray2.68A361-705[»]
    3RGYX-ray2.00A361-705[»]
    3SDFX-ray2.10A361-705[»]
    3TAJX-ray1.70A361-705[»]
    3TODX-ray1.38A361-695[»]
    B700-705[»]
    3TTRX-ray2.27A361-705[»]
    3TUSX-ray2.50A361-705[»]
    3U72X-ray2.20A361-695[»]
    B700-705[»]
    3U8QX-ray1.97A361-695[»]
    B700-705[»]
    3UGWX-ray1.87A361-695[»]
    B700-705[»]
    3UK4X-ray1.98A361-695[»]
    B700-705[»]
    3USDX-ray2.40A361-695[»]
    B700-705[»]
    3V5AX-ray1.44A361-695[»]
    B700-705[»]
    3VDFX-ray1.46A361-695[»]
    B700-705[»]
    4DIGX-ray1.80A361-695[»]
    B700-705[»]
    4DXUX-ray1.46A361-695[»]
    B700-705[»]
    4FIMX-ray1.80A361-695[»]
    B700-705[»]
    4FJPX-ray1.68A361-695[»]
    B700-705[»]
    4FORX-ray1.58A361-695[»]
    B700-705[»]
    4G2ZX-ray1.90A361-695[»]
    B700-705[»]
    4G77X-ray1.98A361-705[»]
    4G8HX-ray1.88A361-705[»]
    4GRKX-ray1.68A361-695[»]
    B700-705[»]
    4N6PX-ray1.40A361-695[»]
    B700-705[»]
    4NEDX-ray2.10A361-705[»]
    4OQOX-ray2.42A/B361-708[»]
    5CRYX-ray2.79A/B361-708[»]
    5HBCX-ray2.79A/B361-708[»]
    SMRiP24627
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi158240, 1 interactor
    IntActiP24627, 4 interactors
    MINTiP24627
    STRINGi9913.ENSBTAP00000001704

    Chemistry databases

    ChEMBLiCHEMBL2796

    Protein family/group databases

    Allergomei1065 Bos d LF
    MEROPSiS60.001

    PTM databases

    CarbonylDBiP24627
    GlyConnecti319
    UniCarbKBiP24627

    Proteomic databases

    PaxDbiP24627
    PeptideAtlasiP24627
    PRIDEiP24627

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSBTAT00000001704; ENSBTAP00000001704; ENSBTAG00000001292
    GeneIDi280846
    KEGGibta:280846

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    4057
    VGNCiVGNC:31077 LTF

    Phylogenomic databases

    eggNOGiENOG410IEAI Eukaryota
    ENOG410XQ36 LUCA
    GeneTreeiENSGT00940000156055
    HOGENOMiHOG000043759
    InParanoidiP24627
    KOiK17283
    OMAiNKCAFSS
    OrthoDBi232859at2759
    TreeFamiTF324013

    Enzyme and pathway databases

    ReactomeiR-BTA-6798695 Neutrophil degranulation
    R-BTA-6799990 Metal sequestration by antimicrobial proteins
    R-BTA-6803157 Antimicrobial peptides
    SABIO-RKiP24627

    Miscellaneous databases

    EvolutionaryTraceiP24627
    PMAP-CutDBiP24627

    Gene expression databases

    BgeeiENSBTAG00000001292 Expressed in 9 organ(s), highest expression level in colon
    ExpressionAtlasiP24627 baseline and differential

    Family and domain databases

    InterProiView protein in InterPro
    IPR030684 Lactotransferrin
    IPR016357 Transferrin
    IPR001156 Transferrin-like_dom
    IPR018195 Transferrin_Fe_BS
    PfamiView protein in Pfam
    PF00405 Transferrin, 2 hits
    PIRSFiPIRSF500683 Lactotransferrin, 1 hit
    PIRSF002549 Transferrin, 1 hit
    PRINTSiPR00422 TRANSFERRIN
    SMARTiView protein in SMART
    SM00094 TR_FER, 2 hits
    PROSITEiView protein in PROSITE
    PS00205 TRANSFERRIN_LIKE_1, 2 hits
    PS00206 TRANSFERRIN_LIKE_2, 2 hits
    PS00207 TRANSFERRIN_LIKE_3, 2 hits
    PS51408 TRANSFERRIN_LIKE_4, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRFL_BOVIN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24627
    Secondary accession number(s): Q1JQC9
    , Q29629, Q6LEC7, Q9MZY3
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: October 1, 1993
    Last modified: May 8, 2019
    This is version 186 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
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