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Protein

Alpha-crystallin A chain

Gene

Cryaa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102Zinc 1By similarity1
Metal bindingi123Zinc 2By similarity1
Metal bindingi125Zinc 2By similarity1
Metal bindingi130Zinc 1By similarity1
Metal bindingi138Zinc 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Eye lens protein
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-crystallin A chain
Gene namesi
Name:Cryaa
Synonyms:Crya1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:88515 Cryaa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001258721 – 196Alpha-crystallin A chainAdd BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarityCurated1
Modified residuei6Deamidated glutamine; partialBy similarity1
Modified residuei21Omega-N-methylated arginineBy similarity1
Modified residuei45PhosphoserineBy similarity1
Modified residuei50Deamidated glutamine; partialBy similarity1
Modified residuei93N6-acetyllysineBy similarity1
Modified residuei122N6-acetyllysineBy similarity1
Modified residuei124Deamidated asparagine; partialBy similarity1
Modified residuei145PhosphoserineBy similarity1
Modified residuei146Deamidated asparagine; partialBy similarity1
Modified residuei170Deamidated glutamine; partialBy similarity1
Glycosylationi185O-linked (GlcNAc) serineBy similarity1

Post-translational modificationi

Acetylation at Lys-93 seems to increase chaperone activity.By similarity
Undergoes age-dependent proteolytical cleavage at the C-terminus.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP24622
PRIDEiP24622

PTM databases

iPTMnetiP24622
PhosphoSitePlusiP24622
UniCarbKBiP24622

Expressioni

Gene expression databases

BgeeiENSMUSG00000024041 Expressed in 64 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_CRYAA
ExpressionAtlasiP24622 baseline and differential
GenevisibleiP24622 MM

Interactioni

Subunit structurei

Heteropolymer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and higher homooligomers (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019192

Structurei

3D structure databases

ProteinModelPortaliP24622
SMRiP24622
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 185sHSPPROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000233954
HOVERGENiHBG054766
InParanoidiP24622
KOiK09541
OMAiGERQDDH
OrthoDBiEOG091G0USC
PhylomeDBiP24622
TreeFamiTF105049

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR012274 Alpha-crystallin_A
IPR003090 Alpha-crystallin_N
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PTHR11527:SF36 PTHR11527:SF36, 1 hit
PfamiView protein in Pfam
PF00525 Crystallin, 1 hit
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P24622-1) [UniParc]FASTAAdd to basket
Also known as: Minor, Alpha-A(ins)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVTIQHPWF KRALGPFYPS RLFDQFFGEG LFEYDLLPFL SSTISPYYRQ
60 70 80 90 100
SLFRTVLDSG ISELMTHMWF VMHQPHAGNP KNNPVKVRSD RDKFVIFLDV
110 120 130 140 150
KHFSPEDLTV KVLEDFVEIH GKHNERQDDH GYISREFHRR YRLPSNVDQS
160 170 180 190
ALSCSLSADG MLTFSGPKVQ SGLDAGHSER AIPVSREEKP SSAPSS
Note: Constitutes approximately 10% of the total alpha-A-crystallin in the lens.
Length:196
Mass (Da):22,489
Last modified:March 1, 1992 - v1
Checksum:iA6063BB21EEB8E78
GO
Isoform 2 (identifier: P24622-2) [UniParc]FASTAAdd to basket
Also known as: Major

The sequence of this isoform differs from the canonical sequence as follows:
     64-86: Missing.

Show »
Length:173
Mass (Da):19,792
Checksum:iE146E3F488591F93
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01191664 – 86Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00730 Genomic DNA Translation: CAA24108.2
V00730 Genomic DNA Translation: CAA24109.2
J00375 Genomic DNA Translation: AAA37469.1
J00375 Genomic DNA Translation: AAA37470.1
J00376 mRNA Translation: AAA37471.1
CCDSiCCDS37551.1 [P24622-1]
PIRiA02893 CYMSA
B18860
RefSeqiNP_038529.1, NM_013501.3 [P24622-1]
UniGeneiMm.1228

Genome annotation databases

EnsembliENSMUST00000019192; ENSMUSP00000019192; ENSMUSG00000024041 [P24622-1]
ENSMUST00000228716; ENSMUSP00000154747; ENSMUSG00000024041 [P24622-2]
GeneIDi12954
KEGGimmu:12954
UCSCiuc008bvp.2 mouse [P24622-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00730 Genomic DNA Translation: CAA24108.2
V00730 Genomic DNA Translation: CAA24109.2
J00375 Genomic DNA Translation: AAA37469.1
J00375 Genomic DNA Translation: AAA37470.1
J00376 mRNA Translation: AAA37471.1
CCDSiCCDS37551.1 [P24622-1]
PIRiA02893 CYMSA
B18860
RefSeqiNP_038529.1, NM_013501.3 [P24622-1]
UniGeneiMm.1228

3D structure databases

ProteinModelPortaliP24622
SMRiP24622
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019192

PTM databases

iPTMnetiP24622
PhosphoSitePlusiP24622
UniCarbKBiP24622

Proteomic databases

PaxDbiP24622
PRIDEiP24622

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019192; ENSMUSP00000019192; ENSMUSG00000024041 [P24622-1]
ENSMUST00000228716; ENSMUSP00000154747; ENSMUSG00000024041 [P24622-2]
GeneIDi12954
KEGGimmu:12954
UCSCiuc008bvp.2 mouse [P24622-1]

Organism-specific databases

CTDi1409
MGIiMGI:88515 Cryaa

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000233954
HOVERGENiHBG054766
InParanoidiP24622
KOiK09541
OMAiGERQDDH
OrthoDBiEOG091G0USC
PhylomeDBiP24622
TreeFamiTF105049

Miscellaneous databases

ChiTaRSiCryaa mouse
PROiPR:P24622
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024041 Expressed in 64 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_CRYAA
ExpressionAtlasiP24622 baseline and differential
GenevisibleiP24622 MM

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR012274 Alpha-crystallin_A
IPR003090 Alpha-crystallin_N
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PTHR11527:SF36 PTHR11527:SF36, 1 hit
PfamiView protein in Pfam
PF00525 Crystallin, 1 hit
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRYAA_MOUSE
AccessioniPrimary (citable) accession number: P24622
Secondary accession number(s): P02490
, P02496, P82532, Q61444, Q6LEL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 1, 1992
Last modified: September 12, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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