UniProtKB - P24594 (IBP5_RAT)
Protein
Insulin-like growth factor-binding protein 5
Gene
Igfbp5
Organism
Rattus norvegicus (Rat)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
GO - Molecular functioni
- fibronectin binding Source: RGD
- insulin-like growth factor binding Source: RGD
- insulin-like growth factor I binding Source: RGD
- insulin-like growth factor II binding Source: GO_Central
GO - Biological processi
- aging Source: RGD
- cellular response to cAMP Source: RGD
- cellular response to organic cyclic compound Source: RGD
- female pregnancy Source: RGD
- glucose homeostasis Source: RGD
- hair follicle morphogenesis Source: RGD
- intracellular signal transduction Source: RGD
- lung alveolus development Source: RGD
- mammary gland involution Source: RGD
- negative regulation of cell migration Source: RGD
- negative regulation of growth Source: RGD
- negative regulation of insulin-like growth factor receptor signaling pathway Source: RGD
- negative regulation of muscle tissue development Source: RGD
- negative regulation of osteoblast differentiation Source: RGD
- negative regulation of skeletal muscle hypertrophy Source: RGD
- negative regulation of smooth muscle cell migration Source: RGD
- negative regulation of smooth muscle cell proliferation Source: RGD
- negative regulation of translation Source: RGD
- osteoblast differentiation Source: RGD
- positive regulation of insulin-like growth factor receptor signaling pathway Source: RGD
- positive regulation of protein kinase B signaling Source: RGD
- positive regulation of vascular associated smooth muscle cell migration Source: RGD
- positive regulation of vascular associated smooth muscle cell proliferation Source: RGD
- regulation of cell growth Source: RGD
- regulation of growth Source: RGD
- regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
- response to growth hormone Source: AgBase
- striated muscle cell differentiation Source: RGD
- type B pancreatic cell proliferation Source: RGD
Keywordsi
Molecular function | Growth factor binding |
Enzyme and pathway databases
Reactomei | R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-RNO-8957275, Post-translational protein phosphorylation |
Protein family/group databases
MEROPSi | I31.952 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 5Short name: IBP-5 Short name: IGF-binding protein 5 Short name: IGFBP-5 |
Gene namesi | Name:Igfbp5 Synonyms:Igfbp-5 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2876, Igfbp5 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
- insulin-like growth factor ternary complex Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000014388 | 20 – 271 | Insulin-like growth factor-binding protein 5Add BLAST | 252 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 58 | PROSITE-ProRule annotation | ||
Disulfide bondi | 66 ↔ 79 | PROSITE-ProRule annotation | ||
Modified residuei | 115 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 191 ↔ 218 | PROSITE-ProRule annotation | ||
Disulfide bondi | 229 ↔ 240 | PROSITE-ProRule annotation | ||
Disulfide bondi | 242 ↔ 262 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
PaxDbi | P24594 |
PRIDEi | P24594 |
PTM databases
iPTMneti | P24594 |
PhosphoSitePlusi | P24594 |
Expressioni
Tissue specificityi
Mostly in kidney.
Gene expression databases
Bgeei | ENSRNOG00000017206, Expressed in esophagus and 20 other tissues |
ExpressionAtlasi | P24594, baseline and differential |
Genevisiblei | P24594, RN |
Interactioni
GO - Molecular functioni
- fibronectin binding Source: RGD
- insulin-like growth factor binding Source: RGD
- insulin-like growth factor I binding Source: RGD
- insulin-like growth factor II binding Source: GO_Central
Protein-protein interaction databases
MINTi | P24594 |
STRINGi | 10116.ENSRNOP00000023530 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 102 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 188 – 262 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 75 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QUPK, Eukaryota |
GeneTreei | ENSGT00940000155890 |
InParanoidi | P24594 |
OMAi | YTERCAL |
OrthoDBi | 979270at2759 |
PhylomeDBi | P24594 |
TreeFami | TF331211 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012213, IGFBP-5 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF4, PTHR11551:SF4, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01981, IGFBPFAMILY5 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P24594-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVISVVLLLL AACAVPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP
60 70 80 90 100
GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL
110 120 130 140 150
NEKSYGEQTK IERDSREHEE PTTSEMAEET YSPKVFRPKH TRISELKAEA
160 170 180 190 200
VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP EMRQESDQGP CRRHMEASLQ
210 220 230 240 250
EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL
260 270
PGMEYVDGDF QCHAFDSSNV E
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JVW1 | A0A0G2JVW1_RAT | Insulin-like growth factor-binding ... | Igfbp5 | 271 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M62781 mRNA Translation: AAA53533.1 L08275 Genomic DNA No translation available. |
PIRi | JC1463 |
RefSeqi | NP_036949.1, NM_012817.1 |
Genome annotation databases
Ensembli | ENSRNOT00000023530; ENSRNOP00000023530; ENSRNOG00000017206 |
GeneIDi | 25285 |
KEGGi | rno:25285 |
UCSCi | RGD:2876, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M62781 mRNA Translation: AAA53533.1 L08275 Genomic DNA No translation available. |
PIRi | JC1463 |
RefSeqi | NP_036949.1, NM_012817.1 |
3D structure databases
SMRi | P24594 |
ModBasei | Search... |
Protein-protein interaction databases
MINTi | P24594 |
STRINGi | 10116.ENSRNOP00000023530 |
Protein family/group databases
MEROPSi | I31.952 |
PTM databases
iPTMneti | P24594 |
PhosphoSitePlusi | P24594 |
Proteomic databases
PaxDbi | P24594 |
PRIDEi | P24594 |
Genome annotation databases
Ensembli | ENSRNOT00000023530; ENSRNOP00000023530; ENSRNOG00000017206 |
GeneIDi | 25285 |
KEGGi | rno:25285 |
UCSCi | RGD:2876, rat |
Organism-specific databases
CTDi | 3488 |
RGDi | 2876, Igfbp5 |
Phylogenomic databases
eggNOGi | ENOG502QUPK, Eukaryota |
GeneTreei | ENSGT00940000155890 |
InParanoidi | P24594 |
OMAi | YTERCAL |
OrthoDBi | 979270at2759 |
PhylomeDBi | P24594 |
TreeFami | TF331211 |
Enzyme and pathway databases
Reactomei | R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-RNO-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
PROi | PR:P24594 |
Gene expression databases
Bgeei | ENSRNOG00000017206, Expressed in esophagus and 20 other tissues |
ExpressionAtlasi | P24594, baseline and differential |
Genevisiblei | P24594, RN |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012213, IGFBP-5 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF4, PTHR11551:SF4, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01981, IGFBPFAMILY5 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP5_RAT | |
Accessioni | P24594Primary (citable) accession number: P24594 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |