UniProtKB - P24593 (IBP5_HUMAN)
Protein
Insulin-like growth factor-binding protein 5
Gene
IGFBP5
Organism
Homo sapiens (Human)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
GO - Molecular functioni
- fibronectin binding Source: GO_Central
- insulin-like growth factor I binding Source: BHF-UCL
- insulin-like growth factor II binding Source: GO_Central
GO - Biological processi
- aging Source: Ensembl
- cellular protein metabolic process Source: Reactome
- cellular response to cAMP Source: UniProtKB
- cellular response to organic cyclic compound Source: UniProtKB
- female pregnancy Source: Ensembl
- glucose homeostasis Source: Ensembl
- hair follicle morphogenesis Source: Ensembl
- intracellular signal transduction Source: Ensembl
- lung alveolus development Source: Ensembl
- mammary gland involution Source: Ensembl
- negative regulation of cell migration Source: BHF-UCL
- negative regulation of growth Source: Ensembl
- negative regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
- negative regulation of muscle tissue development Source: Ensembl
- negative regulation of osteoblast differentiation Source: Ensembl
- negative regulation of skeletal muscle hypertrophy Source: Ensembl
- negative regulation of smooth muscle cell migration Source: BHF-UCL
- negative regulation of smooth muscle cell proliferation Source: BHF-UCL
- negative regulation of translation Source: BHF-UCL
- osteoblast differentiation Source: Ensembl
- positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
- positive regulation of protein kinase B signaling Source: Ensembl
- positive regulation of vascular associated smooth muscle cell migration Source: BHF-UCL
- positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
- post-translational protein modification Source: Reactome
- regulation of cell growth Source: Ensembl
- regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
- response to growth hormone Source: AgBase
- signal transduction Source: ProtInc
- striated muscle cell differentiation Source: Ensembl
- type B pancreatic cell proliferation Source: Ensembl
Keywordsi
Molecular function | Growth factor binding |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000115461-MONOMER |
PathwayCommonsi | P24593 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SIGNORi | P24593 |
Protein family/group databases
MEROPSi | I31.952 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 5Short name: IBP-5 Short name: IGF-binding protein 5 Short name: IGFBP-5 |
Gene namesi | Name:IGFBP5 Synonyms:IBP5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5474, IGFBP5 |
MIMi | 146734, gene |
neXtProti | NX_P24593 |
VEuPathDBi | HostDB:ENSG00000115461.4 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
- insulin-like growth factor binding protein complex Source: BHF-UCL
- insulin-like growth factor ternary complex Source: BHF-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 3488 |
OpenTargetsi | ENSG00000115461 |
PharmGKBi | PA29707 |
Miscellaneous databases
Pharosi | P24593, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2665 |
DrugBanki | DB01277, Mecasermin |
Genetic variation databases
BioMutai | IGFBP5 |
DMDMi | 124069 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000014385 | 21 – 272 | Insulin-like growth factor-binding protein 5Add BLAST | 252 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 45 ↔ 59 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 67 ↔ 80 | PROSITE-ProRule annotation1 Publication | ||
Modified residuei | 116 | Phosphoserine; by FAM20C1 Publication | 1 | |
Glycosylationi | 172 | O-linked (HexNAc...) threonine1 Publication | 1 | |
Disulfide bondi | 192 ↔ 219 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 230 ↔ 241 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 243 ↔ 263 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | P24593 |
MassIVEi | P24593 |
PaxDbi | P24593 |
PeptideAtlasi | P24593 |
PRIDEi | P24593 |
ProteomicsDBi | 54219 |
PTM databases
GlyGeni | P24593, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | P24593 |
PhosphoSitePlusi | P24593 |
Expressioni
Tissue specificityi
Osteosarcoma, and at lower levels in liver, kidney and brain.
Gene expression databases
Bgeei | ENSG00000115461, Expressed in metanephric glomerulus and 254 other tissues |
ExpressionAtlasi | P24593, baseline and differential |
Genevisiblei | P24593, HS |
Organism-specific databases
HPAi | ENSG00000115461, Tissue enhanced (ovary) |
Interactioni
Binary interactionsi
P24593
GO - Molecular functioni
- fibronectin binding Source: GO_Central
- insulin-like growth factor I binding Source: BHF-UCL
- insulin-like growth factor II binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 109709, 97 interactors |
DIPi | DIP-48433N |
IntActi | P24593, 81 interactors |
STRINGi | 9606.ENSP00000233813 |
Chemistry databases
BindingDBi | P24593 |
Miscellaneous databases
RNActi | P24593, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P24593 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P24593 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 103 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 189 – 263 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 75 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QUPK, Eukaryota |
GeneTreei | ENSGT00940000155890 |
HOGENOMi | CLU_070833_1_1_1 |
InParanoidi | P24593 |
OMAi | YTERCAL |
OrthoDBi | 979270at2759 |
PhylomeDBi | P24593 |
TreeFami | TF331211 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012213, IGFBP-5 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF4, PTHR11551:SF4, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01981, IGFBPFAMILY5 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P24593-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE
60 70 80 90 100
PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC
110 120 130 140 150
LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE
160 170 180 190 200
AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL
210 220 230 240 250
QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK
260 270
LPGMEYVDGD FQCHTFDSSN VE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JXX4 | C9JXX4_HUMAN | Insulin-like growth factor-binding ... | IGFBP5 | 233 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019284 | 138 | R → W1 PublicationCorresponds to variant dbSNP:rs11575194Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M65062 mRNA Translation: AAD04730.1 M62782 mRNA Translation: AAA53505.1 L27559 , L27556, L27557, L27558 Genomic DNA Translation: AAA72051.1 AF055033 mRNA Translation: AAC09368.1 BT019706 mRNA Translation: AAV38512.1 BT019707 mRNA Translation: AAV38513.1 AY534685 Genomic DNA Translation: AAS16353.1 BC011453 mRNA Translation: AAH11453.1 |
CCDSi | CCDS2405.1 |
PIRi | A53748 |
RefSeqi | NP_000590.1, NM_000599.3 |
Genome annotation databases
Ensembli | ENST00000233813; ENSP00000233813; ENSG00000115461 |
GeneIDi | 3488 |
KEGGi | hsa:3488 |
UCSCi | uc002vgj.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M65062 mRNA Translation: AAD04730.1 M62782 mRNA Translation: AAA53505.1 L27559 , L27556, L27557, L27558 Genomic DNA Translation: AAA72051.1 AF055033 mRNA Translation: AAC09368.1 BT019706 mRNA Translation: AAV38512.1 BT019707 mRNA Translation: AAV38513.1 AY534685 Genomic DNA Translation: AAS16353.1 BC011453 mRNA Translation: AAH11453.1 |
CCDSi | CCDS2405.1 |
PIRi | A53748 |
RefSeqi | NP_000590.1, NM_000599.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BOE | NMR | - | A | 60-106 | [»] | |
1H59 | X-ray | 2.10 | B | 60-112 | [»] | |
SMRi | P24593 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109709, 97 interactors |
DIPi | DIP-48433N |
IntActi | P24593, 81 interactors |
STRINGi | 9606.ENSP00000233813 |
Chemistry databases
BindingDBi | P24593 |
ChEMBLi | CHEMBL2665 |
DrugBanki | DB01277, Mecasermin |
Protein family/group databases
MEROPSi | I31.952 |
PTM databases
GlyGeni | P24593, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | P24593 |
PhosphoSitePlusi | P24593 |
Genetic variation databases
BioMutai | IGFBP5 |
DMDMi | 124069 |
Proteomic databases
jPOSTi | P24593 |
MassIVEi | P24593 |
PaxDbi | P24593 |
PeptideAtlasi | P24593 |
PRIDEi | P24593 |
ProteomicsDBi | 54219 |
Protocols and materials databases
Antibodypediai | 3978, 437 antibodies |
DNASUi | 3488 |
Genome annotation databases
Ensembli | ENST00000233813; ENSP00000233813; ENSG00000115461 |
GeneIDi | 3488 |
KEGGi | hsa:3488 |
UCSCi | uc002vgj.5, human |
Organism-specific databases
CTDi | 3488 |
DisGeNETi | 3488 |
GeneCardsi | IGFBP5 |
HGNCi | HGNC:5474, IGFBP5 |
HPAi | ENSG00000115461, Tissue enhanced (ovary) |
MIMi | 146734, gene |
neXtProti | NX_P24593 |
OpenTargetsi | ENSG00000115461 |
PharmGKBi | PA29707 |
VEuPathDBi | HostDB:ENSG00000115461.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUPK, Eukaryota |
GeneTreei | ENSGT00940000155890 |
HOGENOMi | CLU_070833_1_1_1 |
InParanoidi | P24593 |
OMAi | YTERCAL |
OrthoDBi | 979270at2759 |
PhylomeDBi | P24593 |
TreeFami | TF331211 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000115461-MONOMER |
PathwayCommonsi | P24593 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
SIGNORi | P24593 |
Miscellaneous databases
BioGRID-ORCSi | 3488, 4 hits in 880 CRISPR screens |
ChiTaRSi | IGFBP5, human |
EvolutionaryTracei | P24593 |
GeneWikii | IGFBP5 |
GenomeRNAii | 3488 |
Pharosi | P24593, Tchem |
PROi | PR:P24593 |
RNActi | P24593, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115461, Expressed in metanephric glomerulus and 254 other tissues |
ExpressionAtlasi | P24593, baseline and differential |
Genevisiblei | P24593, HS |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012213, IGFBP-5 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF4, PTHR11551:SF4, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01981, IGFBPFAMILY5 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP5_HUMAN | |
Accessioni | P24593Primary (citable) accession number: P24593 Secondary accession number(s): Q5U0A3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | February 10, 2021 | |
This is version 213 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references