IGFBP5

Functionⁱ

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functionⁱ

fibronectin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
insulin-like growth factor I binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10766744
insulin-like growth factor II binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
cellular protein metabolic process Source: Reactome
cellular response to cAMP
Source: UniProtKB
Inferred from direct assayⁱ
- 7559606
cellular response to organic cyclic compound
Source: UniProtKB
Inferred from direct assayⁱ
- 7559606
female pregnancy Source: Ensembl
glucose homeostasis Source: Ensembl
glucose metabolic process Source: Ensembl
hair follicle morphogenesis Source: Ensembl
intracellular signal transduction Source: Ensembl
lung alveolus development Source: Ensembl
mammary gland involution Source: Ensembl
negative regulation of cell migration
Source: BHF-UCL
Inferred from direct assayⁱ
- 15700281
negative regulation of growth Source: Ensembl
negative regulation of insulin-like growth factor receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10766744
negative regulation of muscle tissue development Source: Ensembl
negative regulation of osteoblast differentiation Source: Ensembl
negative regulation of skeletal muscle hypertrophy Source: Ensembl
negative regulation of smooth muscle cell migration
Source: BHF-UCL
Inferred from direct assayⁱ
- 10766744
negative regulation of smooth muscle cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10766744
negative regulation of translation
Source: BHF-UCL
Inferred from direct assayⁱ
- 15700281
osteoblast differentiation Source: Ensembl
positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
positive regulation of protein kinase B signaling Source: Ensembl
positive regulation of vascular associated smooth muscle cell migration
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 29016699
positive regulation of vascular smooth muscle cell proliferation
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 29016699
post-translational protein modification Source: Reactome
regulation of cell growth Source: Ensembl
regulation of glucose metabolic process Source: Ensembl
response to growth hormone Source: AgBase
signal transduction
Source: ProtInc
Non-traceable author statementⁱ
- 7525452
striated muscle cell differentiation Source: Ensembl
type B pancreatic cell proliferation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding

Molecular function

Growth factor binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000115461-MONOMER
Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation
SIGNORⁱ	P24593

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 5 Short name: IBP-5 Short name: IGF-binding protein 5 Short name: IGFBP-5
Gene namesⁱ	Name:IGFBP5 Synonyms:IBP5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000115461.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5474 IGFBP5
MIMⁱ	146734 gene
neXtProtⁱ	NX_P24593

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3488
Open Targets More...OpenTargetsⁱ	ENSG00000115461
PharmGKBⁱ	PA29707

Chemistry databases

ChEMBLⁱ	CHEMBL2665

ChEMBLⁱ

CHEMBL2665

Polymorphism and mutation databases

BioMutaⁱ	IGFBP5
DMDMⁱ	124069

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000014385	21 – 272	Insulin-like growth factor-binding protein 5Add BLAST		252

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	45 ↔ 59	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	67 ↔ 80	PROSITE-ProRule annotation1 Publication
Modified residueⁱ	116	Phosphoserine; by FAM20C1 Publication	1
Glycosylationⁱ	172	O-linked (HexNAc...) threonine1 Publication	1
Disulfide bondⁱ	192 ↔ 219	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	230 ↔ 241	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	243 ↔ 263	PROSITE-ProRule annotation1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P24593
PaxDbⁱ	P24593
PeptideAtlas More...PeptideAtlasⁱ	P24593
PRIDEⁱ	P24593
ProteomicsDBⁱ	54219

PTM databases

iPTMnetⁱ	P24593
PhosphoSitePlusⁱ	P24593

Miscellaneous databases

PMAP-CutDBⁱ	P24593

PMAP-CutDBⁱ

P24593

Expressionⁱ

Tissue specificityⁱ

Osteosarcoma, and at lower levels in liver, kidney and brain.

Gene expression databases

Bgeeⁱ	ENSG00000115461 Expressed in 247 organ(s), highest expression level in metanephric glomerulus
CleanExⁱ	HS_IGFBP5
ExpressionAtlasⁱ	P24593 baseline and differential
Genevisibleⁱ	P24593 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA059827

HPAⁱ

HPA059827

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CREB3	O43889-2	3	EBI-720480,EBI-625022

With

Entry

#Exp.

IntAct

Notes

CREB3

O43889-2

3

EBI-720480,EBI-625022

GO - Molecular functionⁱ

fibronectin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
insulin-like growth factor I binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10766744
insulin-like growth factor II binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109709, 23 interactors
Database of interacting proteins More...DIPⁱ	DIP-48433N
IntActⁱ	P24593, 66 interactors
STRINGⁱ	9606.ENSP00000233813

Chemistry databases

BindingDBⁱ

P24593

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	79 – 81	Combined sources	3
Turnⁱ	84 – 86	Combined sources	3
Helixⁱ	89 – 94	Combined sources	6
Beta strandⁱ	98 – 101	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P24593
SMRⁱ	P24593
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P24593

EvolutionaryTraceⁱ

P24593

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	23 – 103	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST		81
Domainⁱ	189 – 263	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		75

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IJJ2 Eukaryota ENOG4111GGG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P24593
OMAⁱ	LPIDKHE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EIN
PhylomeDBⁱ	P24593
TreeFamⁱ	TF331211

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR012213 IGFBP-5 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF4 PTHR11551:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01981 IGFBPFAMILY5
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P24593-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE 
        60         70         80         90        100
PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC 
       110        120        130        140        150
LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE 
       160        170        180        190        200
AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL 
       210        220        230        240        250
QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK 
       260        270 
LPGMEYVDGD FQCHTFDSSN VE

Length:272

Mass (Da):30,570

Last modified:March 1, 1992 - v1

Checksum:ⁱ0A7AD37C6EEA3A81

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9JXX4	C9JXX4_HUMAN		Insulin-like growth factor-binding ... Insulin-like growth factor-binding protein 5	IGFBP5	233	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_019284	138	R → W1 PublicationCorresponds to variant dbSNP:rs11575194Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M65062 mRNA Translation: AAD04730.1 M62782 mRNA Translation: AAA53505.1 L27559 , L27556, L27557, L27558 Genomic DNA Translation: AAA72051.1 AF055033 mRNA Translation: AAC09368.1 BT019706 mRNA Translation: AAV38512.1 BT019707 mRNA Translation: AAV38513.1 AY534685 Genomic DNA Translation: AAS16353.1 BC011453 mRNA Translation: AAH11453.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2405.1
PIRⁱ	A53748
NCBI Reference Sequences More...RefSeqⁱ	NP_000590.1, NM_000599.3
UniGeneⁱ	Hs.607212

Genome annotation databases

Ensemblⁱ	ENST00000233813; ENSP00000233813; ENSG00000115461
GeneIDⁱ	3488
KEGGⁱ	hsa:3488
UCSC genome browser More...UCSCⁱ	uc002vgj.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24593	Insulin-like growth factor binding protein 5, isoform CRA_a		HUMAN		272	UniRef100_P24593

Protein	Similar proteins		Species	Score	Length	Source
P24593	Insulin-like growth factor-binding protein 5		RAT		271	UniRef90_P24593
Insulin-like growth factor-binding protein 5		PIG		271
Insulin-like growth factor-binding protein 5		MOUSE		271
Insulin-like growth factor-binding protein 5		BOVIN		271
Insulin-like growth factor binding protein 5, isoform CRA_a		HUMAN		272
+122

Protein	Similar proteins		Species	Score	Length	Source
P24593	Insulin-like growth factor-binding protein 5		PIG		271	UniRef50_P24593
Insulin-like growth factor-binding protein 5		MOUSE		271
Insulin-like growth factor-binding protein 5		RAT		271
Insulin-like growth factor-binding protein 5		BOVIN		271
Insulin-like growth factor binding protein 5, isoform CRA_a		HUMAN		272
+176

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M65062 mRNA Translation: AAD04730.1 M62782 mRNA Translation: AAA53505.1 L27559 , L27556, L27557, L27558 Genomic DNA Translation: AAA72051.1 AF055033 mRNA Translation: AAC09368.1 BT019706 mRNA Translation: AAV38512.1 BT019707 mRNA Translation: AAV38513.1 AY534685 Genomic DNA Translation: AAS16353.1 BC011453 mRNA Translation: AAH11453.1
CCDSⁱ	CCDS2405.1
PIRⁱ	A53748
RefSeqⁱ	NP_000590.1, NM_000599.3
UniGeneⁱ	Hs.607212

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BOE	NMR	-	A	60-106	[»]
	1H59	X-ray	2.10	B	60-112	[»]
ProteinModelPortalⁱ	P24593
SMRⁱ	P24593
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109709, 23 interactors
DIPⁱ	DIP-48433N
IntActⁱ	P24593, 66 interactors
STRINGⁱ	9606.ENSP00000233813

Chemistry databases

BindingDBⁱ	P24593
ChEMBLⁱ	CHEMBL2665

Protein family/group databases

MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

PTM databases

iPTMnetⁱ	P24593
PhosphoSitePlusⁱ	P24593

Polymorphism and mutation databases

BioMutaⁱ	IGFBP5
DMDMⁱ	124069

Proteomic databases

EPDⁱ	P24593
PaxDbⁱ	P24593
PeptideAtlasⁱ	P24593
PRIDEⁱ	P24593
ProteomicsDBⁱ	54219

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3488
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000233813; ENSP00000233813; ENSG00000115461
GeneIDⁱ	3488
KEGGⁱ	hsa:3488
UCSCⁱ	uc002vgj.5 human

Organism-specific databases

CTDⁱ	3488
DisGeNETⁱ	3488
EuPathDBⁱ	HostDB:ENSG00000115461.4
GeneCardsⁱ	IGFBP5
HGNCⁱ	HGNC:5474 IGFBP5
HPAⁱ	HPA059827
MIMⁱ	146734 gene
neXtProtⁱ	NX_P24593
OpenTargetsⁱ	ENSG00000115461
PharmGKBⁱ	PA29707
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJJ2 Eukaryota ENOG4111GGG LUCA
GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P24593
OMAⁱ	LPIDKHE
OrthoDBⁱ	EOG091G0EIN
PhylomeDBⁱ	P24593
TreeFamⁱ	TF331211

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000115461-MONOMER
Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation
SIGNORⁱ	P24593

Miscellaneous databases

ChiTaRSⁱ	IGFBP5 human
EvolutionaryTraceⁱ	P24593
GeneWikiⁱ	IGFBP5
GenomeRNAiⁱ	3488
PMAP-CutDBⁱ	P24593
Protein Ontology More...PROⁱ	PR:P24593
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000115461 Expressed in 247 organ(s), highest expression level in metanephric glomerulus
CleanExⁱ	HS_IGFBP5
ExpressionAtlasⁱ	P24593 baseline and differential
Genevisibleⁱ	P24593 HS

Family and domain databases

CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR012213 IGFBP-5 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF4 PTHR11551:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01981 IGFBPFAMILY5
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IBP5_HUMAN
Accessionⁱ	P24593Primary (citable) accession number: P24593 Secondary accession number(s): Q5U0A3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	March 1, 1992
	Last modified:	November 7, 2018
	This is version 197 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P24593 (IBP5_HUMAN)

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Insulin-like growth factor-binding protein 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ