Insulin-like growth factor-binding protein 5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• fibronectin binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor I binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions."
    Imai Y., Moralez A., Andag U., Clarke J.B., Busby W.H. Jr., Clemmons D.R.
    J. Biol. Chem. 275:18188-18194(2000) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor II binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• aging Source: Ensembl
• cellular protein metabolic process Source: Reactome
• cellular response to cAMP Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression."
    Duan C., Clemmons D.R.
    J. Biol. Chem. 270:24844-24851(1995) [PubMed] [Europe PMC] [Abstract]
• cellular response to organic cyclic compound Source: UniProtKBInferred from direct assayⁱ
  • "Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression."
    Duan C., Clemmons D.R.
    J. Biol. Chem. 270:24844-24851(1995) [PubMed] [Europe PMC] [Abstract]
• female pregnancy Source: Ensembl
• glucose homeostasis Source: Ensembl
• hair follicle morphogenesis Source: Ensembl
• intracellular signal transduction Source: Ensembl
• lung alveolus development Source: Ensembl
• mammary gland involution Source: Ensembl
• negative regulation of cell migration Source: BHF-UCLInferred from direct assayⁱ
  • "Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions."
    Moralez A.M., Maile L.A., Clarke J., Busby W.H. Jr., Clemmons D.R.
    J. Cell. Physiol. 203:328-334(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of growth Source: Ensembl
• negative regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions."
    Imai Y., Moralez A., Andag U., Clarke J.B., Busby W.H. Jr., Clemmons D.R.
    J. Biol. Chem. 275:18188-18194(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of muscle tissue development Source: Ensembl
• negative regulation of osteoblast differentiation Source: Ensembl
• negative regulation of skeletal muscle hypertrophy Source: Ensembl
• negative regulation of smooth muscle cell migration Source: BHF-UCLInferred from direct assayⁱ
  • "Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions."
    Imai Y., Moralez A., Andag U., Clarke J.B., Busby W.H. Jr., Clemmons D.R.
    J. Biol. Chem. 275:18188-18194(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of smooth muscle cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • "Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions."
    Imai Y., Moralez A., Andag U., Clarke J.B., Busby W.H. Jr., Clemmons D.R.
    J. Biol. Chem. 275:18188-18194(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of translation Source: BHF-UCLInferred from direct assayⁱ
  • "Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions."
    Moralez A.M., Maile L.A., Clarke J., Busby W.H. Jr., Clemmons D.R.
    J. Cell. Physiol. 203:328-334(2005) [PubMed] [Europe PMC] [Abstract]
• osteoblast differentiation Source: Ensembl
• positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
• positive regulation of protein kinase B signaling Source: Ensembl
• positive regulation of vascular associated smooth muscle cell migration Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "MiR-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR/STAT3 signaling."
    Pan J., Li K., Huang W., Zhang X.
    PLoS ONE 12:e0186245-e0186245(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCLInferred from genetic interactionⁱ
  • "MiR-137 inhibited cell proliferation and migration of vascular smooth muscle cells via targeting IGFBP-5 and modulating the mTOR/STAT3 signaling."
    Pan J., Li K., Huang W., Zhang X.
    PLoS ONE 12:e0186245-e0186245(2017) [PubMed] [Europe PMC] [Abstract]
• post-translational protein modification Source: Reactome
• regulation of cell growth Source: Ensembl
• regulation of insulin-like growth factor receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to growth hormone Source: AgBase
• signal transduction Source: ProtInc <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11."
    Kou K., James P.L., Clemmons D.R., Copeland N.G., Gilbert D.J., Jenkins N.A., Rotwein P.
    Genomics 21:653-655(1994) [PubMed] [Europe PMC] [Abstract]
• striated muscle cell differentiation Source: Ensembl
• type B pancreatic cell proliferation Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

        10         20         30         40         50
MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE 
        60         70         80         90        100
PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC 
       110        120        130        140        150
LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE 
       160        170        180        190        200
AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL 
       210        220        230        240        250
QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK 
       260        270 
LPGMEYVDGD FQCHTFDSSN VE