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Protein

Insulin-like growth factor-binding protein 5

Gene

IGFBP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  • fibronectin binding Source: GO_Central
  • insulin-like growth factor I binding Source: BHF-UCL
  • insulin-like growth factor II binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000115461-MONOMER
ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiP24593

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 5
Short name:
IBP-5
Short name:
IGF-binding protein 5
Short name:
IGFBP-5
Gene namesi
Name:IGFBP5
Synonyms:IBP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115461.4
HGNCiHGNC:5474 IGFBP5
MIMi146734 gene
neXtProtiNX_P24593

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3488
OpenTargetsiENSG00000115461
PharmGKBiPA29707

Chemistry databases

ChEMBLiCHEMBL2665

Polymorphism and mutation databases

BioMutaiIGFBP5
DMDMi124069

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001438521 – 272Insulin-like growth factor-binding protein 5Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 59PROSITE-ProRule annotation1 Publication
Disulfide bondi67 ↔ 80PROSITE-ProRule annotation1 Publication
Modified residuei116Phosphoserine; by FAM20C1 Publication1
Glycosylationi172O-linked (HexNAc...) threonine1 Publication1
Disulfide bondi192 ↔ 219PROSITE-ProRule annotation1 Publication
Disulfide bondi230 ↔ 241PROSITE-ProRule annotation1 Publication
Disulfide bondi243 ↔ 263PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP24593
PaxDbiP24593
PeptideAtlasiP24593
PRIDEiP24593
ProteomicsDBi54219

PTM databases

iPTMnetiP24593
PhosphoSitePlusiP24593

Miscellaneous databases

PMAP-CutDBiP24593

Expressioni

Tissue specificityi

Osteosarcoma, and at lower levels in liver, kidney and brain.

Gene expression databases

BgeeiENSG00000115461 Expressed in 247 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_IGFBP5
ExpressionAtlasiP24593 baseline and differential
GenevisibleiP24593 HS

Organism-specific databases

HPAiHPA059827

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3O43889-23EBI-720480,EBI-625022

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109709, 23 interactors
DIPiDIP-48433N
IntActiP24593, 66 interactors
STRINGi9606.ENSP00000233813

Chemistry databases

BindingDBiP24593

Structurei

Secondary structure

1272
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP24593
SMRiP24593
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24593

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 103IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST81
Domaini189 – 263Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJJ2 Eukaryota
ENOG4111GGG LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP24593
OMAiLPIDKHE
OrthoDBiEOG091G0EIN
PhylomeDBiP24593
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012213 IGFBP-5
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF4 PTHR11551:SF4, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01981 IGFBPFAMILY5
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P24593-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE
60 70 80 90 100
PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC
110 120 130 140 150
LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE
160 170 180 190 200
AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL
210 220 230 240 250
QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK
260 270
LPGMEYVDGD FQCHTFDSSN VE
Length:272
Mass (Da):30,570
Last modified:March 1, 1992 - v1
Checksum:i0A7AD37C6EEA3A81
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JXX4C9JXX4_HUMAN
Insulin-like growth factor-binding ...
IGFBP5
233Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019284138R → W1 PublicationCorresponds to variant dbSNP:rs11575194Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65062 mRNA Translation: AAD04730.1
M62782 mRNA Translation: AAA53505.1
L27559
, L27556, L27557, L27558 Genomic DNA Translation: AAA72051.1
AF055033 mRNA Translation: AAC09368.1
BT019706 mRNA Translation: AAV38512.1
BT019707 mRNA Translation: AAV38513.1
AY534685 Genomic DNA Translation: AAS16353.1
BC011453 mRNA Translation: AAH11453.1
CCDSiCCDS2405.1
PIRiA53748
RefSeqiNP_000590.1, NM_000599.3
UniGeneiHs.607212

Genome annotation databases

EnsembliENST00000233813; ENSP00000233813; ENSG00000115461
GeneIDi3488
KEGGihsa:3488
UCSCiuc002vgj.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65062 mRNA Translation: AAD04730.1
M62782 mRNA Translation: AAA53505.1
L27559
, L27556, L27557, L27558 Genomic DNA Translation: AAA72051.1
AF055033 mRNA Translation: AAC09368.1
BT019706 mRNA Translation: AAV38512.1
BT019707 mRNA Translation: AAV38513.1
AY534685 Genomic DNA Translation: AAS16353.1
BC011453 mRNA Translation: AAH11453.1
CCDSiCCDS2405.1
PIRiA53748
RefSeqiNP_000590.1, NM_000599.3
UniGeneiHs.607212

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BOENMR-A60-106[»]
1H59X-ray2.10B60-112[»]
ProteinModelPortaliP24593
SMRiP24593
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109709, 23 interactors
DIPiDIP-48433N
IntActiP24593, 66 interactors
STRINGi9606.ENSP00000233813

Chemistry databases

BindingDBiP24593
ChEMBLiCHEMBL2665

Protein family/group databases

MEROPSiI31.952

PTM databases

iPTMnetiP24593
PhosphoSitePlusiP24593

Polymorphism and mutation databases

BioMutaiIGFBP5
DMDMi124069

Proteomic databases

EPDiP24593
PaxDbiP24593
PeptideAtlasiP24593
PRIDEiP24593
ProteomicsDBi54219

Protocols and materials databases

DNASUi3488
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233813; ENSP00000233813; ENSG00000115461
GeneIDi3488
KEGGihsa:3488
UCSCiuc002vgj.5 human

Organism-specific databases

CTDi3488
DisGeNETi3488
EuPathDBiHostDB:ENSG00000115461.4
GeneCardsiIGFBP5
HGNCiHGNC:5474 IGFBP5
HPAiHPA059827
MIMi146734 gene
neXtProtiNX_P24593
OpenTargetsiENSG00000115461
PharmGKBiPA29707
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJJ2 Eukaryota
ENOG4111GGG LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP24593
OMAiLPIDKHE
OrthoDBiEOG091G0EIN
PhylomeDBiP24593
TreeFamiTF331211

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000115461-MONOMER
ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiP24593

Miscellaneous databases

ChiTaRSiIGFBP5 human
EvolutionaryTraceiP24593
GeneWikiiIGFBP5
GenomeRNAii3488
PMAP-CutDBiP24593
PROiPR:P24593
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115461 Expressed in 247 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_IGFBP5
ExpressionAtlasiP24593 baseline and differential
GenevisibleiP24593 HS

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012213 IGFBP-5
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF4 PTHR11551:SF4, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01981 IGFBPFAMILY5
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIBP5_HUMAN
AccessioniPrimary (citable) accession number: P24593
Secondary accession number(s): Q5U0A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 7, 2018
This is version 197 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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