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Protein

Insulin-like growth factor-binding protein 6

Gene

IGFBP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  • fibronectin binding Source: GO_Central
  • insulin-like growth factor I binding Source: GO_Central
  • insulin-like growth factor II binding Source: CAFA
  • signaling receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 6
Short name:
IBP-6
Short name:
IGF-binding protein 6
Short name:
IGFBP-6
Gene namesi
Name:IGFBP6
Synonyms:IBP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000167779.7
HGNCiHGNC:5475 IGFBP6
MIMi146735 gene
neXtProtiNX_P24592

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3489
OpenTargetsiENSG00000167779
PharmGKBiPA29708

Chemistry databases

ChEMBLiCHEMBL2139

Polymorphism and mutation databases

BioMutaiIGFBP6
DMDMi124068

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 273 PublicationsAdd BLAST27
ChainiPRO_000001438928 – 240Insulin-like growth factor-binding protein 6Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 32PROSITE-ProRule annotation1 Publication
Disulfide bondi40 ↔ 44PROSITE-ProRule annotation1 Publication
Disulfide bondi57 ↔ 63PROSITE-ProRule annotation1 Publication
Disulfide bondi71 ↔ 84PROSITE-ProRule annotation1 Publication
Disulfide bondi78 ↔ 104PROSITE-ProRule annotation1 Publication
Glycosylationi126O-linked (HexNAc...) threonine2 Publications1
Glycosylationi144O-linked (HexNAc...) serineBy similarity1
Glycosylationi145O-linked (HexNAc...) threonineBy similarity1
Glycosylationi146O-linked (HexNAc...) threonineBy similarity1
Glycosylationi152O-linked (HexNAc...) serineBy similarity1
Disulfide bondi163 ↔ 190PROSITE-ProRule annotation1 Publication
Disulfide bondi201 ↔ 212PROSITE-ProRule annotation1 Publication
Disulfide bondi214 ↔ 234PROSITE-ProRule annotation1 Publication

Post-translational modificationi

O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP24592
MaxQBiP24592
PaxDbiP24592
PeptideAtlasiP24592
PRIDEiP24592
ProteomicsDBi54218

PTM databases

GlyConnecti656
iPTMnetiP24592
PhosphoSitePlusiP24592
UniCarbKBiP24592

Expressioni

Gene expression databases

BgeeiENSG00000167779 Expressed in 222 organ(s), highest expression level in endocervix
CleanExiHS_IGFBP6
ExpressionAtlasiP24592 baseline and differential
GenevisibleiP24592 HS

Organism-specific databases

HPAiHPA008005

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109710, 8 interactors
IntActiP24592, 34 interactors
STRINGi9606.ENSP00000301464

Chemistry databases

BindingDBiP24592

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00211
ProteinModelPortaliP24592
SMRiP24592
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24592

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 107IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST80
Domaini160 – 234Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVZ3 Eukaryota
ENOG410YQXU LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP24592
OMAiRPNPGGV
OrthoDBiEOG091G0L46
PhylomeDBiP24592
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR022326 IGFBP-6
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF14 PTHR11551:SF14, 1 hit
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01982 IGFBPFAMILY6
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P24592-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPHRLLPPL LLLLALLLAA SPGGALARCP GCGQGVQAGC PGGCVEEEDG
60 70 80 90 100
GSPAEGCAEA EGCLRREGQE CGVYTPNCAP GLQCHPPKDD EAPLRALLLG
110 120 130 140 150
RGRCLPARAP AVAEENPKES KPQAGTARPQ DVNRRDQQRN PGTSTTPSQP
160 170 180 190 200
NSAGVQDTEM GPCRRHLDSV LQQLQTEVYR GAQTLYVPNC DHRGFYRKRQ
210 220 230 240
CRSSQGQRRG PCWCVDRMGK SLPGSPDGNG SSSCPTGSSG
Length:240
Mass (Da):25,322
Last modified:March 1, 1992 - v1
Checksum:i285308231C025009
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VYK9F8VYK9_HUMAN
Insulin-like growth factor-binding ...
IGFBP6
238Annotation score:
F8VVA5F8VVA5_HUMAN
Insulin-like growth factor-binding ...
IGFBP6
136Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2T → C in AAA88070 (PubMed:1719383).Curated1
Sequence conflicti28 – 29RC → AA AA sequence (PubMed:1697583).Curated2
Sequence conflicti28 – 29RC → LA AA sequence (PubMed:2154495).Curated2
Sequence conflicti32C → H AA sequence (PubMed:1697583).Curated1
Sequence conflicti55 – 57EGC → QGG AA sequence (PubMed:1697583).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018932128R → G1 PublicationCorresponds to variant dbSNP:rs9658616Ensembl.1
Natural variantiVAR_049565134R → L. Corresponds to variant dbSNP:rs34995393Ensembl.1
Natural variantiVAR_018933217R → Q1 PublicationCorresponds to variant dbSNP:rs6413498Ensembl.1
Natural variantiVAR_011907236T → P. Corresponds to variant dbSNP:rs1053134Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62402 mRNA Translation: AAB06187.1
AJ006952 Genomic DNA Translation: CAA07346.1
AY443494 Genomic DNA Translation: AAR05445.1
BC003507 mRNA Translation: AAH03507.1
BC005007 mRNA Translation: AAH05007.1
BC010162 mRNA Translation: AAH10162.1
BC011708 mRNA Translation: AAH11708.1
M69054 mRNA Translation: AAA88070.1
CCDSiCCDS8846.1
PIRiA39842
S05699
RefSeqiNP_002169.1, NM_002178.2
UniGeneiHs.274313

Genome annotation databases

EnsembliENST00000301464; ENSP00000301464; ENSG00000167779
GeneIDi3489
KEGGihsa:3489
UCSCiuc001sbu.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62402 mRNA Translation: AAB06187.1
AJ006952 Genomic DNA Translation: CAA07346.1
AY443494 Genomic DNA Translation: AAR05445.1
BC003507 mRNA Translation: AAH03507.1
BC005007 mRNA Translation: AAH05007.1
BC010162 mRNA Translation: AAH10162.1
BC011708 mRNA Translation: AAH11708.1
M69054 mRNA Translation: AAA88070.1
CCDSiCCDS8846.1
PIRiA39842
S05699
RefSeqiNP_002169.1, NM_002178.2
UniGeneiHs.274313

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RMJNMR-A161-240[»]
DisProtiDP00211
ProteinModelPortaliP24592
SMRiP24592
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109710, 8 interactors
IntActiP24592, 34 interactors
STRINGi9606.ENSP00000301464

Chemistry databases

BindingDBiP24592
ChEMBLiCHEMBL2139

Protein family/group databases

MEROPSiI31.952

PTM databases

GlyConnecti656
iPTMnetiP24592
PhosphoSitePlusiP24592
UniCarbKBiP24592

Polymorphism and mutation databases

BioMutaiIGFBP6
DMDMi124068

Proteomic databases

EPDiP24592
MaxQBiP24592
PaxDbiP24592
PeptideAtlasiP24592
PRIDEiP24592
ProteomicsDBi54218

Protocols and materials databases

DNASUi3489
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301464; ENSP00000301464; ENSG00000167779
GeneIDi3489
KEGGihsa:3489
UCSCiuc001sbu.2 human

Organism-specific databases

CTDi3489
DisGeNETi3489
EuPathDBiHostDB:ENSG00000167779.7
GeneCardsiIGFBP6
HGNCiHGNC:5475 IGFBP6
HPAiHPA008005
MIMi146735 gene
neXtProtiNX_P24592
OpenTargetsiENSG00000167779
PharmGKBiPA29708
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVZ3 Eukaryota
ENOG410YQXU LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP24592
OMAiRPNPGGV
OrthoDBiEOG091G0L46
PhylomeDBiP24592
TreeFamiTF331211

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Miscellaneous databases

EvolutionaryTraceiP24592
GeneWikiiIGFBP6
GenomeRNAii3489
PROiPR:P24592
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167779 Expressed in 222 organ(s), highest expression level in endocervix
CleanExiHS_IGFBP6
ExpressionAtlasiP24592 baseline and differential
GenevisibleiP24592 HS

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR022326 IGFBP-6
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF14 PTHR11551:SF14, 1 hit
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01982 IGFBPFAMILY6
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIBP6_HUMAN
AccessioniPrimary (citable) accession number: P24592
Secondary accession number(s): Q14492
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 7, 2018
This is version 190 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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