UniProtKB - P24592 (IBP6_HUMAN)
Protein
Insulin-like growth factor-binding protein 6
Gene
IGFBP6
Organism
Homo sapiens (Human)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration (PubMed:24003225).1 Publication
GO - Molecular functioni
- fibronectin binding Source: GO_Central
- identical protein binding Source: IntAct
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: CAFA
- signaling receptor binding Source: ParkinsonsUK-UCL
GO - Biological processi
- activation of MAPK activity Source: UniProtKB
- cell migration Source: UniProtKB
- cellular protein metabolic process Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
- negative regulation of cell population proliferation Source: ProtInc
- regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Growth factor binding |
Enzyme and pathway databases
PathwayCommonsi | P24592 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Protein family/group databases
MEROPSi | I31.952 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 6CuratedShort name: IBP-6 Short name: IGF-binding protein 6 Short name: IGFBP-6 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167779.7 |
HGNCi | HGNC:5475, IGFBP6 |
MIMi | 146735, gene |
neXtProti | NX_P24592 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
- insulin-like growth factor binary complex Source: CAFA
Golgi apparatus
- Golgi apparatus Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 3489 |
OpenTargetsi | ENSG00000167779 |
PharmGKBi | PA29708 |
Miscellaneous databases
Pharosi | P24592, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2139 |
DrugBanki | DB01277, Mecasermin |
Polymorphism and mutation databases
BioMutai | IGFBP6 |
DMDMi | 124068 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | 3 PublicationsAdd BLAST | 27 | |
ChainiPRO_0000014389 | 28 – 240 | Insulin-like growth factor-binding protein 6Add BLAST | 213 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 32 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 40 ↔ 44 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 57 ↔ 63 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 71 ↔ 84 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 78 ↔ 104 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 126 | O-linked (HexNAc...) threonine2 Publications | 1 | |
Glycosylationi | 144 | O-linked (HexNAc...) serineBy similarity | 1 | |
Glycosylationi | 145 | O-linked (HexNAc...) threonineBy similarity | 1 | |
Glycosylationi | 146 | O-linked (HexNAc...) threonineBy similarity | 1 | |
Glycosylationi | 152 | O-linked (HexNAc...) serineBy similarity | 1 | |
Disulfide bondi | 163 ↔ 190 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 201 ↔ 212 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 214 ↔ 234 | PROSITE-ProRule annotation1 Publication |
Post-translational modificationi
O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.2 Publications
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P24592 |
jPOSTi | P24592 |
MassIVEi | P24592 |
MaxQBi | P24592 |
PaxDbi | P24592 |
PeptideAtlasi | P24592 |
PRIDEi | P24592 |
ProteomicsDBi | 54218 |
PTM databases
GlyConnecti | 656, 2 O-Linked glycans (1 site) |
GlyGeni | P24592, 5 sites, 4 O-linked glycans (4 sites) |
iPTMneti | P24592 |
PhosphoSitePlusi | P24592 |
UniCarbKBi | P24592 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167779, Expressed in endocervix and 230 other tissues |
ExpressionAtlasi | P24592, baseline and differential |
Genevisiblei | P24592, HS |
Organism-specific databases
HPAi | ENSG00000167779, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via C-terminal domain) with PHB2.
1 PublicationBinary interactionsi
Hide detailsP24592
GO - Molecular functioni
- fibronectin binding Source: GO_Central
- identical protein binding Source: IntAct
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: CAFA
- signaling receptor binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 109710, 42 interactors |
IntActi | P24592, 39 interactors |
STRINGi | 9606.ENSP00000301464 |
Chemistry databases
BindingDBi | P24592 |
Miscellaneous databases
RNActi | P24592, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P24592 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P24592 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 107 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 160 – 234 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 75 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QV3Q, Eukaryota |
GeneTreei | ENSGT00940000160528 |
InParanoidi | P24592 |
OMAi | IAHCGSW |
OrthoDBi | 979270at2759 |
PhylomeDBi | P24592 |
TreeFami | TF331211 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
DisProti | DP00211 |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022326, IGFBP-6 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF14, PTHR11551:SF14, 1 hit |
Pfami | View protein in Pfam PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01982, IGFBPFAMILY6 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P24592-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPHRLLPPL LLLLALLLAA SPGGALARCP GCGQGVQAGC PGGCVEEEDG
60 70 80 90 100
GSPAEGCAEA EGCLRREGQE CGVYTPNCAP GLQCHPPKDD EAPLRALLLG
110 120 130 140 150
RGRCLPARAP AVAEENPKES KPQAGTARPQ DVNRRDQQRN PGTSTTPSQP
160 170 180 190 200
NSAGVQDTEM GPCRRHLDSV LQQLQTEVYR GAQTLYVPNC DHRGFYRKRQ
210 220 230 240
CRSSQGQRRG PCWCVDRMGK SLPGSPDGNG SSSCPTGSSG
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VYK9 | F8VYK9_HUMAN | Insulin-like growth factor-binding ... | IGFBP6 | 238 | Annotation score: | ||
A0A3B3IUE0 | A0A3B3IUE0_HUMAN | Insulin-like growth factor-binding ... | IGFBP6 | 81 | Annotation score: | ||
F8VVA5 | F8VVA5_HUMAN | Insulin-like growth factor-binding ... | IGFBP6 | 136 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | T → C in AAA88070 (PubMed:1719383).Curated | 1 | |
Sequence conflicti | 28 – 29 | RC → AA AA sequence (PubMed:1697583).Curated | 2 | |
Sequence conflicti | 28 – 29 | RC → LA AA sequence (PubMed:2154495).Curated | 2 | |
Sequence conflicti | 32 | C → H AA sequence (PubMed:1697583).Curated | 1 | |
Sequence conflicti | 55 – 57 | EGC → QGG AA sequence (PubMed:1697583).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018932 | 128 | R → G1 PublicationCorresponds to variant dbSNP:rs9658616Ensembl. | 1 | |
Natural variantiVAR_049565 | 134 | R → L. Corresponds to variant dbSNP:rs34995393Ensembl. | 1 | |
Natural variantiVAR_018933 | 217 | R → Q1 PublicationCorresponds to variant dbSNP:rs6413498EnsemblClinVar. | 1 | |
Natural variantiVAR_011907 | 236 | T → P. Corresponds to variant dbSNP:rs1053134Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M62402 mRNA Translation: AAB06187.1 AJ006952 Genomic DNA Translation: CAA07346.1 AY443494 Genomic DNA Translation: AAR05445.1 BC003507 mRNA Translation: AAH03507.1 BC005007 mRNA Translation: AAH05007.1 BC010162 mRNA Translation: AAH10162.1 BC011708 mRNA Translation: AAH11708.1 M69054 mRNA Translation: AAA88070.1 |
CCDSi | CCDS8846.1 |
PIRi | A39842 S05699 |
RefSeqi | NP_002169.1, NM_002178.2 |
Genome annotation databases
Ensembli | ENST00000301464; ENSP00000301464; ENSG00000167779 |
GeneIDi | 3489 |
KEGGi | hsa:3489 |
UCSCi | uc001sbu.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M62402 mRNA Translation: AAB06187.1 AJ006952 Genomic DNA Translation: CAA07346.1 AY443494 Genomic DNA Translation: AAR05445.1 BC003507 mRNA Translation: AAH03507.1 BC005007 mRNA Translation: AAH05007.1 BC010162 mRNA Translation: AAH10162.1 BC011708 mRNA Translation: AAH11708.1 M69054 mRNA Translation: AAA88070.1 |
CCDSi | CCDS8846.1 |
PIRi | A39842 S05699 |
RefSeqi | NP_002169.1, NM_002178.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1RMJ | NMR | - | A | 161-240 | [»] | |
SMRi | P24592 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109710, 42 interactors |
IntActi | P24592, 39 interactors |
STRINGi | 9606.ENSP00000301464 |
Chemistry databases
BindingDBi | P24592 |
ChEMBLi | CHEMBL2139 |
DrugBanki | DB01277, Mecasermin |
Protein family/group databases
MEROPSi | I31.952 |
PTM databases
GlyConnecti | 656, 2 O-Linked glycans (1 site) |
GlyGeni | P24592, 5 sites, 4 O-linked glycans (4 sites) |
iPTMneti | P24592 |
PhosphoSitePlusi | P24592 |
UniCarbKBi | P24592 |
Polymorphism and mutation databases
BioMutai | IGFBP6 |
DMDMi | 124068 |
Proteomic databases
EPDi | P24592 |
jPOSTi | P24592 |
MassIVEi | P24592 |
MaxQBi | P24592 |
PaxDbi | P24592 |
PeptideAtlasi | P24592 |
PRIDEi | P24592 |
ProteomicsDBi | 54218 |
Protocols and materials databases
Antibodypediai | 1291, 348 antibodies |
DNASUi | 3489 |
Genome annotation databases
Ensembli | ENST00000301464; ENSP00000301464; ENSG00000167779 |
GeneIDi | 3489 |
KEGGi | hsa:3489 |
UCSCi | uc001sbu.2, human |
Organism-specific databases
CTDi | 3489 |
DisGeNETi | 3489 |
EuPathDBi | HostDB:ENSG00000167779.7 |
GeneCardsi | IGFBP6 |
HGNCi | HGNC:5475, IGFBP6 |
HPAi | ENSG00000167779, Low tissue specificity |
MIMi | 146735, gene |
neXtProti | NX_P24592 |
OpenTargetsi | ENSG00000167779 |
PharmGKBi | PA29708 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QV3Q, Eukaryota |
GeneTreei | ENSGT00940000160528 |
InParanoidi | P24592 |
OMAi | IAHCGSW |
OrthoDBi | 979270at2759 |
PhylomeDBi | P24592 |
TreeFami | TF331211 |
Enzyme and pathway databases
PathwayCommonsi | P24592 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Miscellaneous databases
BioGRID-ORCSi | 3489, 6 hits in 840 CRISPR screens |
ChiTaRSi | IGFBP6, human |
EvolutionaryTracei | P24592 |
GeneWikii | IGFBP6 |
GenomeRNAii | 3489 |
Pharosi | P24592, Tchem |
PROi | PR:P24592 |
RNActi | P24592, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167779, Expressed in endocervix and 230 other tissues |
ExpressionAtlasi | P24592, baseline and differential |
Genevisiblei | P24592, HS |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
DisProti | DP00211 |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022326, IGFBP-6 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF14, PTHR11551:SF14, 1 hit |
Pfami | View protein in Pfam PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01982, IGFBPFAMILY6 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP6_HUMAN | |
Accessioni | P24592Primary (citable) accession number: P24592 Secondary accession number(s): Q14492 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 204 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations