IGFBP6

Functionⁱ

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functionⁱ

fibronectin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
insulin-like growth factor I binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
insulin-like growth factor II binding
Source: CAFA
Inferred from mutant phenotypeⁱ
- 15308688
signaling receptor binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24431302

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein metabolic process Source: Reactome
negative regulation of canonical Wnt signaling pathway
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24431302
negative regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 7539002
regulation of cell growth Source: InterPro
signal transduction
Source: ProtInc
Non-traceable author statementⁱ
- 10087296

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding

Molecular function

Growth factor binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Reactomeⁱ

R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 6 Short name: IBP-6 Short name: IGF-binding protein 6 Short name: IGFBP-6
Gene namesⁱ	Name:IGFBP6 Synonyms:IBP6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167779.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5475 IGFBP6
MIMⁱ	146735 gene
neXtProtⁱ	NX_P24592

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3489
Open Targets More...OpenTargetsⁱ	ENSG00000167779
PharmGKBⁱ	PA29708

Chemistry databases

ChEMBLⁱ	CHEMBL2139

ChEMBLⁱ

CHEMBL2139

Polymorphism and mutation databases

BioMutaⁱ	IGFBP6
DMDMⁱ	124068

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 27	3 PublicationsAdd BLAST		27
ChainⁱPRO_0000014389	28 – 240	Insulin-like growth factor-binding protein 6Add BLAST		213

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	29 ↔ 32	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	40 ↔ 44	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	57 ↔ 63	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	71 ↔ 84	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	78 ↔ 104	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	126	O-linked (HexNAc...) threonine2 Publications	1
Glycosylationⁱ	144	O-linked (HexNAc...) serineBy similarity	1
Glycosylationⁱ	145	O-linked (HexNAc...) threonineBy similarity	1
Glycosylationⁱ	146	O-linked (HexNAc...) threonineBy similarity	1
Glycosylationⁱ	152	O-linked (HexNAc...) serineBy similarity	1
Disulfide bondⁱ	163 ↔ 190	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	201 ↔ 212	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	214 ↔ 234	PROSITE-ProRule annotation1 Publication

Post-translational modificationⁱ

O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid.2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P24592
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P24592
PaxDbⁱ	P24592
PeptideAtlas More...PeptideAtlasⁱ	P24592
PRIDEⁱ	P24592
ProteomicsDBⁱ	54218

PTM databases

GlyConnectⁱ	656
iPTMnetⁱ	P24592
PhosphoSitePlusⁱ	P24592
UniCarbKBⁱ	P24592

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000167779 Expressed in 222 organ(s), highest expression level in endocervix
CleanExⁱ	HS_IGFBP6
ExpressionAtlasⁱ	P24592 baseline and differential
Genevisibleⁱ	P24592 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA008005

HPAⁱ

HPA008005

Interactionⁱ

GO - Molecular functionⁱ

fibronectin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
insulin-like growth factor I binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
insulin-like growth factor II binding
Source: CAFA
Inferred from mutant phenotypeⁱ
- 15308688
signaling receptor binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24431302

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109710, 8 interactors
IntActⁱ	P24592, 34 interactors
STRINGⁱ	9606.ENSP00000301464

Chemistry databases

BindingDBⁱ

P24592

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	162 – 177	Combined sources	16
Turnⁱ	179 – 181	Combined sources	3
Beta strandⁱ	182 – 188	Combined sources	7
Beta strandⁱ	198 – 208	Combined sources	11
Beta strandⁱ	212 – 215	Combined sources	4
Turnⁱ	226 – 228	Combined sources	3
Turnⁱ	231 – 233	Combined sources	3
Beta strandⁱ	234 – 236	Combined sources	3

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00211
ProteinModelPortalⁱ	P24592
SMRⁱ	P24592
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P24592

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 107	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST		80
Domainⁱ	160 – 234	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		75

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IVZ3 Eukaryota ENOG410YQXU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P24592
OMAⁱ	RPNPGGV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L46
PhylomeDBⁱ	P24592
TreeFamⁱ	TF331211

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR022326 IGFBP-6 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF14 PTHR11551:SF14, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01982 IGFBPFAMILY6
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P24592-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTPHRLLPPL LLLLALLLAA SPGGALARCP GCGQGVQAGC PGGCVEEEDG 
        60         70         80         90        100
GSPAEGCAEA EGCLRREGQE CGVYTPNCAP GLQCHPPKDD EAPLRALLLG 
       110        120        130        140        150
RGRCLPARAP AVAEENPKES KPQAGTARPQ DVNRRDQQRN PGTSTTPSQP 
       160        170        180        190        200
NSAGVQDTEM GPCRRHLDSV LQQLQTEVYR GAQTLYVPNC DHRGFYRKRQ 
       210        220        230        240
CRSSQGQRRG PCWCVDRMGK SLPGSPDGNG SSSCPTGSSG

Length:240

Mass (Da):25,322

Last modified:March 1, 1992 - v1

Checksum:ⁱ285308231C025009

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VYK9	F8VYK9_HUMAN	Insulin-like growth factor-binding ... Insulin-like growth factor-binding protein 6	IGFBP6	238	Annotation score:
F8VVA5	F8VVA5_HUMAN	Insulin-like growth factor-binding ... Insulin-like growth factor-binding protein 6	IGFBP6	136	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	2	T → C in AAA88070 (PubMed:1719383).Curated	1
Sequence conflictⁱ	28 – 29	RC → AA AA sequence (PubMed:1697583).Curated	2
Sequence conflictⁱ	28 – 29	RC → LA AA sequence (PubMed:2154495).Curated	2
Sequence conflictⁱ	32	C → H AA sequence (PubMed:1697583).Curated	1
Sequence conflictⁱ	55 – 57	EGC → QGG AA sequence (PubMed:1697583).Curated	3

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018932	128	R → G1 PublicationCorresponds to variant dbSNP:rs9658616Ensembl.	1
Natural variantⁱVAR_049565	134	R → L. Corresponds to variant dbSNP:rs34995393Ensembl.	1
Natural variantⁱVAR_018933	217	R → Q1 PublicationCorresponds to variant dbSNP:rs6413498Ensembl.	1
Natural variantⁱVAR_011907	236	T → P. Corresponds to variant dbSNP:rs1053134Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M62402 mRNA Translation: AAB06187.1 AJ006952 Genomic DNA Translation: CAA07346.1 AY443494 Genomic DNA Translation: AAR05445.1 BC003507 mRNA Translation: AAH03507.1 BC005007 mRNA Translation: AAH05007.1 BC010162 mRNA Translation: AAH10162.1 BC011708 mRNA Translation: AAH11708.1 M69054 mRNA Translation: AAA88070.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8846.1
PIRⁱ	A39842 S05699
NCBI Reference Sequences More...RefSeqⁱ	NP_002169.1, NM_002178.2
UniGeneⁱ	Hs.274313

Genome annotation databases

Ensemblⁱ	ENST00000301464; ENSP00000301464; ENSG00000167779
GeneIDⁱ	3489
KEGGⁱ	hsa:3489
UCSC genome browser More...UCSCⁱ	uc001sbu.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24592	Insulin-like growth factor binding protein 6 (Fragment)		HUMAN		111	UniRef100_P24592

Protein	Similar proteins		Species	Score	Length	Source
P24592	Insulin-like growth factor binding protein 6 (Fragment)		HUMAN		111	UniRef90_P24592
IGFBP6 isoform 3		PANTR		241
Uncharacterized protein		PANPA		241
Uncharacterized protein		PONAB		240
Uncharacterized protein		NOMLE		240
+25

Protein	Similar proteins		Species	Score	Length	Source
P24592	Insulin-like growth factor-binding protein 6		BOVIN		237	UniRef50_P24592
Insulin-like growth factor binding protein 6 (Fragment)		HUMAN		111
IGFBP6 isoform 3		PANTR		241
Uncharacterized protein		PANPA		241
Uncharacterized protein		PONAB		240
+102

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M62402 mRNA Translation: AAB06187.1 AJ006952 Genomic DNA Translation: CAA07346.1 AY443494 Genomic DNA Translation: AAR05445.1 BC003507 mRNA Translation: AAH03507.1 BC005007 mRNA Translation: AAH05007.1 BC010162 mRNA Translation: AAH10162.1 BC011708 mRNA Translation: AAH11708.1 M69054 mRNA Translation: AAA88070.1
CCDSⁱ	CCDS8846.1
PIRⁱ	A39842 S05699
RefSeqⁱ	NP_002169.1, NM_002178.2
UniGeneⁱ	Hs.274313

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1RMJ	NMR	-	A	161-240	[»]
DisProtⁱ	DP00211
ProteinModelPortalⁱ	P24592
SMRⁱ	P24592
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109710, 8 interactors
IntActⁱ	P24592, 34 interactors
STRINGⁱ	9606.ENSP00000301464

Chemistry databases

BindingDBⁱ	P24592
ChEMBLⁱ	CHEMBL2139

Protein family/group databases

MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

PTM databases

GlyConnectⁱ	656
iPTMnetⁱ	P24592
PhosphoSitePlusⁱ	P24592
UniCarbKBⁱ	P24592

Polymorphism and mutation databases

BioMutaⁱ	IGFBP6
DMDMⁱ	124068

Proteomic databases

EPDⁱ	P24592
MaxQBⁱ	P24592
PaxDbⁱ	P24592
PeptideAtlasⁱ	P24592
PRIDEⁱ	P24592
ProteomicsDBⁱ	54218

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3489
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000301464; ENSP00000301464; ENSG00000167779
GeneIDⁱ	3489
KEGGⁱ	hsa:3489
UCSCⁱ	uc001sbu.2 human

Organism-specific databases

CTDⁱ	3489
DisGeNETⁱ	3489
EuPathDBⁱ	HostDB:ENSG00000167779.7
GeneCardsⁱ	IGFBP6
HGNCⁱ	HGNC:5475 IGFBP6
HPAⁱ	HPA008005
MIMⁱ	146735 gene
neXtProtⁱ	NX_P24592
OpenTargetsⁱ	ENSG00000167779
PharmGKBⁱ	PA29708
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVZ3 Eukaryota ENOG410YQXU LUCA
GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P24592
OMAⁱ	RPNPGGV
OrthoDBⁱ	EOG091G0L46
PhylomeDBⁱ	P24592
TreeFamⁱ	TF331211

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Reactomeⁱ

R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Miscellaneous databases

EvolutionaryTraceⁱ	P24592
GeneWikiⁱ	IGFBP6
GenomeRNAiⁱ	3489
Protein Ontology More...PROⁱ	PR:P24592
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167779 Expressed in 222 organ(s), highest expression level in endocervix
CleanExⁱ	HS_IGFBP6
ExpressionAtlasⁱ	P24592 baseline and differential
Genevisibleⁱ	P24592 HS

Family and domain databases

CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR022326 IGFBP-6 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF14 PTHR11551:SF14, 1 hit
Pfamⁱ	View protein in Pfam PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01982 IGFBPFAMILY6
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IBP6_HUMAN
Accessionⁱ	P24592Primary (citable) accession number: P24592 Secondary accession number(s): Q14492
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	March 1, 1992
	Last modified:	November 7, 2018
	This is version 190 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - P24592 (IBP6_HUMAN)

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Insulin-like growth factor-binding protein 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Golgi apparatus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ