Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein kinase C-like 1

Gene

PKC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for cell growth and for the G2->M transition of the cell division cycle. Mediates a protein kinase cascade; it activates BCK1 which itself activates MKK1/MKK2.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei853ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei949Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri414 – 461Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri481 – 531Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi830 – 838ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • protein kinase C activity Source: SGD
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-28989-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.13 984

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-114508 Effects of PIP2 hydrolysis
R-SCE-114516 Disinhibition of SNARE formation
R-SCE-1169091 Activation of NF-kappaB in B cells
R-SCE-1489509 DAG and IP3 signaling
R-SCE-202424 Downstream TCR signaling
R-SCE-2029485 Role of phospholipids in phagocytosis
R-SCE-2179392 EGFR Transactivation by Gastrin
R-SCE-2871837 FCERI mediated NF-kB activation
R-SCE-399997 Acetylcholine regulates insulin secretion
R-SCE-4419969 Depolymerisation of the Nuclear Lamina
R-SCE-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-SCE-5218921 VEGFR2 mediated cell proliferation
R-SCE-5607764 CLEC7A (Dectin-1) signaling
R-SCE-5625740 RHO GTPases activate PKNs
R-SCE-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-SCE-6798695 Neutrophil degranulation
R-SCE-76005 Response to elevated platelet cytosolic Ca2+

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein kinase C-like 1 (EC:2.7.11.13)
Short name:
PKC 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PKC1
Synonyms:HPO2, STT1
Ordered Locus Names:YBL105C
ORF Names:YBL0807
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000201 PKC1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000557381 – 1151Protein kinase C-like 1Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei226PhosphoserineCombined sources1
Modified residuei761PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P24583

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P24583

PRoteomics IDEntifications database

More...
PRIDEi
P24583

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P24583

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P24583

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TOP2P067862EBI-9860,EBI-19352

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
32598, 1089 interactors

Database of interacting proteins

More...
DIPi
DIP-1516N

Protein interaction database and analysis system

More...
IntActi
P24583, 18 interactors

Molecular INTeraction database

More...
MINTi
P24583

STRING: functional protein association networks

More...
STRINGi
4932.YBL105C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P24583

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P24583

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 67REM-1 1PROSITE-ProRule annotationAdd BLAST67
Domaini106 – 183REM-1 2PROSITE-ProRule annotationAdd BLAST78
Domaini196 – 288C2Add BLAST93
Domaini824 – 1083Protein kinasePROSITE-ProRule annotationAdd BLAST260
Domaini1084 – 1151AGC-kinase C-terminalAdd BLAST68

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri414 – 461Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri481 – 531Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168328

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000176156

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24583

KEGG Orthology (KO)

More...
KOi
K02677

Identification of Orthologs from Complete Genome Data

More...
OMAi
LNHRIPH

Database of Orthologous Groups

More...
OrthoDBi
EOG092C0HH3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029 C1, 2 hits
cd08689 C2_fungal_Pkc1p, 1 hit
cd11620 HR1_PKC-like_2_fungi, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961 AGC-kinase_C
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037778 C2_fungal_PKC
IPR011072 HR1_rho-bd
IPR036274 HR1_rpt_sf
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR037312 PKC-like_HR1
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130 C1_1, 2 hits
PF00168 C2, 1 hit
PF02185 HR1, 1 hit
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109 C1, 2 hits
SM00239 C2, 1 hit
SM00742 Hr1, 2 hits
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46585 SSF46585, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS51860 REM_1, 2 hits
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P24583-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFSQLEQNI KKKIAVEENI IRGASALKKK TSNVMVIQKC NTNIREARQN
60 70 80 90 100
LEYLEDSLKK LRLKTAQQSQ GENGSEDNER CNSKEYGFLS TKSPNEHIFS
110 120 130 140 150
RLDLVKYDCP SLAQRIQYML QQLEFKLQVE KQYQEANTKL TKLYQIDGDQ
160 170 180 190 200
RSSSAAEGGA MESKYRIQML NKALKKYQAI NVDFDQFKHQ PNDIMDNQQP
210 220 230 240 250
KFRRKQLTGV LTIGITAARD VDHIQSPMFA RKPESYVTIK IDDTIKARTK
260 270 280 290 300
PSRNDRWSED FQIPVEKGNE IEITVYDKVN DSLIPVAIMW LLLSDIAEEI
310 320 330 340 350
RKKKAGQTNE QQGWVNASNI NGGSSLASEE GSTLTSTYSN SAIQSTSAKN
360 370 380 390 400
VQGENTSTSQ ISTNSWFVLE PSGQILLTLG FHKSSQIERK QLMGGLHRHG
410 420 430 440 450
AIINRKEEIF EQHGHHFVQK SFYNIMCCAY CGDFLRYTGF QCQDCKFLCH
460 470 480 490 500
KKCYTNVVTK CIAKTSTDTD PDEAKLNHRI PHRFLPTSNR GTKWCCHCGY
510 520 530 540 550
ILPWGRHKVR KCSECGIMCH AQCAHLVPDF CGMSMEMANK ILKTIQDTKR
560 570 580 590 600
NQEKKKRTVP SAQLGSSIGT ANGSDLSPSK LAERANAPLP PQPRKHDKTP
610 620 630 640 650
SPQKVGRDSP TKQHDPIIDK RISLQTHGRE KLNKFIDENE AYLNFTEGAQ
660 670 680 690 700
QTAEFSSPEK TLDPTSNRRS LGLTDLSIEH SQTWESKDDL MRDELELWKA
710 720 730 740 750
QREEMELEIK QDSGEIQEDL EVDHIDLETK QKLDWENKND FREADLTIDS
760 770 780 790 800
THTNPFRDMN SETFQIEQDH ASKEVLQETV SLAPTSTHAS RTTDQQSPQK
810 820 830 840 850
SQTSTSAKHK KRAAKRRKVS LDNFVLLKVL GKGNFGKVIL SKSKNTDRLC
860 870 880 890 900
AIKVLKKDNI IQNHDIESAR AEKKVFLLAT KTKHPFLTNL YCSFQTENRI
910 920 930 940 950
YFAMEFIGGG DLMWHVQNQR LSVRRAKFYA AEVLLALKYF HDNGVIYRDL
960 970 980 990 1000
KLENILLTPE GHIKIADYGL CKDEMWYGNR TSTFCGTPEF MAPEILKEQE
1010 1020 1030 1040 1050
YTKAVDWWAF GVLLYQMLLC QSPFSGDDED EVFNAILTDE PLYPIDMAGE
1060 1070 1080 1090 1100
IVQIFQGLLT KDPEKRLGAG PRDADEVMEE PFFRNINFDD ILNLRVKPPY
1110 1120 1130 1140 1150
IPEIKSPEDT SYFEQEFTSA PPTLTPLPSV LTTSQQEEFR GFSFMPDDLD

L
Length:1,151
Mass (Da):131,477
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8200EC2A2C6E649E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81C → F in CAA55990 (PubMed:7502586).Curated1
Sequence conflicti81C → F in CAA84932 (PubMed:7813418).Curated1
Sequence conflicti244T → S in AAA34878 (PubMed:2196995).Curated1
Sequence conflicti606G → E in AAA34878 (PubMed:2196995).Curated1
Sequence conflicti621R → K in AAA34878 (PubMed:2196995).Curated1
Sequence conflicti621R → K in CAA55990 (PubMed:7502586).Curated1
Sequence conflicti621R → K in CAA84932 (PubMed:7813418).Curated1
Sequence conflicti623S → P in AAA34878 (PubMed:2196995).Curated1
Sequence conflicti789A → P in CAA55990 (PubMed:7502586).Curated1
Sequence conflicti789A → P in CAA84932 (PubMed:7813418).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti958T → I in cly5; temperature-sensitive mutation that cause cell lysis at high temperature. 1
Natural varianti1023P → S in cly7; temperature-sensitive mutation that cause cell lysis at high temperature. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M32491 mRNA Translation: AAA34878.1
X79489 Genomic DNA Translation: CAA55990.1
Z35866 Genomic DNA Translation: CAA84932.1
BK006936 Genomic DNA Translation: DAA07018.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S45390

NCBI Reference Sequences

More...
RefSeqi
NP_009445.2, NM_001178345.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBL105C_mRNA; YBL105C_mRNA; YBL105C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852169

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBL105C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32491 mRNA Translation: AAA34878.1
X79489 Genomic DNA Translation: CAA55990.1
Z35866 Genomic DNA Translation: CAA84932.1
BK006936 Genomic DNA Translation: DAA07018.2
PIRiS45390
RefSeqiNP_009445.2, NM_001178345.2

3D structure databases

ProteinModelPortaliP24583
SMRiP24583
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32598, 1089 interactors
DIPiDIP-1516N
IntActiP24583, 18 interactors
MINTiP24583
STRINGi4932.YBL105C

PTM databases

CarbonylDBiP24583
iPTMnetiP24583

Proteomic databases

MaxQBiP24583
PaxDbiP24583
PRIDEiP24583

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL105C_mRNA; YBL105C_mRNA; YBL105C
GeneIDi852169
KEGGisce:YBL105C

Organism-specific databases

SGDiS000000201 PKC1

Phylogenomic databases

GeneTreeiENSGT00940000168328
HOGENOMiHOG000176156
InParanoidiP24583
KOiK02677
OMAiLNHRIPH
OrthoDBiEOG092C0HH3

Enzyme and pathway databases

BioCyciYEAST:G3O-28989-MONOMER
BRENDAi2.7.11.13 984
ReactomeiR-SCE-114508 Effects of PIP2 hydrolysis
R-SCE-114516 Disinhibition of SNARE formation
R-SCE-1169091 Activation of NF-kappaB in B cells
R-SCE-1489509 DAG and IP3 signaling
R-SCE-202424 Downstream TCR signaling
R-SCE-2029485 Role of phospholipids in phagocytosis
R-SCE-2179392 EGFR Transactivation by Gastrin
R-SCE-2871837 FCERI mediated NF-kB activation
R-SCE-399997 Acetylcholine regulates insulin secretion
R-SCE-4419969 Depolymerisation of the Nuclear Lamina
R-SCE-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-SCE-5218921 VEGFR2 mediated cell proliferation
R-SCE-5607764 CLEC7A (Dectin-1) signaling
R-SCE-5625740 RHO GTPases activate PKNs
R-SCE-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-SCE-6798695 Neutrophil degranulation
R-SCE-76005 Response to elevated platelet cytosolic Ca2+

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P24583

Family and domain databases

CDDicd00029 C1, 2 hits
cd08689 C2_fungal_Pkc1p, 1 hit
cd11620 HR1_PKC-like_2_fungi, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037778 C2_fungal_PKC
IPR011072 HR1_rho-bd
IPR036274 HR1_rpt_sf
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR037312 PKC-like_HR1
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00168 C2, 1 hit
PF02185 HR1, 1 hit
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00239 C2, 1 hit
SM00742 Hr1, 2 hits
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF46585 SSF46585, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS51860 REM_1, 2 hits
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKPC1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24583
Secondary accession number(s): D6VPP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 27, 2011
Last modified: December 5, 2018
This is version 195 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again