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Protein

Non-structural protein 1

Gene

1C

Organism
Human respiratory syncytial virus B (strain 18537)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a major role in antagonizing the type I IFN-mediated antiviral response. Acts cooperatively with NS2 to repress activation and nuclear translocation of host IFN-regulatory factor IRF-3. Interacts with host MAVS and prevents the interaction with its upstream partner DDX58/RIG-I in the signaling pathway leading to interferon production. Mediates the proteasomal degradation of host STAT2 with elongin-cullin E3 ligase. Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism and thus facilitates virus growth. Additionally, NS1 may serve some inhibitory role in viral transcription and RNA replication (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host MAVS by virus, Inhibition of host RLR pathway by virus, Inhibition of host STAT2 by virus, Interferon antiviral system evasion, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1
Alternative name(s):
Non-structural protein 1C
Gene namesi
Name:1C
Synonyms:NS1
OrganismiHuman respiratory syncytial virus B (strain 18537)
Taxonomic identifieri11251 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesPneumoviridaeOrthopneumovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001427821 – 139Non-structural protein 1Add BLAST139

Interactioni

Subunit structurei

Homomultimerizes. Interacts with the matrix protein M. Interacts with host TCEB1 and CUL2. interacts with host MAVS; this interaction inhibits signaling pathway leading to interferon production (By similarity).By similarity

Structurei

3D structure databases

SMRiP24568
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR005099 Pneumo_NS1
PfamiView protein in Pfam
PF03438 Pneumo_NS1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009407 Pneumo_NS1, 1 hit

Sequencei

Sequence statusi: Complete.

P24568-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCNSLSMIK VRLQNLFDND EVALLKITCY TDKLILLTNA LAKAVIHTIK
60 70 80 90 100
LNGIVFIHVI TSSEVCPDNN IVVKSNFTTM PILQNGGYIW ELIELTHCSQ
110 120 130
SNGLMVDNCE IKFSKRLSDS VMTNYMNQIS DLLGLDLNS
Length:139
Mass (Da):15,512
Last modified:March 1, 1992 - v1
Checksum:iEAE76C3CB850ECC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00736 Genomic RNA Translation: BAA00635.1
PIRiA32063 MNNZ18

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00736 Genomic RNA Translation: BAA00635.1
PIRiA32063 MNNZ18

3D structure databases

SMRiP24568
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR005099 Pneumo_NS1
PfamiView protein in Pfam
PF03438 Pneumo_NS1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009407 Pneumo_NS1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNS1_HRSV1
AccessioniPrimary (citable) accession number: P24568
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 25, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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