UniProtKB - P24557 (THAS_HUMAN)
Protein
Thromboxane-A synthase
Gene
TBXAS1
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:8436233, PubMed:11297515, PubMed:9873013, PubMed:11097184, PubMed:24009185, PubMed:22735388). Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2 (PubMed:11297515, PubMed:9873013, PubMed:22735388). Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE (PubMed:17459323).7 Publications
Caution
It is uncertain whether Met-1 is the initiator. An alternative upstream Met is found in primates, but not in other mammals.Curated
Catalytic activityi
- EC:5.3.99.56 PublicationsThis reaction proceeds in the forward3 Publications direction.
- EC:4.2.1.1521 PublicationThis reaction proceeds in the forward1 Publication direction.
- (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O1 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
heme1 Publication
Kineticsi
- KM=80 µM for 15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15-HPETE)1 Publication
- KM=32 µM for prostaglandin H21 Publication
- KM=20 µM for prostaglandin H21 Publication
- Vmax=12 µmol/min/mg enzyme for prostaglandin H2 as substrate1 Publication
: fatty acid metabolism Pathwayi
This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.CuratedView all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 479 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- 12-hydroxyheptadecatrienoic acid synthase activity Source: Reactome
- heme binding Source: UniProtKB
- hydroperoxy icosatetraenoate dehydratase activity Source: UniProtKB
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
- thromboxane-A synthase activity Source: UniProtKB
GO - Biological processi
- cyclooxygenase pathway Source: Reactome
- icosanoid metabolic process Source: UniProtKB
- prostaglandin biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Isomerase, Lyase, Monooxygenase, Oxidoreductase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS00728-MONOMER |
PathwayCommonsi | P24557 |
Reactomei | R-HSA-211979, Eicosanoids R-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-5579032, Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) |
SIGNORi | P24557 |
UniPathwayi | UPA00199 |
Chemistry databases
SwissLipidsi | SLP:000001099 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TBXAS1 Synonyms:CYP5, CYP5A11 Publication, TXAS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11609, TBXAS1 |
MIMi | 274180, gene |
neXtProti | NX_P24557 |
VEuPathDBi | HostDB:ENSG00000059377.15 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | Cytoplasmic1 Publication | 10 | |
Transmembranei | 11 – 31 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 32 – 75 | Lumenal1 PublicationAdd BLAST | 44 | |
Transmembranei | 76 – 96 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 97 – 223 | Cytoplasmic1 PublicationAdd BLAST | 127 | |
Transmembranei | 224 – 244 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 245 – 335 | Lumenal1 PublicationAdd BLAST | 91 | |
Transmembranei | 336 – 356 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 357 – 533 | Cytoplasmic1 PublicationAdd BLAST | 177 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Involvement in diseasei
Ghosal hematodiaphyseal dysplasia (GHDD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionRare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_044386 | 82 | L → P in GHDD. 1 PublicationCorresponds to variant dbSNP:rs140005285Ensembl. | 1 | |
Natural variantiVAR_044388 | 412 | R → Q in GHDD. 1 PublicationCorresponds to variant dbSNP:rs199422117EnsemblClinVar. | 1 | |
Natural variantiVAR_044389 | 481 | G → W in GHDD. 1 PublicationCorresponds to variant dbSNP:rs199422116Ensembl. | 1 | |
Natural variantiVAR_044390 | 487 | L → P in GHDD. 1 PublicationCorresponds to variant dbSNP:rs199422114Ensembl. | 1 |
Thromboxane synthetase deficiency has been detected in some patients with a bleeding disorder due to platelet dysfunction.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 109 | N → I: Loss of thromboxane-A synthase activity. Decreased heme-binding. 1 Publication | 1 | |
Mutagenesisi | 132 | W → F: Loss of thromboxane-A synthase activity. Decreased heme-binding. 1 Publication | 1 | |
Mutagenesisi | 134 | E → D: Does not affect thromboxane-A synthase activity. Does not affect heme-binding. 1 Publication | 1 | |
Mutagenesisi | 136 | R → A or K: Loss of thromboxane-A synthase activity. Decreased heme-binding. 1 Publication | 1 | |
Mutagenesisi | 409 | R → G: Does not affect thromboxane-A synthase activity. Does not affect heme-binding. 1 Publication | 1 | |
Mutagenesisi | 412 | R → K: Loss of thromboxane-A synthase activity. Decreased heme-binding. 1 Publication | 1 | |
Mutagenesisi | 414 | A → V: Does not affect thromboxane-A synthase activity. Does not affect heme-binding. 1 Publication | 1 | |
Mutagenesisi | 477 | R → A: Loss of thromboxane-A synthase activity. Decreased heme-binding. 1 Publication | 1 | |
Mutagenesisi | 479 | C → S, H or Y: Loss of thromboxane-A synthase activity. Decreased heme-binding. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 6916 |
MalaCardsi | TBXAS1 |
MIMi | 231095, phenotype |
OpenTargetsi | ENSG00000059377 |
Orphaneti | 1802, Ghosal hematodiaphyseal dysplasia |
PharmGKBi | PA349 |
Miscellaneous databases
Pharosi | P24557, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1835 |
DrugBanki | DB03052, Dazoxiben DB05505, NM-702 DB01207, Ridogrel DB00795, Sulfasalazine |
DrugCentrali | P24557 |
GuidetoPHARMACOLOGYi | 1353 |
Genetic variation databases
BioMutai | TBXAS1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000052256 | 1 – 533 | Thromboxane-A synthaseAdd BLAST | 533 |
Proteomic databases
EPDi | P24557 |
jPOSTi | P24557 |
MassIVEi | P24557 |
MaxQBi | P24557 |
PeptideAtlasi | P24557 |
PRIDEi | P24557 |
ProteomicsDBi | 17017 17264 17954 54216 [P24557-1] |
PTM databases
iPTMneti | P24557 |
PhosphoSitePlusi | P24557 |
Expressioni
Tissue specificityi
Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.2 Publications
Gene expression databases
Bgeei | ENSG00000059377, Expressed in monocyte and 144 other tissues |
ExpressionAtlasi | P24557, baseline and differential |
Genevisiblei | P24557, HS |
Organism-specific databases
HPAi | ENSG00000059377, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Monomer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 112778, 4 interactors |
IntActi | P24557, 4 interactors |
MINTi | P24557 |
STRINGi | 9606.ENSP00000389414 |
Chemistry databases
BindingDBi | P24557 |
Miscellaneous databases
RNActi | P24557, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00940000157903 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | P24557 |
OMAi | FDIVRQV |
OrthoDBi | 750182at2759 |
PhylomeDBi | P24557 |
TreeFami | TF105087 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 2 hits |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P24557-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEALGFLKLE VNGPMVTVAL SVALLALLKW YSTSAFSRLE KLGLRHPKPS
60 70 80 90 100
PFIGNLTFFR QGFWESQMEL RKLYGPLCGY YLGRRMFIVI SEPDMIKQVL
110 120 130 140 150
VENFSNFTNR MASGLEFKSV ADSVLFLRDK RWEEVRGALM SAFSPEKLNE
160 170 180 190 200
MVPLISQACD LLLAHLKRYA ESGDAFDIQR CYCNYTTDVV ASVAFGTPVD
210 220 230 240 250
SWQAPEDPFV KHCKRFFEFC IPRPILVLLL SFPSIMVPLA RILPNKNRDE
260 270 280 290 300
LNGFFNKLIR NVIALRDQQA AEERRRDFLQ MVLDARHSAS PMGVQDFDIV
310 320 330 340 350
RDVFSSTGCK PNPSRQHQPS PMARPLTVDE IVGQAFIFLI AGYEIITNTL
360 370 380 390 400
SFATYLLATN PDCQEKLLRE VDVFKEKHMA PEFCSLEEGL PYLDMVIAET
410 420 430 440 450
LRMYPPAFRF TREAAQDCEV LGQRIPAGAV LEMAVGALHH DPEHWPSPET
460 470 480 490 500
FNPERFTAEA RQQHRPFTYL PFGAGPRSCL GVRLGLLEVK LTLLHVLHKF
510 520 530
RFQACPETQV PLQLESKSAL GPKNGVYIKI VSR
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DH47 | A0A0C4DH47_HUMAN | Thromboxane-A synthase | TBXAS1 | 580 | Annotation score: | ||
Q53F23 | Q53F23_HUMAN | HCG14925, isoform CRA_a | TBXAS1 hCG_14925 | 534 | Annotation score: | ||
F8WC80 | F8WC80_HUMAN | Thromboxane-A synthase | TBXAS1 | 80 | Annotation score: | ||
F8WD37 | F8WD37_HUMAN | Thromboxane-A synthase | TBXAS1 | 79 | Annotation score: | ||
A0A0A0MSK3 | A0A0A0MSK3_HUMAN | HCG14925, isoform CRA_b | TBXAS1 hCG_14925 | 460 | Annotation score: | ||
C9JS68 | C9JS68_HUMAN | Thromboxane-A synthase | TBXAS1 | 150 | Annotation score: | ||
A0A498U6I9 | A0A498U6I9_HUMAN | Thromboxane-A synthase | TBXAS1 | 151 | Annotation score: |
Sequence cautioni
The sequence AAA60617 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAA60618 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAC01761 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAC01761 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF99269 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAF99270 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAF99271 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAF99272 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAF99273 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAF99274 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAF99275 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAF99276 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAF99277 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAF99278 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAF99279 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH41157 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAG58828 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence EAW83934 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 102 | E → Q in AAA36742 (PubMed:2043115).Curated | 1 | |
Sequence conflicti | 148 | L → V in AAC01761 (Ref. 4) Curated | 1 | |
Sequence conflicti | 194 | A → P in AAA60617 (PubMed:1730669).Curated | 1 | |
Sequence conflicti | 194 | A → P in AAA60618 (PubMed:1730669).Curated | 1 | |
Sequence conflicti | 194 | A → P in AAC01761 (Ref. 4) Curated | 1 | |
Sequence conflicti | 194 | A → P in AAF99269 (PubMed:11465543).Curated | 1 | |
Sequence conflicti | 194 | A → P in AAF99270 (PubMed:11465543).Curated | 1 | |
Sequence conflicti | 194 | A → P in AAF99271 (PubMed:11465543).Curated | 1 | |
Sequence conflicti | 194 | A → P in AAF99272 (PubMed:11465543).Curated | 1 | |
Sequence conflicti | 194 | A → P in AAF99273 (PubMed:11465543).Curated | 1 | |
Sequence conflicti | 194 | A → P in AAF99274 (PubMed:11465543).Curated | 1 | |
Sequence conflicti | 194 | A → P in AAF99275 (PubMed:11465543).Curated | 1 | |
Sequence conflicti | 194 | A → P in AAF99276 (PubMed:11465543).Curated | 1 | |
Sequence conflicti | 194 | A → P in AAF99277 (PubMed:11465543).Curated | 1 | |
Sequence conflicti | 194 | A → P in AAF99278 (PubMed:11465543).Curated | 1 | |
Sequence conflicti | 194 | A → P in AAF99279 (PubMed:11465543).Curated | 1 | |
Sequence conflicti | 194 | A → P in AAA36742 (PubMed:2043115).Curated | 1 | |
Sequence conflicti | 385 | S → G no nucleotide entry (PubMed:1714723).Curated | 1 | |
Sequence conflicti | 483 | R → H in BAA07011 (PubMed:7925341).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014157 | 60 | R → H in allele CYP5A1*2. 2 PublicationsCorresponds to variant dbSNP:rs6138Ensembl. | 1 | |
Natural variantiVAR_058465 | 70 | L → P. Corresponds to variant dbSNP:rs13306050Ensembl. | 1 | |
Natural variantiVAR_058466 | 70 | L → V. Corresponds to variant dbSNP:rs4529EnsemblClinVar. | 1 | |
Natural variantiVAR_044386 | 82 | L → P in GHDD. 1 PublicationCorresponds to variant dbSNP:rs140005285Ensembl. | 1 | |
Natural variantiVAR_036294 | 85 | R → W in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1016604233Ensembl. | 1 | |
Natural variantiVAR_018378 | 124 | V → I1 PublicationCorresponds to variant dbSNP:rs8192833Ensembl. | 1 | |
Natural variantiVAR_010919 | 160 | D → E in allele CYP5A1*3. 2 PublicationsCorresponds to variant dbSNP:rs5768EnsemblClinVar. | 1 | |
Natural variantiVAR_014158 | 162 | L → I1 PublicationCorresponds to variant dbSNP:rs6137Ensembl. | 1 | |
Natural variantiVAR_010920 | 245 | N → S in allele CYP5A1*4. 1 PublicationCorresponds to variant dbSNP:rs55856189Ensembl. | 1 | |
Natural variantiVAR_014647 | 257 | K → E The KM value is about 1.5 higher for PEG2; in allele CYP5A1*5; KM value about 1.5 higher for PEG2; Vmax/KM approximately 50% of that of the wild-type. 1 PublicationCorresponds to variant dbSNP:rs5769EnsemblClinVar. | 1 | |
Natural variantiVAR_014648 | 260 | R → G. Corresponds to variant dbSNP:rs5770Ensembl. | 1 | |
Natural variantiVAR_014649 | 316 | Q → K. Corresponds to variant dbSNP:rs5771Ensembl. | 1 | |
Natural variantiVAR_014159 | 331 | I → T1 PublicationCorresponds to variant dbSNP:rs6140EnsemblClinVar. | 1 | |
Natural variantiVAR_010921 | 356 | L → V in allele CYP5A1*5; KM value about 1.5 higher for PEG2; Vmax/KM approximately 27% of that of the wild-type. 4 PublicationsCorresponds to variant dbSNP:rs4529EnsemblClinVar. | 1 | |
Natural variantiVAR_044387 | 357 | L → V. Corresponds to variant dbSNP:rs4529EnsemblClinVar. | 1 | |
Natural variantiVAR_055565 | 387 | E → K. Corresponds to variant dbSNP:rs3735354EnsemblClinVar. | 1 | |
Natural variantiVAR_018379 | 388 | E → K1 PublicationCorresponds to variant dbSNP:rs3735354EnsemblClinVar. | 1 | |
Natural variantiVAR_016158 | 389 | G → V. Corresponds to variant dbSNP:rs5760Ensembl. | 1 | |
Natural variantiVAR_044388 | 412 | R → Q in GHDD. 1 PublicationCorresponds to variant dbSNP:rs199422117EnsemblClinVar. | 1 | |
Natural variantiVAR_010922 | 416 | Q → E in allele CYP5A1*6; does not affect KM value for PEG2; does not affect Vmax/KM value. 4 PublicationsCorresponds to variant dbSNP:rs4528EnsemblClinVar. | 1 | |
Natural variantiVAR_014160 | 424 | R → C1 PublicationCorresponds to variant dbSNP:rs5762Ensembl. | 1 | |
Natural variantiVAR_014161 | 429 | A → T2 PublicationsCorresponds to variant dbSNP:rs4526EnsemblClinVar. | 1 | |
Natural variantiVAR_010923 | 449 | E → K in allele CYP5A1*7; does not affect KM value for PEG2; does not affect Vmax/KM value. 3 PublicationsCorresponds to variant dbSNP:rs8192868EnsemblClinVar. | 1 | |
Natural variantiVAR_010924 | 450 | T → N in allele CYP5A1*8; KM value about 1.5 higher for PEG2; Vmax/KM approximately 56 % of that of the wild-type. 2 PublicationsCorresponds to variant dbSNP:rs5763EnsemblClinVar. | 1 | |
Natural variantiVAR_010925 | 465 | R → Q in allele CYP5A1*9. 1 PublicationCorresponds to variant dbSNP:rs41311778Ensembl. | 1 | |
Natural variantiVAR_044389 | 481 | G → W in GHDD. 1 PublicationCorresponds to variant dbSNP:rs199422116Ensembl. | 1 | |
Natural variantiVAR_044390 | 487 | L → P in GHDD. 1 PublicationCorresponds to variant dbSNP:rs199422114Ensembl. | 1 | |
Natural variantiVAR_018380 | 501 | R → Q1 PublicationCorresponds to variant dbSNP:rs8192864Ensembl. | 1 | |
Natural variantiVAR_055566 | 511 | P → L. Corresponds to variant dbSNP:rs13306050Ensembl. | 1 | |
Natural variantiVAR_044391 | 512 | L → P. Corresponds to variant dbSNP:rs13306050Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047217 | 1 – 67 | Missing in isoform 2. 1 PublicationAdd BLAST | 67 | |
Alternative sequenceiVSP_054121 | 150 | E → ELGLLIMQERIKGHMGGQQA PQRIPPTRLSKPSGIYVNLH YATLPFC in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_054122 | 456 – 459 | FTAE → YRCS in isoform 4. 1 Publication | 4 | |
Alternative sequenceiVSP_054123 | 460 – 533 | Missing in isoform 4. 1 PublicationAdd BLAST | 74 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80646 mRNA Translation: AAA60617.1 Different initiation. M80647 mRNA Translation: AAA60618.1 Different initiation. D34625 Genomic DNA Translation: BAA07011.1 L36085 , L36075, L36076, L36077, L36078, L36079, L36080, L36081, L36082, L36083, L36084 Genomic DNA Translation: AAC01761.1 Different initiation. AF233615 Genomic DNA Translation: AAF99269.1 Different initiation. AF233616 Genomic DNA Translation: AAF99270.1 Different initiation. AF233617 Genomic DNA Translation: AAF99271.1 Different initiation. AF233618 Genomic DNA Translation: AAF99272.1 Different initiation. AF233619 Genomic DNA Translation: AAF99273.1 Different initiation. AF233620 Genomic DNA Translation: AAF99274.1 Different initiation. AF233621 Genomic DNA Translation: AAF99275.1 Different initiation. AF233622 Genomic DNA Translation: AAF99276.1 Different initiation. AF233623 Genomic DNA Translation: AAF99277.1 Different initiation. AF233624 Genomic DNA Translation: AAF99278.1 Different initiation. AF233625 Genomic DNA Translation: AAF99279.1 Different initiation. AK296069 mRNA Translation: BAG58828.1 Different initiation. AC004914 Genomic DNA No translation available. AC004961 Genomic DNA No translation available. AC006021 Genomic DNA No translation available. CH471070 Genomic DNA Translation: EAW83934.1 Different initiation. BC014117 mRNA Translation: AAH14117.1 BC041157 mRNA Translation: AAH41157.1 Different initiation. M74055 mRNA Translation: AAA36742.1 |
CCDSi | CCDS55174.1 [P24557-3] CCDS55175.1 [P24557-2] CCDS5855.1 [P24557-1] CCDS5856.1 [P24557-4] |
PIRi | A41766 S48161 |
RefSeqi | NP_001052.2, NM_001061.4 [P24557-1] NP_001124438.1, NM_001130966.2 [P24557-1] NP_001159725.1, NM_001166253.1 [P24557-3] NP_001159726.1, NM_001166254.1 [P24557-2] NP_112246.2, NM_030984.3 [P24557-4] |
Genome annotation databases
Ensembli | ENST00000336425; ENSP00000338087; ENSG00000059377 [P24557-1] ENST00000411653; ENSP00000411326; ENSG00000059377 [P24557-4] ENST00000425687; ENSP00000388736; ENSG00000059377 [P24557-2] ENST00000448866; ENSP00000402536; ENSG00000059377 [P24557-1] ENST00000458722; ENSP00000411274; ENSG00000059377 [P24557-3] |
GeneIDi | 6916 |
KEGGi | hsa:6916 |
UCSCi | uc010lne.4, human [P24557-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Cytochrome P450 Allele Nomenclature Committee CYP5A1 alleles |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80646 mRNA Translation: AAA60617.1 Different initiation. M80647 mRNA Translation: AAA60618.1 Different initiation. D34625 Genomic DNA Translation: BAA07011.1 L36085 , L36075, L36076, L36077, L36078, L36079, L36080, L36081, L36082, L36083, L36084 Genomic DNA Translation: AAC01761.1 Different initiation. AF233615 Genomic DNA Translation: AAF99269.1 Different initiation. AF233616 Genomic DNA Translation: AAF99270.1 Different initiation. AF233617 Genomic DNA Translation: AAF99271.1 Different initiation. AF233618 Genomic DNA Translation: AAF99272.1 Different initiation. AF233619 Genomic DNA Translation: AAF99273.1 Different initiation. AF233620 Genomic DNA Translation: AAF99274.1 Different initiation. AF233621 Genomic DNA Translation: AAF99275.1 Different initiation. AF233622 Genomic DNA Translation: AAF99276.1 Different initiation. AF233623 Genomic DNA Translation: AAF99277.1 Different initiation. AF233624 Genomic DNA Translation: AAF99278.1 Different initiation. AF233625 Genomic DNA Translation: AAF99279.1 Different initiation. AK296069 mRNA Translation: BAG58828.1 Different initiation. AC004914 Genomic DNA No translation available. AC004961 Genomic DNA No translation available. AC006021 Genomic DNA No translation available. CH471070 Genomic DNA Translation: EAW83934.1 Different initiation. BC014117 mRNA Translation: AAH14117.1 BC041157 mRNA Translation: AAH41157.1 Different initiation. M74055 mRNA Translation: AAA36742.1 |
CCDSi | CCDS55174.1 [P24557-3] CCDS55175.1 [P24557-2] CCDS5855.1 [P24557-1] CCDS5856.1 [P24557-4] |
PIRi | A41766 S48161 |
RefSeqi | NP_001052.2, NM_001061.4 [P24557-1] NP_001124438.1, NM_001130966.2 [P24557-1] NP_001159725.1, NM_001166253.1 [P24557-3] NP_001159726.1, NM_001166254.1 [P24557-2] NP_112246.2, NM_030984.3 [P24557-4] |
3D structure databases
SMRi | P24557 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112778, 4 interactors |
IntActi | P24557, 4 interactors |
MINTi | P24557 |
STRINGi | 9606.ENSP00000389414 |
Chemistry databases
BindingDBi | P24557 |
ChEMBLi | CHEMBL1835 |
DrugBanki | DB03052, Dazoxiben DB05505, NM-702 DB01207, Ridogrel DB00795, Sulfasalazine |
DrugCentrali | P24557 |
GuidetoPHARMACOLOGYi | 1353 |
SwissLipidsi | SLP:000001099 |
PTM databases
iPTMneti | P24557 |
PhosphoSitePlusi | P24557 |
Genetic variation databases
BioMutai | TBXAS1 |
Proteomic databases
EPDi | P24557 |
jPOSTi | P24557 |
MassIVEi | P24557 |
MaxQBi | P24557 |
PeptideAtlasi | P24557 |
PRIDEi | P24557 |
ProteomicsDBi | 17017 17264 17954 54216 [P24557-1] |
Protocols and materials databases
Antibodypediai | 18246, 431 antibodies |
DNASUi | 6916 |
Genome annotation databases
Ensembli | ENST00000336425; ENSP00000338087; ENSG00000059377 [P24557-1] ENST00000411653; ENSP00000411326; ENSG00000059377 [P24557-4] ENST00000425687; ENSP00000388736; ENSG00000059377 [P24557-2] ENST00000448866; ENSP00000402536; ENSG00000059377 [P24557-1] ENST00000458722; ENSP00000411274; ENSG00000059377 [P24557-3] |
GeneIDi | 6916 |
KEGGi | hsa:6916 |
UCSCi | uc010lne.4, human [P24557-1] |
Organism-specific databases
CTDi | 6916 |
DisGeNETi | 6916 |
GeneCardsi | TBXAS1 |
HGNCi | HGNC:11609, TBXAS1 |
HPAi | ENSG00000059377, Tissue enhanced (blood, lymphoid tissue) |
MalaCardsi | TBXAS1 |
MIMi | 231095, phenotype 274180, gene |
neXtProti | NX_P24557 |
OpenTargetsi | ENSG00000059377 |
Orphaneti | 1802, Ghosal hematodiaphyseal dysplasia |
PharmGKBi | PA349 |
VEuPathDBi | HostDB:ENSG00000059377.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00940000157903 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | P24557 |
OMAi | FDIVRQV |
OrthoDBi | 750182at2759 |
PhylomeDBi | P24557 |
TreeFami | TF105087 |
Enzyme and pathway databases
UniPathwayi | UPA00199 |
BioCyci | MetaCyc:HS00728-MONOMER |
PathwayCommonsi | P24557 |
Reactomei | R-HSA-211979, Eicosanoids R-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-5579032, Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) |
SIGNORi | P24557 |
Miscellaneous databases
BioGRID-ORCSi | 6916, 7 hits in 877 CRISPR screens |
ChiTaRSi | TBXAS1, human |
GeneWikii | Thromboxane-A_synthase |
GenomeRNAii | 6916 |
Pharosi | P24557, Tchem |
PROi | PR:P24557 |
RNActi | P24557, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000059377, Expressed in monocyte and 144 other tissues |
ExpressionAtlasi | P24557, baseline and differential |
Genevisiblei | P24557, HS |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 2 hits |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THAS_HUMAN | |
Accessioni | P24557Primary (citable) accession number: P24557 Secondary accession number(s): B4DJG6 Q9HD84 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | July 28, 2009 | |
Last modified: | February 10, 2021 | |
This is version 217 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM