TBXAS1

Functionⁱ

Caution

It is uncertain whether Met-1 is the initiator. An alternative upstream Met is found in primates, but not in other mammals.Curated

Catalytic activityⁱ

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.

Cofactorⁱ

heme

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	479	Iron (heme axial ligand)By similarity		1

GO - Molecular functionⁱ

12-hydroxyheptadecatrienoic acid synthase activity Source: Reactome
heme binding Source: InterPro
iron ion binding Source: InterPro
monooxygenase activity Source: UniProtKB-KW
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
thromboxane-A synthase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cyclooxygenase pathway Source: Reactome
icosanoid metabolic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase, Monooxygenase, Oxidoreductase
Biological process	Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS00728-MONOMER
Reactomeⁱ	R-HSA-211979 Eicosanoids R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-5579032 Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
SIGNORⁱ	P24557

Chemistry databases

SwissLipidsⁱ	SLP:000001099

SwissLipidsⁱ

SLP:000001099

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thromboxane-A synthase (EC:5.3.99.5) Short name: TXA synthase Short name: TXS Alternative name(s): Cytochrome P450 5A1
Gene namesⁱ	Name:TBXAS1 Synonyms:CYP5, CYP5A1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000059377.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11609 TBXAS1
MIMⁱ	274180 gene
neXtProtⁱ	NX_P24557

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 10	CytoplasmicSequence analysis	10
Transmembraneⁱ	11 – 31	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	32 – 75	LumenalSequence analysisAdd BLAST	44
Transmembraneⁱ	76 – 96	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	97 – 223	CytoplasmicSequence analysisAdd BLAST	127
Transmembraneⁱ	224 – 244	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	245 – 335	LumenalSequence analysisAdd BLAST	91
Transmembraneⁱ	336 – 356	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	357 – 533	CytoplasmicSequence analysisAdd BLAST	177

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ghosal hematodiaphyseal dysplasia (GHDD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionRare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_044386	82	L → P in GHDD. 1 PublicationCorresponds to variant dbSNP:rs140005285Ensembl.	1
Natural variantⁱVAR_044388	412	R → Q in GHDD. 1 PublicationCorresponds to variant dbSNP:rs199422117Ensembl.	1
Natural variantⁱVAR_044389	481	G → W in GHDD. 1 PublicationCorresponds to variant dbSNP:rs199422116Ensembl.	1
Natural variantⁱVAR_044390	487	L → P in GHDD. 1 PublicationCorresponds to variant dbSNP:rs199422114Ensembl.	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6916
MalaCards human disease database More...MalaCardsⁱ	TBXAS1
MIMⁱ	231095 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000059377
Orphanetⁱ	1802 Ghosal hematodiaphyseal dysplasia
PharmGKBⁱ	PA349

Chemistry databases

ChEMBLⁱ	CHEMBL1835
Drug and drug target database More...DrugBankⁱ	DB03052 Dazoxiben DB05505 NM-702 DB01207 Ridogrel DB00795 Sulfasalazine
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1353

Polymorphism and mutation databases

BioMutaⁱ	TBXAS1

BioMutaⁱ

TBXAS1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000052256	1 – 533	Thromboxane-A synthaseAdd BLAST		533

Proteomic databases

EPDⁱ	P24557
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P24557
PeptideAtlas More...PeptideAtlasⁱ	P24557
PRIDEⁱ	P24557
ProteomicsDBⁱ	54216

PTM databases

iPTMnetⁱ	P24557
PhosphoSitePlusⁱ	P24557

Expressionⁱ

Tissue specificityⁱ

Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.

Gene expression databases

Bgeeⁱ	ENSG00000059377 Expressed in 124 organ(s), highest expression level in blood
ExpressionAtlasⁱ	P24557 baseline and differential
Genevisibleⁱ	P24557 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031257 HPA031258 HPA031259

HPAⁱ

HPA031257
HPA031258
HPA031259

Interactionⁱ

Subunit structureⁱ

Monomer.

Protein-protein interaction databases

BioGridⁱ	112778, 2 interactors
IntActⁱ	P24557, 2 interactors
Molecular INTeraction database More...MINTⁱ	P24557

Chemistry databases

BindingDBⁱ

P24557

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P24557
SMRⁱ	P24557
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140779
HOGENOMⁱ	HOG000039127
HOVERGENⁱ	HBG108567
InParanoidⁱ	P24557
KEGG Orthology (KO) More...KOⁱ	K01832
OMAⁱ	PFVRHAQ
PhylomeDBⁱ	P24557
TreeFamⁱ	TF105087

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 2 hits
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P24557-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALGFLKLE VNGPMVTVAL SVALLALLKW YSTSAFSRLE KLGLRHPKPS 
        60         70         80         90        100
PFIGNLTFFR QGFWESQMEL RKLYGPLCGY YLGRRMFIVI SEPDMIKQVL 
       110        120        130        140        150
VENFSNFTNR MASGLEFKSV ADSVLFLRDK RWEEVRGALM SAFSPEKLNE 
       160        170        180        190        200
MVPLISQACD LLLAHLKRYA ESGDAFDIQR CYCNYTTDVV ASVAFGTPVD 
       210        220        230        240        250
SWQAPEDPFV KHCKRFFEFC IPRPILVLLL SFPSIMVPLA RILPNKNRDE 
       260        270        280        290        300
LNGFFNKLIR NVIALRDQQA AEERRRDFLQ MVLDARHSAS PMGVQDFDIV 
       310        320        330        340        350
RDVFSSTGCK PNPSRQHQPS PMARPLTVDE IVGQAFIFLI AGYEIITNTL 
       360        370        380        390        400
SFATYLLATN PDCQEKLLRE VDVFKEKHMA PEFCSLEEGL PYLDMVIAET 
       410        420        430        440        450
LRMYPPAFRF TREAAQDCEV LGQRIPAGAV LEMAVGALHH DPEHWPSPET 
       460        470        480        490        500
FNPERFTAEA RQQHRPFTYL PFGAGPRSCL GVRLGLLEVK LTLLHVLHKF 
       510        520        530 
RFQACPETQV PLQLESKSAL GPKNGVYIKI VSR

Length:533

Mass (Da):60,518

Last modified:July 28, 2009 - v3

Checksum:ⁱE95E7B7EA77E6DDC

GO

Isoform 2 (identifier: P24557-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-67: Missing.

« Hide

        10         20         30         40         50
MELRKLYGPL CGYYLGRRMF IVISEPDMIK QVLVENFSNF TNRMASGLEF 
        60         70         80         90        100
KSVADSVLFL RDKRWEEVRG ALMSAFSPEK LNEMVPLISQ ACDLLLAHLK 
       110        120        130        140        150
RYAESGDAFD IQRCYCNYTT DVVASVAFGT PVDSWQAPED PFVKHCKRFF 
       160        170        180        190        200
EFCIPRPILV LLLSFPSIMV PLARILPNKN RDELNGFFNK LIRNVIALRD 
       210        220        230        240        250
QQAAEERRRD FLQMVLDARH SASPMGVQDF DIVRDVFSST GCKPNPSRQH 
       260        270        280        290        300
QPSPMARPLT VDEIVGQAFI FLIAGYEIIT NTLSFATYLL ATNPDCQEKL 
       310        320        330        340        350
LREVDVFKEK HMAPEFCSLE EGLPYLDMVI AETLRMYPPA FRFTREAAQD 
       360        370        380        390        400
CEVLGQRIPA GAVLEMAVGA LHHDPEHWPS PETFNPERFT AEARQQHRPF 
       410        420        430        440        450
TYLPFGAGPR SCLGVRLGLL EVKLTLLHVL HKFRFQACPE TQVPLQLESK 
       460 
SALGPKNGVY IKIVSR

Note: No experimental confirmation available.

Show »

Length:466

Mass (Da):52,995

Checksum:ⁱE214331AAC1B7797

GO

Isoform 3 (identifier: P24557-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
150-150: E → ELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFC

« Hide

        10         20         30         40         50
MEALGFLKLE VNGPMVTVAL SVALLALLKW YSTSAFSRLE KLGLRHPKPS 
        60         70         80         90        100
PFIGNLTFFR QGFWESQMEL RKLYGPLCGY YLGRRMFIVI SEPDMIKQVL 
       110        120        130        140        150
VENFSNFTNR MASGLEFKSV ADSVLFLRDK RWEEVRGALM SAFSPEKLNE 
       160        170        180        190        200
LGLLIMQERI KGHMGGQQAP QRIPPTRLSK PSGIYVNLHY ATLPFCMVPL 
       210        220        230        240        250
ISQACDLLLA HLKRYAESGD AFDIQRCYCN YTTDVVASVA FGTPVDSWQA 
       260        270        280        290        300
PEDPFVKHCK RFFEFCIPRP ILVLLLSFPS IMVPLARILP NKNRDELNGF 
       310        320        330        340        350
FNKLIRNVIA LRDQQAAEER RRDFLQMVLD ARHSASPMGV QDFDIVRDVF 
       360        370        380        390        400
SSTGCKPNPS RQHQPSPMAR PLTVDEIVGQ AFIFLIAGYE IITNTLSFAT 
       410        420        430        440        450
YLLATNPDCQ EKLLREVDVF KEKHMAPEFC SLEEGLPYLD MVIAETLRMY 
       460        470        480        490        500
PPAFRFTREA AQDCEVLGQR IPAGAVLEMA VGALHHDPEH WPSPETFNPE 
       510        520        530        540        550
RFTAEARQQH RPFTYLPFGA GPRSCLGVRL GLLEVKLTLL HVLHKFRFQA 
       560        570 
CPETQVPLQL ESKSALGPKN GVYIKIVSR

Show »

Length:579

Mass (Da):65,632

Checksum:ⁱB3FF6087E8892CCF

GO

Isoform 4 (identifier: P24557-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
456-459: FTAE → YRCS
460-533: Missing.

« Hide

        10         20         30         40         50
MEALGFLKLE VNGPMVTVAL SVALLALLKW YSTSAFSRLE KLGLRHPKPS 
        60         70         80         90        100
PFIGNLTFFR QGFWESQMEL RKLYGPLCGY YLGRRMFIVI SEPDMIKQVL 
       110        120        130        140        150
VENFSNFTNR MASGLEFKSV ADSVLFLRDK RWEEVRGALM SAFSPEKLNE 
       160        170        180        190        200
MVPLISQACD LLLAHLKRYA ESGDAFDIQR CYCNYTTDVV ASVAFGTPVD 
       210        220        230        240        250
SWQAPEDPFV KHCKRFFEFC IPRPILVLLL SFPSIMVPLA RILPNKNRDE 
       260        270        280        290        300
LNGFFNKLIR NVIALRDQQA AEERRRDFLQ MVLDARHSAS PMGVQDFDIV 
       310        320        330        340        350
RDVFSSTGCK PNPSRQHQPS PMARPLTVDE IVGQAFIFLI AGYEIITNTL 
       360        370        380        390        400
SFATYLLATN PDCQEKLLRE VDVFKEKHMA PEFCSLEEGL PYLDMVIAET 
       410        420        430        440        450
LRMYPPAFRF TREAAQDCEV LGQRIPAGAV LEMAVGALHH DPEHWPSPET 

FNPERYRCS

Show »

Length:459

Mass (Da):52,287

Checksum:ⁱ7AE5A27B6467D359

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0C4DH47	A0A0C4DH47_HUMAN	Thromboxane-A synthase Thromboxane-A synthase	TBXAS1	580	Annotation score:
Q53F23	Q53F23_HUMAN	HCG14925, isoform CRA_a HCG14925, isoform CRA_a (Thromboxane A synthase 1 (Platelet, cytochrome P450, family 5, subfamily A) isoform TXS-I variant) (Thromboxane-A synthase)	TBXAS1 hCG_14925	534	Annotation score:
A0A0A0MSK3	A0A0A0MSK3_HUMAN	HCG14925, isoform CRA_b HCG14925, isoform CRA_b (Thromboxane-A synthase)	TBXAS1 hCG_14925	460	Annotation score:
C9JS68	C9JS68_HUMAN	Thromboxane-A synthase Thromboxane-A synthase	TBXAS1	151	Annotation score:
B7Z6W1	B7Z6W1_HUMAN	Thromboxane-A synthase Thromboxane-A synthase (cDNA FLJ52771, highly similar to Thromboxane-A synthase)	TBXAS1	152	Annotation score:
F8WD37	F8WD37_HUMAN	Thromboxane-A synthase Thromboxane-A synthase	TBXAS1	80	Annotation score:
F8WC80	F8WC80_HUMAN	Thromboxane-A synthase Thromboxane-A synthase	TBXAS1	81	Annotation score:

Sequence cautionⁱ

The sequence AAA60617 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAA60618 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAC01761 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAC01761 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence AAF99269 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAF99270 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAF99271 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAF99272 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAF99273 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAF99274 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAF99275 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAF99276 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAF99277 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAF99278 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAF99279 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence AAH41157 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAG58828 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence EAW83934 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	102	E → Q in AAA36742 (PubMed:2043115).Curated	1
Sequence conflictⁱ	148	L → V in AAC01761 (Ref. 4) Curated	1
Sequence conflictⁱ	194	A → P in AAA60617 (PubMed:1730669).Curated	1
Sequence conflictⁱ	194	A → P in AAA60618 (PubMed:1730669).Curated	1
Sequence conflictⁱ	194	A → P in AAC01761 (Ref. 4) Curated	1
Sequence conflictⁱ	194	A → P in AAF99269 (PubMed:11465543).Curated	1
Sequence conflictⁱ	194	A → P in AAF99270 (PubMed:11465543).Curated	1
Sequence conflictⁱ	194	A → P in AAF99271 (PubMed:11465543).Curated	1
Sequence conflictⁱ	194	A → P in AAF99272 (PubMed:11465543).Curated	1
Sequence conflictⁱ	194	A → P in AAF99273 (PubMed:11465543).Curated	1
Sequence conflictⁱ	194	A → P in AAF99274 (PubMed:11465543).Curated	1
Sequence conflictⁱ	194	A → P in AAF99275 (PubMed:11465543).Curated	1
Sequence conflictⁱ	194	A → P in AAF99276 (PubMed:11465543).Curated	1
Sequence conflictⁱ	194	A → P in AAF99277 (PubMed:11465543).Curated	1
Sequence conflictⁱ	194	A → P in AAF99278 (PubMed:11465543).Curated	1
Sequence conflictⁱ	194	A → P in AAF99279 (PubMed:11465543).Curated	1
Sequence conflictⁱ	194	A → P in AAA36742 (PubMed:2043115).Curated	1
Sequence conflictⁱ	385	S → G no nucleotide entry (PubMed:1714723).Curated	1
Sequence conflictⁱ	483	R → H in BAA07011 (PubMed:7925341).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_014157	60	R → H in allele CYP5A1*2. 2 PublicationsCorresponds to variant dbSNP:rs6138Ensembl.	1
Natural variantⁱVAR_058465	70	L → P. Corresponds to variant dbSNP:rs13306050Ensembl.	1
Natural variantⁱVAR_058466	70	L → V. Corresponds to variant dbSNP:rs4529EnsemblClinVar.	1
Natural variantⁱVAR_044386	82	L → P in GHDD. 1 PublicationCorresponds to variant dbSNP:rs140005285Ensembl.	1
Natural variantⁱVAR_036294	85	R → W in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_018378	124	V → I1 PublicationCorresponds to variant dbSNP:rs8192833Ensembl.	1
Natural variantⁱVAR_010919	160	D → E in allele CYP5A1*3. 2 PublicationsCorresponds to variant dbSNP:rs5768Ensembl.	1
Natural variantⁱVAR_014158	162	L → I1 PublicationCorresponds to variant dbSNP:rs6137Ensembl.	1
Natural variantⁱVAR_010920	245	N → S in allele CYP5A1*4. 1 PublicationCorresponds to variant dbSNP:rs55856189Ensembl.	1
Natural variantⁱVAR_014647	257	K → E. Corresponds to variant dbSNP:rs5769Ensembl.	1
Natural variantⁱVAR_014648	260	R → G. Corresponds to variant dbSNP:rs5770Ensembl.	1
Natural variantⁱVAR_014649	316	Q → K. Corresponds to variant dbSNP:rs5771Ensembl.	1
Natural variantⁱVAR_014159	331	I → T1 PublicationCorresponds to variant dbSNP:rs6140Ensembl.	1
Natural variantⁱVAR_010921	356	L → V in allele CYP5A1*5. 3 PublicationsCorresponds to variant dbSNP:rs4529EnsemblClinVar.	1
Natural variantⁱVAR_044387	357	L → V. Corresponds to variant dbSNP:rs4529EnsemblClinVar.	1
Natural variantⁱVAR_055565	387	E → K. Corresponds to variant dbSNP:rs3735354EnsemblClinVar.	1
Natural variantⁱVAR_018379	388	E → K1 PublicationCorresponds to variant dbSNP:rs3735354EnsemblClinVar.	1
Natural variantⁱVAR_016158	389	G → V. Corresponds to variant dbSNP:rs5760Ensembl.	1
Natural variantⁱVAR_044388	412	R → Q in GHDD. 1 PublicationCorresponds to variant dbSNP:rs199422117Ensembl.	1
Natural variantⁱVAR_010922	416	Q → E in allele CYP5A1*6. 3 PublicationsCorresponds to variant dbSNP:rs4528Ensembl.	1
Natural variantⁱVAR_014160	424	R → C1 PublicationCorresponds to variant dbSNP:rs5762Ensembl.	1
Natural variantⁱVAR_014161	429	A → T2 PublicationsCorresponds to variant dbSNP:rs4526Ensembl.	1
Natural variantⁱVAR_010923	449	E → K in allele CYP5A1*7. 2 PublicationsCorresponds to variant dbSNP:rs8192868Ensembl.	1
Natural variantⁱVAR_010924	450	T → N in allele CYP5A1*8. 1 PublicationCorresponds to variant dbSNP:rs5763Ensembl.	1
Natural variantⁱVAR_010925	465	R → Q in allele CYP5A1*9. 1 PublicationCorresponds to variant dbSNP:rs41311778Ensembl.	1
Natural variantⁱVAR_044389	481	G → W in GHDD. 1 PublicationCorresponds to variant dbSNP:rs199422116Ensembl.	1
Natural variantⁱVAR_044390	487	L → P in GHDD. 1 PublicationCorresponds to variant dbSNP:rs199422114Ensembl.	1
Natural variantⁱVAR_018380	501	R → Q1 PublicationCorresponds to variant dbSNP:rs8192864Ensembl.	1
Natural variantⁱVAR_055566	511	P → L. Corresponds to variant dbSNP:rs13306050Ensembl.	1
Natural variantⁱVAR_044391	512	L → P. Corresponds to variant dbSNP:rs13306050Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_047217	1 – 67	Missing in isoform 2. 1 PublicationAdd BLAST	67
Alternative sequenceⁱVSP_054121	150	E → ELGLLIMQERIKGHMGGQQA PQRIPPTRLSKPSGIYVNLH YATLPFC in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_054122	456 – 459	FTAE → YRCS in isoform 4. 1 Publication	4
Alternative sequenceⁱVSP_054123	460 – 533	Missing in isoform 4. 1 PublicationAdd BLAST	74

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M80646 mRNA Translation: AAA60617.1 Different initiation. M80647 mRNA Translation: AAA60618.1 Different initiation. D34625 Genomic DNA Translation: BAA07011.1 L36085 L36084 Genomic DNA Translation: AAC01761.1 Different initiation. AF233615 Genomic DNA Translation: AAF99269.1 Different initiation. AF233616 Genomic DNA Translation: AAF99270.1 Different initiation. AF233617 Genomic DNA Translation: AAF99271.1 Different initiation. AF233618 Genomic DNA Translation: AAF99272.1 Different initiation. AF233619 Genomic DNA Translation: AAF99273.1 Different initiation. AF233620 Genomic DNA Translation: AAF99274.1 Different initiation. AF233621 Genomic DNA Translation: AAF99275.1 Different initiation. AF233622 Genomic DNA Translation: AAF99276.1 Different initiation. AF233623 Genomic DNA Translation: AAF99277.1 Different initiation. AF233624 Genomic DNA Translation: AAF99278.1 Different initiation. AF233625 Genomic DNA Translation: AAF99279.1 Different initiation. AK296069 mRNA Translation: BAG58828.1 Different initiation. AC004914 Genomic DNA No translation available. AC004961 Genomic DNA No translation available. AC006021 Genomic DNA No translation available. CH471070 Genomic DNA Translation: EAW83934.1 Different initiation. BC014117 mRNA Translation: AAH14117.1 BC041157 mRNA Translation: AAH41157.1 Different initiation. M74055 mRNA Translation: AAA36742.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS55175.1 [P24557-2]
PIRⁱ	A41766 S48161
NCBI Reference Sequences More...RefSeqⁱ	NP_001052.2, NM_001061.4 NP_001124438.1, NM_001130966.2 NP_001159725.1, NM_001166253.1 NP_001159726.1, NM_001166254.1 [P24557-2] NP_112246.2, NM_030984.3
UniGeneⁱ	Hs.520757

Genome annotation databases

Ensemblⁱ	ENST00000425687; ENSP00000388736; ENSG00000059377 [P24557-2]
GeneIDⁱ	6916
KEGGⁱ	hsa:6916
UCSC genome browser More...UCSCⁱ	uc010lne.4 human [P24557-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24557	HCG14925, isoform CRA_a (Fragment)		HUMAN		534	UniRef100_P24557
Isoform 2 of Thromboxane-A synthase		HUMAN		466
UPI0000416A05		HUMAN		448
P24557-3	Thromboxane-A synthase		HUMAN		580	UniRef100_A0A0C4DH47
TBXAS1 isoform 11		PANTR		80
Thromboxane-A synthase		HUMAN		80
Thromboxane-A synthase (Fragment)		HUMAN		151
TBXAS1 isoform 8 (Fragment)		PANTR		151
P24557-4	HCG14925, isoform CRA_b		HUMAN		460	UniRef100_A0A0A0MSK3

Protein	Similar proteins		Species	Score	Length	Source
P24557	Thromboxane-A synthase		MACFA		533	UniRef90_P24557
HCG14925, isoform CRA_a (Fragment)		HUMAN		534
Thromboxane A synthase 1		SAIBB		572
TBXAS1 isoform 10		PANTR		534
Thromboxane-A synthase isoform 1		CALJA		534
+69
P24557-3	Thromboxane-A synthase		HUMAN		580	UniRef90_A0A0C4DH47
TBXAS1 isoform 11		PANTR		80
Thromboxane A synthase 1		MACMU		580
Uncharacterized protein		MACFA		580
Thromboxane A synthase 1		SAIBB		580
+30

Protein	Similar proteins		Species	Score	Length	Source
P24557	Thromboxane-A synthase		MACFA		533	UniRef50_P24557
HCG14925, isoform CRA_a (Fragment)		HUMAN		534
Thromboxane A synthase 1		SAIBB		572
TBXAS1 isoform 3		PONAB		534
Uncharacterized protein		CERAT		534
+80
P24557-3	Thromboxane-A synthase		MOUSE		533	UniRef50_P36423
Thromboxane-A synthase		BOVIN		533
Uncharacterized protein		FELCA		459
thromboxane-A synthase		URSMA		543
Thromboxane A synthase 1		AILME		503
+144

Cross-referencesⁱ

Web resourcesⁱ

Cytochrome P450 Allele Nomenclature Committee

CYP5A1 alleles

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M80646 mRNA Translation: AAA60617.1 Different initiation. M80647 mRNA Translation: AAA60618.1 Different initiation. D34625 Genomic DNA Translation: BAA07011.1 L36085 L36084 Genomic DNA Translation: AAC01761.1 Different initiation. AF233615 Genomic DNA Translation: AAF99269.1 Different initiation. AF233616 Genomic DNA Translation: AAF99270.1 Different initiation. AF233617 Genomic DNA Translation: AAF99271.1 Different initiation. AF233618 Genomic DNA Translation: AAF99272.1 Different initiation. AF233619 Genomic DNA Translation: AAF99273.1 Different initiation. AF233620 Genomic DNA Translation: AAF99274.1 Different initiation. AF233621 Genomic DNA Translation: AAF99275.1 Different initiation. AF233622 Genomic DNA Translation: AAF99276.1 Different initiation. AF233623 Genomic DNA Translation: AAF99277.1 Different initiation. AF233624 Genomic DNA Translation: AAF99278.1 Different initiation. AF233625 Genomic DNA Translation: AAF99279.1 Different initiation. AK296069 mRNA Translation: BAG58828.1 Different initiation. AC004914 Genomic DNA No translation available. AC004961 Genomic DNA No translation available. AC006021 Genomic DNA No translation available. CH471070 Genomic DNA Translation: EAW83934.1 Different initiation. BC014117 mRNA Translation: AAH14117.1 BC041157 mRNA Translation: AAH41157.1 Different initiation. M74055 mRNA Translation: AAA36742.1
CCDSⁱ	CCDS55175.1 [P24557-2]
PIRⁱ	A41766 S48161
RefSeqⁱ	NP_001052.2, NM_001061.4 NP_001124438.1, NM_001130966.2 NP_001159725.1, NM_001166253.1 NP_001159726.1, NM_001166254.1 [P24557-2] NP_112246.2, NM_030984.3
UniGeneⁱ	Hs.520757

3D structure databases

ProteinModelPortalⁱ	P24557
SMRⁱ	P24557
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112778, 2 interactors
IntActⁱ	P24557, 2 interactors
MINTⁱ	P24557

Chemistry databases

BindingDBⁱ	P24557
ChEMBLⁱ	CHEMBL1835
DrugBankⁱ	DB03052 Dazoxiben DB05505 NM-702 DB01207 Ridogrel DB00795 Sulfasalazine
GuidetoPHARMACOLOGYⁱ	1353
SwissLipidsⁱ	SLP:000001099

PTM databases

iPTMnetⁱ	P24557
PhosphoSitePlusⁱ	P24557

Polymorphism and mutation databases

BioMutaⁱ	TBXAS1

BioMutaⁱ

TBXAS1

Proteomic databases

EPDⁱ	P24557
MaxQBⁱ	P24557
PeptideAtlasⁱ	P24557
PRIDEⁱ	P24557
ProteomicsDBⁱ	54216

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6916
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000425687; ENSP00000388736; ENSG00000059377 [P24557-2]
GeneIDⁱ	6916
KEGGⁱ	hsa:6916
UCSCⁱ	uc010lne.4 human [P24557-1]

Organism-specific databases

CTDⁱ	6916
DisGeNETⁱ	6916
EuPathDBⁱ	HostDB:ENSG00000059377.15
GeneCardsⁱ	TBXAS1
HGNCⁱ	HGNC:11609 TBXAS1
HPAⁱ	HPA031257 HPA031258 HPA031259
MalaCardsⁱ	TBXAS1
MIMⁱ	231095 phenotype 274180 gene
neXtProtⁱ	NX_P24557
OpenTargetsⁱ	ENSG00000059377
Orphanetⁱ	1802 Ghosal hematodiaphyseal dysplasia
PharmGKBⁱ	PA349
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00900000140779
HOGENOMⁱ	HOG000039127
HOVERGENⁱ	HBG108567
InParanoidⁱ	P24557
KOⁱ	K01832
OMAⁱ	PFVRHAQ
PhylomeDBⁱ	P24557
TreeFamⁱ	TF105087

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS00728-MONOMER
Reactomeⁱ	R-HSA-211979 Eicosanoids R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-5579032 Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
SIGNORⁱ	P24557

Miscellaneous databases

ChiTaRSⁱ	TBXAS1 human
GeneWikiⁱ	Thromboxane-A_synthase
GenomeRNAiⁱ	6916
Protein Ontology More...PROⁱ	PR:P24557
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000059377 Expressed in 124 organ(s), highest expression level in blood
ExpressionAtlasⁱ	P24557 baseline and differential
Genevisibleⁱ	P24557 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 2 hits
PRINTSⁱ	PR00463 EP450I PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	THAS_HUMAN
Accessionⁱ	P24557Primary (citable) accession number: P24557 Secondary accession number(s): B4DJG6 Q9HD84
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	July 28, 2009
	Last modified:	November 7, 2018
	This is version 201 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - P24557 (THAS_HUMAN)

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Thromboxane-A synthase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Endoplasmic reticulum

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Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

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Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ