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Protein

ATP synthase F(0) complex subunit B1, mitochondrial

Gene

ATP5PB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha3beta3 subcomplex and subunit a/ATP6 static relative to the rotary elements.

GO - Molecular functioni

  • proton transmembrane transporter activity Source: InterPro
  • transmembrane transporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-163210 Formation of ATP by chemiosmotic coupling
R-HSA-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase F(0) complex subunit B1, mitochondrialCurated
Alternative name(s):
ATP synthase peripheral stalk-membrane subunit bCurated
ATP synthase proton-transporting mitochondrial F(0) complex subunit B1
ATP synthase subunit b
Short name:
ATPase subunit b
Gene namesi
Name:ATP5PBImported
Synonyms:ATP5F1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116459.10
HGNCiHGNC:840 ATP5PB
MIMi603270 gene
neXtProtiNX_P24539

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi515
OpenTargetsiENSG00000116459
PharmGKBiPA25130

Polymorphism and mutation databases

BioMutaiATP5F1
DMDMi20455474

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionCombined sourcesAdd BLAST42
ChainiPRO_000000251343 – 256ATP synthase F(0) complex subunit B1, mitochondrialAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131N6-succinyllysineBy similarity1
Modified residuei139N6-acetyllysineBy similarity1
Modified residuei154N6-acetyllysineBy similarity1
Modified residuei162N6-acetyllysineBy similarity1
Modified residuei221N6-acetyllysineCombined sources1
Modified residuei233N6-acetyllysineCombined sources1
Modified residuei244N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP24539
PaxDbiP24539
PeptideAtlasiP24539
PRIDEiP24539
ProteomicsDBi54215
TopDownProteomicsiP24539

PTM databases

iPTMnetiP24539
PhosphoSitePlusiP24539
SwissPalmiP24539

Expressioni

Gene expression databases

BgeeiENSG00000116459 Expressed in 236 organ(s), highest expression level in colon
CleanExiHS_ATP5F1
ExpressionAtlasiP24539 baseline and differential
GenevisibleiP24539 HS

Organism-specific databases

HPAiHPA046067
HPA057347

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MD and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi107000, 126 interactors
CORUMiP24539
IntActiP24539, 42 interactors
MINTiP24539
STRINGi9606.ENSP00000358737

Structurei

3D structure databases

ProteinModelPortaliP24539
SMRiP24539
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ATPase B chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410INNH Eukaryota
ENOG4111WYE LUCA
GeneTreeiENSGT00390000001958
HOGENOMiHOG000007163
HOVERGENiHBG050604
InParanoidiP24539
KOiK02127
OMAiKEIYVIN
OrthoDBiEOG091G0DPN
PhylomeDBiP24539
TreeFamiTF313250

Family and domain databases

InterProiView protein in InterPro
IPR008688 ATP_synth_Bsub_B/MI25
IPR013837 ATP_synth_F0_suB
PANTHERiPTHR12733 PTHR12733, 1 hit
PfamiView protein in Pfam
PF05405 Mt_ATP-synt_B, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P24539-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSRVVLSAA ATAAPSLKNA AFLGPGVLQA TRTFHTGQPH LVPVPPLPEY
60 70 80 90 100
GGKVRYGLIP EEFFQFLYPK TGVTGPYVLG TGLILYALSK EIYVISAETF
110 120 130 140 150
TALSVLGVMV YGIKKYGPFV ADFADKLNEQ KLAQLEEAKQ ASIQHIQNAI
160 170 180 190 200
DTEKSQQALV QKRHYLFDVQ RNNIAMALEV TYRERLYRVY KEVKNRLDYH
210 220 230 240 250
ISVQNMMRRK EQEHMINWVE KHVVQSISTQ QEKETIAKCI ADLKLLAKKA

QAQPVM
Length:256
Mass (Da):28,909
Last modified:May 2, 2002 - v2
Checksum:i743B1C54BFFEBBBD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5QNZ2Q5QNZ2_HUMAN
ATP synthase F(0) complex subunit B...
ATP5PB
195Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84I → V in CAA42782 (PubMed:1831354).Curated1
Sequence conflicti91E → G in AAH05960 (PubMed:15489334).Curated1
Sequence conflicti194K → R in AAH05960 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033534152T → M. Corresponds to variant dbSNP:rs1264895Ensembl.1
Natural variantiVAR_013176152T → N. Corresponds to variant dbSNP:rs1264895Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60221 mRNA Translation: CAA42782.1
AL390195 Genomic DNA No translation available.
BC005366 mRNA Translation: AAH05366.1
BC005960 mRNA Translation: AAH05960.1
BC016350 mRNA Translation: AAH16350.1
CCDSiCCDS836.1
PIRiJQ1144
RefSeqiNP_001679.2, NM_001688.4
UniGeneiHs.514870

Genome annotation databases

EnsembliENST00000369722; ENSP00000358737; ENSG00000116459
GeneIDi515
KEGGihsa:515

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60221 mRNA Translation: CAA42782.1
AL390195 Genomic DNA No translation available.
BC005366 mRNA Translation: AAH05366.1
BC005960 mRNA Translation: AAH05960.1
BC016350 mRNA Translation: AAH16350.1
CCDSiCCDS836.1
PIRiJQ1144
RefSeqiNP_001679.2, NM_001688.4
UniGeneiHs.514870

3D structure databases

ProteinModelPortaliP24539
SMRiP24539
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107000, 126 interactors
CORUMiP24539
IntActiP24539, 42 interactors
MINTiP24539
STRINGi9606.ENSP00000358737

PTM databases

iPTMnetiP24539
PhosphoSitePlusiP24539
SwissPalmiP24539

Polymorphism and mutation databases

BioMutaiATP5F1
DMDMi20455474

Proteomic databases

EPDiP24539
PaxDbiP24539
PeptideAtlasiP24539
PRIDEiP24539
ProteomicsDBi54215
TopDownProteomicsiP24539

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369722; ENSP00000358737; ENSG00000116459
GeneIDi515
KEGGihsa:515

Organism-specific databases

CTDi515
DisGeNETi515
EuPathDBiHostDB:ENSG00000116459.10
GeneCardsiATP5PB
HGNCiHGNC:840 ATP5PB
HPAiHPA046067
HPA057347
MIMi603270 gene
neXtProtiNX_P24539
OpenTargetsiENSG00000116459
PharmGKBiPA25130
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INNH Eukaryota
ENOG4111WYE LUCA
GeneTreeiENSGT00390000001958
HOGENOMiHOG000007163
HOVERGENiHBG050604
InParanoidiP24539
KOiK02127
OMAiKEIYVIN
OrthoDBiEOG091G0DPN
PhylomeDBiP24539
TreeFamiTF313250

Enzyme and pathway databases

ReactomeiR-HSA-163210 Formation of ATP by chemiosmotic coupling
R-HSA-8949613 Cristae formation

Miscellaneous databases

GeneWikiiATP5F1
GenomeRNAii515
PROiPR:P24539
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116459 Expressed in 236 organ(s), highest expression level in colon
CleanExiHS_ATP5F1
ExpressionAtlasiP24539 baseline and differential
GenevisibleiP24539 HS

Family and domain databases

InterProiView protein in InterPro
IPR008688 ATP_synth_Bsub_B/MI25
IPR013837 ATP_synth_F0_suB
PANTHERiPTHR12733 PTHR12733, 1 hit
PfamiView protein in Pfam
PF05405 Mt_ATP-synt_B, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAT5F1_HUMAN
AccessioniPrimary (citable) accession number: P24539
Secondary accession number(s): Q9BQ68, Q9BRU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: May 2, 2002
Last modified: November 7, 2018
This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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