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Entry version 221 (16 Oct 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Elongation factor 1-beta

Gene

EEF1B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156842 Eukaryotic Translation Elongation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P24534

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elongation factor 1-beta
Short name:
EF-1-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EEF1B2
Synonyms:EEF1B, EF1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3208 EEF1B2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600655 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P24534

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1933

Open Targets

More...
OpenTargetsi
ENSG00000114942

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27644

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P24534

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EEF1B2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
119163

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001550212 – 225Elongation factor 1-betaAdd BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7N6-acetyllysineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei88PhosphothreonineBy similarity1
Modified residuei93PhosphothreonineCombined sources1
Modified residuei95PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei174PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation affects the GDP/GTP exchange rate.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-66
CPTAC-67

Encyclopedia of Proteome Dynamics

More...
EPDi
P24534

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P24534

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P24534

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P24534

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P24534

PeptideAtlas

More...
PeptideAtlasi
P24534

PRoteomics IDEntifications database

More...
PRIDEi
P24534

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54214

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P24534

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P24534

USC-OGP 2-DE database

More...
OGPi
P24534

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P24534

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P24534

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P24534

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P24534

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P24534

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114942 Expressed in 88 organ(s), highest expression level in body of pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P24534 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P24534 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB012477
HPA035029

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108253, 96 interactors

Protein interaction database and analysis system

More...
IntActi
P24534, 49 interactors

Molecular INTeraction database

More...
MINTi
P24534

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376056

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P24534

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P24534

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 84GST C-terminalAdd BLAST83

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EF-1-beta/EF-1-delta family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1668 Eukaryota
COG2092 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183014

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000207273

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24534

KEGG Orthology (KO)

More...
KOi
K03232

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSQADVH

Database of Orthologous Groups

More...
OrthoDBi
1464823at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P24534

TreeFam database of animal gene trees

More...
TreeFami
TF313134

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00292 EF1B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036219 eEF-1beta-like_sf
IPR018940 EF-1_beta_acid_region_euk
IPR014038 EF1B_bsu/dsu_GNE
IPR036282 Glutathione-S-Trfase_C_sf
IPR014717 Transl_elong_EF1B/ribosomal_S6
IPR001326 Transl_elong_EF1B_B/D_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10587 EF-1_beta_acid, 1 hit
PF00736 EF1_GNE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01182 EF-1_beta_acid, 1 hit
SM00888 EF1_GNE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47616 SSF47616, 1 hit
SSF54984 SSF54984, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00824 EF1BD_1, 1 hit
PS00825 EF1BD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P24534-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFGDLKSPA GLQVLNDYLA DKSYIEGYVP SQADVAVFEA VSSPPPADLC
60 70 80 90 100
HALRWYNHIK SYEKEKASLP GVKKALGKYG PADVEDTTGS GATDSKDDDD
110 120 130 140 150
IDLFGSDDEE ESEEAKRLRE ERLAQYESKK AKKPALVAKS SILLDVKPWD
160 170 180 190 200
DETDMAKLEE CVRSIQADGL VWGSSKLVPV GYGIKKLQIQ CVVEDDKVGT
210 220
DMLEEQITAF EDYVQSMDVA AFNKI
Length:225
Mass (Da):24,764
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDE763ADBF127822
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JZW3C9JZW3_HUMAN
Elongation factor 1-beta
EEF1B2
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2G2F2Z2G2_HUMAN
Elongation factor 1-beta
EEF1B2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF65F8WF65_HUMAN
Elongation factor 1-beta
EEF1B2
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WFC9F8WFC9_HUMAN
Elongation factor 1-beta
EEF1B2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X60489 mRNA Translation: CAA43019.1
X60656 mRNA Translation: CAA43063.1
BT007079 mRNA Translation: AAP35742.1
CR456825 mRNA Translation: CAG33106.1
AK291910 mRNA Translation: BAF84599.1
AC007383 Genomic DNA Translation: AAY15062.1
CH471063 Genomic DNA Translation: EAW70381.1
BC000211 mRNA Translation: AAH00211.1
BC004931 mRNA Translation: AAH04931.1
BC067787 mRNA Translation: AAH67787.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2367.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S25432

NCBI Reference Sequences

More...
RefSeqi
NP_001032752.1, NM_001037663.1
NP_001950.1, NM_001959.3
NP_066944.1, NM_021121.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000236957; ENSP00000236957; ENSG00000114942
ENST00000392221; ENSP00000376055; ENSG00000114942
ENST00000392222; ENSP00000376056; ENSG00000114942
ENST00000635728; ENSP00000489993; ENSG00000283391
ENST00000636275; ENSP00000490326; ENSG00000283391
ENST00000637253; ENSP00000490214; ENSG00000283391

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1933

UCSC genome browser

More...
UCSCi
uc002vbf.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60489 mRNA Translation: CAA43019.1
X60656 mRNA Translation: CAA43063.1
BT007079 mRNA Translation: AAP35742.1
CR456825 mRNA Translation: CAG33106.1
AK291910 mRNA Translation: BAF84599.1
AC007383 Genomic DNA Translation: AAY15062.1
CH471063 Genomic DNA Translation: EAW70381.1
BC000211 mRNA Translation: AAH00211.1
BC004931 mRNA Translation: AAH04931.1
BC067787 mRNA Translation: AAH67787.1
CCDSiCCDS2367.1
PIRiS25432
RefSeqiNP_001032752.1, NM_001037663.1
NP_001950.1, NM_001959.3
NP_066944.1, NM_021121.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B64NMR-A136-225[»]
5DQSX-ray2.10D1-88[»]
SMRiP24534
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi108253, 96 interactors
IntActiP24534, 49 interactors
MINTiP24534
STRINGi9606.ENSP00000376056

PTM databases

iPTMnetiP24534
PhosphoSitePlusiP24534
SwissPalmiP24534

Polymorphism and mutation databases

BioMutaiEEF1B2
DMDMi119163

2D gel databases

DOSAC-COBS-2DPAGEiP24534
OGPiP24534
SWISS-2DPAGEiP24534

Proteomic databases

CPTACiCPTAC-66
CPTAC-67
EPDiP24534
jPOSTiP24534
MassIVEiP24534
MaxQBiP24534
PaxDbiP24534
PeptideAtlasiP24534
PRIDEiP24534
ProteomicsDBi54214
TopDownProteomicsiP24534

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1933

Genome annotation databases

EnsembliENST00000236957; ENSP00000236957; ENSG00000114942
ENST00000392221; ENSP00000376055; ENSG00000114942
ENST00000392222; ENSP00000376056; ENSG00000114942
ENST00000635728; ENSP00000489993; ENSG00000283391
ENST00000636275; ENSP00000490326; ENSG00000283391
ENST00000637253; ENSP00000490214; ENSG00000283391
GeneIDi1933
KEGGihsa:1933
UCSCiuc002vbf.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1933
DisGeNETi1933

GeneCards: human genes, protein and diseases

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GeneCardsi
EEF1B2
HGNCiHGNC:3208 EEF1B2
HPAiCAB012477
HPA035029
MIMi600655 gene
neXtProtiNX_P24534
OpenTargetsiENSG00000114942
PharmGKBiPA27644

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1668 Eukaryota
COG2092 LUCA
GeneTreeiENSGT00950000183014
HOGENOMiHOG000207273
InParanoidiP24534
KOiK03232
OMAiPSQADVH
OrthoDBi1464823at2759
PhylomeDBiP24534
TreeFamiTF313134

Enzyme and pathway databases

ReactomeiR-HSA-156842 Eukaryotic Translation Elongation
SIGNORiP24534

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EEF1B2 human
EvolutionaryTraceiP24534

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
EEF1B2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1933
PharosiP24534
PMAP-CutDBiP24534

Protein Ontology

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PROi
PR:P24534

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000114942 Expressed in 88 organ(s), highest expression level in body of pancreas
ExpressionAtlasiP24534 baseline and differential
GenevisibleiP24534 HS

Family and domain databases

CDDicd00292 EF1B, 1 hit
Gene3Di3.30.70.60, 1 hit
InterProiView protein in InterPro
IPR036219 eEF-1beta-like_sf
IPR018940 EF-1_beta_acid_region_euk
IPR014038 EF1B_bsu/dsu_GNE
IPR036282 Glutathione-S-Trfase_C_sf
IPR014717 Transl_elong_EF1B/ribosomal_S6
IPR001326 Transl_elong_EF1B_B/D_CS
PfamiView protein in Pfam
PF10587 EF-1_beta_acid, 1 hit
PF00736 EF1_GNE, 1 hit
SMARTiView protein in SMART
SM01182 EF-1_beta_acid, 1 hit
SM00888 EF1_GNE, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF54984 SSF54984, 1 hit
PROSITEiView protein in PROSITE
PS00824 EF1BD_1, 1 hit
PS00825 EF1BD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEF1B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24534
Secondary accession number(s): A8K795, Q6IBH9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 221 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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