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UniProtKB - P24534 (EF1B_HUMAN)

Entry version 232 (02 Jun 2021)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Elongation factor 1-beta

Gene

EEF1B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P24534

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156842, Eukaryotic Translation Elongation

SIGNOR Signaling Network Open Resource

More...SIGNORi		P24534

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elongation factor 1-beta
Short name:
EF-1-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EEF1B2
Synonyms:EEF1B, EF1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3208, EEF1B2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600655, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P24534

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000114942.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1933

MalaCards human disease database

More...MalaCardsi		EEF1B2

Open Targets

More...OpenTargetsi		ENSG00000114942

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27644

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P24534, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295731

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		EEF1B2

Domain mapping of disease mutations (DMDM)

More...DMDMi		119163

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001550212 – 225Elongation factor 1-betaAdd BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7N6-acetyllysineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei88PhosphothreonineBy similarity1
Modified residuei93PhosphothreonineCombined sources1
Modified residuei95PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei174PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation affects the GDP/GTP exchange rate.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-66
CPTAC-67

Encyclopedia of Proteome Dynamics

More...EPDi		P24534

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P24534

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P24534

MaxQB - The MaxQuant DataBase

More...MaxQBi		P24534

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P24534

PeptideAtlas

More...PeptideAtlasi		P24534

PRoteomics IDEntifications database

More...PRIDEi		P24534

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54214

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P24534

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P24534

USC-OGP 2-DE database

More...OGPi		P24534

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P24534

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P24534

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P24534

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P24534

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000114942, Expressed in body of pancreas and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P24534, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P24534, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000114942, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108253, 131 interactors

Protein interaction database and analysis system

More...IntActi		P24534, 60 interactors

Molecular INTeraction database

More...MINTi		P24534

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000376056

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P24534, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P24534

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P24534

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P24534

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 84GST C-terminalAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni78 – 115DisorderedSequence analysisAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EF-1-beta/EF-1-delta family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1668, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183014

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_050172_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P24534

Identification of Orthologs from Complete Genome Data

More...OMAi		RSYVEGY

Database of Orthologous Groups

More...OrthoDBi		1464823at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P24534

TreeFam database of animal gene trees

More...TreeFami		TF313134

Family and domain databases

Conserved Domains Database

More...CDDi		cd00292, EF1B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036219, eEF-1beta-like_sf
IPR018940, EF-1_beta_acid_region_euk
IPR014038, EF1B_bsu/dsu_GNE
IPR036282, Glutathione-S-Trfase_C_sf
IPR014717, Transl_elong_EF1B/ribosomal_S6
IPR001326, Transl_elong_EF1B_B/D_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10587, EF-1_beta_acid, 1 hit
PF00736, EF1_GNE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01182, EF-1_beta_acid, 1 hit
SM00888, EF1_GNE, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47616, SSF47616, 1 hit
SSF54984, SSF54984, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00824, EF1BD_1, 1 hit
PS00825, EF1BD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P24534-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFGDLKSPA GLQVLNDYLA DKSYIEGYVP SQADVAVFEA VSSPPPADLC 
        60         70         80         90        100
HALRWYNHIK SYEKEKASLP GVKKALGKYG PADVEDTTGS GATDSKDDDD 
       110        120        130        140        150
IDLFGSDDEE ESEEAKRLRE ERLAQYESKK AKKPALVAKS SILLDVKPWD 
       160        170        180        190        200
DETDMAKLEE CVRSIQADGL VWGSSKLVPV GYGIKKLQIQ CVVEDDKVGT 
       210        220 
DMLEEQITAF EDYVQSMDVA AFNKI
Length:225
Mass (Da):24,764
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDE763ADBF127822
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JZW3C9JZW3_HUMAN
Elongation factor 1-beta
EEF1B2
123Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2G2F2Z2G2_HUMAN
Elongation factor 1-beta
EEF1B2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF65F8WF65_HUMAN
Elongation factor 1-beta
EEF1B2
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WFC9F8WFC9_HUMAN
Elongation factor 1-beta
EEF1B2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X60489 mRNA Translation: CAA43019.1
X60656 mRNA Translation: CAA43063.1
BT007079 mRNA Translation: AAP35742.1
CR456825 mRNA Translation: CAG33106.1
AK291910 mRNA Translation: BAF84599.1
AC007383 Genomic DNA Translation: AAY15062.1
CH471063 Genomic DNA Translation: EAW70381.1
BC000211 mRNA Translation: AAH00211.1
BC004931 mRNA Translation: AAH04931.1
BC067787 mRNA Translation: AAH67787.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2367.1

Protein sequence database of the Protein Information Resource

More...PIRi		S25432

NCBI Reference Sequences

More...RefSeqi		NP_001032752.1, NM_001037663.1
NP_001950.1, NM_001959.3
NP_066944.1, NM_021121.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000236957; ENSP00000236957; ENSG00000114942
ENST00000392221; ENSP00000376055; ENSG00000114942
ENST00000392222; ENSP00000376056; ENSG00000114942
ENST00000635728; ENSP00000489993; ENSG00000283391
ENST00000636275; ENSP00000490326; ENSG00000283391
ENST00000637253; ENSP00000490214; ENSG00000283391

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1933

UCSC genome browser

More...UCSCi		uc002vbf.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60489 mRNA Translation: CAA43019.1
X60656 mRNA Translation: CAA43063.1
BT007079 mRNA Translation: AAP35742.1
CR456825 mRNA Translation: CAG33106.1
AK291910 mRNA Translation: BAF84599.1
AC007383 Genomic DNA Translation: AAY15062.1
CH471063 Genomic DNA Translation: EAW70381.1
BC000211 mRNA Translation: AAH00211.1
BC004931 mRNA Translation: AAH04931.1
BC067787 mRNA Translation: AAH67787.1
CCDSiCCDS2367.1
PIRiS25432
RefSeqiNP_001032752.1, NM_001037663.1
NP_001950.1, NM_001959.3
NP_066944.1, NM_021121.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B64NMR-A136-225[»]
5DQSX-ray2.10D1-88[»]
BMRBiP24534
SMRiP24534
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108253, 131 interactors
IntActiP24534, 60 interactors
MINTiP24534
STRINGi9606.ENSP00000376056

Chemistry databases

ChEMBLiCHEMBL4295731

PTM databases

iPTMnetiP24534
PhosphoSitePlusiP24534
SwissPalmiP24534

Genetic variation databases

BioMutaiEEF1B2
DMDMi119163

2D gel databases

DOSAC-COBS-2DPAGEiP24534
OGPiP24534
SWISS-2DPAGEiP24534

Proteomic databases

CPTACiCPTAC-66
CPTAC-67
EPDiP24534
jPOSTiP24534
MassIVEiP24534
MaxQBiP24534
PaxDbiP24534
PeptideAtlasiP24534
PRIDEiP24534
ProteomicsDBi54214
TopDownProteomicsiP24534

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34177, 198 antibodies

The DNASU plasmid repository

More...DNASUi		1933

Genome annotation databases

EnsembliENST00000236957; ENSP00000236957; ENSG00000114942
ENST00000392221; ENSP00000376055; ENSG00000114942
ENST00000392222; ENSP00000376056; ENSG00000114942
ENST00000635728; ENSP00000489993; ENSG00000283391
ENST00000636275; ENSP00000490326; ENSG00000283391
ENST00000637253; ENSP00000490214; ENSG00000283391
GeneIDi1933
KEGGihsa:1933
UCSCiuc002vbf.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1933
DisGeNETi1933

GeneCards: human genes, protein and diseases

More...GeneCardsi		EEF1B2
HGNCiHGNC:3208, EEF1B2
HPAiENSG00000114942, Low tissue specificity
MalaCardsiEEF1B2
MIMi600655, gene
neXtProtiNX_P24534
OpenTargetsiENSG00000114942
PharmGKBiPA27644
VEuPathDBiHostDB:ENSG00000114942.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1668, Eukaryota
GeneTreeiENSGT00950000183014
HOGENOMiCLU_050172_0_0_1
InParanoidiP24534
OMAiRSYVEGY
OrthoDBi1464823at2759
PhylomeDBiP24534
TreeFamiTF313134

Enzyme and pathway databases

PathwayCommonsiP24534
ReactomeiR-HSA-156842, Eukaryotic Translation Elongation
SIGNORiP24534

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1933, 600 hits in 925 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		EEF1B2, human
EvolutionaryTraceiP24534

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		EEF1B2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1933
PharosiP24534, Tbio

Protein Ontology

More...PROi		PR:P24534
RNActiP24534, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000114942, Expressed in body of pancreas and 114 other tissues
ExpressionAtlasiP24534, baseline and differential
GenevisibleiP24534, HS

Family and domain databases

CDDicd00292, EF1B, 1 hit
Gene3Di3.30.70.60, 1 hit
InterProiView protein in InterPro
IPR036219, eEF-1beta-like_sf
IPR018940, EF-1_beta_acid_region_euk
IPR014038, EF1B_bsu/dsu_GNE
IPR036282, Glutathione-S-Trfase_C_sf
IPR014717, Transl_elong_EF1B/ribosomal_S6
IPR001326, Transl_elong_EF1B_B/D_CS
PfamiView protein in Pfam
PF10587, EF-1_beta_acid, 1 hit
PF00736, EF1_GNE, 1 hit
SMARTiView protein in SMART
SM01182, EF-1_beta_acid, 1 hit
SM00888, EF1_GNE, 1 hit
SUPFAMiSSF47616, SSF47616, 1 hit
SSF54984, SSF54984, 1 hit
PROSITEiView protein in PROSITE
PS00824, EF1BD_1, 1 hit
PS00825, EF1BD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEF1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24534
Secondary accession number(s): A8K795, Q6IBH9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 232 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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