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Protein

Elongation factor 1-beta

Gene

EEF1B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

GO - Molecular functioni

  • translation elongation factor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-156842 Eukaryotic Translation Elongation
SIGNORiP24534

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-beta
Short name:
EF-1-beta
Gene namesi
Name:EEF1B2
Synonyms:EEF1B, EF1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000114942.13
HGNCiHGNC:3208 EEF1B2
MIMi600655 gene
neXtProtiNX_P24534

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi1933
OpenTargetsiENSG00000114942
PharmGKBiPA27644

Polymorphism and mutation databases

BioMutaiEEF1B2
DMDMi119163

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001550212 – 225Elongation factor 1-betaAdd BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7N6-acetyllysineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei88PhosphothreonineBy similarity1
Modified residuei93PhosphothreonineCombined sources1
Modified residuei95PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei174PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation affects the GDP/GTP exchange rate.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP24534
MaxQBiP24534
PaxDbiP24534
PeptideAtlasiP24534
PRIDEiP24534
ProteomicsDBi54214
TopDownProteomicsiP24534

2D gel databases

DOSAC-COBS-2DPAGEiP24534
OGPiP24534
SWISS-2DPAGEiP24534

PTM databases

iPTMnetiP24534
PhosphoSitePlusiP24534
SwissPalmiP24534

Miscellaneous databases

PMAP-CutDBiP24534

Expressioni

Inductioni

By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.1 Publication

Gene expression databases

BgeeiENSG00000114942
CleanExiHS_EEF1B2
ExpressionAtlasiP24534 baseline and differential
GenevisibleiP24534 HS

Organism-specific databases

HPAiCAB012477
HPA035029

Interactioni

Subunit structurei

EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi108253, 74 interactors
IntActiP24534, 31 interactors
MINTiP24534
STRINGi9606.ENSP00000236957

Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 18Combined sources10
Turni19 – 21Combined sources3
Beta strandi23 – 26Combined sources4
Helixi32 – 41Combined sources10
Helixi50 – 60Combined sources11
Helixi61 – 65Combined sources5
Beta strandi69 – 71Combined sources3
Helixi76 – 78Combined sources3
Beta strandi79 – 81Combined sources3
Beta strandi140 – 150Combined sources11
Helixi155 – 164Combined sources10
Beta strandi171 – 183Combined sources13
Beta strandi185 – 193Combined sources9
Helixi200 – 207Combined sources8
Turni211 – 213Combined sources3
Beta strandi214 – 220Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B64NMR-A136-225[»]
5DQSX-ray2.10D1-88[»]
ProteinModelPortaliP24534
SMRiP24534
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24534

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 84GST C-terminalAdd BLAST83

Sequence similaritiesi

Belongs to the EF-1-beta/EF-1-delta family.Curated

Phylogenomic databases

eggNOGiKOG1668 Eukaryota
COG2092 LUCA
GeneTreeiENSGT00390000011747
HOGENOMiHOG000207273
HOVERGENiHBG000787
InParanoidiP24534
KOiK03232
OMAiPSQADVH
OrthoDBiEOG091G0P0Z
PhylomeDBiP24534
TreeFamiTF313134

Family and domain databases

CDDicd00292 EF1B, 1 hit
Gene3Di3.30.70.60, 1 hit
InterProiView protein in InterPro
IPR036219 eEF-1beta-like_sf
IPR018940 EF-1_beta_acid_region_euk
IPR014038 EF1B_bsu/dsu_GNE
IPR036282 Glutathione-S-Trfase_C_sf
IPR014717 Transl_elong_EF1B/ribosomal_S6
IPR001326 Transl_elong_EF1B_B/D_CS
PfamiView protein in Pfam
PF10587 EF-1_beta_acid, 1 hit
PF00736 EF1_GNE, 1 hit
SMARTiView protein in SMART
SM01182 EF-1_beta_acid, 1 hit
SM00888 EF1_GNE, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF54984 SSF54984, 1 hit
PROSITEiView protein in PROSITE
PS00824 EF1BD_1, 1 hit
PS00825 EF1BD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFGDLKSPA GLQVLNDYLA DKSYIEGYVP SQADVAVFEA VSSPPPADLC
60 70 80 90 100
HALRWYNHIK SYEKEKASLP GVKKALGKYG PADVEDTTGS GATDSKDDDD
110 120 130 140 150
IDLFGSDDEE ESEEAKRLRE ERLAQYESKK AKKPALVAKS SILLDVKPWD
160 170 180 190 200
DETDMAKLEE CVRSIQADGL VWGSSKLVPV GYGIKKLQIQ CVVEDDKVGT
210 220
DMLEEQITAF EDYVQSMDVA AFNKI
Length:225
Mass (Da):24,764
Last modified:January 23, 2007 - v3
Checksum:iCDE763ADBF127822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60489 mRNA Translation: CAA43019.1
X60656 mRNA Translation: CAA43063.1
BT007079 mRNA Translation: AAP35742.1
CR456825 mRNA Translation: CAG33106.1
AK291910 mRNA Translation: BAF84599.1
AC007383 Genomic DNA Translation: AAY15062.1
CH471063 Genomic DNA Translation: EAW70381.1
BC000211 mRNA Translation: AAH00211.1
BC004931 mRNA Translation: AAH04931.1
BC067787 mRNA Translation: AAH67787.1
CCDSiCCDS2367.1
PIRiS25432
RefSeqiNP_001032752.1, NM_001037663.1
NP_001950.1, NM_001959.3
NP_066944.1, NM_021121.3
UniGeneiHs.421608

Genome annotation databases

EnsembliENST00000236957; ENSP00000236957; ENSG00000114942
ENST00000392221; ENSP00000376055; ENSG00000114942
ENST00000392222; ENSP00000376056; ENSG00000114942
ENST00000635728; ENSP00000489993; ENSG00000283391
ENST00000636275; ENSP00000490326; ENSG00000283391
ENST00000637253; ENSP00000490214; ENSG00000283391
GeneIDi1933
KEGGihsa:1933
UCSCiuc002vbf.2 human

Similar proteinsi

Entry informationi

Entry nameiEF1B_HUMAN
AccessioniPrimary (citable) accession number: P24534
Secondary accession number(s): A8K795, Q6IBH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 207 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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