EEF1B2

Functionⁱ

EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

GO - Molecular functionⁱ

translation elongation factor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 1886777

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

response to ethanol Source: Ensembl
translational elongation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Elongation factor
Biological process	Protein biosynthesis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156842 Eukaryotic Translation Elongation
SIGNORⁱ	P24534

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Elongation factor 1-beta Short name: EF-1-beta
Gene namesⁱ	Name:EEF1B2 Synonyms:EEF1B, EF1B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000114942.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3208 EEF1B2
MIMⁱ	600655 gene
neXtProtⁱ	NX_P24534

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1933
Open Targets More...OpenTargetsⁱ	ENSG00000114942
PharmGKBⁱ	PA27644

Polymorphism and mutation databases

BioMutaⁱ	EEF1B2
DMDMⁱ	119163

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000155021	2 – 225	Elongation factor 1-betaAdd BLAST		224

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	7	N6-acetyllysineCombined sources	1
Modified residueⁱ	8	PhosphoserineCombined sources	1
Modified residueⁱ	42	PhosphoserineCombined sources	1
Modified residueⁱ	88	PhosphothreonineBy similarity	1
Modified residueⁱ	93	PhosphothreonineCombined sources	1
Modified residueⁱ	95	PhosphoserineCombined sources	1
Modified residueⁱ	106	PhosphoserineCombined sources	1
Cross-linkⁱ	147	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	174	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation affects the GDP/GTP exchange rate.

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P24534
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P24534
PaxDbⁱ	P24534
PeptideAtlas More...PeptideAtlasⁱ	P24534
PRIDEⁱ	P24534
ProteomicsDBⁱ	54214
TopDownProteomicsⁱ	P24534

2D gel databases

DOSAC-COBS 2D-PAGE database More...DOSAC-COBS-2DPAGEⁱ	P24534
USC-OGP 2-DE database More...OGPⁱ	P24534
SWISS-2DPAGEⁱ	P24534

PTM databases

iPTMnetⁱ	P24534
PhosphoSitePlusⁱ	P24534
SwissPalmⁱ	P24534

Miscellaneous databases

PMAP-CutDBⁱ	P24534

PMAP-CutDBⁱ

P24534

Expressionⁱ

Inductionⁱ

By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000114942 Expressed in 88 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_EEF1B2
ExpressionAtlasⁱ	P24534 baseline and differential
Genevisibleⁱ	P24534 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB012477 HPA035029

HPAⁱ

CAB012477
HPA035029

Interactionⁱ

Subunit structureⁱ

EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
EEF1G	P26641	5	EBI-354334,EBI-351467
EEF1G	P26641-2	3	EBI-354334,EBI-10177695

Protein-protein interaction databases

BioGridⁱ	108253, 75 interactors
IntActⁱ	P24534, 37 interactors
Molecular INTeraction database More...MINTⁱ	P24534
STRINGⁱ	9606.ENSP00000236957

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	9 – 18	Combined sources	10
Turnⁱ	19 – 21	Combined sources	3
Beta strandⁱ	23 – 26	Combined sources	4
Helixⁱ	32 – 41	Combined sources	10
Helixⁱ	50 – 60	Combined sources	11
Helixⁱ	61 – 65	Combined sources	5
Beta strandⁱ	69 – 71	Combined sources	3
Helixⁱ	76 – 78	Combined sources	3
Beta strandⁱ	79 – 81	Combined sources	3
Beta strandⁱ	140 – 150	Combined sources	11
Helixⁱ	155 – 164	Combined sources	10
Beta strandⁱ	171 – 183	Combined sources	13
Beta strandⁱ	185 – 193	Combined sources	9
Helixⁱ	200 – 207	Combined sources	8
Turnⁱ	211 – 213	Combined sources	3
Beta strandⁱ	214 – 220	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P24534
SMRⁱ	P24534
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P24534

EvolutionaryTraceⁱ

P24534

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 84	GST C-terminalAdd BLAST		83

Sequence similaritiesⁱ

Belongs to the EF-1-beta/EF-1-delta family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1668 Eukaryota COG2092 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011747
HOGENOMⁱ	HOG000207273
HOVERGENⁱ	HBG000787
InParanoidⁱ	P24534
KEGG Orthology (KO) More...KOⁱ	K03232
OMAⁱ	PSQADVH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0P0Z
PhylomeDBⁱ	P24534
TreeFamⁱ	TF313134

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00292 EF1B, 1 hit
Gene3Dⁱ	3.30.70.60, 1 hit
InterProⁱ	View protein in InterPro IPR036219 eEF-1beta-like_sf IPR018940 EF-1_beta_acid_region_euk IPR014038 EF1B_bsu/dsu_GNE IPR036282 Glutathione-S-Trfase_C_sf IPR014717 Transl_elong_EF1B/ribosomal_S6 IPR001326 Transl_elong_EF1B_B/D_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10587 EF-1_beta_acid, 1 hit PF00736 EF1_GNE, 1 hit
SMARTⁱ	View protein in SMART SM01182 EF-1_beta_acid, 1 hit SM00888 EF1_GNE, 1 hit
SUPFAMⁱ	SSF47616 SSF47616, 1 hit SSF54984 SSF54984, 1 hit
PROSITEⁱ	View protein in PROSITE PS00824 EF1BD_1, 1 hit PS00825 EF1BD_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

P24534-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGFGDLKSPA GLQVLNDYLA DKSYIEGYVP SQADVAVFEA VSSPPPADLC 
        60         70         80         90        100
HALRWYNHIK SYEKEKASLP GVKKALGKYG PADVEDTTGS GATDSKDDDD 
       110        120        130        140        150
IDLFGSDDEE ESEEAKRLRE ERLAQYESKK AKKPALVAKS SILLDVKPWD 
       160        170        180        190        200
DETDMAKLEE CVRSIQADGL VWGSSKLVPV GYGIKKLQIQ CVVEDDKVGT 
       210        220 
DMLEEQITAF EDYVQSMDVA AFNKI

Length:225

Mass (Da):24,764

Last modified:January 23, 2007 - v3

Checksum:ⁱCDE763ADBF127822

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JZW3	C9JZW3_HUMAN	Elongation factor 1-beta Elongation factor 1-beta	EEF1B2	123	Annotation score:
F2Z2G2	F2Z2G2_HUMAN	Elongation factor 1-beta Elongation factor 1-beta	EEF1B2	68	Annotation score:
F8WF65	F8WF65_HUMAN	Elongation factor 1-beta Elongation factor 1-beta	EEF1B2	29	Annotation score:
F8WFC9	F8WFC9_HUMAN	Elongation factor 1-beta Elongation factor 1-beta	EEF1B2	68	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X60489 mRNA Translation: CAA43019.1 X60656 mRNA Translation: CAA43063.1 BT007079 mRNA Translation: AAP35742.1 CR456825 mRNA Translation: CAG33106.1 AK291910 mRNA Translation: BAF84599.1 AC007383 Genomic DNA Translation: AAY15062.1 CH471063 Genomic DNA Translation: EAW70381.1 BC000211 mRNA Translation: AAH00211.1 BC004931 mRNA Translation: AAH04931.1 BC067787 mRNA Translation: AAH67787.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2367.1
PIRⁱ	S25432
NCBI Reference Sequences More...RefSeqⁱ	NP_001032752.1, NM_001037663.1 NP_001950.1, NM_001959.3 NP_066944.1, NM_021121.3
UniGeneⁱ	Hs.421608

Genome annotation databases

Protein	Similar proteins		Species	Score	Length	Source
P24534	Eukaryotic translation elongation factor 1 beta 2, isoform CRA_a		HUMAN		225	UniRef100_P24534
EEF1B2 isoform 1		PANTR		225
Uncharacterized protein		PANPA		225
Eukaryotic translation elongation factor 1 beta 2		GORGO		225
Elongation factor 1-beta (Fragment)		HUMAN		123
+1

Protein	Similar proteins		Species	Score	Length	Source
P24534	Elongation factor 1-beta		MOUSE		225	UniRef90_P24534
Elongation factor 1-beta		BOVIN		225
Elongation factor 1-beta		CHICK		225
Elongation factor 1-beta		RABIT		225
Eukaryotic translation elongation factor 1 beta 2, isoform CRA_a		HUMAN		225
+148

Protein	Similar proteins		Species	Score	Length	Source
P24534	Elongation factor 1-beta		RABIT		225	UniRef50_P24534
Elongation factor 1-beta		MOUSE		225
Elongation factor 1-beta		BOVIN		225
Elongation factor 1-beta		CHICK		225
Eukaryotic translation elongation factor 1 beta 2, isoform CRA_a		HUMAN		225
+178

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X60489 mRNA Translation: CAA43019.1 X60656 mRNA Translation: CAA43063.1 BT007079 mRNA Translation: AAP35742.1 CR456825 mRNA Translation: CAG33106.1 AK291910 mRNA Translation: BAF84599.1 AC007383 Genomic DNA Translation: AAY15062.1 CH471063 Genomic DNA Translation: EAW70381.1 BC000211 mRNA Translation: AAH00211.1 BC004931 mRNA Translation: AAH04931.1 BC067787 mRNA Translation: AAH67787.1
CCDSⁱ	CCDS2367.1
PIRⁱ	S25432
RefSeqⁱ	NP_001032752.1, NM_001037663.1 NP_001950.1, NM_001959.3 NP_066944.1, NM_021121.3
UniGeneⁱ	Hs.421608

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1B64	NMR	-	A	136-225	[»]
	5DQS	X-ray	2.10	D	1-88	[»]
ProteinModelPortalⁱ	P24534
SMRⁱ	P24534
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108253, 75 interactors
IntActⁱ	P24534, 37 interactors
MINTⁱ	P24534
STRINGⁱ	9606.ENSP00000236957

PTM databases

iPTMnetⁱ	P24534
PhosphoSitePlusⁱ	P24534
SwissPalmⁱ	P24534

Polymorphism and mutation databases

BioMutaⁱ	EEF1B2
DMDMⁱ	119163

2D gel databases

DOSAC-COBS-2DPAGEⁱ	P24534
OGPⁱ	P24534
SWISS-2DPAGEⁱ	P24534

Proteomic databases

EPDⁱ	P24534
MaxQBⁱ	P24534
PaxDbⁱ	P24534
PeptideAtlasⁱ	P24534
PRIDEⁱ	P24534
ProteomicsDBⁱ	54214
TopDownProteomicsⁱ	P24534

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1933
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000236957; ENSP00000236957; ENSG00000114942 ENST00000392221; ENSP00000376055; ENSG00000114942 ENST00000392222; ENSP00000376056; ENSG00000114942 ENST00000635728; ENSP00000489993; ENSG00000283391 ENST00000636275; ENSP00000490326; ENSG00000283391 ENST00000637253; ENSP00000490214; ENSG00000283391
GeneIDⁱ	1933
KEGGⁱ	hsa:1933
UCSCⁱ	uc002vbf.2 human

Organism-specific databases

CTDⁱ	1933
DisGeNETⁱ	1933
EuPathDBⁱ	HostDB:ENSG00000114942.13
GeneCardsⁱ	EEF1B2
HGNCⁱ	HGNC:3208 EEF1B2
HPAⁱ	CAB012477 HPA035029
MIMⁱ	600655 gene
neXtProtⁱ	NX_P24534
OpenTargetsⁱ	ENSG00000114942
PharmGKBⁱ	PA27644
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1668 Eukaryota COG2092 LUCA
GeneTreeⁱ	ENSGT00390000011747
HOGENOMⁱ	HOG000207273
HOVERGENⁱ	HBG000787
InParanoidⁱ	P24534
KOⁱ	K03232
OMAⁱ	PSQADVH
OrthoDBⁱ	EOG091G0P0Z
PhylomeDBⁱ	P24534
TreeFamⁱ	TF313134

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156842 Eukaryotic Translation Elongation
SIGNORⁱ	P24534

Miscellaneous databases

ChiTaRSⁱ	EEF1B2 human
EvolutionaryTraceⁱ	P24534
GeneWikiⁱ	EEF1B2
GenomeRNAiⁱ	1933
PMAP-CutDBⁱ	P24534
Protein Ontology More...PROⁱ	PR:P24534
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000114942 Expressed in 88 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_EEF1B2
ExpressionAtlasⁱ	P24534 baseline and differential
Genevisibleⁱ	P24534 HS

Family and domain databases

CDDⁱ	cd00292 EF1B, 1 hit
Gene3Dⁱ	3.30.70.60, 1 hit
InterProⁱ	View protein in InterPro IPR036219 eEF-1beta-like_sf IPR018940 EF-1_beta_acid_region_euk IPR014038 EF1B_bsu/dsu_GNE IPR036282 Glutathione-S-Trfase_C_sf IPR014717 Transl_elong_EF1B/ribosomal_S6 IPR001326 Transl_elong_EF1B_B/D_CS
Pfamⁱ	View protein in Pfam PF10587 EF-1_beta_acid, 1 hit PF00736 EF1_GNE, 1 hit
SMARTⁱ	View protein in SMART SM01182 EF-1_beta_acid, 1 hit SM00888 EF1_GNE, 1 hit
SUPFAMⁱ	SSF47616 SSF47616, 1 hit SSF54984 SSF54984, 1 hit
PROSITEⁱ	View protein in PROSITE PS00824 EF1BD_1, 1 hit PS00825 EF1BD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EF1B_HUMAN
Accessionⁱ	P24534Primary (citable) accession number: P24534 Secondary accession number(s): A8K795, Q6IBH9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	January 23, 2007
	Last modified:	October 10, 2018
	This is version 210 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P24534 (EF1B_HUMAN)

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Elongation factor 1-beta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ