UniProtKB - P24534 (EF1B_HUMAN)
Protein
Elongation factor 1-beta
Gene
EEF1B2
Organism
Homo sapiens (Human)
Status
Functioni
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: GO_Central
- translation elongation factor activity Source: UniProtKB
GO - Biological processi
- response to ethanol Source: Ensembl
- translational elongation Source: GO_Central
Keywordsi
Molecular function | Elongation factor |
Biological process | Protein biosynthesis |
Enzyme and pathway databases
PathwayCommonsi | P24534 |
Reactomei | R-HSA-156842, Eukaryotic Translation Elongation |
SIGNORi | P24534 |
Names & Taxonomyi
Protein namesi | Recommended name: Elongation factor 1-betaShort name: EF-1-beta |
Gene namesi | Name:EEF1B2 Synonyms:EEF1B, EF1B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3208, EEF1B2 |
MIMi | 600655, gene |
neXtProti | NX_P24534 |
VEuPathDBi | HostDB:ENSG00000114942.13 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
- eukaryotic translation elongation factor 1 complex Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1933 |
MalaCardsi | EEF1B2 |
OpenTargetsi | ENSG00000114942 |
PharmGKBi | PA27644 |
Miscellaneous databases
Pharosi | P24534, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295731 |
Genetic variation databases
BioMutai | EEF1B2 |
DMDMi | 119163 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000155021 | 2 – 225 | Elongation factor 1-betaAdd BLAST | 224 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 7 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 8 | PhosphoserineCombined sources | 1 | |
Modified residuei | 42 | PhosphoserineCombined sources | 1 | |
Modified residuei | 88 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 93 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 95 | PhosphoserineCombined sources | 1 | |
Modified residuei | 106 | PhosphoserineCombined sources | 1 | |
Cross-linki | 147 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 174 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylation affects the GDP/GTP exchange rate.
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-66 CPTAC-67 |
EPDi | P24534 |
jPOSTi | P24534 |
MassIVEi | P24534 |
MaxQBi | P24534 |
PaxDbi | P24534 |
PeptideAtlasi | P24534 |
PRIDEi | P24534 |
ProteomicsDBi | 54214 |
TopDownProteomicsi | P24534 |
2D gel databases
DOSAC-COBS-2DPAGEi | P24534 |
OGPi | P24534 |
SWISS-2DPAGEi | P24534 |
PTM databases
iPTMneti | P24534 |
PhosphoSitePlusi | P24534 |
SwissPalmi | P24534 |
Expressioni
Inductioni
By homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress.1 Publication
Gene expression databases
Bgeei | ENSG00000114942, Expressed in body of pancreas and 113 other tissues |
ExpressionAtlasi | P24534, baseline and differential |
Genevisiblei | P24534, HS |
Organism-specific databases
HPAi | ENSG00000114942, Low tissue specificity |
Interactioni
Subunit structurei
EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
Binary interactionsi
Hide detailsP24534
With | #Exp. | IntAct |
---|---|---|
EEF1G [P26641] | 9 | EBI-354334,EBI-351467 |
EEF1G - isoform 2 [P26641-2] | 3 | EBI-354334,EBI-10177695 |
HTT [P42858] | 7 | EBI-354334,EBI-466029 |
SPRYD4 [Q8WW59] | 3 | EBI-354334,EBI-8602056 |
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 108253, 123 interactors |
IntActi | P24534, 59 interactors |
MINTi | P24534 |
STRINGi | 9606.ENSP00000376056 |
Miscellaneous databases
RNActi | P24534, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P24534 |
SMRi | P24534 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P24534 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 84 | GST C-terminalAdd BLAST | 83 |
Sequence similaritiesi
Belongs to the EF-1-beta/EF-1-delta family.Curated
Phylogenomic databases
eggNOGi | KOG1668, Eukaryota |
GeneTreei | ENSGT00950000183014 |
HOGENOMi | CLU_050172_0_0_1 |
InParanoidi | P24534 |
OMAi | RSYVEGY |
OrthoDBi | 1464823at2759 |
PhylomeDBi | P24534 |
TreeFami | TF313134 |
Family and domain databases
CDDi | cd00292, EF1B, 1 hit |
Gene3Di | 3.30.70.60, 1 hit |
InterProi | View protein in InterPro IPR036219, eEF-1beta-like_sf IPR018940, EF-1_beta_acid_region_euk IPR014038, EF1B_bsu/dsu_GNE IPR036282, Glutathione-S-Trfase_C_sf IPR014717, Transl_elong_EF1B/ribosomal_S6 IPR001326, Transl_elong_EF1B_B/D_CS |
Pfami | View protein in Pfam PF10587, EF-1_beta_acid, 1 hit PF00736, EF1_GNE, 1 hit |
SMARTi | View protein in SMART SM01182, EF-1_beta_acid, 1 hit SM00888, EF1_GNE, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF54984, SSF54984, 1 hit |
PROSITEi | View protein in PROSITE PS00824, EF1BD_1, 1 hit PS00825, EF1BD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P24534-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGFGDLKSPA GLQVLNDYLA DKSYIEGYVP SQADVAVFEA VSSPPPADLC
60 70 80 90 100
HALRWYNHIK SYEKEKASLP GVKKALGKYG PADVEDTTGS GATDSKDDDD
110 120 130 140 150
IDLFGSDDEE ESEEAKRLRE ERLAQYESKK AKKPALVAKS SILLDVKPWD
160 170 180 190 200
DETDMAKLEE CVRSIQADGL VWGSSKLVPV GYGIKKLQIQ CVVEDDKVGT
210 220
DMLEEQITAF EDYVQSMDVA AFNKI
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JZW3 | C9JZW3_HUMAN | Elongation factor 1-beta | EEF1B2 | 123 | Annotation score: | ||
F2Z2G2 | F2Z2G2_HUMAN | Elongation factor 1-beta | EEF1B2 | 68 | Annotation score: | ||
F8WF65 | F8WF65_HUMAN | Elongation factor 1-beta | EEF1B2 | 29 | Annotation score: | ||
F8WFC9 | F8WFC9_HUMAN | Elongation factor 1-beta | EEF1B2 | 68 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60489 mRNA Translation: CAA43019.1 X60656 mRNA Translation: CAA43063.1 BT007079 mRNA Translation: AAP35742.1 CR456825 mRNA Translation: CAG33106.1 AK291910 mRNA Translation: BAF84599.1 AC007383 Genomic DNA Translation: AAY15062.1 CH471063 Genomic DNA Translation: EAW70381.1 BC000211 mRNA Translation: AAH00211.1 BC004931 mRNA Translation: AAH04931.1 BC067787 mRNA Translation: AAH67787.1 |
CCDSi | CCDS2367.1 |
PIRi | S25432 |
RefSeqi | NP_001032752.1, NM_001037663.1 NP_001950.1, NM_001959.3 NP_066944.1, NM_021121.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60489 mRNA Translation: CAA43019.1 X60656 mRNA Translation: CAA43063.1 BT007079 mRNA Translation: AAP35742.1 CR456825 mRNA Translation: CAG33106.1 AK291910 mRNA Translation: BAF84599.1 AC007383 Genomic DNA Translation: AAY15062.1 CH471063 Genomic DNA Translation: EAW70381.1 BC000211 mRNA Translation: AAH00211.1 BC004931 mRNA Translation: AAH04931.1 BC067787 mRNA Translation: AAH67787.1 |
CCDSi | CCDS2367.1 |
PIRi | S25432 |
RefSeqi | NP_001032752.1, NM_001037663.1 NP_001950.1, NM_001959.3 NP_066944.1, NM_021121.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B64 | NMR | - | A | 136-225 | [»] | |
5DQS | X-ray | 2.10 | D | 1-88 | [»] | |
BMRBi | P24534 | |||||
SMRi | P24534 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108253, 123 interactors |
IntActi | P24534, 59 interactors |
MINTi | P24534 |
STRINGi | 9606.ENSP00000376056 |
Chemistry databases
ChEMBLi | CHEMBL4295731 |
PTM databases
iPTMneti | P24534 |
PhosphoSitePlusi | P24534 |
SwissPalmi | P24534 |
Genetic variation databases
BioMutai | EEF1B2 |
DMDMi | 119163 |
2D gel databases
DOSAC-COBS-2DPAGEi | P24534 |
OGPi | P24534 |
SWISS-2DPAGEi | P24534 |
Proteomic databases
CPTACi | CPTAC-66 CPTAC-67 |
EPDi | P24534 |
jPOSTi | P24534 |
MassIVEi | P24534 |
MaxQBi | P24534 |
PaxDbi | P24534 |
PeptideAtlasi | P24534 |
PRIDEi | P24534 |
ProteomicsDBi | 54214 |
TopDownProteomicsi | P24534 |
Protocols and materials databases
Antibodypediai | 34177, 190 antibodies |
DNASUi | 1933 |
Genome annotation databases
Organism-specific databases
CTDi | 1933 |
DisGeNETi | 1933 |
GeneCardsi | EEF1B2 |
HGNCi | HGNC:3208, EEF1B2 |
HPAi | ENSG00000114942, Low tissue specificity |
MalaCardsi | EEF1B2 |
MIMi | 600655, gene |
neXtProti | NX_P24534 |
OpenTargetsi | ENSG00000114942 |
PharmGKBi | PA27644 |
VEuPathDBi | HostDB:ENSG00000114942.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1668, Eukaryota |
GeneTreei | ENSGT00950000183014 |
HOGENOMi | CLU_050172_0_0_1 |
InParanoidi | P24534 |
OMAi | RSYVEGY |
OrthoDBi | 1464823at2759 |
PhylomeDBi | P24534 |
TreeFami | TF313134 |
Enzyme and pathway databases
PathwayCommonsi | P24534 |
Reactomei | R-HSA-156842, Eukaryotic Translation Elongation |
SIGNORi | P24534 |
Miscellaneous databases
BioGRID-ORCSi | 1933, 595 hits in 846 CRISPR screens |
ChiTaRSi | EEF1B2, human |
EvolutionaryTracei | P24534 |
GeneWikii | EEF1B2 |
GenomeRNAii | 1933 |
Pharosi | P24534, Tbio |
PROi | PR:P24534 |
RNActi | P24534, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114942, Expressed in body of pancreas and 113 other tissues |
ExpressionAtlasi | P24534, baseline and differential |
Genevisiblei | P24534, HS |
Family and domain databases
CDDi | cd00292, EF1B, 1 hit |
Gene3Di | 3.30.70.60, 1 hit |
InterProi | View protein in InterPro IPR036219, eEF-1beta-like_sf IPR018940, EF-1_beta_acid_region_euk IPR014038, EF1B_bsu/dsu_GNE IPR036282, Glutathione-S-Trfase_C_sf IPR014717, Transl_elong_EF1B/ribosomal_S6 IPR001326, Transl_elong_EF1B_B/D_CS |
Pfami | View protein in Pfam PF10587, EF-1_beta_acid, 1 hit PF00736, EF1_GNE, 1 hit |
SMARTi | View protein in SMART SM01182, EF-1_beta_acid, 1 hit SM00888, EF1_GNE, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF54984, SSF54984, 1 hit |
PROSITEi | View protein in PROSITE PS00824, EF1BD_1, 1 hit PS00825, EF1BD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EF1B_HUMAN | |
Accessioni | P24534Primary (citable) accession number: P24534 Secondary accession number(s): A8K795, Q6IBH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 230 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM