UniProtKB - P24530 (EDNRB_HUMAN)
Protein
Endothelin receptor type B
Gene
EDNRB
Organism
Homo sapiens (Human)
Status
Functioni
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.1 Publication
GO - Molecular functioni
- endothelin receptor activity Source: BHF-UCL
- peptide hormone binding Source: BHF-UCL
- type 1 angiotensin receptor binding Source: Ensembl
GO - Biological processi
- aging Source: Ensembl
- calcium-mediated signaling Source: UniProtKB
- cell surface receptor signaling pathway Source: ProtInc
- cellular response to lipopolysaccharide Source: Ensembl
- cGMP-mediated signaling Source: Ensembl
- endothelin receptor signaling pathway Source: BHF-UCL
- enteric nervous system development Source: BHF-UCL
- enteric smooth muscle cell differentiation Source: BHF-UCL
- epithelial fluid transport Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- macrophage chemotaxis Source: BHF-UCL
- melanocyte differentiation Source: Ensembl
- negative regulation of adenylate cyclase activity Source: ProtInc
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of cellular protein metabolic process Source: BHF-UCL
- negative regulation of neuron maturation Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- nervous system development Source: ProtInc
- neural crest cell migration Source: Ensembl
- peripheral nervous system development Source: Ensembl
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of penile erection Source: Ensembl
- positive regulation of protein phosphorylation Source: Ensembl
- positive regulation of renal sodium excretion Source: Ensembl
- positive regulation of urine volume Source: Ensembl
- posterior midgut development Source: Ensembl
- regulation of blood pressure Source: Ensembl
- regulation of epithelial cell proliferation Source: Ensembl
- regulation of fever generation Source: Ensembl
- regulation of pH Source: Ensembl
- regulation of sensory perception of pain Source: Ensembl
- response to endothelin Source: Ensembl
- response to organic cyclic compound Source: Ensembl
- response to pain Source: Ensembl
- sensory perception of pain Source: Ensembl
- vasoconstriction Source: BHF-UCL
- vasodilation Source: Ensembl
- vein smooth muscle contraction Source: BHF-UCL
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P24530 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P24530 |
SIGNORi | P24530 |
Names & Taxonomyi
Protein namesi | Recommended name: Endothelin receptor type BCuratedShort name: ET-B Short name: ET-BR Alternative name(s): Endothelin receptor non-selective type |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3180, EDNRB |
MIMi | 131244, gene |
neXtProti | NX_P24530 |
VEuPathDBi | HostDB:ENSG00000136160.14 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein
Note: internalized after activation by endothelins.1 Publication
Nucleus
- nuclear membrane Source: Ensembl
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: UniProtKB
Other locations
- membrane raft Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 101 | ExtracellularSequence analysisAdd BLAST | 75 | |
Transmembranei | 102 – 126 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 127 – 137 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 138 – 163 | Helical; Name=2Sequence analysisAdd BLAST | 26 | |
Topological domaini | 164 – 175 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 176 – 197 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 198 – 218 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 219 – 243 | Helical; Name=4Sequence analysisAdd BLAST | 25 | |
Topological domaini | 244 – 271 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 272 – 296 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 297 – 324 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 325 – 350 | Helical; Name=6Sequence analysisAdd BLAST | 26 | |
Topological domaini | 351 – 362 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 363 – 389 | Helical; Name=7Sequence analysisAdd BLAST | 27 | |
Topological domaini | 390 – 442 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Waardenburg syndrome 4A (WS4A)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by the association of Waardenburg features (depigmentation and deafness) with the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003470 | 183 | A → G in WS4A. 1 PublicationCorresponds to variant dbSNP:rs104894388EnsemblClinVar. | 1 | |
Natural variantiVAR_015294 | 292 | F → L in WS4A. 1 Publication | 1 |
Hirschsprung disease 2 (HSCR2)5 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003471 | 276 | W → C in HSCR2. 1 PublicationCorresponds to variant dbSNP:rs104894387EnsemblClinVar. | 1 | |
Natural variantiVAR_003473 | 319 | R → W in HSCR2; sporadic. 2 PublicationsCorresponds to variant dbSNP:rs200363611Ensembl. | 1 | |
Natural variantiVAR_003474 | 374 | M → I in HSCR2; decreased calcium release; no effect on cell membrane location. 2 Publications | 1 | |
Natural variantiVAR_003475 | 383 | P → L in HSCR2; familial; loss of cell membrane location; new cytoplasmic location. 3 Publications | 1 |
ABCD syndrome (ABCDS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome characterized by albinism, black lock at temporal occipital region, bilateral deafness, aganglionosis of the large intestine and total absence of neurocytes and nerve fibers in the small intestine.
Related information in OMIMHeterozygous mutations in EDNRB may be responsible for Waardenburg syndrome 2, an autosomal dominant disorder characterized by sensorineural deafness and pigmentary disturbances.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 402 | C → S: Abolishes palmitoylation; when associated with S-403 and S-405. 1 Publication | 1 | |
Mutagenesisi | 403 | C → S: Abolishes palmitoylation; when associated with S-402 and S-405. 1 Publication | 1 | |
Mutagenesisi | 405 | C → S: Abolishes palmitoylation; when associated with S-402 and S-403. 1 Publication | 1 |
Keywords - Diseasei
Albinism, Deafness, Disease variant, Hirschsprung disease, Waardenburg syndromeOrganism-specific databases
DisGeNETi | 1910 |
MalaCardsi | EDNRB |
MIMi | 142623, phenotype 277580, phenotype 600155, phenotype 600501, phenotype |
OpenTargetsi | ENSG00000136160 |
Orphaneti | 388, Hirschsprung disease 895, Waardenburg syndrome type 2 897, Waardenburg-Shah syndrome |
PharmGKBi | PA27618 |
Miscellaneous databases
Pharosi | P24530, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1785 |
DrugBanki | DB06403, Ambrisentan DB00559, Bosentan DB06460, Enrasentan DB06138, IRL-1620 DB08932, Macitentan DB06268, Sitaxentan DB06558, Tezosentan |
DrugCentrali | P24530 |
GuidetoPHARMACOLOGYi | 220 |
Genetic variation databases
BioMutai | EDNRB |
DMDMi | 119622 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000012729 | 27 – 442 | Endothelin receptor type BAdd BLAST | 416 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 59 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 174 ↔ 255 | PROSITE-ProRule annotation | ||
Modified residuei | 305 | PhosphoserineBy similarity | 1 | |
Lipidationi | 402 | S-palmitoyl cysteine1 Publication | 1 | |
Lipidationi | 403 | S-palmitoyl cysteineSequence analysis | 1 | |
Lipidationi | 405 | S-palmitoyl cysteineSequence analysis | 1 | |
Modified residuei | 419 | PhosphoserineBy similarity | 1 | |
Modified residuei | 439 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 440 | PhosphoserineBy similarity | 1 | |
Modified residuei | 441 | PhosphoserineBy similarity | 1 | |
Modified residuei | 442 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403 and Cys-405.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
jPOSTi | P24530 |
MassIVEi | P24530 |
MaxQBi | P24530 |
PaxDbi | P24530 |
PeptideAtlasi | P24530 |
PRIDEi | P24530 |
ProteomicsDBi | 54211 [P24530-1] 54212 [P24530-2] 54213 [P24530-3] |
PTM databases
GlyGeni | P24530, 1 site |
iPTMneti | P24530 |
PhosphoSitePlusi | P24530 |
SwissPalmi | P24530 |
Expressioni
Tissue specificityi
Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells.1 Publication
Gene expression databases
Bgeei | ENSG00000136160, Expressed in spinal cord and 229 other tissues |
ExpressionAtlasi | P24530, baseline and differential |
Genevisiblei | P24530, HS |
Organism-specific databases
HPAi | ENSG00000136160, Tissue enhanced (placenta) |
Interactioni
Binary interactionsi
P24530
With | #Exp. | IntAct |
---|---|---|
EDN1 [P05305] | 2 | EBI-6624656,EBI-715181 |
GO - Molecular functioni
- type 1 angiotensin receptor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 108232, 33 interactors |
IntActi | P24530, 25 interactors |
MINTi | P24530 |
STRINGi | 9606.ENSP00000366416 |
Chemistry databases
BindingDBi | P24530 |
Miscellaneous databases
RNActi | P24530, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P24530 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230470 |
HOGENOMi | CLU_009579_28_0_1 |
InParanoidi | P24530 |
OMAi | GFDMITT |
PhylomeDBi | P24530 |
TreeFami | TF331292 |
Family and domain databases
InterProi | View protein in InterPro IPR000499, Endthln_rcpt IPR001112, ETB_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00571, ENDOTHELINBR PR00366, ENDOTHELINR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform A (identifier: P24530-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQPPPSLCGR ALVALVLACG LSRIWGEERG FPPDRATPLL QTAEIMTPPT
60 70 80 90 100
KTLWPKGSNA SLARSLAPAE VPKGDRTAGS PPRTISPPPC QGPIEIKETF
110 120 130 140 150
KYINTVVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH
160 170 180 190 200
IVIDIPINVY KLLAEDWPFG AEMCKLVPFI QKASVGITVL SLCALSIDRY
210 220 230 240 250
RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF DIITMDYKGS
260 270 280 290 300
YLRICLLHPV QKTAFMQFYK TAKDWWLFSF YFCLPLAITA FFYTLMTCEM
310 320 330 340 350
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY
360 370 380 390 400
NQNDPNRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC
410 420 430 440
LCCWCQSFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y748 | A0A2R8Y748_HUMAN | Endothelin receptor non-selective t... | EDNRB | 409 | Annotation score: | ||
A0A2R8YGF7 | A0A2R8YGF7_HUMAN | Endothelin receptor type B | EDNRB | 162 | Annotation score: |
Sequence cautioni
The sequence BAD92435 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 10 | R → P in AAB19411 (PubMed:1713452).Curated | 1 | ||
Sequence conflicti | 16 | V → L (PubMed:7536888).Curated | 1 | ||
Sequence conflicti | 22 – 24 | SRI → LGV (PubMed:7536888).Curated | 3 | ||
Sequence conflicti | 35 | R → K (PubMed:7536888).Curated | 1 | ||
Sequence conflicti | 45 | I → M in BAD92435 (Ref. 12) Curated | 1 | ||
Sequence conflicti | 58 | S → P in BAF83388 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 140 | I → V (PubMed:7536888).Curated | 1 | ||
Sequence conflicti | 385 | A → V in BAF83388 (PubMed:14702039).Curated | 1 | ||
Isoform C (identifier: P24530-3) | |||||
Sequence conflicti | 79 – 84 | SGHRTP → RPPDA in AAD24541 (PubMed:10072757).Curated | 6 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019285 | 5 | P → T1 PublicationCorresponds to variant dbSNP:rs12720160Ensembl. | 1 | |
Natural variantiVAR_014675 | 7 | L → Q. Corresponds to variant dbSNP:rs5345Ensembl. | 1 | |
Natural variantiVAR_014676 | 17 | L → F No effect on cell membrane location. 1 PublicationCorresponds to variant dbSNP:rs5346EnsemblClinVar. | 1 | |
Natural variantiVAR_078312 | 17 | L → P Probable disease-associated variant found in patients with Waardenburg syndrome 2; loss of cell membrane location; new cytoplasmic location. 1 Publication | 1 | |
Natural variantiVAR_003469 | 57 | G → S Associated with increased susceptibility for Hirschsprung disease; sex-dependent gene dosage effect. 4 PublicationsCorresponds to variant dbSNP:rs1801710EnsemblClinVar. | 1 | |
Natural variantiVAR_024255 | 76 | R → M. Corresponds to variant dbSNP:rs2228271Ensembl. | 1 | |
Natural variantiVAR_014677 | 112 | F → V. Corresponds to variant dbSNP:rs5347Ensembl. | 1 | |
Natural variantiVAR_078313 | 137 | N → Y Probable disease-associated variant found in patients with Waardenburg syndrome 2; decreased calcium release upon endothelin 3 exposure; loss of downstream pathway activation upon endothelin 3 exposure; no effect on cell membrane location; no effect on internalization upon endothelin 3 exposure. 1 Publication | 1 | |
Natural variantiVAR_078314 | 156 | P → R Probable disease-associated variant found in patients with Waardenburg syndrome 2; loss of cell membrane location; new cytoplasmic location. 1 Publication | 1 | |
Natural variantiVAR_003470 | 183 | A → G in WS4A. 1 PublicationCorresponds to variant dbSNP:rs104894388EnsemblClinVar. | 1 | |
Natural variantiVAR_078315 | 226 – 442 | Missing Probable disease-associated variant found in patients with Waardenburg syndrome 2; loss of cell membrane location; new cytoplasmic location. 1 PublicationAdd BLAST | 217 | |
Natural variantiVAR_014678 | 244 | T → M. Corresponds to variant dbSNP:rs5350EnsemblClinVar. | 1 | |
Natural variantiVAR_003471 | 276 | W → C in HSCR2. 1 PublicationCorresponds to variant dbSNP:rs104894387EnsemblClinVar. | 1 | |
Natural variantiVAR_015294 | 292 | F → L in WS4A. 1 Publication | 1 | |
Natural variantiVAR_003472 | 305 | S → N2 PublicationsCorresponds to variant dbSNP:rs5352EnsemblClinVar. | 1 | |
Natural variantiVAR_003473 | 319 | R → W in HSCR2; sporadic. 2 PublicationsCorresponds to variant dbSNP:rs200363611Ensembl. | 1 | |
Natural variantiVAR_003474 | 374 | M → I in HSCR2; decreased calcium release; no effect on cell membrane location. 2 Publications | 1 | |
Natural variantiVAR_003475 | 383 | P → L in HSCR2; familial; loss of cell membrane location; new cytoplasmic location. 3 Publications | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001878 | 1 | M → MNKSTCLMAAETPSKRWRLH CLAFSQRFVRAGPACSSREA CSSPRAGWNPAGFRLPGRWS PFVALHLVCQIREALKLRSG HRTPSGAGSSM in isoform C. 1 Publication | 1 | |
Alternative sequenceiVSP_001879 | 399 – 442 | SCLCC…KYSSS → AGPHVGNKLVMLFSVNIECD GTVNQNPTMWPERKSNNN in isoform B. 1 PublicationAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74921 mRNA Translation: AAA58465.1 D90402 mRNA Translation: BAA14398.1 S44866 mRNA Translation: AAB19411.1 S57283 mRNA Translation: AAB25531.1 D13168 Genomic DNA Translation: BAA02445.1 L06623 mRNA Translation: AAA52342.1 X99250 mRNA Translation: CAA67623.1 AF114165 mRNA Translation: AAD24541.1 AY275463 mRNA Translation: AAP32295.1 AB209198 mRNA Translation: BAD92435.1 Different initiation. AK290699 mRNA Translation: BAF83388.1 AY547312 Genomic DNA Translation: AAS38516.1 AL139002 Genomic DNA No translation available. CH471093 Genomic DNA Translation: EAW80573.1 CH471093 Genomic DNA Translation: EAW80575.1 BC014472 mRNA Translation: AAH14472.1 AJ458188 Genomic DNA Translation: CAD30645.1 AJ458189 Genomic DNA Translation: CAD30646.1 AJ458190 Genomic DNA Translation: CAD30647.1 AJ458191 Genomic DNA Translation: CAD30648.1 |
CCDSi | CCDS45059.1 [P24530-2] CCDS55902.1 [P24530-3] CCDS9461.1 [P24530-1] |
PIRi | A46609, JQ1042 |
RefSeqi | NP_000106.1, NM_000115.4 [P24530-1] NP_001116131.1, NM_001122659.2 [P24530-1] NP_001188326.1, NM_001201397.1 [P24530-3] NP_003982.1, NM_003991.3 [P24530-2] |
Genome annotation databases
Ensembli | ENST00000377211; ENSP00000366416; ENSG00000136160 [P24530-3] ENST00000475537; ENSP00000487082; ENSG00000136160 [P24530-1] ENST00000626030; ENSP00000486202; ENSG00000136160 [P24530-2] ENST00000646605; ENSP00000494278; ENSG00000136160 [P24530-1] ENST00000646607; ENSP00000493527; ENSG00000136160 [P24530-1] ENST00000646948; ENSP00000493895; ENSG00000136160 [P24530-1] |
GeneIDi | 1910 |
KEGGi | hsa:1910 |
UCSCi | uc001vko.3, human [P24530-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74921 mRNA Translation: AAA58465.1 D90402 mRNA Translation: BAA14398.1 S44866 mRNA Translation: AAB19411.1 S57283 mRNA Translation: AAB25531.1 D13168 Genomic DNA Translation: BAA02445.1 L06623 mRNA Translation: AAA52342.1 X99250 mRNA Translation: CAA67623.1 AF114165 mRNA Translation: AAD24541.1 AY275463 mRNA Translation: AAP32295.1 AB209198 mRNA Translation: BAD92435.1 Different initiation. AK290699 mRNA Translation: BAF83388.1 AY547312 Genomic DNA Translation: AAS38516.1 AL139002 Genomic DNA No translation available. CH471093 Genomic DNA Translation: EAW80573.1 CH471093 Genomic DNA Translation: EAW80575.1 BC014472 mRNA Translation: AAH14472.1 AJ458188 Genomic DNA Translation: CAD30645.1 AJ458189 Genomic DNA Translation: CAD30646.1 AJ458190 Genomic DNA Translation: CAD30647.1 AJ458191 Genomic DNA Translation: CAD30648.1 |
CCDSi | CCDS45059.1 [P24530-2] CCDS55902.1 [P24530-3] CCDS9461.1 [P24530-1] |
PIRi | A46609, JQ1042 |
RefSeqi | NP_000106.1, NM_000115.4 [P24530-1] NP_001116131.1, NM_001122659.2 [P24530-1] NP_001188326.1, NM_001201397.1 [P24530-3] NP_003982.1, NM_003991.3 [P24530-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5GLH | X-ray | 2.80 | A | 66-303 | [»] | |
A | 313-395 | [»] | ||||
5GLI | X-ray | 2.50 | A | 66-303 | [»] | |
A | 313-395 | [»] | ||||
5X93 | X-ray | 2.20 | A | 66-303 | [»] | |
A | 311-407 | [»] | ||||
5XPR | X-ray | 3.60 | A | 66-303 | [»] | |
A | 311-407 | [»] | ||||
6IGK | X-ray | 2.00 | A | 66-407 | [»] | |
6IGL | X-ray | 2.70 | A | 66-407 | [»] | |
6LRY | X-ray | 3.00 | A | 66-407 | [»] | |
SMRi | P24530 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108232, 33 interactors |
IntActi | P24530, 25 interactors |
MINTi | P24530 |
STRINGi | 9606.ENSP00000366416 |
Chemistry databases
BindingDBi | P24530 |
ChEMBLi | CHEMBL1785 |
DrugBanki | DB06403, Ambrisentan DB00559, Bosentan DB06460, Enrasentan DB06138, IRL-1620 DB08932, Macitentan DB06268, Sitaxentan DB06558, Tezosentan |
DrugCentrali | P24530 |
GuidetoPHARMACOLOGYi | 220 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P24530, 1 site |
iPTMneti | P24530 |
PhosphoSitePlusi | P24530 |
SwissPalmi | P24530 |
Genetic variation databases
BioMutai | EDNRB |
DMDMi | 119622 |
Proteomic databases
jPOSTi | P24530 |
MassIVEi | P24530 |
MaxQBi | P24530 |
PaxDbi | P24530 |
PeptideAtlasi | P24530 |
PRIDEi | P24530 |
ProteomicsDBi | 54211 [P24530-1] 54212 [P24530-2] 54213 [P24530-3] |
Protocols and materials databases
ABCDi | P24530, 3 sequenced antibodies |
Antibodypediai | 4509, 464 antibodies |
DNASUi | 1910 |
Genome annotation databases
Ensembli | ENST00000377211; ENSP00000366416; ENSG00000136160 [P24530-3] ENST00000475537; ENSP00000487082; ENSG00000136160 [P24530-1] ENST00000626030; ENSP00000486202; ENSG00000136160 [P24530-2] ENST00000646605; ENSP00000494278; ENSG00000136160 [P24530-1] ENST00000646607; ENSP00000493527; ENSG00000136160 [P24530-1] ENST00000646948; ENSP00000493895; ENSG00000136160 [P24530-1] |
GeneIDi | 1910 |
KEGGi | hsa:1910 |
UCSCi | uc001vko.3, human [P24530-1] |
Organism-specific databases
CTDi | 1910 |
DisGeNETi | 1910 |
GeneCardsi | EDNRB |
HGNCi | HGNC:3180, EDNRB |
HPAi | ENSG00000136160, Tissue enhanced (placenta) |
MalaCardsi | EDNRB |
MIMi | 131244, gene 142623, phenotype 277580, phenotype 600155, phenotype 600501, phenotype |
neXtProti | NX_P24530 |
OpenTargetsi | ENSG00000136160 |
Orphaneti | 388, Hirschsprung disease 895, Waardenburg syndrome type 2 897, Waardenburg-Shah syndrome |
PharmGKBi | PA27618 |
VEuPathDBi | HostDB:ENSG00000136160.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230470 |
HOGENOMi | CLU_009579_28_0_1 |
InParanoidi | P24530 |
OMAi | GFDMITT |
PhylomeDBi | P24530 |
TreeFami | TF331292 |
Enzyme and pathway databases
PathwayCommonsi | P24530 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P24530 |
SIGNORi | P24530 |
Miscellaneous databases
BioGRID-ORCSi | 1910, 5 hits in 992 CRISPR screens |
ChiTaRSi | EDNRB, human |
GeneWikii | Endothelin_receptor_type_B |
GenomeRNAii | 1910 |
Pharosi | P24530, Tclin |
PROi | PR:P24530 |
RNActi | P24530, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136160, Expressed in spinal cord and 229 other tissues |
ExpressionAtlasi | P24530, baseline and differential |
Genevisiblei | P24530, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000499, Endthln_rcpt IPR001112, ETB_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00571, ENDOTHELINBR PR00366, ENDOTHELINR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EDNRB_HUMAN | |
Accessioni | P24530Primary (citable) accession number: P24530 Secondary accession number(s): A2A2Z8 Q9UQK3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 230 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families