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Protein

Myelin P2 protein

Gene

Pmp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in lipid transport protein in Schwann cells. May bind cholesterol (By similarity).By similarity

Miscellaneous

P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107Fatty acidBy similarity1

GO - Molecular functioni

GO - Biological processi

  • membrane organization Source: MGI

Keywordsi

Biological processTransport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin P2 protein
Gene namesi
Name:Pmp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:102667 Pmp2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000673892 – 132Myelin P2 proteinAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP24526
PaxDbiP24526
PeptideAtlasiP24526
PRIDEiP24526

PTM databases

iPTMnetiP24526
PhosphoSitePlusiP24526

Expressioni

Gene expression databases

BgeeiENSMUSG00000052468 Expressed in 9 organ(s), highest expression level in testis
CleanExiMM_PMP2
GenevisibleiP24526 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiP24526, 1 interactor
STRINGi10090.ENSMUSP00000029034

Structurei

3D structure databases

ProteinModelPortaliP24526
SMRiP24526
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 129Fatty acid bindingBy similarity3

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP24526
OMAiMCNRFVG
OrthoDBiEOG091G0QSV
PhylomeDBiP24526
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR031256 Myelin_P2
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF64 PTHR11955:SF64, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24526-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNKFLGTWK LVSSEHFDDY MKALGVGLAN RKLGNLAKPT VIISKKGDYI
60 70 80 90 100
TIRTESAFKN TEISFKLGQE FDETTADNRK AKSIVTLERG SLKQVQKWDG
110 120 130
KETAIRRTLL DGRMVVECIM KGVVCTRIYE KV
Length:132
Mass (Da):14,935
Last modified:January 23, 2007 - v2
Checksum:iAB6A4E7F3834107C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S39508 Genomic DNA Translation: AAB19249.2
BC099520 mRNA Translation: AAH99520.1
CCDSiCCDS17236.1
PIRiJH0407
RefSeqiNP_001025476.1, NM_001030305.2
UniGeneiMm.371777

Genome annotation databases

EnsembliENSMUST00000029034; ENSMUSP00000029034; ENSMUSG00000052468
GeneIDi18857
KEGGimmu:18857
UCSCiuc008oph.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S39508 Genomic DNA Translation: AAB19249.2
BC099520 mRNA Translation: AAH99520.1
CCDSiCCDS17236.1
PIRiJH0407
RefSeqiNP_001025476.1, NM_001030305.2
UniGeneiMm.371777

3D structure databases

ProteinModelPortaliP24526
SMRiP24526
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP24526, 1 interactor
STRINGi10090.ENSMUSP00000029034

PTM databases

iPTMnetiP24526
PhosphoSitePlusiP24526

Proteomic databases

MaxQBiP24526
PaxDbiP24526
PeptideAtlasiP24526
PRIDEiP24526

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029034; ENSMUSP00000029034; ENSMUSG00000052468
GeneIDi18857
KEGGimmu:18857
UCSCiuc008oph.1 mouse

Organism-specific databases

CTDi5375
MGIiMGI:102667 Pmp2

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP24526
OMAiMCNRFVG
OrthoDBiEOG091G0QSV
PhylomeDBiP24526
TreeFamiTF316894

Miscellaneous databases

PROiPR:P24526
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052468 Expressed in 9 organ(s), highest expression level in testis
CleanExiMM_PMP2
GenevisibleiP24526 MM

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR031256 Myelin_P2
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF64 PTHR11955:SF64, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYP2_MOUSE
AccessioniPrimary (citable) accession number: P24526
Secondary accession number(s): Q4KL10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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