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UniProtKB - P24492 (DIPA_DROME)

Entry version 152 (02 Dec 2020)
Sequence version 1 (01 Mar 1992)
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Protein

Diptericin A

Gene

DptA

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required to resist Gram-negative bacterial infections, regulated by Dredd.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial
Biological processImmunity, Innate immunity

Protein family/group databases

Transport Classification Database

More...TCDBi		1.C.115.1.1, the membrane-permeabilizing peptide, atticin (atticin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diptericin AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DptAImported
Synonyms:Dipt1 Publication, Dpt1 Publication
ORF Names:CG12763Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0004240, DptA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19CuratedAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000490820 – 23Removed by a dipeptidylpeptidaseCurated4
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000490924 – 106Diptericin AAdd BLAST83

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P24492

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Constitutive expression of diptericin occurs in early pupae and in adults.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By bacterial infection.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0004240, Expressed in arthropod fat body and 22 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P24492, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-20883N

Protein interaction database and analysis system

More...IntActi		P24492, 1 interactor

STRING: functional protein association networks

More...STRINGi		7227.FBpp0085802

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi30 – 37Pro-rich8
Compositional biasi42 – 106Gly-richAdd BLAST65
Compositional biasi42 – 46Poly-Gly5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the attacin/sarcotoxin-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000176590

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_168494_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P24492

Identification of Orthologs from Complete Genome Data

More...OMAi		TYRFPNF

Database for complete collections of gene phylogenies

More...PhylomeDBi		P24492

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040428, Attacin/Sarcotoxin-2

The PANTHER Classification System

More...PANTHERi		PTHR38333, PTHR38333, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P24492-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQFTIAVALL CCAIASTLAY PMPDDMTMKP TPPPQYPLNL QGGGGGQSGD 
        60         70         80         90        100
GFGFAVQGHQ KVWTSDNGRH EIGLNGGYGQ HLGGPYGNSE PSWKVGSTYT 

YRFPNF
Length:106
Mass (Da):11,314
Last modified:March 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C498DF4A4DECEF7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti48S → R in strain: B306, Z18, Z22 and Z24. 1
Natural varianti48S → T in strain: B101. 1
Natural varianti55A → G in strain: B306, Z18 and Z22. 1
Natural varianti65S → T in strain: Z22. 1
Natural varianti73G → R in strain: B141. 1
Natural varianti90E → Q in strain: Z24. 1
Natural varianti98T → N in strain: B101. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M55432 mRNA Translation: AAA28466.1
Z11728 Genomic DNA Translation: CAA77791.1
AF019020 Genomic DNA Translation: AAB82517.1
AF019021 Genomic DNA Translation: AAB82518.1
AF019022 Genomic DNA Translation: AAB82519.1
AF019023 Genomic DNA Translation: AAB82520.1
AF019024 Genomic DNA Translation: AAB82521.1
AF019025 Genomic DNA Translation: AAB82522.1
AF019026 Genomic DNA Translation: AAB82523.1
AF019027 Genomic DNA Translation: AAB82524.1
AF019028 Genomic DNA Translation: AAB82525.1
AF019029 Genomic DNA Translation: AAB82526.1
AF019030 Genomic DNA Translation: AAB82527.1
AF019031 Genomic DNA Translation: AAB82528.1
AF019032 Genomic DNA Translation: AAB82529.1
AF019033 Genomic DNA Translation: AAB82530.1
AF019034 Genomic DNA Translation: AAB82531.1
AE013599 Genomic DNA Translation: AAF57619.1
AY071667 mRNA Translation: AAL49289.1

Protein sequence database of the Protein Information Resource

More...PIRi		S20878

NCBI Reference Sequences

More...RefSeqi		NP_476808.1, NM_057460.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0086620; FBpp0085802; FBgn0004240

Database of genes from NCBI RefSeq genomes

More...GeneIDi		37183

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG12763

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55432 mRNA Translation: AAA28466.1
Z11728 Genomic DNA Translation: CAA77791.1
AF019020 Genomic DNA Translation: AAB82517.1
AF019021 Genomic DNA Translation: AAB82518.1
AF019022 Genomic DNA Translation: AAB82519.1
AF019023 Genomic DNA Translation: AAB82520.1
AF019024 Genomic DNA Translation: AAB82521.1
AF019025 Genomic DNA Translation: AAB82522.1
AF019026 Genomic DNA Translation: AAB82523.1
AF019027 Genomic DNA Translation: AAB82524.1
AF019028 Genomic DNA Translation: AAB82525.1
AF019029 Genomic DNA Translation: AAB82526.1
AF019030 Genomic DNA Translation: AAB82527.1
AF019031 Genomic DNA Translation: AAB82528.1
AF019032 Genomic DNA Translation: AAB82529.1
AF019033 Genomic DNA Translation: AAB82530.1
AF019034 Genomic DNA Translation: AAB82531.1
AE013599 Genomic DNA Translation: AAF57619.1
AY071667 mRNA Translation: AAL49289.1
PIRiS20878
RefSeqiNP_476808.1, NM_057460.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-20883N
IntActiP24492, 1 interactor
STRINGi7227.FBpp0085802

Protein family/group databases

TCDBi1.C.115.1.1, the membrane-permeabilizing peptide, atticin (atticin) family

Proteomic databases

PaxDbiP24492

Genome annotation databases

EnsemblMetazoaiFBtr0086620; FBpp0085802; FBgn0004240
GeneIDi37183
KEGGidme:Dmel_CG12763

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		37183
FlyBaseiFBgn0004240, DptA

Phylogenomic databases

GeneTreeiENSGT00940000176590
HOGENOMiCLU_168494_0_0_1
InParanoidiP24492
OMAiTYRFPNF
PhylomeDBiP24492

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		37183, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		37183

Protein Ontology

More...PROi		PR:P24492

Gene expression databases

BgeeiFBgn0004240, Expressed in arthropod fat body and 22 other tissues
ExpressionAtlasiP24492, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR040428, Attacin/Sarcotoxin-2
PANTHERiPTHR38333, PTHR38333, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIPA_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24492
Secondary accession number(s): O16838
, O16839, O16840, O16841, O18669, Q9V8P5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: December 2, 2020
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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