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Entry version 165 (29 Sep 2021)
Sequence version 1 (01 Mar 1992)
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Protein

ATP synthase subunit alpha, mitochondrial

Gene

atp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei398Required for activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi197 – 204ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-163210, Formation of ATP by chemiosmotic coupling
R-SPO-8949613, Cristae formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP synthase subunit alpha, mitochondrial
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:atp1
ORF Names:SPAC14C4.14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC14C4.14, atp1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC14C4.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 27MitochondrionAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000243228 – 536ATP synthase subunit alpha, mitochondrialAdd BLAST509

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P24487

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P24487

PRoteomics IDEntifications database

More...
PRIDEi
P24487

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P24487

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
278026, 4 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC14C4.14.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P24487

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1353, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010091_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24487

Identification of Orthologs from Complete Genome Data

More...
OMAi
MEVFTQF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P24487

Family and domain databases

Conserved Domains Database

More...
CDDi
cd18113, ATP-synt_F1_alpha_C, 1 hit
cd01132, F1_ATPase_alpha, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.150.20, 1 hit
2.40.30.20, 1 hit
3.40.50.300, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01346, ATP_synth_alpha_bact, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023366, ATP_synth_asu-like_sf
IPR000793, ATP_synth_asu_C
IPR038376, ATP_synth_asu_C_sf
IPR033732, ATP_synth_F1_a
IPR005294, ATP_synth_F1_asu
IPR020003, ATPase_a/bsu_AS
IPR004100, ATPase_F1/V1/A1_a/bsu_N
IPR036121, ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF00306, ATP-synt_ab_C, 1 hit
PF02874, ATP-synt_ab_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF039088, F_ATPase_subunit_alpha, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50615, SSF50615, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00962, atpA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00152, ATPASE_ALPHA_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P24487-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRQAGTRLL KVPVCGLRPS ITLKRGYAEK AAPTEVPSIL EERIRGAYNQ
60 70 80 90 100
AQMMESGRVL SIGDGIARIS GLSNVQAEEL VEFSSGIKGM ALNLEADTVG
110 120 130 140 150
CVLFGNDRLV REGEVVKRTR HIVDVPVGEA LLGRVVDALG NPIDGKGPIK
160 170 180 190 200
TTERRRVQLK APGILPRTSV CEPMQTGLKA IDSMVPIGRG QRELIIGDRQ
210 220 230 240 250
TGKTAIALDT ILNHKRWNNS SDESKKLYCV YVAVGQKRST VAQLVQKLEE
260 270 280 290 300
NDSLKYSIIV AATASESAPL QYLAPFSGCA MGEWFRDNGK HGLVVYDDLS
310 320 330 340 350
KQAVAYRQMS LLLRRPPGRE AYPGDVFYLH SRLLERAAKM SPKHGGGSLT
360 370 380 390 400
ALPVIETQGG DVSAYIPTNV ISITDGQIFL ESELFFKGIR PAINVGLSVS
410 420 430 440 450
RVGSAAQVKA MKQVAGQIKL FLAQYREVAS FAQFGSDLDA GTRATLDRGL
460 470 480 490 500
RLTELLKQPQ YSPLAVEEQV PLIYCGVKGY LDKIPVDRVV EFEHKFIPYL
510 520 530
RSSGAEIMEA IRKEGVLSKT TEDSLKAVIK EFLSSF
Length:536
Mass (Da):58,588
Last modified:March 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i064C05B60A1274B8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M57955 Genomic DNA Translation: AAA35286.1
CU329670 Genomic DNA Translation: CAB11207.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A39036

NCBI Reference Sequences

More...
RefSeqi
NP_594919.1, NM_001020351.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC14C4.14.1; SPAC14C4.14.1:pep; SPAC14C4.14

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541526

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC14C4.14

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57955 Genomic DNA Translation: AAA35286.1
CU329670 Genomic DNA Translation: CAB11207.1
PIRiA39036
RefSeqiNP_594919.1, NM_001020351.2

3D structure databases

SMRiP24487
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi278026, 4 interactors
STRINGi4896.SPAC14C4.14.1

PTM databases

iPTMnetiP24487

Proteomic databases

MaxQBiP24487
PaxDbiP24487
PRIDEiP24487

Genome annotation databases

EnsemblFungiiSPAC14C4.14.1; SPAC14C4.14.1:pep; SPAC14C4.14
GeneIDi2541526
KEGGispo:SPAC14C4.14

Organism-specific databases

PomBaseiSPAC14C4.14, atp1
VEuPathDBiFungiDB:SPAC14C4.14

Phylogenomic databases

eggNOGiKOG1353, Eukaryota
HOGENOMiCLU_010091_2_1_1
InParanoidiP24487
OMAiMEVFTQF
PhylomeDBiP24487

Enzyme and pathway databases

ReactomeiR-SPO-163210, Formation of ATP by chemiosmotic coupling
R-SPO-8949613, Cristae formation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P24487

Family and domain databases

CDDicd18113, ATP-synt_F1_alpha_C, 1 hit
cd01132, F1_ATPase_alpha, 1 hit
Gene3Di1.20.150.20, 1 hit
2.40.30.20, 1 hit
3.40.50.300, 1 hit
HAMAPiMF_01346, ATP_synth_alpha_bact, 1 hit
InterProiView protein in InterPro
IPR023366, ATP_synth_asu-like_sf
IPR000793, ATP_synth_asu_C
IPR038376, ATP_synth_asu_C_sf
IPR033732, ATP_synth_F1_a
IPR005294, ATP_synth_F1_asu
IPR020003, ATPase_a/bsu_AS
IPR004100, ATPase_F1/V1/A1_a/bsu_N
IPR036121, ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF00306, ATP-synt_ab_C, 1 hit
PF02874, ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039088, F_ATPase_subunit_alpha, 1 hit
SUPFAMiSSF50615, SSF50615, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00962, atpA, 1 hit
PROSITEiView protein in PROSITE
PS00152, ATPASE_ALPHA_BETA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATPA_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24487
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 29, 2021
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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