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Protein

COUP transcription factor 2

Gene

NR2F2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi76 – 151Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri79 – 99NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri115 – 139NR C4-typePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P24468

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P24468

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
COUP transcription factor 2
Short name:
COUP-TF2
Alternative name(s):
Apolipoprotein A-I regulatory protein 1
Short name:
ARP-1
COUP transcription factor II
Short name:
COUP-TF II
Nuclear receptor subfamily 2 group F member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NR2F2
Synonyms:ARP1, TFCOUP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000185551.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7976 NR2F2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
107773 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P24468

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital heart defects, multiple types, 4 (CHTD4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by congenital developmental abnormalities involving structures of the heart. Common defects include transposition of the great arteries, aortic stenosis, atrial septal defect, ventricular septal defect, pulmonic stenosis, and patent ductus arteriosus. Some patients also have cardiac arrhythmias, which may be due to the anatomic defect itself or to surgical interventions.
See also OMIM:615779
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07176675Q → QQ in CHTD4; the mutation results in reduced transcription activation of the EGR1 promoter; does not affect transcription activation of the APOB FT promoter. 1 Publication1
Natural variantiVAR_071767170D → V in CHTD4. 1 Publication1
Natural variantiVAR_071768205N → I in CHTD4; the mutation results in increased transcription activation of the EGR1 promoter; transcription activation of the APOB promoter is decreased. 1 PublicationCorresponds to variant dbSNP:rs587777372Ensembl.1
Natural variantiVAR_071769251E → D in CHTD4. 1 Publication1
Natural variantiVAR_071770341S → Y in CHTD4; the mutation results in reduced transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs587777371EnsemblClinVar.1
Natural variantiVAR_071771412A → S in CHTD4. 1 PublicationCorresponds to variant dbSNP:rs201527820Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi228R → E: Reduces transcription activation by 40%; when associated with R-398. 1 Publication1
Mutagenesisi249W → A: Reduces transcription activation by 50%; when associated with A-250. 1 Publication1
Mutagenesisi250S → A: Reduces transcription activation by 50%; when associated with A-249. 1 Publication1
Mutagenesisi250S → W: Reduces transcription activation by 50%. 1 Publication1
Mutagenesisi253 – 254FV → AA: Reduces transcription activation by 50%. 1 Publication2
Mutagenesisi269 – 270LL → AA: Reduces transcription activation by 50%. 2
Mutagenesisi364 – 365LL → AA: Reduces transcription activation by 80%. 1 Publication2
Mutagenesisi398D → R: Reduces transcription activation by 40%; when associated with E-228. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7026

MalaCards human disease database

More...
MalaCardsi
NR2F2
MIMi615779 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000185551

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99066 Complete atrioventricular canal-left heart obstruction syndrome
99068 Complete atrioventricular canal-tetralogy of Fallot syndrome
99067 Complete atrioventricular canal-ventricle hypoplasia syndrome
1330 Partial atrioventricular canal

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31759

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1961790

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NR2F2

Domain mapping of disease mutations (DMDM)

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DMDMi
114203

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000536061 – 414COUP transcription factor 2Add BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei51PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P24468

MaxQB - The MaxQuant DataBase

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MaxQBi
P24468

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P24468

PeptideAtlas

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PeptideAtlasi
P24468

PRoteomics IDEntifications database

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PRIDEi
P24468

ProteomicsDB human proteome resource

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ProteomicsDBi
54206
54207 [P24468-2]
54208 [P24468-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P24468

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P24468

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000185551 Expressed in 244 organ(s), highest expression level in female gonad

CleanEx database of gene expression profiles

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CleanExi
HS_NR2F2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P24468 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P24468 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA058974

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SMAD4Q134854EBI-2795198,EBI-347263

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112884, 73 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P24468

Database of interacting proteins

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DIPi
DIP-29713N

Protein interaction database and analysis system

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IntActi
P24468, 17 interactors

Molecular INTeraction database

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MINTi
P24468

STRING: functional protein association networks

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STRINGi
9606.ENSP00000377721

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P24468

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1414
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P24468

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P24468

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P24468

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini177 – 403NR LBDPROSITE-ProRule annotationAdd BLAST227

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni117 – 414Interaction with ZFPM2By similarityAdd BLAST298
Regioni337 – 414Important for dimerizationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi71 – 75Poly-Gln5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri79 – 99NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri115 – 139NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3575 Eukaryota
ENOG410XRZC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157540

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000260820

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005606

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P24468

KEGG Orthology (KO)

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KOi
K08548

Identification of Orthologs from Complete Genome Data

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OMAi
HHVIKED

Database of Orthologous Groups

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OrthoDBi
EOG091G0YX6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P24468

TreeFam database of animal gene trees

More...
TreeFami
TF352097

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003068 COUP_TF
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01282 COUPTNFACTOR
PR00398 STRDHORMONER
PR00047 STROIDFINGER

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48508 SSF48508, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P24468-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS
60 70 80 90 100
TPAQTAAGGQ GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK
110 120 130 140 150
SFFKRSVRRN LSYTCRANRN CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ
160 170 180 190 200
RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEP YPTSRFGSQC
210 220 230 240 250
MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD QVALLRLTWS
260 270 280 290 300
ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE
310 320 330 340 350
KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR
360 370 380 390 400
SQYPNQPTRF GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML
410
LSGSSFNWPY MAIQ
Length:414
Mass (Da):45,571
Last modified:March 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC24CB2E8C8A27E8C
GO
Isoform 2 (identifier: P24468-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-147: MAMVVSTWRD...KCLKVGMRRE → MQAVWDLEQGKYGF

Show »
Length:281
Mass (Da):31,484
Checksum:i038DD27B80868BB5
GO
Isoform 3 (identifier: P24468-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Show »
Length:261
Mass (Da):29,163
Checksum:i5526AD057E2A639E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BTC2H3BTC2_HUMAN
COUP transcription factor 2
NR2F2
93Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07176675Q → QQ in CHTD4; the mutation results in reduced transcription activation of the EGR1 promoter; does not affect transcription activation of the APOB FT promoter. 1 Publication1
Natural variantiVAR_071767170D → V in CHTD4. 1 Publication1
Natural variantiVAR_071768205N → I in CHTD4; the mutation results in increased transcription activation of the EGR1 promoter; transcription activation of the APOB promoter is decreased. 1 PublicationCorresponds to variant dbSNP:rs587777372Ensembl.1
Natural variantiVAR_071769251E → D in CHTD4. 1 Publication1
Natural variantiVAR_071770341S → Y in CHTD4; the mutation results in reduced transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs587777371EnsemblClinVar.1
Natural variantiVAR_071771412A → S in CHTD4. 1 PublicationCorresponds to variant dbSNP:rs201527820Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0438971 – 153Missing in isoform 3. 2 PublicationsAdd BLAST153
Alternative sequenceiVSP_0426301 – 147MAMVV…GMRRE → MQAVWDLEQGKYGF in isoform 2. 4 PublicationsAdd BLAST147

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M64497 mRNA Translation: AAA86429.1
U60477 Genomic DNA Translation: AAB09475.1
AB307711 mRNA Translation: BAH02302.1
FM208183 mRNA Translation: CAR63888.1
AK298824 mRNA Translation: BAG60954.1
AK301595 mRNA Translation: BAG63083.1
AK316086 mRNA Translation: BAH14457.1
HQ692849 mRNA Translation: ADZ17360.1
HQ692850 mRNA Translation: ADZ17361.1
AC016251 Genomic DNA No translation available.
CH471101 Genomic DNA Translation: EAX02195.1
CH471101 Genomic DNA Translation: EAX02196.1
CH471101 Genomic DNA Translation: EAX02197.1
BC014664 mRNA Translation: AAH14664.1
BC042897 mRNA Translation: AAH42897.1
BC106083 mRNA Translation: AAI06084.1
M62760 mRNA Translation: AAA21479.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10375.1 [P24468-1]
CCDS45358.1 [P24468-2]
CCDS45359.1 [P24468-3]

Protein sequence database of the Protein Information Resource

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PIRi
A37133

NCBI Reference Sequences

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RefSeqi
NP_001138627.1, NM_001145155.1 [P24468-2]
NP_001138628.1, NM_001145156.1 [P24468-3]
NP_001138629.1, NM_001145157.1 [P24468-3]
NP_066285.1, NM_021005.3 [P24468-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.347991

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000394166; ENSP00000377721; ENSG00000185551 [P24468-1]
ENST00000394171; ENSP00000377726; ENSG00000185551 [P24468-3]
ENST00000421109; ENSP00000401674; ENSG00000185551 [P24468-2]
ENST00000453270; ENSP00000389853; ENSG00000185551 [P24468-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7026

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7026

UCSC genome browser

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UCSCi
uc002btp.4 human [P24468-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64497 mRNA Translation: AAA86429.1
U60477 Genomic DNA Translation: AAB09475.1
AB307711 mRNA Translation: BAH02302.1
FM208183 mRNA Translation: CAR63888.1
AK298824 mRNA Translation: BAG60954.1
AK301595 mRNA Translation: BAG63083.1
AK316086 mRNA Translation: BAH14457.1
HQ692849 mRNA Translation: ADZ17360.1
HQ692850 mRNA Translation: ADZ17361.1
AC016251 Genomic DNA No translation available.
CH471101 Genomic DNA Translation: EAX02195.1
CH471101 Genomic DNA Translation: EAX02196.1
CH471101 Genomic DNA Translation: EAX02197.1
BC014664 mRNA Translation: AAH14664.1
BC042897 mRNA Translation: AAH42897.1
BC106083 mRNA Translation: AAI06084.1
M62760 mRNA Translation: AAA21479.1
CCDSiCCDS10375.1 [P24468-1]
CCDS45358.1 [P24468-2]
CCDS45359.1 [P24468-3]
PIRiA37133
RefSeqiNP_001138627.1, NM_001145155.1 [P24468-2]
NP_001138628.1, NM_001145156.1 [P24468-3]
NP_001138629.1, NM_001145157.1 [P24468-3]
NP_066285.1, NM_021005.3 [P24468-1]
UniGeneiHs.347991

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CJWX-ray1.48A175-414[»]
ProteinModelPortaliP24468
SMRiP24468
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112884, 73 interactors
CORUMiP24468
DIPiDIP-29713N
IntActiP24468, 17 interactors
MINTiP24468
STRINGi9606.ENSP00000377721

Chemistry databases

BindingDBiP24468
ChEMBLiCHEMBL1961790

PTM databases

iPTMnetiP24468
PhosphoSitePlusiP24468

Polymorphism and mutation databases

BioMutaiNR2F2
DMDMi114203

Proteomic databases

EPDiP24468
MaxQBiP24468
PaxDbiP24468
PeptideAtlasiP24468
PRIDEiP24468
ProteomicsDBi54206
54207 [P24468-2]
54208 [P24468-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394166; ENSP00000377721; ENSG00000185551 [P24468-1]
ENST00000394171; ENSP00000377726; ENSG00000185551 [P24468-3]
ENST00000421109; ENSP00000401674; ENSG00000185551 [P24468-2]
ENST00000453270; ENSP00000389853; ENSG00000185551 [P24468-3]
GeneIDi7026
KEGGihsa:7026
UCSCiuc002btp.4 human [P24468-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7026
DisGeNETi7026
EuPathDBiHostDB:ENSG00000185551.12

GeneCards: human genes, protein and diseases

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GeneCardsi
NR2F2
HGNCiHGNC:7976 NR2F2
HPAiHPA058974
MalaCardsiNR2F2
MIMi107773 gene
615779 phenotype
neXtProtiNX_P24468
OpenTargetsiENSG00000185551
Orphaneti99066 Complete atrioventricular canal-left heart obstruction syndrome
99068 Complete atrioventricular canal-tetralogy of Fallot syndrome
99067 Complete atrioventricular canal-ventricle hypoplasia syndrome
1330 Partial atrioventricular canal
PharmGKBiPA31759

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00940000157540
HOGENOMiHOG000260820
HOVERGENiHBG005606
InParanoidiP24468
KOiK08548
OMAiHHVIKED
OrthoDBiEOG091G0YX6
PhylomeDBiP24468
TreeFamiTF352097

Enzyme and pathway databases

ReactomeiR-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkiP24468
SIGNORiP24468

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NR2F2 human
EvolutionaryTraceiP24468

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
COUP-TFII

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7026

Protein Ontology

More...
PROi
PR:P24468

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185551 Expressed in 244 organ(s), highest expression level in female gonad
CleanExiHS_NR2F2
ExpressionAtlasiP24468 baseline and differential
GenevisibleiP24468 HS

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003068 COUP_TF
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01282 COUPTNFACTOR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24468
Secondary accession number(s): B4DQJ2
, B6ZGU1, Q03754, Q3KQR7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: December 5, 2018
This is version 191 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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