NR2F2

Functionⁱ

Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	76 – 151	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	76
Zinc fingerⁱ	79 – 99	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	115 – 139	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9343308
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049
nuclear receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18798693
protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 18798693
retinoic acid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18798693
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9343308
steroid hormone receptor activity Source: InterPro
transcription corepressor activity
Source: ProtInc
Traceable author statementⁱ
- 1899293
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior pattern specification Source: Ensembl
blood vessel morphogenesis Source: Ensembl
fertilization Source: Ensembl
forebrain development Source: Ensembl
limb development Source: Ensembl
lipid metabolic process
Source: ProtInc
Traceable author statementⁱ
- 1899293
maternal placenta development Source: Ensembl
negative regulation of cyclin-dependent protein serine/threonine kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19210544
negative regulation of endothelial cell migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19210544
negative regulation of endothelial cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19210544
negative regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from direct assayⁱ
- 19210544
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 9343308
neuron migration Source: Ensembl
placenta blood vessel development Source: Ensembl
positive regulation of systemic arterial blood pressure Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 18798693
radial pattern formation Source: Ensembl
regulation of transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 1899293
regulation of transcription involved in lymphatic endothelial cell fate commitment
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18815287
response to estradiol Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 1899293
skeletal muscle tissue development Source: Ensembl
trophoblast giant cell differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkⁱ	P24468
SIGNORⁱ	P24468

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: COUP transcription factor 2 Short name: COUP-TF2 Alternative name(s): Apolipoprotein A-I regulatory protein 1 Short name: ARP-1 COUP transcription factor II Short name: COUP-TF II Nuclear receptor subfamily 2 group F member 2
Gene namesⁱ	Name:NR2F2 Synonyms:ARP1, TFCOUP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185551.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7976 NR2F2
MIMⁱ	107773 gene
neXtProtⁱ	NX_P24468

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Congenital heart defects, multiple types, 4 (CHTD4)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by congenital developmental abnormalities involving structures of the heart. Common defects include transposition of the great arteries, aortic stenosis, atrial septal defect, ventricular septal defect, pulmonic stenosis, and patent ductus arteriosus. Some patients also have cardiac arrhythmias, which may be due to the anatomic defect itself or to surgical interventions.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	228	R → E: Reduces transcription activation by 40%; when associated with R-398. 1 Publication	1
Mutagenesisⁱ	249	W → A: Reduces transcription activation by 50%; when associated with A-250. 1 Publication	1
Mutagenesisⁱ	250	S → A: Reduces transcription activation by 50%; when associated with A-249. 1 Publication	1
Mutagenesisⁱ	250	S → W: Reduces transcription activation by 50%. 1 Publication	1
Mutagenesisⁱ	253 – 254	FV → AA: Reduces transcription activation by 50%. 1 Publication	2
Mutagenesisⁱ	269 – 270	LL → AA: Reduces transcription activation by 50%.	2
Mutagenesisⁱ	364 – 365	LL → AA: Reduces transcription activation by 80%. 1 Publication	2
Mutagenesisⁱ	398	D → R: Reduces transcription activation by 40%; when associated with E-228. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7026
MalaCards human disease database More...MalaCardsⁱ	NR2F2
MIMⁱ	615779 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000185551
Orphanetⁱ	99066 Complete atrioventricular canal-left heart obstruction syndrome 99068 Complete atrioventricular canal-tetralogy of Fallot syndrome 99067 Complete atrioventricular canal-ventricle hypoplasia syndrome 1330 Partial atrioventricular canal
PharmGKBⁱ	PA31759

Chemistry databases

ChEMBLⁱ	CHEMBL1961790

ChEMBLⁱ

CHEMBL1961790

Polymorphism and mutation databases

BioMutaⁱ	NR2F2
DMDMⁱ	114203

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053606	1 – 414	COUP transcription factor 2Add BLAST		414

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	51	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P24468
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P24468
PaxDbⁱ	P24468
PeptideAtlas More...PeptideAtlasⁱ	P24468
PRIDEⁱ	P24468
ProteomicsDBⁱ	54206 54207 [P24468-2] 54208 [P24468-3]

PTM databases

iPTMnetⁱ	P24468
PhosphoSitePlusⁱ	P24468

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000185551 Expressed in 244 organ(s), highest expression level in female gonad
CleanExⁱ	HS_NR2F2
ExpressionAtlasⁱ	P24468 baseline and differential
Genevisibleⁱ	P24468 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA058974

HPAⁱ

HPA058974

Interactionⁱ

Subunit structureⁱ

Interacts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SMAD4	Q13485	4	EBI-2795198,EBI-347263

With

Entry

#Exp.

IntAct

Notes

SMAD4

Q13485

4

EBI-2795198,EBI-347263

GO - Molecular functionⁱ

protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 18798693

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112884, 73 interactors
CORUMⁱ	P24468
Database of interacting proteins More...DIPⁱ	DIP-29713N
IntActⁱ	P24468, 16 interactors
Molecular INTeraction database More...MINTⁱ	P24468
STRINGⁱ	9606.ENSP00000377721

Chemistry databases

BindingDBⁱ

P24468

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	175 – 187	Combined sources	13
Helixⁱ	212 – 229	Combined sources	18
Beta strandⁱ	230 – 232	Combined sources	3
Helixⁱ	233 – 235	Combined sources	3
Helixⁱ	238 – 260	Combined sources	23
Helixⁱ	290 – 304	Combined sources	15
Helixⁱ	309 – 320	Combined sources	12
Helixⁱ	331 – 352	Combined sources	22
Helixⁱ	359 – 364	Combined sources	6
Helixⁱ	367 – 372	Combined sources	6
Helixⁱ	375 – 382	Combined sources	8
Helixⁱ	384 – 387	Combined sources	4
Helixⁱ	392 – 394	Combined sources	3
Helixⁱ	396 – 400	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P24468
SMRⁱ	P24468
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P24468

EvolutionaryTraceⁱ

P24468

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	177 – 403	NR LBDPROSITE-ProRule annotationAdd BLAST		227

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	117 – 414	Interaction with ZFPM2By similarityAdd BLAST		298
Regionⁱ	337 – 414	Important for dimerizationAdd BLAST		78

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	71 – 75	Poly-Gln		5

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR2 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	79 – 99	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	115 – 139	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118948
HOGENOMⁱ	HOG000260820
HOVERGENⁱ	HBG005606
InParanoidⁱ	P24468
KEGG Orthology (KO) More...KOⁱ	K08548
OMAⁱ	HHVIKED
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YX6
PhylomeDBⁱ	P24468
TreeFamⁱ	TF352097

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003068 COUP_TF IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01282 COUPTNFACTOR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P24468-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS 
        60         70         80         90        100
TPAQTAAGGQ GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK 
       110        120        130        140        150
SFFKRSVRRN LSYTCRANRN CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ 
       160        170        180        190        200
RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEP YPTSRFGSQC 
       210        220        230        240        250
MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD QVALLRLTWS 
       260        270        280        290        300
ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE 
       310        320        330        340        350
KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR 
       360        370        380        390        400
SQYPNQPTRF GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML 
       410 
LSGSSFNWPY MAIQ

Length:414

Mass (Da):45,571

Last modified:March 1, 1992 - v1

Checksum:ⁱC24CB2E8C8A27E8C

GO

Isoform 2 (identifier: P24468-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-147: MAMVVSTWRD...KCLKVGMRRE → MQAVWDLEQGKYGF

« Hide

        10         20         30         40         50
MQAVWDLEQG KYGFAVQRGR MPPTQPTHGQ FALTNGDPLN CHSYLSGYIS 
        60         70         80         90        100
LLLRAEPYPT SRFGSQCMQP NNIMGIENIC ELAARMLFSA VEWARNIPFF 
       110        120        130        140        150
PDLQITDQVA LLRLTWSELF VLNAAQCSMP LHVAPLLAAA GLHASPMSAD 
       160        170        180        190        200
RVVAFMDHIR IFQEQVEKLK ALHVDSAEYS CLKAIVLFTS DACGLSDVAH 
       210        220        230        240        250
VESLQEKSQC ALEEYVRSQY PNQPTRFGKL LLRLPSLRTV SSSVIEQLFF 
       260        270        280 
VRLVGKTPIE TLIRDMLLSG SSFNWPYMAI Q

Show »

Length:281

Mass (Da):31,484

Checksum:ⁱ038DD27B80868BB5

GO

Isoform 3 (identifier: P24468-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-153: Missing.

« Hide

        10         20         30         40         50
MPPTQPTHGQ FALTNGDPLN CHSYLSGYIS LLLRAEPYPT SRFGSQCMQP 
        60         70         80         90        100
NNIMGIENIC ELAARMLFSA VEWARNIPFF PDLQITDQVA LLRLTWSELF 
       110        120        130        140        150
VLNAAQCSMP LHVAPLLAAA GLHASPMSAD RVVAFMDHIR IFQEQVEKLK 
       160        170        180        190        200
ALHVDSAEYS CLKAIVLFTS DACGLSDVAH VESLQEKSQC ALEEYVRSQY 
       210        220        230        240        250
PNQPTRFGKL LLRLPSLRTV SSSVIEQLFF VRLVGKTPIE TLIRDMLLSG 
       260 
SSFNWPYMAI Q

Show »

Length:261

Mass (Da):29,163

Checksum:ⁱ5526AD057E2A639E

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H3BTC2	H3BTC2_HUMAN		COUP transcription factor 2 COUP transcription factor 2	NR2F2	93	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_071766	75	Q → QQ in CHTD4; the mutation results in reduced transcription activation of the EGR1 promoter; does not affect transcription activation of the APOB FT promoter. 1 Publication	1
Natural variantⁱVAR_071767	170	D → V in CHTD4. 1 Publication	1
Natural variantⁱVAR_071768	205	N → I in CHTD4; the mutation results in increased transcription activation of the EGR1 promoter; transcription activation of the APOB promoter is decreased. 1 PublicationCorresponds to variant dbSNP:rs587777372Ensembl.	1
Natural variantⁱVAR_071769	251	E → D in CHTD4. 1 Publication	1
Natural variantⁱVAR_071770	341	S → Y in CHTD4; the mutation results in reduced transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs587777371EnsemblClinVar.	1
Natural variantⁱVAR_071771	412	A → S in CHTD4. 1 PublicationCorresponds to variant dbSNP:rs201527820Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043897	1 – 153	Missing in isoform 3. 2 PublicationsAdd BLAST		153
Alternative sequenceⁱVSP_042630	1 – 147	MAMVV…GMRRE → MQAVWDLEQGKYGF in isoform 2. 4 PublicationsAdd BLAST		147

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M64497 mRNA Translation: AAA86429.1 U60477 Genomic DNA Translation: AAB09475.1 AB307711 mRNA Translation: BAH02302.1 FM208183 mRNA Translation: CAR63888.1 AK298824 mRNA Translation: BAG60954.1 AK301595 mRNA Translation: BAG63083.1 AK316086 mRNA Translation: BAH14457.1 HQ692849 mRNA Translation: ADZ17360.1 HQ692850 mRNA Translation: ADZ17361.1 AC016251 Genomic DNA No translation available. CH471101 Genomic DNA Translation: EAX02195.1 CH471101 Genomic DNA Translation: EAX02196.1 CH471101 Genomic DNA Translation: EAX02197.1 BC014664 mRNA Translation: AAH14664.1 BC042897 mRNA Translation: AAH42897.1 BC106083 mRNA Translation: AAI06084.1 M62760 mRNA Translation: AAA21479.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10375.1 [P24468-1] CCDS45358.1 [P24468-2] CCDS45359.1 [P24468-3]
PIRⁱ	A37133
NCBI Reference Sequences More...RefSeqⁱ	NP_001138627.1, NM_001145155.1 [P24468-2] NP_001138628.1, NM_001145156.1 [P24468-3] NP_001138629.1, NM_001145157.1 [P24468-3] NP_066285.1, NM_021005.3 [P24468-1]
UniGeneⁱ	Hs.347991

Genome annotation databases

Ensemblⁱ	ENST00000394166; ENSP00000377721; ENSG00000185551 [P24468-1] ENST00000394171; ENSP00000377726; ENSG00000185551 [P24468-3] ENST00000421109; ENSP00000401674; ENSG00000185551 [P24468-2] ENST00000453270; ENSP00000389853; ENSG00000185551 [P24468-3]
GeneIDⁱ	7026
KEGGⁱ	hsa:7026
UCSC genome browser More...UCSCⁱ	uc002btp.4 human [P24468-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24468	COUP transcription factor 2		MOUSE		414	UniRef100_P24468
Nuclear receptor subfamily 2, group F, member 2, isoform CRA_a		HUMAN		414
COUP transcription factor 2 isoform a		CALJA		414
NR2F2 isoform 2		PANTR		414
Uncharacterized protein		PROCO		414
+15
P24468-2	COUP transcription factor 2		MOUSE		281	UniRef100_D3YYP4
COUP transcription factor 2 isoform b		MACMU		281
NR2F2 isoform 1		PANTR		281
COUP transcription factor 2 isoform b		CALJA		281
Orphan nuclear receptor COUP-TFII		PIG		281
+36
P24468-3	Uncharacterized protein		NOMLE		262	UniRef100_A0A2I3FZI9
NR2F2 isoform 4		PANTR		261
Uncharacterized protein (Fragment)		Micrurus lemniscatus lemniscatus		141
Nuclear receptor subfamily 2 group F member 2 (Fragment)		PHOSU		100
COUP transcription factor 2 isoform X2		TARSY		261
+17

Protein	Similar proteins		Species	Score	Length	Source
P24468	COUP transcription factor 2		MOUSE		414	UniRef90_P24468
COUP transcription factor 2		BOVIN		414
COUP transcription factor 2		RAT		414
Nuclear receptor subfamily 2, group F, member 2, isoform CRA_a		HUMAN		414
COUP transcription factor 2 isoform a		CALJA		414
+99
P24468-2	COUP transcription factor 2		MOUSE		281	UniRef90_D3YYP4
COUP transcription factor 2 isoform b		MACMU		281
NR2F2 isoform 1		PANTR		281
COUP transcription factor 2 isoform b		CALJA		281
Orphan nuclear receptor COUP-TFII		PIG		281
+72

Protein	Similar proteins		Species	Score	Length	Source
P24468	COUP transcription factor 2		MOUSE		414	UniRef50_P24468
COUP transcription factor 2		RAT		414
COUP transcription factor 2		BOVIN		414
COUP transcription factor 2		CHICK		410
Nuclear receptor subfamily 2 group F member 5		DANRE		403
+640
P24468-2	COUP transcription factor 2		MOUSE		281	UniRef50_D3YYP4
COUP transcription factor 2 isoform b		MACMU		281
NR2F2 isoform 1		PANTR		281
COUP transcription factor 2 isoform b		CALJA		281
Orphan nuclear receptor COUP-TFII		PIG		281
+118

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M64497 mRNA Translation: AAA86429.1 U60477 Genomic DNA Translation: AAB09475.1 AB307711 mRNA Translation: BAH02302.1 FM208183 mRNA Translation: CAR63888.1 AK298824 mRNA Translation: BAG60954.1 AK301595 mRNA Translation: BAG63083.1 AK316086 mRNA Translation: BAH14457.1 HQ692849 mRNA Translation: ADZ17360.1 HQ692850 mRNA Translation: ADZ17361.1 AC016251 Genomic DNA No translation available. CH471101 Genomic DNA Translation: EAX02195.1 CH471101 Genomic DNA Translation: EAX02196.1 CH471101 Genomic DNA Translation: EAX02197.1 BC014664 mRNA Translation: AAH14664.1 BC042897 mRNA Translation: AAH42897.1 BC106083 mRNA Translation: AAI06084.1 M62760 mRNA Translation: AAA21479.1
CCDSⁱ	CCDS10375.1 [P24468-1] CCDS45358.1 [P24468-2] CCDS45359.1 [P24468-3]
PIRⁱ	A37133
RefSeqⁱ	NP_001138627.1, NM_001145155.1 [P24468-2] NP_001138628.1, NM_001145156.1 [P24468-3] NP_001138629.1, NM_001145157.1 [P24468-3] NP_066285.1, NM_021005.3 [P24468-1]
UniGeneⁱ	Hs.347991

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3CJW	X-ray	1.48	A	175-414	[»]
ProteinModelPortalⁱ	P24468
SMRⁱ	P24468
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112884, 73 interactors
CORUMⁱ	P24468
DIPⁱ	DIP-29713N
IntActⁱ	P24468, 16 interactors
MINTⁱ	P24468
STRINGⁱ	9606.ENSP00000377721

Chemistry databases

BindingDBⁱ	P24468
ChEMBLⁱ	CHEMBL1961790

PTM databases

iPTMnetⁱ	P24468
PhosphoSitePlusⁱ	P24468

Polymorphism and mutation databases

BioMutaⁱ	NR2F2
DMDMⁱ	114203

Proteomic databases

EPDⁱ	P24468
MaxQBⁱ	P24468
PaxDbⁱ	P24468
PeptideAtlasⁱ	P24468
PRIDEⁱ	P24468
ProteomicsDBⁱ	54206 54207 [P24468-2] 54208 [P24468-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000394166; ENSP00000377721; ENSG00000185551 [P24468-1] ENST00000394171; ENSP00000377726; ENSG00000185551 [P24468-3] ENST00000421109; ENSP00000401674; ENSG00000185551 [P24468-2] ENST00000453270; ENSP00000389853; ENSG00000185551 [P24468-3]
GeneIDⁱ	7026
KEGGⁱ	hsa:7026
UCSCⁱ	uc002btp.4 human [P24468-1]

Organism-specific databases

CTDⁱ	7026
DisGeNETⁱ	7026
EuPathDBⁱ	HostDB:ENSG00000185551.12
GeneCardsⁱ	NR2F2
HGNCⁱ	HGNC:7976 NR2F2
HPAⁱ	HPA058974
MalaCardsⁱ	NR2F2
MIMⁱ	107773 gene 615779 phenotype
neXtProtⁱ	NX_P24468
OpenTargetsⁱ	ENSG00000185551
Orphanetⁱ	99066 Complete atrioventricular canal-left heart obstruction syndrome 99068 Complete atrioventricular canal-tetralogy of Fallot syndrome 99067 Complete atrioventricular canal-ventricle hypoplasia syndrome 1330 Partial atrioventricular canal
PharmGKBⁱ	PA31759
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
GeneTreeⁱ	ENSGT00760000118948
HOGENOMⁱ	HOG000260820
HOVERGENⁱ	HBG005606
InParanoidⁱ	P24468
KOⁱ	K08548
OMAⁱ	HHVIKED
OrthoDBⁱ	EOG091G0YX6
PhylomeDBⁱ	P24468
TreeFamⁱ	TF352097

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkⁱ	P24468
SIGNORⁱ	P24468

Miscellaneous databases

ChiTaRSⁱ	NR2F2 human
EvolutionaryTraceⁱ	P24468
GeneWikiⁱ	COUP-TFII
GenomeRNAiⁱ	7026
Protein Ontology More...PROⁱ	PR:P24468
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185551 Expressed in 244 organ(s), highest expression level in female gonad
CleanExⁱ	HS_NR2F2
ExpressionAtlasⁱ	P24468 baseline and differential
Genevisibleⁱ	P24468 HS

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003068 COUP_TF IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01282 COUPTNFACTOR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	COT2_HUMAN
Accessionⁱ	P24468Primary (citable) accession number: P24468 Secondary accession number(s): B4DQJ2 , B6ZGU1, Q03754, Q3KQR7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	March 1, 1992
	Last modified:	November 7, 2018
	This is version 190 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P24468 (COT2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

COUP transcription factor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ