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UniProtKB - P24463 (CP3AC_CANLF)
Protein
Cytochrome P450 3A12
Gene
CYP3A12
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]EC:1.14.14.1
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 442 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- aromatase activity Source: UniProtKB-EC
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB
- steroid hydroxylase activity Source: AgBase
- testosterone 6-beta-hydroxylase activity Source: AgBase
GO - Biological processi
- hormone metabolic process Source: AgBase
- organic hydroxy compound metabolic process Source: AgBase
- oxidative demethylation Source: GO_Central
- progesterone metabolic process Source: AgBase
- steroid metabolic process Source: AgBase
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 3A12 (EC:1.14.14.1)Alternative name(s): CYPIIIA12 Cytochrome P450-PBD-1 |
Gene namesi | Name:CYP3A12 |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051795 | 1 – 503 | Cytochrome P450 3A12Add BLAST | 503 |
Proteomic databases
PaxDbi | P24463 |
PRIDEi | P24463 |
Expressioni
Inductioni
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
InParanoidi | P24463 |
OrthoDBi | 467733at2759 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
P24463-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLIPSFSTE TWLLLAISLV LLYLYGTYTH GIFRKLGIPG PTPLPFVGTA
60 70 80 90 100
LGYRNGFYVF DMKCFSKYGR MWGFYDGRQP VLAITDPDMI KTVLVKECYS
110 120 130 140 150
VFTNRRTLGP VGFMKSAISL SEDEEWKRMR TLLSPTFTTG KLKEMFPIIG
160 170 180 190 200
QYGDVLVNNL RKEAEKGKAI NLKDVFGAYS MDVITSTSFG VNIDSLNHPQ
210 220 230 240 250
DPFVENTKKL LKFDFLDPFF FSILLFPFLT PVFEILNIWL FPKKVTDFFR
260 270 280 290 300
KSVERMKESR LKDKQKHRVD FLQLMINSQN SKEMDTHKAL SDLELVAQSI
310 320 330 340 350
IFIFAGYETT STSLSFLMYE LATHPDVQQK LQEEIDATFP NKALPTYDAL
360 370 380 390 400
VQMEYLDMVL NETLRLYPIA GRLERVCKKD VEISGVFIPK GTVVMVPTFT
410 420 430 440 450
LHRDQSLWPE PEEFRPERFS RKNKDSINPY TYLPFGTGPR NCIGMRFAIM
460 470 480 490 500
NMKLALVRVL QNFSFKPCKE TQIPLKLNAQ GIIQPEKPIV LKVEPRDGSV
NGA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54915 mRNA Translation: CAA38687.1 |
PIRi | S04341 S14275 |
RefSeqi | NP_001003340.1, NM_001003340.1 |
Genome annotation databases
GeneIDi | 415129 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54915 mRNA Translation: CAA38687.1 |
PIRi | S04341 S14275 |
RefSeqi | NP_001003340.1, NM_001003340.1 |
3D structure databases
SMRi | P24463 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000022014 |
Chemistry databases
ChEMBLi | CHEMBL1907982 |
Proteomic databases
PaxDbi | P24463 |
PRIDEi | P24463 |
Genome annotation databases
GeneIDi | 415129 |
Organism-specific databases
CTDi | 415129 |
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
InParanoidi | P24463 |
OrthoDBi | 467733at2759 |
Miscellaneous databases
PROi | PR:P24463 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP3AC_CANLF | |
Accessioni | P24463Primary (citable) accession number: P24463 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families