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Entry version 178 (05 Jun 2019)
Sequence version 3 (12 Sep 2018)
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Protein

Cytochrome P450 3A7

Gene

CYP3A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi442Iron (heme axial ligand)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.14.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-211981 Xenobiotics

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001324

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 3A7Curated (EC:1.14.14.1)
Alternative name(s):
CYPIIIA7
Cytochrome P450-HFLA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP3A7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2640 CYP3A7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605340 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P24462

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
100861540
1551

Open Targets

More...
OpenTargetsi
ENSG00000160870
ENSG00000282301

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA122

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3341582

Drug and drug target database

More...
DrugBanki
DB00802 Alfentanil
DB00404 Alprazolam
DB01424 Aminophenazone
DB01118 Amiodarone
DB00381 Amlodipine
DB00673 Aprepitant
DB01238 Aripiprazole
DB00637 Astemizole
DB01076 Atorvastatin
DB00921 Buprenorphine
DB00490 Buspirone
DB00201 Caffeine
DB00564 Carbamazepine
DB00439 Cerivastatin
DB00446 Chloramphenicol
DB01114 Chlorphenamine
DB01166 Cilostazol
DB00501 Cimetidine
DB00537 Ciprofloxacin
DB00604 Cisapride
DB01211 Clarithromycin
DB00257 Clotrimazole
DB05239 Cobimetinib
DB00907 Cocaine
DB00318 Codeine
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB09102 Daclatasvir
DB00250 Dapsone
DB05804 dehydroepiandrosterone sulfate
DB00705 Delavirdine
DB01234 Dexamethasone
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB00829 Diazepam
DB00343 Diltiazem
DB01248 Docetaxel
DB08930 Dolutegravir
DB01184 Domperidone
DB00700 Eplerenone
DB00199 Erythromycin
DB00783 Estradiol
DB00593 Ethosuximide
DB01466 Ethylmorphine
DB01023 Felodipine
DB00813 Fentanyl
DB01216 Finasteride
DB00196 Fluconazole
DB00588 Fluticasone Propionate
DB00176 Fluvoxamine
DB06730 Gestodene
DB00502 Haloperidol
DB00741 Hydrocortisone
DB01181 Ifosfamide
DB04946 Iloperidone
DB00619 Imatinib
DB00458 Imipramine
DB00224 Indinavir
DB00762 Irinotecan
DB01167 Itraconazole
DB01026 Ketoconazole
DB00528 Lercanidipine
DB01227 Levomethadyl Acetate
DB00281 Lidocaine
DB00227 Lovastatin
DB00333 Methadone
DB01388 Mibefradil
DB00683 Midazolam
DB00834 Mifepristone
DB00731 Nateglinide
DB01149 Nefazodone
DB00220 Nelfinavir
DB01115 Nifedipine
DB00401 Nisoldipine
DB01054 Nitrendipine
DB00717 Norethisterone
DB01059 Norfloxacin
DB00904 Ondansetron
DB00842 Oxazepam
DB00497 Oxycodone
DB01229 Paclitaxel
DB00780 Phenelzine
DB01174 Phenobarbital
DB00252 Phenytoin
DB01100 Pimozide
DB01708 Prasterone
DB01058 Praziquantel
DB00396 Progesterone
DB09396 Propoxyphene napsylate
DB00571 Propranolol
DB01224 Quetiapine
DB00908 Quinidine
DB00468 Quinine
DB01045 Rifampicin
DB01201 Rifapentine
DB00734 Risperidone
DB00503 Ritonavir
DB00938 Salmeterol
DB01232 Saquinavir
DB06731 Seproxetine
DB00203 Sildenafil
DB00641 Simvastatin
DB00877 Sirolimus
DB00398 Sorafenib
DB01268 Sunitinib
DB00864 Tacrolimus
DB00675 Tamoxifen
DB00976 Telithromycin
DB06287 Temsirolimus
DB00342 Terfenadine
DB00624 Testosterone
DB00656 Trazodone
DB00755 Tretinoin
DB00897 Triazolam
DB00197 Troglitazone
DB00661 Verapamil
DB00541 Vincristine
DB00582 Voriconazole
DB00943 Zalcitabine
DB00962 Zaleplon
DB00246 Ziprasidone
DB00425 Zolpidem

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYP3A7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90110014

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000517901 – 503Cytochrome P450 3A7Add BLAST503

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P24462

PeptideAtlas

More...
PeptideAtlasi
P24462

PRoteomics IDEntifications database

More...
PRIDEi
P24462

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54205

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P24462

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P24462

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160870 Expressed in 99 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P24462 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P24462 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA072245

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107930, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000480571

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P24462

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P24462

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0158 Eukaryota
COG2124 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182958

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000039127

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24462

KEGG Orthology (KO)

More...
KOi
K17691

Identification of Orthologs from Complete Genome Data

More...
OMAi
MAYHEMR

Database of Orthologous Groups

More...
OrthoDBi
1488134at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P24462

TreeFam database of animal gene trees

More...
TreeFami
TF105087

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00067 p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48264 SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P24462-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLIPNLAVE TWLLLAVSLI LLYLYGTRTH GLFKKLGIPG PTPLPFLGNA
60 70 80 90 100
LSFRKGYWTF DMECYKKYRK VWGIYDCQQP MLAITDPDMI KTVLVKECYS
110 120 130 140 150
VFTNRRPFGP VGFMKNAISI AEDEEWKRIR SLLSPTFTSG KLKEMVPIIA
160 170 180 190 200
QYGDVLVRNL RREAETGKPV TLKHVFGAYS MDVITSTSFG VSIDSLNNPQ
210 220 230 240 250
DPFVENTKKL LRFNPLDPFV LSIKVFPFLT PILEALNITV FPRKVISFLT
260 270 280 290 300
KSVKQIKEGR LKETQKHRVD FLQLMIDSQN SKDSETHKAL SDLELMAQSI
310 320 330 340 350
IFIFAGYETT SSVLSFIIYE LATHPDVQQK VQKEIDTVLP NKAPPTYDTV
360 370 380 390 400
LQLEYLDMVV NETLRLFPVA MRLERVCKKD VEINGMFIPK GVVVMIPSYV
410 420 430 440 450
LHHDPKYWTE PEKFLPERFS KKNKDNIDPY IYTPFGSGPR NCIGMRFALV
460 470 480 490 500
NMKLALVRVL QNFSFKPCKE TQIPLKLRFG GLLLTEKPIV LKAESRDETV

SGA
Length:503
Mass (Da):57,470
Last modified:September 12, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i087CCEED9BAC314C
GO
Isoform 2 (identifier: P24462-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     500-503: VSGA → FVDMEPIHMDFLRSLAFQGPHLCFFWELLCPTIRSR

Show »
Length:535
Mass (Da):61,492
Checksum:iD42210E526CE1614
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WV96A0A087WV96_HUMAN
Cytochrome P450 3A7
CYP3A7
503Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05556471V → A. Corresponds to variant dbSNP:rs45580339Ensembl.1
Natural variantiVAR_020124409T → R. Corresponds to variant dbSNP:rs2257401Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055577500 – 503VSGA → FVDMEPIHMDFLRSLAFQGP HLCFFWELLCPTIRSR in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D00408 mRNA Translation: BAA00310.1
AF315325 mRNA Translation: AAG48618.1
AF280107 Genomic DNA Translation: AAG32289.1
CH236956 Genomic DNA Translation: EAL23867.1
CH471091 Genomic DNA Translation: EAW76637.1
BC067436 mRNA Translation: AAH67436.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5673.1 [P24462-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JX0062

NCBI Reference Sequences

More...
RefSeqi
NP_000756.3, NM_000765.4 [P24462-1]
NP_001243426.2, NM_001256497.2 [P24462-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336374; ENSP00000337450; ENSG00000160870 [P24462-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100861540
1551

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100861540
hsa:1551

UCSC genome browser

More...
UCSCi
uc003uru.4 human [P24462-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP3A7 alleles

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00408 mRNA Translation: BAA00310.1
AF315325 mRNA Translation: AAG48618.1
AF280107 Genomic DNA Translation: AAG32289.1
CH236956 Genomic DNA Translation: EAL23867.1
CH471091 Genomic DNA Translation: EAW76637.1
BC067436 mRNA Translation: AAH67436.1
CCDSiCCDS5673.1 [P24462-1]
PIRiJX0062
RefSeqiNP_000756.3, NM_000765.4 [P24462-1]
NP_001243426.2, NM_001256497.2 [P24462-2]

3D structure databases

SMRiP24462
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107930, 4 interactors
STRINGi9606.ENSP00000480571

Chemistry databases

BindingDBiP24462
ChEMBLiCHEMBL3341582
DrugBankiDB00802 Alfentanil
DB00404 Alprazolam
DB01424 Aminophenazone
DB01118 Amiodarone
DB00381 Amlodipine
DB00673 Aprepitant
DB01238 Aripiprazole
DB00637 Astemizole
DB01076 Atorvastatin
DB00921 Buprenorphine
DB00490 Buspirone
DB00201 Caffeine
DB00564 Carbamazepine
DB00439 Cerivastatin
DB00446 Chloramphenicol
DB01114 Chlorphenamine
DB01166 Cilostazol
DB00501 Cimetidine
DB00537 Ciprofloxacin
DB00604 Cisapride
DB01211 Clarithromycin
DB00257 Clotrimazole
DB05239 Cobimetinib
DB00907 Cocaine
DB00318 Codeine
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB09102 Daclatasvir
DB00250 Dapsone
DB05804 dehydroepiandrosterone sulfate
DB00705 Delavirdine
DB01234 Dexamethasone
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB00829 Diazepam
DB00343 Diltiazem
DB01248 Docetaxel
DB08930 Dolutegravir
DB01184 Domperidone
DB00700 Eplerenone
DB00199 Erythromycin
DB00783 Estradiol
DB00593 Ethosuximide
DB01466 Ethylmorphine
DB01023 Felodipine
DB00813 Fentanyl
DB01216 Finasteride
DB00196 Fluconazole
DB00588 Fluticasone Propionate
DB00176 Fluvoxamine
DB06730 Gestodene
DB00502 Haloperidol
DB00741 Hydrocortisone
DB01181 Ifosfamide
DB04946 Iloperidone
DB00619 Imatinib
DB00458 Imipramine
DB00224 Indinavir
DB00762 Irinotecan
DB01167 Itraconazole
DB01026 Ketoconazole
DB00528 Lercanidipine
DB01227 Levomethadyl Acetate
DB00281 Lidocaine
DB00227 Lovastatin
DB00333 Methadone
DB01388 Mibefradil
DB00683 Midazolam
DB00834 Mifepristone
DB00731 Nateglinide
DB01149 Nefazodone
DB00220 Nelfinavir
DB01115 Nifedipine
DB00401 Nisoldipine
DB01054 Nitrendipine
DB00717 Norethisterone
DB01059 Norfloxacin
DB00904 Ondansetron
DB00842 Oxazepam
DB00497 Oxycodone
DB01229 Paclitaxel
DB00780 Phenelzine
DB01174 Phenobarbital
DB00252 Phenytoin
DB01100 Pimozide
DB01708 Prasterone
DB01058 Praziquantel
DB00396 Progesterone
DB09396 Propoxyphene napsylate
DB00571 Propranolol
DB01224 Quetiapine
DB00908 Quinidine
DB00468 Quinine
DB01045 Rifampicin
DB01201 Rifapentine
DB00734 Risperidone
DB00503 Ritonavir
DB00938 Salmeterol
DB01232 Saquinavir
DB06731 Seproxetine
DB00203 Sildenafil
DB00641 Simvastatin
DB00877 Sirolimus
DB00398 Sorafenib
DB01268 Sunitinib
DB00864 Tacrolimus
DB00675 Tamoxifen
DB00976 Telithromycin
DB06287 Temsirolimus
DB00342 Terfenadine
DB00624 Testosterone
DB00656 Trazodone
DB00755 Tretinoin
DB00897 Triazolam
DB00197 Troglitazone
DB00661 Verapamil
DB00541 Vincristine
DB00582 Voriconazole
DB00943 Zalcitabine
DB00962 Zaleplon
DB00246 Ziprasidone
DB00425 Zolpidem
SwissLipidsiSLP:000001324

PTM databases

iPTMnetiP24462
PhosphoSitePlusiP24462

Polymorphism and mutation databases

BioMutaiCYP3A7
DMDMi90110014

Proteomic databases

PaxDbiP24462
PeptideAtlasiP24462
PRIDEiP24462
ProteomicsDBi54205

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336374; ENSP00000337450; ENSG00000160870 [P24462-1]
GeneIDi100861540
1551
KEGGihsa:100861540
hsa:1551
UCSCiuc003uru.4 human [P24462-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100861540
1551
DisGeNETi100861540
1551

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYP3A7
CYP3A7-CYP3A51P

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0078768
HGNCiHGNC:2640 CYP3A7
HPAiHPA072245
MIMi605340 gene
neXtProtiNX_P24462
OpenTargetsiENSG00000160870
ENSG00000282301
PharmGKBiPA122

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00950000182958
HOGENOMiHOG000039127
InParanoidiP24462
KOiK17691
OMAiMAYHEMR
OrthoDBi1488134at2759
PhylomeDBiP24462
TreeFamiTF105087

Enzyme and pathway databases

BRENDAi1.14.14.1 2681
ReactomeiR-HSA-211981 Xenobiotics

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CYP3A7

Protein Ontology

More...
PROi
PR:P24462

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160870 Expressed in 99 organ(s), highest expression level in liver
ExpressionAtlasiP24462 baseline and differential
GenevisibleiP24462 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP3A7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24462
Secondary accession number(s): A4D288, Q9H241
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: September 12, 2018
Last modified: June 5, 2019
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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