CYP3A7

Functionⁱ

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityⁱ

RH + [reduced NADPH--hemoprotein reductase] + O₂ = ROH + [oxidized NADPH--hemoprotein reductase] + H₂O.

Cofactorⁱ

hemeBy similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	442	Iron (heme axial ligand)By similarity		1

GO - Molecular functionⁱ

aromatase activity Source: UniProtKB-EC
estrogen 16-alpha-hydroxylase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 14559847
heme binding Source: InterPro
iron ion binding Source: InterPro
monooxygenase activity Source: UniProtKB
oxygen binding
Source: ProtInc
Traceable author statementⁱ
- 2722762
steroid hydroxylase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 14559847

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lipid hydroxylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 14559847
steroid metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 14559847
xenobiotic metabolic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	1.14.14.1 2681
Reactomeⁱ	R-HSA-211981 Xenobiotics

Chemistry databases

SwissLipidsⁱ	SLP:000001324

SwissLipidsⁱ

SLP:000001324

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450 3A7Curated (EC:1.14.14.1) Alternative name(s): CYPIIIA7 Cytochrome P450-HFLA
Gene namesⁱ	Name:CYP3A7Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160870.12 HostDB:ENSG00000282301.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2640 CYP3A7
MIMⁱ	605340 gene
neXtProtⁱ	NX_P24462

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	100861540 1551
PharmGKBⁱ	PA122

Chemistry databases

ChEMBLⁱ	CHEMBL3341582
Drug and drug target database More...DrugBankⁱ	DB00802 Alfentanil DB00404 Alprazolam DB01424 Aminophenazone DB01118 Amiodarone DB00381 Amlodipine DB00673 Aprepitant DB01238 Aripiprazole DB00637 Astemizole DB01076 Atorvastatin DB00921 Buprenorphine DB00490 Buspirone DB00201 Caffeine DB00564 Carbamazepine DB00439 Cerivastatin DB00446 Chloramphenicol DB01114 Chlorphenamine DB01166 Cilostazol DB00501 Cimetidine DB00537 Ciprofloxacin DB00604 Cisapride DB01211 Clarithromycin DB00257 Clotrimazole DB05239 Cobimetinib DB00907 Cocaine DB00318 Codeine DB00531 Cyclophosphamide DB00091 Cyclosporine DB09102 Daclatasvir DB00250 Dapsone DB05804 dehydroepiandrosterone sulfate DB00705 Delavirdine DB01234 Dexamethasone DB00514 Dextromethorphan DB00647 Dextropropoxyphene DB00829 Diazepam DB00343 Diltiazem DB01248 Docetaxel DB08930 Dolutegravir DB01184 Domperidone DB00700 Eplerenone DB00199 Erythromycin DB00783 Estradiol DB00593 Ethosuximide DB01466 Ethylmorphine DB01023 Felodipine DB00813 Fentanyl DB01216 Finasteride DB00196 Fluconazole DB00588 Fluticasone Propionate DB00176 Fluvoxamine DB06730 Gestodene DB00502 Haloperidol DB00741 Hydrocortisone DB01181 Ifosfamide DB04946 Iloperidone DB00619 Imatinib DB00458 Imipramine DB00224 Indinavir DB00762 Irinotecan DB01167 Itraconazole DB01026 Ketoconazole DB00528 Lercanidipine DB01227 Levomethadyl Acetate DB00281 Lidocaine DB00227 Lovastatin DB00333 Methadone DB01388 Mibefradil DB00683 Midazolam DB00834 Mifepristone DB00731 Nateglinide DB01149 Nefazodone DB00220 Nelfinavir DB01115 Nifedipine DB00401 Nisoldipine DB01054 Nitrendipine DB00717 Norethisterone DB01059 Norfloxacin DB00904 Ondansetron DB00842 Oxazepam DB00497 Oxycodone DB01229 Paclitaxel DB00780 Phenelzine DB01174 Phenobarbital DB00252 Phenytoin DB01100 Pimozide DB01708 Prasterone DB01058 Praziquantel DB00396 Progesterone DB09396 Propoxyphene napsylate DB00571 Propranolol DB01224 Quetiapine DB00908 Quinidine DB00468 Quinine DB01045 Rifampicin DB01201 Rifapentine DB00734 Risperidone DB00503 Ritonavir DB00938 Salmeterol DB01232 Saquinavir DB06731 Seproxetine DB00203 Sildenafil DB00641 Simvastatin DB00877 Sirolimus DB00398 Sorafenib DB01268 Sunitinib DB00864 Tacrolimus DB00675 Tamoxifen DB00976 Telithromycin DB06287 Temsirolimus DB00342 Terfenadine DB00624 Testosterone DB00656 Trazodone DB00755 Tretinoin DB00897 Triazolam DB00197 Troglitazone DB00661 Verapamil DB00541 Vincristine DB00582 Voriconazole DB00943 Zalcitabine DB00962 Zaleplon DB00246 Ziprasidone DB00425 Zolpidem

ChEMBLⁱ

CHEMBL3341582

DrugBankⁱ

DB00802 Alfentanil
DB00404 Alprazolam
DB01424 Aminophenazone
DB01118 Amiodarone
DB00381 Amlodipine
DB00673 Aprepitant
DB01238 Aripiprazole
DB00637 Astemizole
DB01076 Atorvastatin
DB00921 Buprenorphine
DB00490 Buspirone
DB00201 Caffeine
DB00564 Carbamazepine
DB00439 Cerivastatin
DB00446 Chloramphenicol
DB01114 Chlorphenamine
DB01166 Cilostazol
DB00501 Cimetidine
DB00537 Ciprofloxacin
DB00604 Cisapride
DB01211 Clarithromycin
DB00257 Clotrimazole
DB05239 Cobimetinib
DB00907 Cocaine
DB00318 Codeine
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB09102 Daclatasvir
DB00250 Dapsone
DB05804 dehydroepiandrosterone sulfate
DB00705 Delavirdine
DB01234 Dexamethasone
DB00514 Dextromethorphan
DB00647 Dextropropoxyphene
DB00829 Diazepam
DB00343 Diltiazem
DB01248 Docetaxel
DB08930 Dolutegravir
DB01184 Domperidone
DB00700 Eplerenone
DB00199 Erythromycin
DB00783 Estradiol
DB00593 Ethosuximide
DB01466 Ethylmorphine
DB01023 Felodipine
DB00813 Fentanyl
DB01216 Finasteride
DB00196 Fluconazole
DB00588 Fluticasone Propionate
DB00176 Fluvoxamine
DB06730 Gestodene
DB00502 Haloperidol
DB00741 Hydrocortisone
DB01181 Ifosfamide
DB04946 Iloperidone
DB00619 Imatinib
DB00458 Imipramine
DB00224 Indinavir
DB00762 Irinotecan
DB01167 Itraconazole
DB01026 Ketoconazole
DB00528 Lercanidipine
DB01227 Levomethadyl Acetate
DB00281 Lidocaine
DB00227 Lovastatin
DB00333 Methadone
DB01388 Mibefradil
DB00683 Midazolam
DB00834 Mifepristone
DB00731 Nateglinide
DB01149 Nefazodone
DB00220 Nelfinavir
DB01115 Nifedipine
DB00401 Nisoldipine
DB01054 Nitrendipine
DB00717 Norethisterone
DB01059 Norfloxacin
DB00904 Ondansetron
DB00842 Oxazepam
DB00497 Oxycodone
DB01229 Paclitaxel
DB00780 Phenelzine
DB01174 Phenobarbital
DB00252 Phenytoin
DB01100 Pimozide
DB01708 Prasterone
DB01058 Praziquantel
DB00396 Progesterone
DB09396 Propoxyphene napsylate
DB00571 Propranolol
DB01224 Quetiapine
DB00908 Quinidine
DB00468 Quinine
DB01045 Rifampicin
DB01201 Rifapentine
DB00734 Risperidone
DB00503 Ritonavir
DB00938 Salmeterol
DB01232 Saquinavir
DB06731 Seproxetine
DB00203 Sildenafil
DB00641 Simvastatin
DB00877 Sirolimus
DB00398 Sorafenib
DB01268 Sunitinib
DB00864 Tacrolimus
DB00675 Tamoxifen
DB00976 Telithromycin
DB06287 Temsirolimus
DB00342 Terfenadine
DB00624 Testosterone
DB00656 Trazodone
DB00755 Tretinoin
DB00897 Triazolam
DB00197 Troglitazone
DB00661 Verapamil
DB00541 Vincristine
DB00582 Voriconazole
DB00943 Zalcitabine
DB00962 Zaleplon
DB00246 Ziprasidone
DB00425 Zolpidem

Polymorphism and mutation databases

BioMutaⁱ	CYP3A7
DMDMⁱ	90110014

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051790	1 – 503	Cytochrome P450 3A7Add BLAST		503

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P24462
PaxDbⁱ	P24462
PeptideAtlas More...PeptideAtlasⁱ	P24462
PRIDEⁱ	P24462
ProteomicsDBⁱ	54205

PTM databases

iPTMnetⁱ	P24462
PhosphoSitePlusⁱ	P24462

Expressionⁱ

Inductionⁱ

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

Bgeeⁱ	ENSG00000160870 Expressed in 99 organ(s), highest expression level in liver
CleanExⁱ	HS_CYP3A7
Genevisibleⁱ	P24462 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA072245

HPAⁱ

HPA072245

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107930, 4 interactors
STRINGⁱ	9606.ENSP00000337450

Chemistry databases

BindingDBⁱ

P24462

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P24462
SMRⁱ	P24462
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0158 Eukaryota COG2124 LUCA
HOGENOMⁱ	HOG000039127
HOVERGENⁱ	HBG108567
InParanoidⁱ	P24462
KEGG Orthology (KO) More...KOⁱ	K17691
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JNC
PhylomeDBⁱ	P24462
TreeFamⁱ	TF105087

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR008072 Cyt_P450_E_CYP3A IPR002402 Cyt_P450_E_grp-II IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00464 EP450II PR01689 EP450IICYP3A PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.ⁱShow all

Isoform 1 (identifier: P24462-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLIPNLAVE TWLLLAVSLI LLYLYGTRTH GLFKKLGIPG PTPLPFLGNA 
        60         70         80         90        100
LSFRKGYWTF DMECYKKYRK VWGIYDCQQP MLAITDPDMI KTVLVKECYS 
       110        120        130        140        150
VFTNRRPFGP VGFMKNAISI AEDEEWKRIR SLLSPTFTSG KLKEMVPIIA 
       160        170        180        190        200
QYGDVLVRNL RREAETGKPV TLKHVFGAYS MDVITSTSFG VSIDSLNNPQ 
       210        220        230        240        250
DPFVENTKKL LRFNPLDPFV LSIKVFPFLT PILEALNITV FPRKVISFLT 
       260        270        280        290        300
KSVKQIKEGR LKETQKHRVD FLQLMIDSQN SKDSETHKAL SDLELMAQSI 
       310        320        330        340        350
IFIFAGYETT SSVLSFIIYE LATHPDVQQK VQKEIDTVLP NKAPPTYDTV 
       360        370        380        390        400
LQLEYLDMVV NETLRLFPVA MRLERVCKKD VEINGMFIPK GVVVMIPSYV 
       410        420        430        440        450
LHHDPKYWTE PEKFLPERFS KKNKDNIDPY IYTPFGSGPR NCIGMRFALV 
       460        470        480        490        500
NMKLALVRVL QNFSFKPCKE TQIPLKLRFG GLLLTEKPIV LKAESRDETV 

SGA

Length:503

Mass (Da):57,470

Last modified:September 12, 2018 - v3

Checksum:ⁱ087CCEED9BAC314C

GO

Isoform 2 (identifier: P24462-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
500-503: VSGA → FVDMEPIHMDFLRSLAFQGPHLCFFWELLCPTIRSR

« Hide

        10         20         30         40         50
MDLIPNLAVE TWLLLAVSLI LLYLYGTRTH GLFKKLGIPG PTPLPFLGNA 
        60         70         80         90        100
LSFRKGYWTF DMECYKKYRK VWGIYDCQQP MLAITDPDMI KTVLVKECYS 
       110        120        130        140        150
VFTNRRPFGP VGFMKNAISI AEDEEWKRIR SLLSPTFTSG KLKEMVPIIA 
       160        170        180        190        200
QYGDVLVRNL RREAETGKPV TLKHVFGAYS MDVITSTSFG VSIDSLNNPQ 
       210        220        230        240        250
DPFVENTKKL LRFNPLDPFV LSIKVFPFLT PILEALNITV FPRKVISFLT 
       260        270        280        290        300
KSVKQIKEGR LKETQKHRVD FLQLMIDSQN SKDSETHKAL SDLELMAQSI 
       310        320        330        340        350
IFIFAGYETT SSVLSFIIYE LATHPDVQQK VQKEIDTVLP NKAPPTYDTV 
       360        370        380        390        400
LQLEYLDMVV NETLRLFPVA MRLERVCKKD VEINGMFIPK GVVVMIPSYV 
       410        420        430        440        450
LHHDPKYWTE PEKFLPERFS KKNKDNIDPY IYTPFGSGPR NCIGMRFALV 
       460        470        480        490        500
NMKLALVRVL QNFSFKPCKE TQIPLKLRFG GLLLTEKPIV LKAESRDETF 
       510        520        530 
VDMEPIHMDF LRSLAFQGPH LCFFWELLCP TIRSR

Show »

Length:535

Mass (Da):61,492

Checksum:ⁱD42210E526CE1614

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	A0A087WV96	A0A087WV96_HUMAN		Cytochrome P450 3A7 Cytochrome P450 3A7	CYP3A7	503	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_055564	71	V → A. Corresponds to variant dbSNP:rs45580339Ensembl.		1
Natural variantⁱVAR_020124	409	T → R. Corresponds to variant dbSNP:rs2257401Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055577	500 – 503	VSGA → FVDMEPIHMDFLRSLAFQGP HLCFFWELLCPTIRSR in isoform 2. 1 Publication		4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D00408 mRNA Translation: BAA00310.1 AF315325 mRNA Translation: AAG48618.1 AF280107 Genomic DNA Translation: AAG32289.1 CH236956 Genomic DNA Translation: EAL23867.1 CH471091 Genomic DNA Translation: EAW76637.1 BC067436 mRNA Translation: AAH67436.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5673.1 [P24462-1]
PIRⁱ	JX0062
NCBI Reference Sequences More...RefSeqⁱ	NP_000756.3, NM_000765.4 NP_001243426.2, NM_001256497.2
UniGeneⁱ	Hs.111944

Genome annotation databases

Ensemblⁱ	ENST00000336374; ENSP00000337450; ENSG00000160870 ENST00000611620; ENSP00000480571; ENSG00000160870
GeneIDⁱ	100861540 1551
KEGGⁱ	hsa:100861540 hsa:1551
UCSC genome browser More...UCSCⁱ	uc003uru.4 human [P24462-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24462	Cytochrome P450 3A8		MACFA		503	UniRef90_P24462
Cytochrome P450 3A5 (Fragment)		PAPSP		20
Cytochrome P450 3A7		MACMU		532
Cytochrome P450 family 3 subfamily A member 4		COLAP		503
CYP3A7 isoform 2		PONAB		503
+88
P24462-2	Cytochrome P450 variant 3A7 (Fragment)		HUMAN		36	UniRef90_P24462-2
Uncharacterized protein		MACMU		533
Uncharacterized protein		GORGO		494
Uncharacterized protein		PANPA		415
UPI000CEFF869		PONAB		454
+4

Protein	Similar proteins		Species	Score	Length	Source
P24462	Cytochrome P450 3A8		MACFA		503	UniRef50_P24462
Cytochrome P450 3A5 (Fragment)		PAPSP		20
Cytochrome P450 3A7		MACMU		532
Uncharacterized protein		MANLE		503
Cytochrome P450 3A4v2		CHLAE		503
+106
P24462-2	Cytochrome P450 3A5	)	HUMAN		502	UniRef50_P20815
Cytochrome P450 3A28		BOVIN		507
CYP3A5 isoform 1		PANTR		525
Cytochrome P450 CYP3A66		MACMU		503
Uncharacterized protein		MACFA		503
+254

Cross-referencesⁱ

Web resourcesⁱ

Cytochrome P450 Allele Nomenclature Committee

CYP3A7 alleles

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D00408 mRNA Translation: BAA00310.1 AF315325 mRNA Translation: AAG48618.1 AF280107 Genomic DNA Translation: AAG32289.1 CH236956 Genomic DNA Translation: EAL23867.1 CH471091 Genomic DNA Translation: EAW76637.1 BC067436 mRNA Translation: AAH67436.1
CCDSⁱ	CCDS5673.1 [P24462-1]
PIRⁱ	JX0062
RefSeqⁱ	NP_000756.3, NM_000765.4 NP_001243426.2, NM_001256497.2
UniGeneⁱ	Hs.111944

3D structure databases

ProteinModelPortalⁱ	P24462
SMRⁱ	P24462
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107930, 4 interactors
STRINGⁱ	9606.ENSP00000337450

Chemistry databases

BindingDBⁱ	P24462
ChEMBLⁱ	CHEMBL3341582
DrugBankⁱ	DB00802 Alfentanil DB00404 Alprazolam DB01424 Aminophenazone DB01118 Amiodarone DB00381 Amlodipine DB00673 Aprepitant DB01238 Aripiprazole DB00637 Astemizole DB01076 Atorvastatin DB00921 Buprenorphine DB00490 Buspirone DB00201 Caffeine DB00564 Carbamazepine DB00439 Cerivastatin DB00446 Chloramphenicol DB01114 Chlorphenamine DB01166 Cilostazol DB00501 Cimetidine DB00537 Ciprofloxacin DB00604 Cisapride DB01211 Clarithromycin DB00257 Clotrimazole DB05239 Cobimetinib DB00907 Cocaine DB00318 Codeine DB00531 Cyclophosphamide DB00091 Cyclosporine DB09102 Daclatasvir DB00250 Dapsone DB05804 dehydroepiandrosterone sulfate DB00705 Delavirdine DB01234 Dexamethasone DB00514 Dextromethorphan DB00647 Dextropropoxyphene DB00829 Diazepam DB00343 Diltiazem DB01248 Docetaxel DB08930 Dolutegravir DB01184 Domperidone DB00700 Eplerenone DB00199 Erythromycin DB00783 Estradiol DB00593 Ethosuximide DB01466 Ethylmorphine DB01023 Felodipine DB00813 Fentanyl DB01216 Finasteride DB00196 Fluconazole DB00588 Fluticasone Propionate DB00176 Fluvoxamine DB06730 Gestodene DB00502 Haloperidol DB00741 Hydrocortisone DB01181 Ifosfamide DB04946 Iloperidone DB00619 Imatinib DB00458 Imipramine DB00224 Indinavir DB00762 Irinotecan DB01167 Itraconazole DB01026 Ketoconazole DB00528 Lercanidipine DB01227 Levomethadyl Acetate DB00281 Lidocaine DB00227 Lovastatin DB00333 Methadone DB01388 Mibefradil DB00683 Midazolam DB00834 Mifepristone DB00731 Nateglinide DB01149 Nefazodone DB00220 Nelfinavir DB01115 Nifedipine DB00401 Nisoldipine DB01054 Nitrendipine DB00717 Norethisterone DB01059 Norfloxacin DB00904 Ondansetron DB00842 Oxazepam DB00497 Oxycodone DB01229 Paclitaxel DB00780 Phenelzine DB01174 Phenobarbital DB00252 Phenytoin DB01100 Pimozide DB01708 Prasterone DB01058 Praziquantel DB00396 Progesterone DB09396 Propoxyphene napsylate DB00571 Propranolol DB01224 Quetiapine DB00908 Quinidine DB00468 Quinine DB01045 Rifampicin DB01201 Rifapentine DB00734 Risperidone DB00503 Ritonavir DB00938 Salmeterol DB01232 Saquinavir DB06731 Seproxetine DB00203 Sildenafil DB00641 Simvastatin DB00877 Sirolimus DB00398 Sorafenib DB01268 Sunitinib DB00864 Tacrolimus DB00675 Tamoxifen DB00976 Telithromycin DB06287 Temsirolimus DB00342 Terfenadine DB00624 Testosterone DB00656 Trazodone DB00755 Tretinoin DB00897 Triazolam DB00197 Troglitazone DB00661 Verapamil DB00541 Vincristine DB00582 Voriconazole DB00943 Zalcitabine DB00962 Zaleplon DB00246 Ziprasidone DB00425 Zolpidem
SwissLipidsⁱ	SLP:000001324

PTM databases

iPTMnetⁱ	P24462
PhosphoSitePlusⁱ	P24462

Polymorphism and mutation databases

BioMutaⁱ	CYP3A7
DMDMⁱ	90110014

Proteomic databases

MaxQBⁱ	P24462
PaxDbⁱ	P24462
PeptideAtlasⁱ	P24462
PRIDEⁱ	P24462
ProteomicsDBⁱ	54205

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000336374; ENSP00000337450; ENSG00000160870 ENST00000611620; ENSP00000480571; ENSG00000160870
GeneIDⁱ	100861540 1551
KEGGⁱ	hsa:100861540 hsa:1551
UCSCⁱ	uc003uru.4 human [P24462-1]

Organism-specific databases

CTDⁱ	100861540 1551
DisGeNETⁱ	100861540 1551
EuPathDBⁱ	HostDB:ENSG00000160870.12 HostDB:ENSG00000282301.1
GeneCardsⁱ	CYP3A7 CYP3A7-CYP3A51P
HGNCⁱ	HGNC:2640 CYP3A7
HPAⁱ	HPA072245
MIMⁱ	605340 gene
neXtProtⁱ	NX_P24462
PharmGKBⁱ	PA122
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0158 Eukaryota COG2124 LUCA
HOGENOMⁱ	HOG000039127
HOVERGENⁱ	HBG108567
InParanoidⁱ	P24462
KOⁱ	K17691
OrthoDBⁱ	EOG091G0JNC
PhylomeDBⁱ	P24462
TreeFamⁱ	TF105087

Enzyme and pathway databases

BRENDAⁱ	1.14.14.1 2681
Reactomeⁱ	R-HSA-211981 Xenobiotics

Miscellaneous databases

GeneWikiⁱ	CYP3A7
Protein Ontology More...PROⁱ	PR:P24462
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160870 Expressed in 99 organ(s), highest expression level in liver
CleanExⁱ	HS_CYP3A7
Genevisibleⁱ	P24462 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR008072 Cyt_P450_E_CYP3A IPR002402 Cyt_P450_E_grp-II IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00464 EP450II PR01689 EP450IICYP3A PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP3A7_HUMAN
Accessionⁱ	P24462Primary (citable) accession number: P24462 Secondary accession number(s): A4D288, Q9H241
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	September 12, 2018
	Last modified:	September 12, 2018
	This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P24462 (CP3A7_HUMAN)

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Cytochrome P450 3A7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ