UniProtKB - P24462 (CP3A7_HUMAN)
Protein
Cytochrome P450 3A7
Gene
CYP3A7
Organism
Homo sapiens (Human)
Status
Functioni
A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis (PubMed:9555064, PubMed:11093772, PubMed:14559847, PubMed:12865317, PubMed:17178770). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9555064, PubMed:11093772, PubMed:14559847, PubMed:12865317, PubMed:17178770). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones (PubMed:9555064, PubMed:17178770). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position (PubMed:14559847, PubMed:12865317). Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics including anticonvulsants (PubMed:9555064).5 Publications
Catalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]3 PublicationsEC:1.14.14.13 PublicationsThis reaction proceeds in the forward3 Publications direction.
- 3β-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH—hemoprotein reductase] = 3β,16α-dihydroxy-androst-5-en-17-one + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 3β-sulfooxy-androst-5-en-17-one + O2 + reduced [NADPH—hemoprotein reductase] = 3β-sulfooxy-16α-hydroxy-androst-5-en-17-one + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- O2 + reduced [NADPH—hemoprotein reductase] + testosterone = 6β,17β-dihydroxyandrost-4-en-3-one + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- estrone + O2 + reduced [NADPH—hemoprotein reductase] = 2-hydroxyestrone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- estrone + O2 + reduced [NADPH—hemoprotein reductase] = 4-hydroxyestrone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- estrone + O2 + reduced [NADPH—hemoprotein reductase] = 16α-hydroxyestrone + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 17β-estradiol + O2 + reduced [NADPH—hemoprotein reductase] = 2-hydroxy-17β-estradiol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 17β-estradiol + O2 + reduced [NADPH—hemoprotein reductase] = 6β-hydroxyestradiol-17β + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- all-trans-retinoate + O2 + reduced [NADPH—hemoprotein reductase] = all-trans-4-hydroxyretinoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- all-trans-retinoate + O2 + reduced [NADPH—hemoprotein reductase] = all-trans-18-hydroxyretinoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
hemeBy similarity
Kineticsi
- KM=10 µM for estrone (16-alpha hydroxylation)1 Publication
- KM=10 µM for estrone (2-hydroxylation)1 Publication
- KM=25.3 µM for estrone (4-hydroxylation)1 Publication
- KM=33.5 µM for 17beta-estradiol (2-hydroxylation)1 Publication
- KM=15 µM for all-trans-retinoate (4-hydroxylation)1 Publication
- KM=5 µM for all-trans-retinoate (18-hydroxylation)1 Publication
- KM=14.8 µM for 3beta-hydroxyandrost-5-en-17-one (16-alpha hydroxylation)1 Publication
- KM=18.5 µM for 3beta-sulfooxy-androst-5-en-17-one (16-alpha hydroxylation)1 Publication
- Vmax=1423 pmol/min/nmol enzyme toward estrone (16-alpha hydroxylation)1 Publication
- Vmax=2109 pmol/min/nmol enzyme toward estrone (2-hydroxylation)1 Publication
- Vmax=328 pmol/min/nmol enzyme toward estrone (4-hydroxylation)1 Publication
- Vmax=616 pmol/min/nmol enzyme toward 17beta-estradiol (2-hydroxylation)1 Publication
- Vmax=1869 pmol/min/nmol enzyme toward all-trans-retinoate (4-hydroxylation)1 Publication
- Vmax=52 pmol/min/nmol enzyme toward all-trans-retinoate (18-hydroxylation)1 Publication
- Vmax=20.8 nmol/min/nmol enzyme toward 3beta-hydroxyandrost-5-en-17-one (16-alpha hydroxylation)1 Publication
- Vmax=6.5 nmol/min/nmol enzyme toward 3beta-sulfooxy-androst-5-en-17-one (16-alpha hydroxylation)1 Publication
: Steroid hormone biosynthesis Pathwayi
This protein is involved in Steroid hormone biosynthesis.3 PublicationsView all proteins of this organism that are known to be involved in Steroid hormone biosynthesis.
Pathwayi: retinol metabolism
This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 442 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- aromatase activity Source: UniProtKB-EC
- estrogen 16-alpha-hydroxylase activity Source: BHF-UCL
- estrogen 2-hydroxylase activity Source: UniProtKB
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB
- oxygen binding Source: ProtInc
- retinoic acid 4-hydroxylase activity Source: UniProtKB
- steroid hydroxylase activity Source: BHF-UCL
- testosterone 6-beta-hydroxylase activity Source: GO_Central
GO - Biological processi
- estrogen metabolic process Source: UniProtKB
- lipid hydroxylation Source: BHF-UCL
- oxidative demethylation Source: GO_Central
- retinoic acid metabolic process Source: UniProtKB
- retinol metabolic process Source: UniProtKB-UniPathway
- steroid biosynthetic process Source: UniProtKB-KW
- steroid metabolic process Source: BHF-UCL
- xenobiotic metabolic process Source: Reactome
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Biological process | Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.14.14.1, 2681 |
PathwayCommonsi | P24462 |
Reactomei | R-HSA-211981, Xenobiotics |
SABIO-RKi | P24462 |
UniPathwayi | UPA00912 |
Chemistry databases
SwissLipidsi | SLP:000001324 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 3A71 Publication (EC:1.14.14.13 Publications)Alternative name(s): CYPIIIA7 Cytochrome P450-HFLA1 Publication P450HLp21 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2640, CYP3A7 |
MIMi | 605340, gene |
neXtProti | NX_P24462 |
VEuPathDBi | HostDB:ENSG00000160870.12 HostDB:ENSG00000282301.1 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 116 | N → S: Has no effect on catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 174 | H → D: Increases catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 214 | N → D: Increases catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 224 | K → T: Reduces affinity for substrate and catalytic efficiency. 1 Publication | 1 | |
Mutagenesisi | 244 | K → E: Reduces affinity for substrate and catalytic efficiency. 1 Publication | 1 | |
Mutagenesisi | 262 | K → E: Has no effect on catalytic activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 100861540 1551 |
OpenTargetsi | ENSG00000160870 ENSG00000282301 |
PharmGKBi | PA122 |
Miscellaneous databases
Pharosi | P24462, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3341582 |
DrugBanki | DB11703, Acalabrutinib DB00802, Alfentanil DB00404, Alprazolam DB13141, Ambroxol acefyllinate DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB00637, Astemizole DB01076, Atorvastatin DB00443, Betamethasone DB12267, Brigatinib DB01222, Budesonide DB00921, Buprenorphine DB00490, Buspirone DB09061, Cannabidiol DB00439, Cerivastatin DB00446, Chloramphenicol DB01114, Chlorpheniramine DB01166, Cilostazol DB00537, Ciprofloxacin DB00604, Cisapride DB00257, Clotrimazole DB09065, Cobicistat DB12483, Copanlisib DB08865, Crizotinib DB09102, Daclatasvir DB00250, Dapsone DB00705, Delavirdine DB01234, Dexamethasone DB14649, Dexamethasone acetate DB00514, Dextromethorphan DB11994, Diacerein DB00829, Diazepam DB00343, Diltiazem DB01248, Docetaxel DB08930, Dolutegravir DB01184, Domperidone DB00625, Efavirenz DB11979, Elagolix DB11574, Elbasvir DB00199, Erythromycin DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00593, Ethosuximide DB01023, Felodipine DB00813, Fentanyl DB01216, Finasteride DB13867, Fluticasone DB08906, Fluticasone furoate DB00588, Fluticasone propionate DB00176, Fluvoxamine DB12307, Foretinib DB06730, Gestodene DB13879, Glecaprevir DB01016, Glyburide DB00502, Haloperidol DB00741, Hydrocortisone DB14538, Hydrocortisone aceponate DB14539, Hydrocortisone acetate DB14540, Hydrocortisone butyrate DB14541, Hydrocortisone cypionate DB14542, Hydrocortisone phosphate DB14543, Hydrocortisone probutate DB14544, Hydrocortisone valerate DB09054, Idelalisib DB04946, Iloperidone DB00619, Imatinib DB00458, Imipramine DB00224, Indinavir DB00762, Irinotecan DB11757, Istradefylline DB01167, Itraconazole DB11951, Lemborexant DB00528, Lercanidipine DB12070, Letermovir DB01227, Levacetylmethadol DB00281, Lidocaine DB01601, Lopinavir DB12130, Lorlatinib DB09212, Loxoprofen DB00643, Mebendazole DB14009, Medical Cannabis DB00333, Methadone DB00959, Methylprednisolone DB00916, Metronidazole DB01388, Mibefradil DB00683, Midazolam DB06595, Midostaurin DB11792, Mirodenafil DB09205, Moxisylyte DB11605, Myrrh DB14011, Nabiximols DB11691, Naldemedine DB00731, Nateglinide DB01149, Nefazodone DB00220, Nelfinavir DB00238, Nevirapine DB00401, Nisoldipine DB01054, Nitrendipine DB00334, Olanzapine DB09568, Omega-3-carboxylic acids DB00904, Ondansetron DB06412, Oxymetholone DB01229, Paclitaxel DB00780, Phenelzine DB01174, Phenobarbital DB00252, Phenytoin DB13878, Pibrentasvir DB01100, Pimozide DB01708, Prasterone DB05804, Prasterone sulfate DB01058, Praziquantel DB14631, Prednisolone phosphate DB00635, Prednisone DB00396, Progesterone DB00571, Propranolol DB01224, Quetiapine DB00908, Quinidine DB00468, Quinine DB13174, Rhein DB01045, Rifampicin DB01201, Rifapentine DB00503, Ritonavir DB12332, Rucaparib DB00938, Salmeterol DB01232, Saquinavir DB15685, Selpercatinib DB06731, Seproxetine DB00203, Sildenafil DB00877, Sirolimus DB00398, Sorafenib DB01268, Sunitinib DB00675, Tamoxifen DB12887, Tazemetostat DB06287, Temsirolimus DB00342, Terfenadine DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate DB00599, Thiopental DB00656, Trazodone DB00755, Tretinoin DB00620, Triamcinolone DB00897, Triazolam DB00197, Troglitazone DB13179, Troleandomycin DB11652, Tucatinib DB00541, Vincristine DB00582, Voriconazole DB00962, Zaleplon DB15035, Zanubrutinib |
DrugCentrali | P24462 |
Genetic variation databases
BioMutai | CYP3A7 |
DMDMi | 90110014 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051790 | 1 – 503 | Cytochrome P450 3A7Add BLAST | 503 |
Proteomic databases
MassIVEi | P24462 |
PaxDbi | P24462 |
PeptideAtlasi | P24462 |
PRIDEi | P24462 |
ProteomicsDBi | 54205 [P24462-1] |
PTM databases
iPTMneti | P24462 |
PhosphoSitePlusi | P24462 |
Expressioni
Tissue specificityi
Expressed in fetal liver (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000160870, Expressed in liver and 131 other tissues |
ExpressionAtlasi | P24462, baseline and differential |
Genevisiblei | P24462, HS |
Organism-specific databases
HPAi | ENSG00000160870, Tissue enriched (liver) ENSG00000282301, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107930, 4 interactors |
IntActi | P24462, 1 interactor |
STRINGi | 9606.ENSP00000480571 |
Chemistry databases
BindingDBi | P24462 |
Miscellaneous databases
RNActi | P24462, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00950000182958 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | P24462 |
OMAi | MAYHEMR |
OrthoDBi | 467733at2759 |
PhylomeDBi | P24462 |
TreeFami | TF105087 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P24462-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDLIPNLAVE TWLLLAVSLI LLYLYGTRTH GLFKKLGIPG PTPLPFLGNA
60 70 80 90 100
LSFRKGYWTF DMECYKKYRK VWGIYDCQQP MLAITDPDMI KTVLVKECYS
110 120 130 140 150
VFTNRRPFGP VGFMKNAISI AEDEEWKRIR SLLSPTFTSG KLKEMVPIIA
160 170 180 190 200
QYGDVLVRNL RREAETGKPV TLKHVFGAYS MDVITSTSFG VSIDSLNNPQ
210 220 230 240 250
DPFVENTKKL LRFNPLDPFV LSIKVFPFLT PILEALNITV FPRKVISFLT
260 270 280 290 300
KSVKQIKEGR LKETQKHRVD FLQLMIDSQN SKDSETHKAL SDLELMAQSI
310 320 330 340 350
IFIFAGYETT SSVLSFIIYE LATHPDVQQK VQKEIDTVLP NKAPPTYDTV
360 370 380 390 400
LQLEYLDMVV NETLRLFPVA MRLERVCKKD VEINGMFIPK GVVVMIPSYV
410 420 430 440 450
LHHDPKYWTE PEKFLPERFS KKNKDNIDPY IYTPFGSGPR NCIGMRFALV
460 470 480 490 500
NMKLALVRVL QNFSFKPCKE TQIPLKLRFG GLLLTEKPIV LKAESRDETV
SGA
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055564 | 71 | V → A. Corresponds to variant dbSNP:rs45580339EnsemblClinVar. | 1 | |
Natural variantiVAR_020124 | 409 | T → R. Corresponds to variant dbSNP:rs2257401Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055577 | 500 – 503 | VSGA → FVDMEPIHMDFLRSLAFQGP HLCFFWELLCPTIRSR in isoform 2. 1 Publication | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D00408 mRNA Translation: BAA00310.1 AF315325 mRNA Translation: AAG48618.1 AF280107 Genomic DNA Translation: AAG32289.1 CH236956 Genomic DNA Translation: EAL23867.1 CH471091 Genomic DNA Translation: EAW76637.1 BC067436 mRNA Translation: AAH67436.1 |
CCDSi | CCDS5673.1 [P24462-1] |
PIRi | JX0062 |
RefSeqi | NP_000756.3, NM_000765.4 [P24462-1] NP_001243426.2, NM_001256497.2 [P24462-2] |
Genome annotation databases
Ensembli | ENST00000336374; ENSP00000337450; ENSG00000160870 [P24462-1] |
GeneIDi | 100861540 1551 |
KEGGi | hsa:100861540 hsa:1551 |
UCSCi | uc003uru.4, human [P24462-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Cytochrome P450 Allele Nomenclature Committee CYP3A7 alleles |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D00408 mRNA Translation: BAA00310.1 AF315325 mRNA Translation: AAG48618.1 AF280107 Genomic DNA Translation: AAG32289.1 CH236956 Genomic DNA Translation: EAL23867.1 CH471091 Genomic DNA Translation: EAW76637.1 BC067436 mRNA Translation: AAH67436.1 |
CCDSi | CCDS5673.1 [P24462-1] |
PIRi | JX0062 |
RefSeqi | NP_000756.3, NM_000765.4 [P24462-1] NP_001243426.2, NM_001256497.2 [P24462-2] |
3D structure databases
SMRi | P24462 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107930, 4 interactors |
IntActi | P24462, 1 interactor |
STRINGi | 9606.ENSP00000480571 |
Chemistry databases
BindingDBi | P24462 |
ChEMBLi | CHEMBL3341582 |
DrugBanki | DB11703, Acalabrutinib DB00802, Alfentanil DB00404, Alprazolam DB13141, Ambroxol acefyllinate DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB00637, Astemizole DB01076, Atorvastatin DB00443, Betamethasone DB12267, Brigatinib DB01222, Budesonide DB00921, Buprenorphine DB00490, Buspirone DB09061, Cannabidiol DB00439, Cerivastatin DB00446, Chloramphenicol DB01114, Chlorpheniramine DB01166, Cilostazol DB00537, Ciprofloxacin DB00604, Cisapride DB00257, Clotrimazole DB09065, Cobicistat DB12483, Copanlisib DB08865, Crizotinib DB09102, Daclatasvir DB00250, Dapsone DB00705, Delavirdine DB01234, Dexamethasone DB14649, Dexamethasone acetate DB00514, Dextromethorphan DB11994, Diacerein DB00829, Diazepam DB00343, Diltiazem DB01248, Docetaxel DB08930, Dolutegravir DB01184, Domperidone DB00625, Efavirenz DB11979, Elagolix DB11574, Elbasvir DB00199, Erythromycin DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB00593, Ethosuximide DB01023, Felodipine DB00813, Fentanyl DB01216, Finasteride DB13867, Fluticasone DB08906, Fluticasone furoate DB00588, Fluticasone propionate DB00176, Fluvoxamine DB12307, Foretinib DB06730, Gestodene DB13879, Glecaprevir DB01016, Glyburide DB00502, Haloperidol DB00741, Hydrocortisone DB14538, Hydrocortisone aceponate DB14539, Hydrocortisone acetate DB14540, Hydrocortisone butyrate DB14541, Hydrocortisone cypionate DB14542, Hydrocortisone phosphate DB14543, Hydrocortisone probutate DB14544, Hydrocortisone valerate DB09054, Idelalisib DB04946, Iloperidone DB00619, Imatinib DB00458, Imipramine DB00224, Indinavir DB00762, Irinotecan DB11757, Istradefylline DB01167, Itraconazole DB11951, Lemborexant DB00528, Lercanidipine DB12070, Letermovir DB01227, Levacetylmethadol DB00281, Lidocaine DB01601, Lopinavir DB12130, Lorlatinib DB09212, Loxoprofen DB00643, Mebendazole DB14009, Medical Cannabis DB00333, Methadone DB00959, Methylprednisolone DB00916, Metronidazole DB01388, Mibefradil DB00683, Midazolam DB06595, Midostaurin DB11792, Mirodenafil DB09205, Moxisylyte DB11605, Myrrh DB14011, Nabiximols DB11691, Naldemedine DB00731, Nateglinide DB01149, Nefazodone DB00220, Nelfinavir DB00238, Nevirapine DB00401, Nisoldipine DB01054, Nitrendipine DB00334, Olanzapine DB09568, Omega-3-carboxylic acids DB00904, Ondansetron DB06412, Oxymetholone DB01229, Paclitaxel DB00780, Phenelzine DB01174, Phenobarbital DB00252, Phenytoin DB13878, Pibrentasvir DB01100, Pimozide DB01708, Prasterone DB05804, Prasterone sulfate DB01058, Praziquantel DB14631, Prednisolone phosphate DB00635, Prednisone DB00396, Progesterone DB00571, Propranolol DB01224, Quetiapine DB00908, Quinidine DB00468, Quinine DB13174, Rhein DB01045, Rifampicin DB01201, Rifapentine DB00503, Ritonavir DB12332, Rucaparib DB00938, Salmeterol DB01232, Saquinavir DB15685, Selpercatinib DB06731, Seproxetine DB00203, Sildenafil DB00877, Sirolimus DB00398, Sorafenib DB01268, Sunitinib DB00675, Tamoxifen DB12887, Tazemetostat DB06287, Temsirolimus DB00342, Terfenadine DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate DB00599, Thiopental DB00656, Trazodone DB00755, Tretinoin DB00620, Triamcinolone DB00897, Triazolam DB00197, Troglitazone DB13179, Troleandomycin DB11652, Tucatinib DB00541, Vincristine DB00582, Voriconazole DB00962, Zaleplon DB15035, Zanubrutinib |
DrugCentrali | P24462 |
SwissLipidsi | SLP:000001324 |
PTM databases
iPTMneti | P24462 |
PhosphoSitePlusi | P24462 |
Genetic variation databases
BioMutai | CYP3A7 |
DMDMi | 90110014 |
Proteomic databases
MassIVEi | P24462 |
PaxDbi | P24462 |
PeptideAtlasi | P24462 |
PRIDEi | P24462 |
ProteomicsDBi | 54205 [P24462-1] |
Protocols and materials databases
Antibodypediai | 16242, 224 antibodies |
Genome annotation databases
Ensembli | ENST00000336374; ENSP00000337450; ENSG00000160870 [P24462-1] |
GeneIDi | 100861540 1551 |
KEGGi | hsa:100861540 hsa:1551 |
UCSCi | uc003uru.4, human [P24462-1] |
Organism-specific databases
CTDi | 100861540 1551 |
DisGeNETi | 100861540 1551 |
GeneCardsi | CYP3A7 |
HGNCi | HGNC:2640, CYP3A7 |
HPAi | ENSG00000160870, Tissue enriched (liver) ENSG00000282301, Tissue enriched (liver) |
MIMi | 605340, gene |
neXtProti | NX_P24462 |
OpenTargetsi | ENSG00000160870 ENSG00000282301 |
PharmGKBi | PA122 |
VEuPathDBi | HostDB:ENSG00000160870.12 HostDB:ENSG00000282301.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0158, Eukaryota |
GeneTreei | ENSGT00950000182958 |
HOGENOMi | CLU_001570_5_2_1 |
InParanoidi | P24462 |
OMAi | MAYHEMR |
OrthoDBi | 467733at2759 |
PhylomeDBi | P24462 |
TreeFami | TF105087 |
Enzyme and pathway databases
UniPathwayi | UPA00912 |
BRENDAi | 1.14.14.1, 2681 |
PathwayCommonsi | P24462 |
Reactomei | R-HSA-211981, Xenobiotics |
SABIO-RKi | P24462 |
Miscellaneous databases
BioGRID-ORCSi | 100861540, 0 hits in 61 CRISPR screens 1551, 2 hits in 858 CRISPR screens |
GeneWikii | CYP3A7 |
Pharosi | P24462, Tclin |
PROi | PR:P24462 |
RNActi | P24462, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160870, Expressed in liver and 131 other tissues |
ExpressionAtlasi | P24462, baseline and differential |
Genevisiblei | P24462, HS |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CP3A7_HUMAN | |
Accessioni | P24462Primary (citable) accession number: P24462 Secondary accession number(s): A4D288, Q9H241 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | September 12, 2018 | |
Last modified: | February 10, 2021 | |
This is version 190 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants