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UniProtKB - P24458 (CP52E_CANMA)
Protein
Cytochrome P450 52A3-B
Gene
CYP52A3-B
Organism
Candida maltosa (Yeast)
Status
Functioni
Together with an NADPH cytochrome P450 the enzyme system catalyzes the terminal hydroxylation as the first step in the assimilation of alkanes and fatty acids.
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 471 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 52A3-B (EC:1.14.14.-)Short name: CYP52A3-B Alternative name(s): Alkane-inducible P450-ALK1-B CYPLIIA3 |
Gene namesi | Name:CYP52A3-B |
Organismi | Candida maltosa (Yeast) |
Taxonomic identifieri | 5479 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Candida/Lodderomyces clade › Candida |
Subcellular locationi
Other locations
- Membrane Curated
- Membrane ; Single-pass membrane protein
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 17 – 34 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000052023 | 2 – 523 | Cytochrome P450 52A3-BAdd BLAST | 522 |
Expressioni
Inductioni
By alkanes.1 Publication
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002974, Cyt_P450_E_CYP52 IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01239, EP450IICYP52 PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P24458-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIEQIIEEV LPYLTKWYTI LFGAAFTYFL SIALRNKYYE YKLKCENPPY
60 70 80 90 100
FKTAGFVGIP GLIDVIKAKN AGKLADYADQ TFDEYPHHSF YMTVAGMLKI
110 120 130 140 150
VLTVDPENIK AVLATQFNDF ALGARHAHFD PLLGDGIFTL DGEGWKHSRA
160 170 180 190 200
MLRPQFAREQ IAHVKALEPH VQVLAKQIKL NKGETFDLQE LFFRFTVDTA
210 220 230 240 250
TEFLFGESVH SLYDEKLGVP PPNNIPGREN FAKAFNTSQH YLATRTYSQM
260 270 280 290 300
FYFLTNPKEF RDCNAKVHKL AQYFVNKALD ASEDEVAEKS KGGYVFLYEL
310 320 330 340 350
VKQTRDPKVL QDQLLNIMVA GRDTTAGLLS FAMFELARNP KIWNKLREEI
360 370 380 390 400
EVNFGLGEEA RVDEISFETL KKCEYLKAVL NETLRMYPSV PVNFRTATRD
410 420 430 440 450
TTLPRGGGKD GTSPIFVPKG SSVVYTVYKT HRLEEYYGKD AYEFRPERWF
460 470 480 490 500
EPSTRKLGWA YVPFNGGPRI CLGQQFALTE ASYVITRLAQ MFEHLESKDE
510 520
TYPPNKCIHL TMNHNEGVFI SAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12475 Genomic DNA Translation: BAA02041.1 S77461 Genomic DNA Translation: AAC60531.1 |
PIRi | JQ1039 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12475 Genomic DNA Translation: BAA02041.1 S77461 Genomic DNA Translation: AAC60531.1 |
PIRi | JQ1039 |
3D structure databases
SMRi | P24458 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002974, Cyt_P450_E_CYP52 IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01239, EP450IICYP52 PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP52E_CANMA | |
Accessioni | P24458Primary (citable) accession number: P24458 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families