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Protein

Cytoplasmic envelopment protein 3

Gene

U71

Organism
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic envelopment protein 3UniRule annotation
Gene namesi
Name:U71
Synonyms:17R
OrganismiHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Taxonomic identifieri10370 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009295 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved; by hostUniRule annotation
ChainiPRO_00001159292 – 77Cytoplasmic envelopment protein 3UniRule annotationAdd BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine; by hostUniRule annotation1

Post-translational modificationi

Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.UniRule annotation
Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.UniRule annotation

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP24448

Interactioni

Subunit structurei

Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus.UniRule annotation

Protein-protein interaction databases

IntActiP24448, 1 interactor

Structurei

3D structure databases

SMRiP24448
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi40 – 46Asp/Glu-rich (acidic)7

Sequence similaritiesi

Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090001RL

Family and domain databases

HAMAPiMF_04041 HSV_CEP3_betahv, 1 hit
InterProiView protein in InterPro
IPR020170 Herpes_UL11_megaloV/roseoloV
IPR034705 HSV_CEP3_betahv
PfamiView protein in Pfam
PF17474 U71, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD019475 Herpes_UL11_megaloV/roseoloV, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24448-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAKCCKPVS CGMCKKTENT LIDYKGNPIL LANEFTVLTD TESEEEGMAD
60 70
LEKPLLEKVV AKCDTEAEKK LPCKSKK
Length:77
Mass (Da):8,469
Last modified:January 23, 2007 - v3
Checksum:iE6BCF2D7637CDB02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83413 Genomic DNA Translation: CAA58363.1
M68963 Genomic DNA Translation: AAA65579.1
PIRiG36769
RefSeqiNP_042964.1, NC_001664.2

Genome annotation databases

GeneIDi1487952

Similar proteinsi

Entry informationi

Entry nameiCEP3_HHV6U
AccessioniPrimary (citable) accession number: P24448
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 76 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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