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Protein

Cytoplasmic envelopment protein 2

Gene

U65

Organism
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid. Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic envelopment protein 2UniRule annotation
Gene namesi
Name:U65
Synonyms:11R
OrganismiHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Taxonomic identifieri10370 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009295 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001159501 – 335Cytoplasmic envelopment protein 2Add BLAST335

Proteomic databases

PRIDEiP24442

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with cytoplasmic envelopment protein 3 and with the capsid.UniRule annotation

Structurei

3D structure databases

SMRiP24442
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae cytoplasmic envelopment protein 2 family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000BB

Family and domain databases

HAMAPiMF_04039 HSV_CEP2, 1 hit
InterProiView protein in InterPro
IPR004286 Herpes_UL16/UL94
PfamiView protein in Pfam
PF03044 Herpes_UL16, 1 hit

Sequencei

Sequence statusi: Complete.

P24442-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAISTFSIGD LGYLRNFLQN ECNWFRICKK TFYREYRSVA TSSPTFSLNN
60 70 80 90 100
KPKKFCMHCE IVIFKRSEEF MFSLAVNGIH FGQFLTGKMK FNKKAVPEGL
110 120 130 140 150
YYYILELGSI TPIDLGFIPR YNSDCVTNMR CVTPEVIYEN CSIVCPEEAN
160 170 180 190 200
RLTVKGSGDN KLTPLGGCGA WCLKNGGDLY IYTFALAYDL FLTCYDKSTF
210 220 230 240 250
PSLAKIIFDM IACESEDCVF CKDHNKHVSQ AGQIVGCVSN QETCFCYTSC
260 270 280 290 300
KKKMANINNP ELISLLCDQE INKIDIMYPK IKASLSLDIN SYAHGYFGDD
310 320 330
PYALKCVNWI PVRISAALSR LIVLSCPVCK RVVMD
Length:335
Mass (Da):37,877
Last modified:March 1, 1992 - v1
Checksum:i177BC8ED39DEE014
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83413 Genomic DNA Translation: CAA58357.1
M68963 Genomic DNA Translation: AAA65574.1
PIRiB36769
RefSeqiNP_042958.1, NC_001664.2

Genome annotation databases

GeneIDi1487947
KEGGivg:1487947

Similar proteinsi

Entry informationi

Entry nameiCEP2_HHV6U
AccessioniPrimary (citable) accession number: P24442
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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