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Protein

Triplex capsid protein 2

Gene

TRX2

Organism
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Triplex capsid protein 2UniRule annotation
Gene namesi
Name:TRX2UniRule annotation
Ordered Locus Names:U56
OrganismiHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Taxonomic identifieri10370 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009295 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157271 – 296Triplex capsid protein 2Add BLAST296

Proteomic databases

PRIDEiP24436

Interactioni

Subunit structurei

Interacts with TRX1 and major capisd protein/MCP.UniRule annotation

Structurei

3D structure databases

SMRiP24436
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRX2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000IF

Family and domain databases

HAMAPiMF_04019 HSV_TRX2, 1 hit
InterProiView protein in InterPro
IPR002690 Herpes_capsid_2
PfamiView protein in Pfam
PF01802 Herpes_V23, 1 hit

Sequencei

Sequence statusi: Complete.

P24436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVYCTFDH KLSLSDISTL CKLMNIVIPI PAHHHLIGSG NLGLYPIVSS
60 70 80 90 100
NKDYVHVRNV LRTMVVTILQ KVEGNQLVLR KPVTGHQYAI KNTGPFPWEK
110 120 130 140 150
GDTLTLIPPL STHSEEKLLK LGDWELTVPL VVPTAIAAEI NIRLLCIGLI
160 170 180 190 200
AVHREYNEMQ TIIDELCSIQ YRDVLIKLPD IVNDKQSMYS MKTACISLSM
210 220 230 240 250
ITAMAPDIVR TYIDRLTLED HSMLLIKCQE LLSKRTTLNT QRCGQLHATE
260 270 280 290
IKDELKKVKS VLTMIDQINS LTNEKTYFVV CDVSADNRMA TCIYKN
Length:296
Mass (Da):33,464
Last modified:March 1, 1992 - v1
Checksum:i2637449E819F36CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83413 Genomic DNA Translation: CAA58390.1
M68963 Genomic DNA Translation: AAA65566.1
PIRiD33560
RefSeqiNP_042949.1, NC_001664.2

Genome annotation databases

GeneIDi1487938
KEGGivg:1487938

Similar proteinsi

Entry informationi

Entry nameiTRX2_HHV6U
AccessioniPrimary (citable) accession number: P24436
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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