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Protein

Membrane protein

Gene

M

Organism
Porcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane proteinUniRule annotation
Short name:
M proteinUniRule annotation
Alternative name(s):
E1 glycoproteinUniRule annotation
Matrix glycoproteinUniRule annotation
Membrane glycoproteinUniRule annotation
Gene namesi
Name:MUniRule annotation
OrganismiPorcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)
Taxonomic identifieri11148 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

  • Virion membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Host Golgi apparatus membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Note: Largely embedded in the lipid bilayer.UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 47Virion surfaceUniRule annotationAdd BLAST30
Transmembranei48 – 68HelicalUniRule annotationAdd BLAST21
Topological domaini69 – 77IntravirionUniRule annotation9
Transmembranei78 – 98HelicalUniRule annotationAdd BLAST21
Topological domaini99 – 112Virion surfaceUniRule annotationAdd BLAST14
Transmembranei113 – 133HelicalUniRule annotationAdd BLAST21
Topological domaini134 – 262IntravirionUniRule annotationAdd BLAST129

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000371571 – 262Membrane proteinAdd BLAST262

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP24412

Interactioni

Subunit structurei

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni237 – 252Interaction with N proteinUniRule annotationAdd BLAST16

Sequence similaritiesi

Belongs to the alphacoronaviruses M protein family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

HAMAPiMF_04201 ALPHA_CORONA_M, 1 hit
InterProiView protein in InterPro
IPR002574 Corona_M
PfamiView protein in Pfam
PF01635 Corona_M, 1 hit

Sequencei

Sequence statusi: Complete.

P24412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILLILACA IACTCGERYC AMKDDTGLSC RNGTASDCES CFNRGDLIWL
60 70 80 90 100
LANWNFSWSI ILIIFITVLQ YGRPQFSWFV YGIKMLIMWL LWPIVLALTI
110 120 130 140 150
FNAYSEYQVS RYVMFGFSIA GAIVTFVLWI MYFVRSIQLY RRTKSWWSFN
160 170 180 190 200
PETNAILCVS ALGRSYVLPL EGVPTGVTLT LLSGNLYAEG FKIAGGMTID
210 220 230 240 250
NLPKYVMVAL PSRTIVYTLV GKKLKASSAT GWAYYVKSKA GDYSTEARTD
260
NLSEQEKLLH MV
Length:262
Mass (Da):29,587
Last modified:March 1, 1992 - v1
Checksum:i2B047572E98A5CE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24675 Genomic RNA Translation: CAA80840.1
PIRiD36607

Similar proteinsi

Entry informationi

Entry nameiVME1_CVPRM
AccessioniPrimary (citable) accession number: P24412
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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