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Protein

Nucleoprotein

Gene

N

Organism
Porcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
NucleoproteinUniRule annotation
Alternative name(s):
Nucleocapsid proteinUniRule annotation
Short name:
NCUniRule annotation
Short name:
Protein NUniRule annotation
Gene namesi
Name:NUniRule annotation
OrganismiPorcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)
Taxonomic identifieri11148 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001060161 – 382NucleoproteinAdd BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9Phosphoserine; by hostUniRule annotation1
Modified residuei156Phosphoserine; by hostUniRule annotation1
Modified residuei254Phosphoserine; by hostUniRule annotation1
Modified residuei256Phosphoserine; by hostUniRule annotation1

Post-translational modificationi

ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.UniRule annotation
Phosphorylated on serine and threonine residues.UniRule annotation

Keywords - PTMi

ADP-ribosylation, Phosphoprotein

Interactioni

Subunit structurei

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP24411
SMRiP24411
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 159RNA-bindingUniRule annotationAdd BLAST127
Regioni231 – 334DimerizationUniRule annotationAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 182Ser-richAdd BLAST27

Sequence similaritiesi

Belongs to the alphacoronavirus nucleocapsid protein family.UniRule annotation

Family and domain databases

HAMAPiMF_04095 ALPHA_CORONA_NCAP, 1 hit
InterProiView protein in InterPro
IPR001218 Corona_nucleocap
IPR037179 Nucleocapsid_C
IPR037195 Nucleocapsid_N
PfamiView protein in Pfam
PF00937 Corona_nucleoca, 1 hit
PIRSFiPIRSF003888 Corona_nucleocap, 1 hit
SUPFAMiSSF103068 SSF103068, 1 hit
SSF110304 SSF110304, 1 hit

Sequencei

Sequence statusi: Complete.

P24411-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANQGQRVSW GDESTKIRGR SNSRGRKINN IPLSFFNPIT LQQGAKFWNS
60 70 80 90 100
CPRDFVPKGI GNRDQQIGYW NRQTRYRMVK GQRKELPERW FFYYLGTGPH
110 120 130 140 150
ADAKFKDKLD GVVWVAKDGA MNKPTTLGSR GANNESKALK FDGKVPGEFQ
160 170 180 190 200
LEVNQSRDNS RSRSQSRSRS RNRSQSRGRQ QSNNKKDDSV EQAVLAALKK
210 220 230 240 250
LGVYTEKQQQ RSRSKSKERS NSKTRDTTPK NENKHTWKRT AGKGDVTRFY
260 270 280 290 300
GARSSSANFG DSDLVANGSS AKHYPQLAEC VPSVSSILFG SYWTSKEDGD
310 320 330 340 350
QIEVTFTHKY HLPKDHPKTE QFLQQINAYA SPSELAKEQR KRKSRSKSAE
360 370 380
RSEQEVVPDS LIENYTDVFD DTQVEMIDEV TN
Length:382
Mass (Da):43,551
Last modified:March 1, 1992 - v1
Checksum:i76EE7091E5D93BC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24675 Genomic RNA Translation: CAA80841.1
PIRiE36607

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24675 Genomic RNA Translation: CAA80841.1
PIRiE36607

3D structure databases

ProteinModelPortaliP24411
SMRiP24411
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_04095 ALPHA_CORONA_NCAP, 1 hit
InterProiView protein in InterPro
IPR001218 Corona_nucleocap
IPR037179 Nucleocapsid_C
IPR037195 Nucleocapsid_N
PfamiView protein in Pfam
PF00937 Corona_nucleoca, 1 hit
PIRSFiPIRSF003888 Corona_nucleocap, 1 hit
SUPFAMiSSF103068 SSF103068, 1 hit
SSF110304 SSF110304, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNCAP_CVPRM
AccessioniPrimary (citable) accession number: P24411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 7, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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