UniProtKB - P24394 (IL4RA_HUMAN)
Interleukin-4 receptor subunit alpha
IL4R
Functioni
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
1 PublicationSoluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 38 | Major IL4 binding determinant | 1 | |
Sitei | 64 | Minor IL4 binding determinant | 1 | |
Sitei | 66 | Minor IL4 binding determinant | 1 | |
Sitei | 92 | Minor IL4 binding determinant | 1 | |
Sitei | 94 | Minor IL4 binding determinant | 1 | |
Sitei | 97 | Major IL4 binding determinant | 1 | |
Sitei | 152 | Minor IL4 binding determinant | 1 | |
Sitei | 208 | Major IL4 binding determinant | 1 |
GO - Molecular functioni
- interleukin-4 receptor activity Source: ProtInc
GO - Biological processi
- defense response to protozoan Source: Ensembl
- immune response Source: ProtInc
- immunoglobulin mediated immune response Source: Ensembl
- negative regulation of T-helper 1 cell differentiation Source: Ensembl
- ovulation Source: Ensembl
- positive regulation of chemokine production Source: Ensembl
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of immunoglobulin production Source: Ensembl
- positive regulation of macrophage activation Source: Ensembl
- positive regulation of mast cell degranulation Source: Ensembl
- positive regulation of myoblast fusion Source: Ensembl
- positive regulation of T-helper 2 cell differentiation Source: Ensembl
- production of molecular mediator involved in inflammatory response Source: InterPro
- regulation of cell population proliferation Source: Ensembl
- response to estrogen Source: Ensembl
- response to odorant Source: Ensembl
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Receptor |
Biological process | Immunity |
Enzyme and pathway databases
PathwayCommonsi | P24394 |
Reactomei | R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling |
SignaLinki | P24394 |
SIGNORi | P24394 |
Protein family/group databases
TCDBi | 8.A.152.1.9, the interleukin receptor (ilr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-4 receptor subunit alphaShort name: IL-4 receptor subunit alpha Short name: IL-4R subunit alpha Short name: IL-4R-alpha Short name: IL-4RA Alternative name(s): CD_antigen: CD124 Cleaved into the following chain: Soluble interleukin-4 receptor subunit alpha Short name: Soluble IL-4 receptor subunit alpha Short name: Soluble IL-4R-alpha Short name: sIL4Ralpha/prot Alternative name(s): IL-4-binding protein Short name: IL4-BP |
Gene namesi | Name:IL4R Synonyms:IL4RA ORF Names:582J2.1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6015, IL4R |
MIMi | 147781, gene |
neXtProti | NX_P24394 |
VEuPathDBi | HostDB:ENSG00000077238 |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
Cytoskeleton
- centriolar satellite Source: HPA
Extracellular region or secreted
- extracellular space Source: Ensembl
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: HPA
Other locations
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 232 | ExtracellularSequence analysisAdd BLAST | 207 | |
Transmembranei | 233 – 256 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 257 – 825 | CytoplasmicSequence analysisAdd BLAST | 569 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 38 | Y → A: 700-fold reduction in IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 38 | Y → F: 25-fold reduction in IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 39 | M → A: No effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 40 | S → A: No effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 64 | L → A: 100-fold reduction in IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 66 | F → A: 45-fold reduction in IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 67 | L → A: No effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 68 | L → A: No effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 91 | D → A: Little effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 92 | D → A: 50-fold reduction in IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 93 | V → A: Little effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 94 | V → A: 35-fold reduction in IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 95 | S → A: No effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 97 | D → A or N: >150-fold reduction in IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 98 | N → A: No effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 99 | Y → A: 10-fold reduction in IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 116 | K → A: Little effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 117 | P → A: Little effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 118 | S → A: No effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 119 | E → A: No effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 150 | D → A: Little effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 151 | N → A: Little effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 152 | Y → A: 40-fold reduction in IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 152 | Y → F: No effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 153 | L → A: Little effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 154 | Y → A: Little effect on IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 208 | Y → A: 500-fold reduction in IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 208 | Y → F: 200-fold reduction in IL4 binding. 1 Publication | 1 | |
Mutagenesisi | 497 | Y → F: Abolishes IRS1 tyrosine phosphorylation. No cell proliferation. 1 Publication | 1 | |
Mutagenesisi | 575 | Y → F: Loss of CD23 gene induction; when associated with F-603 and F-631. 2 Publications | 1 | |
Mutagenesisi | 603 | Y → F: Loss of CD23 gene induction; when associated with F-575 and F-631. 1 Publication | 1 | |
Mutagenesisi | 631 | Y → F: Loss of CD23 gene induction; when associated with F-575 and F-603. 1 Publication | 1 | |
Mutagenesisi | 713 | Y → F: Increased IL4-induced cell proliferation and STAT6 activation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3566 |
MalaCardsi | IL4R |
OpenTargetsi | ENSG00000077238 |
PharmGKBi | PA29832 |
Miscellaneous databases
Pharosi | P24394, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3580490 |
DrugBanki | DB05078, AER001 DB12159, Dupilumab |
DrugCentrali | P24394 |
GuidetoPHARMACOLOGYi | 1697 |
Genetic variation databases
BioMutai | IL4R |
DMDMi | 124335 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | By similarityAdd BLAST | 25 | |
ChainiPRO_0000010887 | 26 – 825 | Interleukin-4 receptor subunit alphaAdd BLAST | 800 | |
ChainiPRO_0000010888 | 26 – ? | Soluble interleukin-4 receptor subunit alpha |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 44 | By similarity | ||
Glycosylationi | 53 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 74 ↔ 86 | By similarity | ||
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 128 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 134 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 176 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 209 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 497 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 575 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 603 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 631 | Phosphotyrosine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | P24394 |
MassIVEi | P24394 |
PaxDbi | P24394 |
PeptideAtlasi | P24394 |
PRIDEi | P24394 |
ProteomicsDBi | 54203 [P24394-1] 54204 [P24394-2] 5656 |
PTM databases
GlyConnecti | 2053, 1 N-Linked glycan (1 site) |
GlyGeni | P24394, 6 sites, 2 N-linked glycans (1 site) |
iPTMneti | P24394 |
PhosphoSitePlusi | P24394 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000077238, Expressed in left adrenal gland and 207 other tissues |
ExpressionAtlasi | P24394, baseline and differential |
Genevisiblei | P24394, HS |
Organism-specific databases
HPAi | ENSG00000077238, Low tissue specificity |
Interactioni
Subunit structurei
The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor (PubMed:7775445, PubMed:8804422).
Interacts with PIK3C3 (By similarity).
Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (PubMed:11714803).
Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5.
Interacts with SOCS5; inhibits IL4 signaling (By similarity).
Interacts with JAK3 (PubMed:7538655).
Interacts with CLM1 (By similarity).
By similarity4 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 109780, 43 interactors |
CORUMi | P24394 |
DIPi | DIP-3223N |
ELMi | P24394 |
IntActi | P24394, 34 interactors |
MINTi | P24394 |
STRINGi | 9606.ENSP00000379111 |
Miscellaneous databases
RNActi | P24394, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P24394 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P24394 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 125 – 224 | Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST | 100 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 373 – 397 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 433 – 485 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 437 – 557 | Required for IRS1 activation and IL4-induced cell growthAdd BLAST | 121 | |
Regioni | 558 – 657 | Required for IL4-induced gene expressionAdd BLAST | 100 | |
Regioni | 651 – 703 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 782 – 809 | DisorderedSequence analysisAdd BLAST | 28 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 212 – 216 | WSXWS motif | 5 | |
Motifi | 262 – 270 | Box 1 motif | 9 | |
Motifi | 711 – 716 | ITIM motif | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 381 – 397 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 784 – 809 | Polar residuesSequence analysisAdd BLAST | 26 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S3Y8, Eukaryota |
GeneTreei | ENSGT00510000049182 |
HOGENOMi | CLU_020561_0_0_1 |
InParanoidi | P24394 |
OMAi | GYKPFQN |
PhylomeDBi | P24394 |
TreeFami | TF337996 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
IDEALi | IID00653 |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003531, Hempt_rcpt_S_F1_CS IPR013783, Ig-like_fold IPR015319, IL-4_rcpt-alpha_N |
Pfami | View protein in Pfam PF09238, IL4Ra_N, 1 hit |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit PS01355, HEMATOPO_REC_S_F1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG
60 70 80 90 100
PTNCSTELRL LYQLVFLLSE AHTCIPENNG GAGCVCHLLM DDVVSADNYT
110 120 130 140 150
LDLWAGQQLL WKGSFKPSEH VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD
160 170 180 190 200
NYLYNHLTYA VNIWSENDPA DFRIYNVTYL EPSLRIAAST LKSGISYRAR
210 220 230 240 250
VRAWAQCYNT TWSEWSPSTK WHNSYREPFE QHLLLGVSVS CIVILAVCLL
260 270 280 290 300
CYVSITKIKK EWWDQIPNPA RSRLVAIIIQ DAQGSQWEKR SRGQEPAKCP
310 320 330 340 350
HWKNCLTKLL PCFLEHNMKR DEDPHKAAKE MPFQGSGKSA WCPVEISKTV
360 370 380 390 400
LWPESISVVR CVELFEAPVE CEEEEEVEEE KGSFCASPES SRDDFQEGRE
410 420 430 440 450
GIVARLTESL FLDLLGEENG GFCQQDMGES CLLPPSGSTS AHMPWDEFPS
460 470 480 490 500
AGPKEAPPWG KEQPLHLEPS PPASPTQSPD NLTCTETPLV IAGNPAYRSF
510 520 530 540 550
SNSLSQSPCP RELGPDPLLA RHLEEVEPEM PCVPQLSEPT TVPQPEPETW
560 570 580 590 600
EQILRRNVLQ HGAAAAPVSA PTSGYQEFVH AVEQGGTQAS AVVGLGPPGE
610 620 630 640 650
AGYKAFSSLL ASSAVSPEKC GFGASSGEEG YKPFQDLIPG CPGDPAPVPV
660 670 680 690 700
PLFTFGLDRE PPRSPQSSHL PSSSPEHLGL EPGEKVEDMP KPPLPQEQAT
710 720 730 740 750
DPLVDSLGSG IVYSALTCHL CGHLKQCHGQ EDGGQTPVMA SPCCGCCCGD
760 770 780 790 800
RSSPPTTPLR APDPSPGGVP LEASLCPASL APSGISEKSK SSSSFHPAPG
810 820
NAQSSSQTPK IVNFVSVGPT YMRVS
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BTD9 | H3BTD9_HUMAN | Interleukin-4 receptor subunit alph... | IL4R | 63 | Annotation score: | ||
H3BRH7 | H3BRH7_HUMAN | Interleukin-4 receptor subunit alph... | IL4R | 124 | Annotation score: | ||
J9JII2 | J9JII2_HUMAN | Interleukin-4 receptor subunit alph... | IL4R | 120 | Annotation score: | ||
I3L4W9 | I3L4W9_HUMAN | Interleukin-4 receptor subunit alph... | IL4R | 193 | Annotation score: | ||
H3BSE7 | H3BSE7_HUMAN | Interleukin-4 receptor subunit alph... | IL4R | 49 | Annotation score: | ||
I3L4H7 | I3L4H7_HUMAN | Interleukin-4 receptor subunit alph... | IL4R | 133 | Annotation score: | ||
Q5FC08 | Q5FC08_HUMAN | IL4R nirs variant 1 | IL4R | 66 | Annotation score: | ||
A0A0G2JLA1 | A0A0G2JLA1_HUMAN | Interleukin-4 receptor subunit alph... | IL4R | 10 | Annotation score: |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059302 | 75 | I → F. Corresponds to variant dbSNP:rs1805010EnsemblClinVar. | 1 | |
Natural variantiVAR_059303 | 75 | I → L. Corresponds to variant dbSNP:rs1805010EnsemblClinVar. | 1 | |
Natural variantiVAR_008034 | 75 | I → V Associated with atopic asthma and cedar pollen sensitization. 5 PublicationsCorresponds to variant dbSNP:rs1805010EnsemblClinVar. | 1 | |
Natural variantiVAR_019999 | 387 | S → L. Corresponds to variant dbSNP:rs6413500EnsemblClinVar. | 1 | |
Natural variantiVAR_011657 | 400 | E → A Associated with cedar pollen sensitization. 4 PublicationsCorresponds to variant dbSNP:rs1805011Ensembl. | 1 | |
Natural variantiVAR_011658 | 431 | C → R3 PublicationsCorresponds to variant dbSNP:rs1805012Ensembl. | 1 | |
Natural variantiVAR_011659 | 436 | S → L3 PublicationsCorresponds to variant dbSNP:rs1805013Ensembl. | 1 | |
Natural variantiVAR_049164 | 492 | A → T. Corresponds to variant dbSNP:rs35606110EnsemblClinVar. | 1 | |
Natural variantiVAR_049165 | 492 | A → V. Corresponds to variant dbSNP:rs34727572Ensembl. | 1 | |
Natural variantiVAR_011660 | 503 | S → P Lowered total IgE concentration. 3 PublicationsCorresponds to variant dbSNP:rs1805015EnsemblClinVar. | 1 | |
Natural variantiVAR_008035 | 576 | Q → R Associated with atopic dermatitis; lowered total IgE concentration; no effect on IL4-induced signal transduction. 6 PublicationsCorresponds to variant dbSNP:rs1801275EnsemblClinVar. | 1 | |
Natural variantiVAR_011661 | 579 | V → I2 PublicationsCorresponds to variant dbSNP:rs3024677EnsemblClinVar. | 1 | |
Natural variantiVAR_020000 | 675 | P → S1 PublicationCorresponds to variant dbSNP:rs3024678Ensembl. | 1 | |
Natural variantiVAR_011662 | 752 | S → A2 PublicationsCorresponds to variant dbSNP:rs1805016Ensembl. | 1 | |
Natural variantiVAR_011663 | 786 | S → P in 1.8% of the population. 2 PublicationsCorresponds to variant dbSNP:rs1805014EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053738 | 1 – 23 | MGWLC…QVASS → MQKDARRE in isoform 3. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_011116 | 225 – 227 | YRE → NIC in isoform 2. Curated | 3 | |
Alternative sequenceiVSP_011117 | 228 – 825 | Missing in isoform 2. CuratedAdd BLAST | 598 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52425 mRNA Translation: CAA36672.1 AC004525 Genomic DNA Translation: AAC23495.1 AF421855 Genomic DNA Translation: AAL12163.1 AJ293647 Genomic DNA Translation: CAC20445.1 AJ293648 Genomic DNA Translation: CAC20446.1 AJ293649 Genomic DNA Translation: CAC20447.1 AJ293650 Genomic DNA Translation: CAC20448.1 AJ293651 Genomic DNA Translation: CAC20449.1 AJ293652 Genomic DNA Translation: CAC20450.1 AJ293653 Genomic DNA Translation: CAC20451.1 AK303255 mRNA Translation: BAG64338.1 AC106739 Genomic DNA No translation available. BC151131 mRNA Translation: AAI51132.1 AJ293654 Genomic DNA Translation: CAC20452.1 |
CCDSi | CCDS10629.1 [P24394-1] CCDS58441.1 [P24394-3] |
PIRi | A60386 |
RefSeqi | NP_000409.1, NM_000418.3 [P24394-1] NP_001244335.1, NM_001257406.1 [P24394-1] NP_001244336.1, NM_001257407.1 [P24394-3] XP_011544127.1, XM_011545825.1 [P24394-1] XP_011544128.1, XM_011545826.2 [P24394-1] XP_011544129.1, XM_011545827.2 [P24394-1] |
Genome annotation databases
Ensembli | ENST00000170630; ENSP00000170630; ENSG00000077238 [P24394-3] ENST00000395762; ENSP00000379111; ENSG00000077238 ENST00000543915; ENSP00000441667; ENSG00000077238 |
GeneIDi | 3566 |
KEGGi | hsa:3566 |
MANE-Selecti | ENST00000395762.7; ENSP00000379111.2; NM_000418.4; NP_000409.1 |
UCSCi | uc002don.5, human [P24394-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
SHMPD The Singapore human mutation and polymorphism database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52425 mRNA Translation: CAA36672.1 AC004525 Genomic DNA Translation: AAC23495.1 AF421855 Genomic DNA Translation: AAL12163.1 AJ293647 Genomic DNA Translation: CAC20445.1 AJ293648 Genomic DNA Translation: CAC20446.1 AJ293649 Genomic DNA Translation: CAC20447.1 AJ293650 Genomic DNA Translation: CAC20448.1 AJ293651 Genomic DNA Translation: CAC20449.1 AJ293652 Genomic DNA Translation: CAC20450.1 AJ293653 Genomic DNA Translation: CAC20451.1 AK303255 mRNA Translation: BAG64338.1 AC106739 Genomic DNA No translation available. BC151131 mRNA Translation: AAI51132.1 AJ293654 Genomic DNA Translation: CAC20452.1 |
CCDSi | CCDS10629.1 [P24394-1] CCDS58441.1 [P24394-3] |
PIRi | A60386 |
RefSeqi | NP_000409.1, NM_000418.3 [P24394-1] NP_001244335.1, NM_001257406.1 [P24394-1] NP_001244336.1, NM_001257407.1 [P24394-3] XP_011544127.1, XM_011545825.1 [P24394-1] XP_011544128.1, XM_011545826.2 [P24394-1] XP_011544129.1, XM_011545827.2 [P24394-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IAR | X-ray | 2.30 | B | 26-232 | [»] | |
1IRS | NMR | - | B | 489-499 | [»] | |
3BPL | X-ray | 2.93 | B | 27-227 | [»] | |
3BPN | X-ray | 3.02 | B | 27-227 | [»] | |
3BPO | X-ray | 3.00 | B | 27-227 | [»] | |
5E4E | X-ray | 3.00 | B | 26-228 | [»] | |
6OEL | X-ray | 3.10 | B | 27-224 | [»] | |
6WGL | X-ray | 2.82 | C | 26-232 | [»] | |
SMRi | P24394 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109780, 43 interactors |
CORUMi | P24394 |
DIPi | DIP-3223N |
ELMi | P24394 |
IntActi | P24394, 34 interactors |
MINTi | P24394 |
STRINGi | 9606.ENSP00000379111 |
Chemistry databases
ChEMBLi | CHEMBL3580490 |
DrugBanki | DB05078, AER001 DB12159, Dupilumab |
DrugCentrali | P24394 |
GuidetoPHARMACOLOGYi | 1697 |
Protein family/group databases
TCDBi | 8.A.152.1.9, the interleukin receptor (ilr) family |
PTM databases
GlyConnecti | 2053, 1 N-Linked glycan (1 site) |
GlyGeni | P24394, 6 sites, 2 N-linked glycans (1 site) |
iPTMneti | P24394 |
PhosphoSitePlusi | P24394 |
Genetic variation databases
BioMutai | IL4R |
DMDMi | 124335 |
Proteomic databases
jPOSTi | P24394 |
MassIVEi | P24394 |
PaxDbi | P24394 |
PeptideAtlasi | P24394 |
PRIDEi | P24394 |
ProteomicsDBi | 54203 [P24394-1] 54204 [P24394-2] 5656 |
Protocols and materials databases
ABCDi | P24394, 48 sequenced antibodies |
Antibodypediai | 3843, 741 antibodies from 40 providers |
DNASUi | 3566 |
Genome annotation databases
Ensembli | ENST00000170630; ENSP00000170630; ENSG00000077238 [P24394-3] ENST00000395762; ENSP00000379111; ENSG00000077238 ENST00000543915; ENSP00000441667; ENSG00000077238 |
GeneIDi | 3566 |
KEGGi | hsa:3566 |
MANE-Selecti | ENST00000395762.7; ENSP00000379111.2; NM_000418.4; NP_000409.1 |
UCSCi | uc002don.5, human [P24394-1] |
Organism-specific databases
CTDi | 3566 |
DisGeNETi | 3566 |
GeneCardsi | IL4R |
HGNCi | HGNC:6015, IL4R |
HPAi | ENSG00000077238, Low tissue specificity |
MalaCardsi | IL4R |
MIMi | 147781, gene |
neXtProti | NX_P24394 |
OpenTargetsi | ENSG00000077238 |
PharmGKBi | PA29832 |
VEuPathDBi | HostDB:ENSG00000077238 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S3Y8, Eukaryota |
GeneTreei | ENSGT00510000049182 |
HOGENOMi | CLU_020561_0_0_1 |
InParanoidi | P24394 |
OMAi | GYKPFQN |
PhylomeDBi | P24394 |
TreeFami | TF337996 |
Enzyme and pathway databases
PathwayCommonsi | P24394 |
Reactomei | R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling |
SignaLinki | P24394 |
SIGNORi | P24394 |
Miscellaneous databases
BioGRID-ORCSi | 3566, 4 hits in 1041 CRISPR screens |
ChiTaRSi | IL4R, human |
EvolutionaryTracei | P24394 |
GeneWikii | Interleukin-4_receptor |
GenomeRNAii | 3566 |
Pharosi | P24394, Tclin |
PROi | PR:P24394 |
RNActi | P24394, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000077238, Expressed in left adrenal gland and 207 other tissues |
ExpressionAtlasi | P24394, baseline and differential |
Genevisiblei | P24394, HS |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
IDEALi | IID00653 |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003531, Hempt_rcpt_S_F1_CS IPR013783, Ig-like_fold IPR015319, IL-4_rcpt-alpha_N |
Pfami | View protein in Pfam PF09238, IL4Ra_N, 1 hit |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit PS01355, HEMATOPO_REC_S_F1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IL4RA_HUMAN | |
Accessioni | P24394Primary (citable) accession number: P24394 Secondary accession number(s): B4E076 Q9H188 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 230 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families