IL4R

Functionⁱ

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.1 Publication

Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	38	Major IL4 binding determinant	1
Siteⁱ	64	Minor IL4 binding determinant	1
Siteⁱ	66	Minor IL4 binding determinant	1
Siteⁱ	92	Minor IL4 binding determinant	1
Siteⁱ	94	Minor IL4 binding determinant	1
Siteⁱ	97	Major IL4 binding determinant	1
Siteⁱ	152	Minor IL4 binding determinant	1
Siteⁱ	208	Major IL4 binding determinant	1

GO - Molecular functionⁱ

interleukin-4 receptor activity
Source: ProtInc
Traceable author statementⁱ
- Ref.1
  "Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily."
  Idzerda R.L., March C.J., Mosley B., Lyman S.D., Bos T.V., Gimpel S.D., Din W.S., Grabstein K.H., Widmer M.B., Park L.S., Cosman D., Beckmann M.P.
  J. Exp. Med. 171:861-873(1990) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Immunity

Enzyme and pathway databases

PathwayCommonsⁱ	P24394
Reactomeⁱ	R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
SignaLinkⁱ	P24394
SIGNORⁱ	P24394

Protein family/group databases

TCDBⁱ	8.A.152.1.9, the interleukin receptor (ilr) family

TCDBⁱ

8.A.152.1.9, the interleukin receptor (ilr) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-4 receptor subunit alpha Short name: IL-4 receptor subunit alpha Short name: IL-4R subunit alpha Short name: IL-4R-alpha Short name: IL-4RA Alternative name(s): CD_antigen: CD124 Cleaved into the following chain: Soluble interleukin-4 receptor subunit alpha Short name: Soluble IL-4 receptor subunit alpha Short name: Soluble IL-4R-alpha Short name: sIL4Ralpha/prot Alternative name(s): IL-4-binding protein Short name: IL4-BP
Gene namesⁱ	Name:IL4R Synonyms:IL4RA ORF Names:582J2.1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6015, IL4R
MIMⁱ	147781, gene
neXtProtⁱ	NX_P24394
VEuPathDBⁱ	HostDB:ENSG00000077238.13

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	26 – 232	ExtracellularSequence analysisAdd BLAST	207
Transmembraneⁱ	233 – 256	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	257 – 825	CytoplasmicSequence analysisAdd BLAST	569

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	38	Y → A: 700-fold reduction in IL4 binding. 1 Publication	1
Mutagenesisⁱ	38	Y → F: 25-fold reduction in IL4 binding. 1 Publication	1
Mutagenesisⁱ	39	M → A: No effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	40	S → A: No effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	64	L → A: 100-fold reduction in IL4 binding. 1 Publication	1
Mutagenesisⁱ	66	F → A: 45-fold reduction in IL4 binding. 1 Publication	1
Mutagenesisⁱ	67	L → A: No effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	68	L → A: No effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	91	D → A: Little effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	92	D → A: 50-fold reduction in IL4 binding. 1 Publication	1
Mutagenesisⁱ	93	V → A: Little effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	94	V → A: 35-fold reduction in IL4 binding. 1 Publication	1
Mutagenesisⁱ	95	S → A: No effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	97	D → A or N: >150-fold reduction in IL4 binding. 1 Publication	1
Mutagenesisⁱ	98	N → A: No effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	99	Y → A: 10-fold reduction in IL4 binding. 1 Publication	1
Mutagenesisⁱ	116	K → A: Little effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	117	P → A: Little effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	118	S → A: No effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	119	E → A: No effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	150	D → A: Little effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	151	N → A: Little effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	152	Y → A: 40-fold reduction in IL4 binding. 1 Publication	1
Mutagenesisⁱ	152	Y → F: No effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	153	L → A: Little effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	154	Y → A: Little effect on IL4 binding. 1 Publication	1
Mutagenesisⁱ	208	Y → A: 500-fold reduction in IL4 binding. 1 Publication	1
Mutagenesisⁱ	208	Y → F: 200-fold reduction in IL4 binding. 1 Publication	1
Mutagenesisⁱ	497	Y → F: Abolishes IRS1 tyrosine phosphorylation. No cell proliferation. 1 Publication	1
Mutagenesisⁱ	575	Y → F: Loss of CD23 gene induction; when associated with F-603 and F-631. 2 Publications	1
Mutagenesisⁱ	603	Y → F: Loss of CD23 gene induction; when associated with F-575 and F-631. 1 Publication	1
Mutagenesisⁱ	631	Y → F: Loss of CD23 gene induction; when associated with F-575 and F-603. 1 Publication	1
Mutagenesisⁱ	713	Y → F: Increased IL4-induced cell proliferation and STAT6 activation. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3566
MalaCards human disease database More...MalaCardsⁱ	IL4R
Open Targets More...OpenTargetsⁱ	ENSG00000077238
PharmGKBⁱ	PA29832

Miscellaneous databases

Pharosⁱ	P24394, Tclin

Pharosⁱ

P24394, Tclin

Chemistry databases

ChEMBLⁱ	CHEMBL3580490
Drug and drug target database More...DrugBankⁱ	DB05078, AER001 DB12159, Dupilumab
DrugCentral More...DrugCentralⁱ	P24394
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1697

Genetic variation databases

BioMutaⁱ	IL4R
DMDMⁱ	124335

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 25	By similarityAdd BLAST	25
ChainⁱPRO_0000010887	26 – 825	Interleukin-4 receptor subunit alphaAdd BLAST	800
ChainⁱPRO_0000010888	26 – ?	Soluble interleukin-4 receptor subunit alpha

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	34 ↔ 44	By similarity
Glycosylationⁱ	53	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	74 ↔ 86	By similarity
Glycosylationⁱ	98	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	128	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	134	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	176	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	209	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	497	Phosphotyrosine1 Publication	1
Modified residueⁱ	575	Phosphotyrosine1 Publication	1
Modified residueⁱ	603	Phosphotyrosine1 Publication	1
Modified residueⁱ	631	Phosphotyrosine1 Publication	1

Post-translational modificationⁱ

On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.1 Publication

The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOSTⁱ	P24394
MassIVEⁱ	P24394
PaxDbⁱ	P24394
PeptideAtlas More...PeptideAtlasⁱ	P24394
PRIDEⁱ	P24394
ProteomicsDBⁱ	54203 [P24394-1] 54204 [P24394-2] 5656

PTM databases

GlyConnectⁱ	2053, 1 N-Linked glycan (1 site)
GlyGenⁱ	P24394, 6 sites, 1 N-linked glycan (1 site)
iPTMnetⁱ	P24394
PhosphoSitePlusⁱ	P24394

Expressionⁱ

Tissue specificityⁱ

Isoform 1 and isoform 2 are highly expressed in activated T-cells.

Gene expression databases

Bgeeⁱ	ENSG00000077238, Expressed in left adrenal gland and 206 other tissues
ExpressionAtlasⁱ	P24394, baseline and differential
Genevisibleⁱ	P24394, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000077238, Low tissue specificity

HPAⁱ

ENSG00000077238, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor (PubMed:7775445, PubMed:8804422).

Interacts with PIK3C3 (By similarity).

Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (PubMed:11714803).

Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5.

Interacts with SOCS5; inhibits IL4 signaling (By similarity).

Interacts with JAK3 (PubMed:7538655).

Interacts with CLM1 (By similarity).

By similarity4 Publications

Binary interactionsⁱ

Hide details

P24394

With	#Exp.	IntAct
IL4 [P05112]	7	EBI-367009,EBI-367025
STAT6 [P42226]	4	EBI-367009,EBI-1186478

Protein-protein interaction databases

BioGRIDⁱ	109780, 43 interactors
CORUMⁱ	P24394
Database of interacting proteins More...DIPⁱ	DIP-3223N
ELMⁱ	P24394
IntActⁱ	P24394, 34 interactors
Molecular INTeraction database More...MINTⁱ	P24394
STRINGⁱ	9606.ENSP00000379111

Miscellaneous databases

RNActⁱ	P24394, protein

RNActⁱ

P24394, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	28 – 36	Combined sources	9
Beta strandⁱ	38 – 50	Combined sources	13
Helixⁱ	54 – 57	Combined sources	4
Beta strandⁱ	58 – 68	Combined sources	11
Beta strandⁱ	72 – 74	Combined sources	3
Beta strandⁱ	77 – 89	Combined sources	13
Beta strandⁱ	99 – 105	Combined sources	7
Beta strandⁱ	108 – 115	Combined sources	8
Helixⁱ	117 – 119	Combined sources	3
Beta strandⁱ	127 – 132	Combined sources	6
Turnⁱ	135 – 137	Combined sources	3
Beta strandⁱ	139 – 144	Combined sources	6
Helixⁱ	154 – 156	Combined sources	3
Beta strandⁱ	158 – 168	Combined sources	11
Beta strandⁱ	172 – 177	Combined sources	6
Beta strandⁱ	179 – 181	Combined sources	3
Beta strandⁱ	183 – 186	Combined sources	4
Helixⁱ	188 – 190	Combined sources	3
Beta strandⁱ	193 – 195	Combined sources	3
Beta strandⁱ	197 – 204	Combined sources	8
Helixⁱ	206 – 208	Combined sources	3
Beta strandⁱ	219 – 221	Combined sources	3
Helixⁱ	495 – 497	Combined sources	3

Show more details

3D structure databases

SMRⁱ	P24394
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P24394

EvolutionaryTraceⁱ

P24394

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	125 – 224	Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST		100

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	437 – 557	Required for IRS1 activation and IL4-induced cell growthAdd BLAST		121
Regionⁱ	558 – 657	Required for IL4-induced gene expressionAdd BLAST		100

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	212 – 216	WSXWS motif	5
Motifⁱ	262 – 270	Box 1 motif	9
Motifⁱ	711 – 716	ITIM motif	6

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	370 – 380	Poly-GluAdd BLAST	11
Compositional biasⁱ	563 – 566	Poly-Ala	4
Compositional biasⁱ	789 – 794	Poly-Ser	6

Domainⁱ

The extracellular domain represents the IL4 binding protein (IL4BP).

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Sequence similaritiesⁱ

Belongs to the type I cytokine receptor family. Type 4 subfamily.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG502S3Y8, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000049182
HOGENOMⁱ	CLU_020561_0_0_1
InParanoidⁱ	P24394
OMAⁱ	WCPVEVS
PhylomeDBⁱ	P24394
TreeFamⁱ	TF337996

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063, FN3, 1 hit
Gene3Dⁱ	2.60.40.10, 2 hits
IDEALⁱ	IID00653
InterProⁱ	View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003531, Hempt_rcpt_S_F1_CS IPR013783, Ig-like_fold IPR015319, IL-4_rcpt-alpha_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09238, IL4Ra_N, 1 hit
SUPFAMⁱ	SSF49265, SSF49265, 2 hits
PROSITEⁱ	View protein in PROSITE PS50853, FN3, 1 hit PS01355, HEMATOPO_REC_S_F1, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P24394-1) [UniParc]FASTA Add to basket

Also known as: Membrane-bound form

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG 
        60         70         80         90        100
PTNCSTELRL LYQLVFLLSE AHTCIPENNG GAGCVCHLLM DDVVSADNYT 
       110        120        130        140        150
LDLWAGQQLL WKGSFKPSEH VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD 
       160        170        180        190        200
NYLYNHLTYA VNIWSENDPA DFRIYNVTYL EPSLRIAAST LKSGISYRAR 
       210        220        230        240        250
VRAWAQCYNT TWSEWSPSTK WHNSYREPFE QHLLLGVSVS CIVILAVCLL 
       260        270        280        290        300
CYVSITKIKK EWWDQIPNPA RSRLVAIIIQ DAQGSQWEKR SRGQEPAKCP 
       310        320        330        340        350
HWKNCLTKLL PCFLEHNMKR DEDPHKAAKE MPFQGSGKSA WCPVEISKTV 
       360        370        380        390        400
LWPESISVVR CVELFEAPVE CEEEEEVEEE KGSFCASPES SRDDFQEGRE 
       410        420        430        440        450
GIVARLTESL FLDLLGEENG GFCQQDMGES CLLPPSGSTS AHMPWDEFPS 
       460        470        480        490        500
AGPKEAPPWG KEQPLHLEPS PPASPTQSPD NLTCTETPLV IAGNPAYRSF 
       510        520        530        540        550
SNSLSQSPCP RELGPDPLLA RHLEEVEPEM PCVPQLSEPT TVPQPEPETW 
       560        570        580        590        600
EQILRRNVLQ HGAAAAPVSA PTSGYQEFVH AVEQGGTQAS AVVGLGPPGE 
       610        620        630        640        650
AGYKAFSSLL ASSAVSPEKC GFGASSGEEG YKPFQDLIPG CPGDPAPVPV 
       660        670        680        690        700
PLFTFGLDRE PPRSPQSSHL PSSSPEHLGL EPGEKVEDMP KPPLPQEQAT 
       710        720        730        740        750
DPLVDSLGSG IVYSALTCHL CGHLKQCHGQ EDGGQTPVMA SPCCGCCCGD 
       760        770        780        790        800
RSSPPTTPLR APDPSPGGVP LEASLCPASL APSGISEKSK SSSSFHPAPG 
       810        820 
NAQSSSQTPK IVNFVSVGPT YMRVS

Length:825

Mass (Da):89,658

Last modified:March 1, 1992 - v1

Checksum:ⁱ9F886DF5612297F8

GO

Isoform 2 (identifier: P24394-2) [UniParc]FASTA Add to basket

Also known as: Soluble form, sIL4Ralpha/splice

The sequence of this isoform differs from the canonical sequence as follows:
225-227: YRE → NIC
228-825: Missing.

« Hide

        10         20         30         40         50
MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG 
        60         70         80         90        100
PTNCSTELRL LYQLVFLLSE AHTCIPENNG GAGCVCHLLM DDVVSADNYT 
       110        120        130        140        150
LDLWAGQQLL WKGSFKPSEH VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD 
       160        170        180        190        200
NYLYNHLTYA VNIWSENDPA DFRIYNVTYL EPSLRIAAST LKSGISYRAR 
       210        220 
VRAWAQCYNT TWSEWSPSTK WHNSNIC

Show »

Length:227

Mass (Da):25,553

Checksum:ⁱ9FE8FCC827717CC5

GO

Isoform 3 (identifier: P24394-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-23: MGWLCSGLLFPVSCLVLLQVASS → MQKDARRE

« Hide

        10         20         30         40         50
MQKDARREGN MKVLQEPTCV SDYMSISTCE WKMNGPTNCS TELRLLYQLV 
        60         70         80         90        100
FLLSEAHTCI PENNGGAGCV CHLLMDDVVS ADNYTLDLWA GQQLLWKGSF 
       110        120        130        140        150
KPSEHVKPRA PGNLTVHTNV SDTLLLTWSN PYPPDNYLYN HLTYAVNIWS 
       160        170        180        190        200
ENDPADFRIY NVTYLEPSLR IAASTLKSGI SYRARVRAWA QCYNTTWSEW 
       210        220        230        240        250
SPSTKWHNSY REPFEQHLLL GVSVSCIVIL AVCLLCYVSI TKIKKEWWDQ 
       260        270        280        290        300
IPNPARSRLV AIIIQDAQGS QWEKRSRGQE PAKCPHWKNC LTKLLPCFLE 
       310        320        330        340        350
HNMKRDEDPH KAAKEMPFQG SGKSAWCPVE ISKTVLWPES ISVVRCVELF 
       360        370        380        390        400
EAPVECEEEE EVEEEKGSFC ASPESSRDDF QEGREGIVAR LTESLFLDLL 
       410        420        430        440        450
GEENGGFCQQ DMGESCLLPP SGSTSAHMPW DEFPSAGPKE APPWGKEQPL 
       460        470        480        490        500
HLEPSPPASP TQSPDNLTCT ETPLVIAGNP AYRSFSNSLS QSPCPRELGP 
       510        520        530        540        550
DPLLARHLEE VEPEMPCVPQ LSEPTTVPQP EPETWEQILR RNVLQHGAAA 
       560        570        580        590        600
APVSAPTSGY QEFVHAVEQG GTQASAVVGL GPPGEAGYKA FSSLLASSAV 
       610        620        630        640        650
SPEKCGFGAS SGEEGYKPFQ DLIPGCPGDP APVPVPLFTF GLDREPPRSP 
       660        670        680        690        700
QSSHLPSSSP EHLGLEPGEK VEDMPKPPLP QEQATDPLVD SLGSGIVYSA 
       710        720        730        740        750
LTCHLCGHLK QCHGQEDGGQ TPVMASPCCG CCCGDRSSPP TTPLRAPDPS 
       760        770        780        790        800
PGGVPLEASL CPASLAPSGI SEKSKSSSSF HPAPGNAQSS SQTPKIVNFV 
       810
SVGPTYMRVS

Show »

Length:810

Mass (Da):88,267

Checksum:ⁱ234ADCAA655651CB

GO

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BRH7	H3BRH7_HUMAN	Interleukin-4 receptor subunit alph... Interleukin-4 receptor subunit alpha	IL4R	124	Annotation score:
H3BTD9	H3BTD9_HUMAN	Interleukin-4 receptor subunit alph... Interleukin-4 receptor subunit alpha	IL4R	63	Annotation score:
J9JII2	J9JII2_HUMAN	Interleukin-4 receptor subunit alph... Interleukin-4 receptor subunit alpha	IL4R	120	Annotation score:
H3BSE7	H3BSE7_HUMAN	Interleukin-4 receptor subunit alph... Interleukin-4 receptor subunit alpha	IL4R	49	Annotation score:
I3L4W9	I3L4W9_HUMAN	Interleukin-4 receptor subunit alph... Interleukin-4 receptor subunit alpha	IL4R	193	Annotation score:
I3L4H7	I3L4H7_HUMAN	Interleukin-4 receptor subunit alph... Interleukin-4 receptor subunit alpha	IL4R	133	Annotation score:
Q5FC08	Q5FC08_HUMAN	IL4R nirs variant 1 IL4R nirs variant 1 (Interleukin-4 receptor subunit alpha)	IL4R	66	Annotation score:
A0A0G2JLA1	A0A0G2JLA1_HUMAN	Interleukin-4 receptor subunit alph... Interleukin-4 receptor subunit alpha	IL4R	10	Annotation score:

Polymorphismⁱ

Allelic variants in IL4RA are associated with a susceptibility to atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema.

Allelic variants in IL4RA are associated with cedar pollen sensitization. Individuals develop Japanese cedar pollinosis with increased exposure to cedar pollen. Japanese cedar pollinosis is a type I allergic disease with ocular and nasal symptoms that develop paroxysmally on contact with Japanese cedar pollen. These symptoms, which occur seasonally each year, are typical features of allergic rhinitis, such as sneezing, excessive nasal secretion, nasal congestion, and conjunctival itching.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_059302	75	I → F. Corresponds to variant dbSNP:rs1805010EnsemblClinVar.	1
Natural variantⁱVAR_059303	75	I → L. Corresponds to variant dbSNP:rs1805010EnsemblClinVar.	1
Natural variantⁱVAR_008034	75	I → V Associated with atopic asthma and cedar pollen sensitization. 5 PublicationsCorresponds to variant dbSNP:rs1805010EnsemblClinVar.	1
Natural variantⁱVAR_019999	387	S → L. Corresponds to variant dbSNP:rs6413500EnsemblClinVar.	1
Natural variantⁱVAR_011657	400	E → A Associated with cedar pollen sensitization. 4 PublicationsCorresponds to variant dbSNP:rs1805011Ensembl.	1
Natural variantⁱVAR_011658	431	C → R3 PublicationsCorresponds to variant dbSNP:rs1805012Ensembl.	1
Natural variantⁱVAR_011659	436	S → L3 PublicationsCorresponds to variant dbSNP:rs1805013Ensembl.	1
Natural variantⁱVAR_049164	492	A → T. Corresponds to variant dbSNP:rs35606110EnsemblClinVar.	1
Natural variantⁱVAR_049165	492	A → V. Corresponds to variant dbSNP:rs34727572Ensembl.	1
Natural variantⁱVAR_011660	503	S → P Lowered total IgE concentration. 3 PublicationsCorresponds to variant dbSNP:rs1805015EnsemblClinVar.	1
Natural variantⁱVAR_008035	576	Q → R Associated with atopic dermatitis; lowered total IgE concentration; no effect on IL4-induced signal transduction. 6 PublicationsCorresponds to variant dbSNP:rs1801275EnsemblClinVar.	1
Natural variantⁱVAR_011661	579	V → I2 PublicationsCorresponds to variant dbSNP:rs3024677EnsemblClinVar.	1
Natural variantⁱVAR_020000	675	P → S1 PublicationCorresponds to variant dbSNP:rs3024678Ensembl.	1
Natural variantⁱVAR_011662	752	S → A2 PublicationsCorresponds to variant dbSNP:rs1805016Ensembl.	1
Natural variantⁱVAR_011663	786	S → P in 1.8% of the population. 2 PublicationsCorresponds to variant dbSNP:rs1805014EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053738	1 – 23	MGWLC…QVASS → MQKDARRE in isoform 3. 1 PublicationAdd BLAST	23
Alternative sequenceⁱVSP_011116	225 – 227	YRE → NIC in isoform 2. Curated	3
Alternative sequenceⁱVSP_011117	228 – 825	Missing in isoform 2. CuratedAdd BLAST	598

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X52425 mRNA Translation: CAA36672.1 AC004525 Genomic DNA Translation: AAC23495.1 AF421855 Genomic DNA Translation: AAL12163.1 AJ293647 Genomic DNA Translation: CAC20445.1 AJ293648 Genomic DNA Translation: CAC20446.1 AJ293649 Genomic DNA Translation: CAC20447.1 AJ293650 Genomic DNA Translation: CAC20448.1 AJ293651 Genomic DNA Translation: CAC20449.1 AJ293652 Genomic DNA Translation: CAC20450.1 AJ293653 Genomic DNA Translation: CAC20451.1 AK303255 mRNA Translation: BAG64338.1 AC106739 Genomic DNA No translation available. BC151131 mRNA Translation: AAI51132.1 AJ293654 Genomic DNA Translation: CAC20452.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10629.1 [P24394-1] CCDS58441.1 [P24394-3]
PIRⁱ	A60386
NCBI Reference Sequences More...RefSeqⁱ	NP_000409.1, NM_000418.3 [P24394-1] NP_001244335.1, NM_001257406.1 [P24394-1] NP_001244336.1, NM_001257407.1 [P24394-3] XP_011544127.1, XM_011545825.1 [P24394-1] XP_011544128.1, XM_011545826.2 [P24394-1] XP_011544129.1, XM_011545827.2 [P24394-1]

Genome annotation databases

Ensemblⁱ	ENST00000170630; ENSP00000170630; ENSG00000077238 [P24394-3] ENST00000395762; ENSP00000379111; ENSG00000077238 [P24394-1] ENST00000543915; ENSP00000441667; ENSG00000077238 [P24394-1]
GeneIDⁱ	3566
KEGGⁱ	hsa:3566
UCSC genome browser More...UCSCⁱ	uc002don.5, human [P24394-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24394	Interleukin-4 receptor subunit alpha (Fragment)		HUMAN		120	UniRef100_P24394
+3

Protein	Similar proteins		Species	Score	Length	Source
P24394	Interleukin-4 receptor subunit alpha (Fragment)		HUMAN		120	UniRef90_P24394
Interleukin-4 receptor subunit alpha		PANPA		873
Interleukin-4 receptor subunit alpha		PONAB		871
Interleukin-4 receptor subunit alpha		PANTR		827
Interleukin-4 receptor subunit alpha		CERAT		825
+59

Protein	Similar proteins		Species	Score	Length	Source
P24394	Interleukin-4 receptor subunit alpha		HORSE		809	UniRef50_P24394
Interleukin-4 receptor subunit alpha		PIG		830
Interleukin-4 receptor subunit alpha (Fragment)		HUMAN		120
Interleukin-4 receptor subunit alpha		PANPA		873
Interleukin-4 receptor subunit alpha		PONAB		871
+258
P24394-2	interleukin-4 receptor subunit alpha-like		SHEEP		202	UniRef50_P24394-2
Isoform 2 of Interleukin-4 receptor subunit alpha		HORSE		224
IL4R		CEREH		224
Interleukin-4 receptor subunit alpha (Fragment)		BOVIN		234
+5

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X52425 mRNA Translation: CAA36672.1 AC004525 Genomic DNA Translation: AAC23495.1 AF421855 Genomic DNA Translation: AAL12163.1 AJ293647 Genomic DNA Translation: CAC20445.1 AJ293648 Genomic DNA Translation: CAC20446.1 AJ293649 Genomic DNA Translation: CAC20447.1 AJ293650 Genomic DNA Translation: CAC20448.1 AJ293651 Genomic DNA Translation: CAC20449.1 AJ293652 Genomic DNA Translation: CAC20450.1 AJ293653 Genomic DNA Translation: CAC20451.1 AK303255 mRNA Translation: BAG64338.1 AC106739 Genomic DNA No translation available. BC151131 mRNA Translation: AAI51132.1 AJ293654 Genomic DNA Translation: CAC20452.1
CCDSⁱ	CCDS10629.1 [P24394-1] CCDS58441.1 [P24394-3]
PIRⁱ	A60386
RefSeqⁱ	NP_000409.1, NM_000418.3 [P24394-1] NP_001244335.1, NM_001257406.1 [P24394-1] NP_001244336.1, NM_001257407.1 [P24394-3] XP_011544127.1, XM_011545825.1 [P24394-1] XP_011544128.1, XM_011545826.2 [P24394-1] XP_011544129.1, XM_011545827.2 [P24394-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IAR	X-ray	2.30	B	26-232	[»]
	1IRS	NMR	-	B	489-499	[»]
	1ITE	model	-	C	26-232	[»]
	3BPL	X-ray	2.93	B	27-227	[»]
	3BPN	X-ray	3.02	B	27-227	[»]
	3BPO	X-ray	3.00	B	27-227	[»]
	5E4E	X-ray	3.00	B	26-228	[»]
	6OEL	X-ray	3.10	B	27-224	[»]
	6WGL	X-ray	2.82	C	26-232	[»]
SMRⁱ	P24394
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	109780, 43 interactors
CORUMⁱ	P24394
DIPⁱ	DIP-3223N
ELMⁱ	P24394
IntActⁱ	P24394, 34 interactors
MINTⁱ	P24394
STRINGⁱ	9606.ENSP00000379111

Chemistry databases

ChEMBLⁱ	CHEMBL3580490
DrugBankⁱ	DB05078, AER001 DB12159, Dupilumab
DrugCentralⁱ	P24394
GuidetoPHARMACOLOGYⁱ	1697

Protein family/group databases

TCDBⁱ	8.A.152.1.9, the interleukin receptor (ilr) family

TCDBⁱ

8.A.152.1.9, the interleukin receptor (ilr) family

PTM databases

GlyConnectⁱ	2053, 1 N-Linked glycan (1 site)
GlyGenⁱ	P24394, 6 sites, 1 N-linked glycan (1 site)
iPTMnetⁱ	P24394
PhosphoSitePlusⁱ	P24394

Genetic variation databases

BioMutaⁱ	IL4R
DMDMⁱ	124335

Proteomic databases

jPOSTⁱ	P24394
MassIVEⁱ	P24394
PaxDbⁱ	P24394
PeptideAtlasⁱ	P24394
PRIDEⁱ	P24394
ProteomicsDBⁱ	54203 [P24394-1] 54204 [P24394-2] 5656

Protocols and materials databases

ABCDⁱ	P24394, 48 sequenced antibodies
Antibodypediaⁱ	3843, 685 antibodies

Genome annotation databases

Ensemblⁱ	ENST00000170630; ENSP00000170630; ENSG00000077238 [P24394-3] ENST00000395762; ENSP00000379111; ENSG00000077238 [P24394-1] ENST00000543915; ENSP00000441667; ENSG00000077238 [P24394-1]
GeneIDⁱ	3566
KEGGⁱ	hsa:3566
UCSCⁱ	uc002don.5, human [P24394-1]

Organism-specific databases

CTDⁱ	3566
DisGeNETⁱ	3566
GeneCardsⁱ	IL4R
HGNCⁱ	HGNC:6015, IL4R
HPAⁱ	ENSG00000077238, Low tissue specificity
MalaCardsⁱ	IL4R
MIMⁱ	147781, gene
neXtProtⁱ	NX_P24394
OpenTargetsⁱ	ENSG00000077238
PharmGKBⁱ	PA29832
VEuPathDBⁱ	HostDB:ENSG00000077238.13
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502S3Y8, Eukaryota
GeneTreeⁱ	ENSGT00510000049182
HOGENOMⁱ	CLU_020561_0_0_1
InParanoidⁱ	P24394
OMAⁱ	WCPVEVS
PhylomeDBⁱ	P24394
TreeFamⁱ	TF337996

Enzyme and pathway databases

PathwayCommonsⁱ	P24394
Reactomeⁱ	R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
SignaLinkⁱ	P24394
SIGNORⁱ	P24394

Miscellaneous databases

BioGRID-ORCSⁱ	3566, 3 hits in 990 CRISPR screens
ChiTaRSⁱ	IL4R, human
EvolutionaryTraceⁱ	P24394
GeneWikiⁱ	Interleukin-4_receptor
GenomeRNAiⁱ	3566
Pharosⁱ	P24394, Tclin
Protein Ontology More...PROⁱ	PR:P24394
RNActⁱ	P24394, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000077238, Expressed in left adrenal gland and 206 other tissues
ExpressionAtlasⁱ	P24394, baseline and differential
Genevisibleⁱ	P24394, HS

Family and domain databases

CDDⁱ	cd00063, FN3, 1 hit
Gene3Dⁱ	2.60.40.10, 2 hits
IDEALⁱ	IID00653
InterProⁱ	View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003531, Hempt_rcpt_S_F1_CS IPR013783, Ig-like_fold IPR015319, IL-4_rcpt-alpha_N
Pfamⁱ	View protein in Pfam PF09238, IL4Ra_N, 1 hit
SUPFAMⁱ	SSF49265, SSF49265, 2 hits
PROSITEⁱ	View protein in PROSITE PS50853, FN3, 1 hit PS01355, HEMATOPO_REC_S_F1, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL4RA_HUMAN
Accessionⁱ	P24394Primary (citable) accession number: P24394 Secondary accession number(s): B4E076 Q9H188
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	March 1, 1992
	Last modified:	April 7, 2021
	This is version 227 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P24394 (IL4RA_HUMAN)

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Interleukin-4 receptor subunit alpha

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - Cellular componenti

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

P24394

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

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Alternative sequence

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

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Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

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Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ