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Protein

Corticotropin-releasing factor-binding protein

Gene

CRHBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

GO - Molecular functioni

  • corticotropin-releasing hormone binding Source: UniProtKB
  • peptide binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Corticotropin-releasing factor-binding protein
Short name:
CRF-BP
Short name:
CRF-binding protein
Alternative name(s):
Corticotropin-releasing hormone-binding protein
Short name:
CRH-BP
Gene namesi
Name:CRHBP
Synonyms:CRFBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145708.10
HGNCiHGNC:2356 CRHBP
MIMi122559 gene
neXtProtiNX_P24387

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1393
OpenTargetsiENSG00000145708
PharmGKBiPA26873

Chemistry databases

ChEMBLiCHEMBL5930

Polymorphism and mutation databases

BioMutaiCRHBP
DMDMi544099

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000002099425 – 322Corticotropin-releasing factor-binding proteinAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 811 Publication
Disulfide bondi104 ↔ 1411 Publication
Disulfide bondi183 ↔ 2051 Publication
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi237 ↔ 2641 Publication
Disulfide bondi277 ↔ 3181 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP24387
PeptideAtlasiP24387
PRIDEiP24387
ProteomicsDBi54201

PTM databases

iPTMnetiP24387
PhosphoSitePlusiP24387

Expressioni

Gene expression databases

BgeeiENSG00000145708 Expressed in 126 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_CRHBP
ExpressionAtlasiP24387 baseline and differential
GenevisibleiP24387 HS

Organism-specific databases

HPAiHPA046120

Interactioni

Protein-protein interaction databases

BioGridi107783, 13 interactors
STRINGi9606.ENSP00000274368

Chemistry databases

BindingDBiP24387

Structurei

3D structure databases

ProteinModelPortaliP24387
SMRiP24387
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CRF-binding protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II3D Eukaryota
ENOG4111JUQ LUCA
GeneTreeiENSGT00390000001362
HOGENOMiHOG000004819
HOVERGENiHBG051117
InParanoidiP24387
OMAiEITMKHY
OrthoDBiEOG091G094Q
PhylomeDBiP24387
TreeFamiTF105383

Family and domain databases

InterProiView protein in InterPro
IPR008435 CRF-bd
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR10278 PTHR10278, 1 hit
PfamiView protein in Pfam
PF05428 CRF-BP, 1 hit
PIRSFiPIRSF009279 CRF_bd, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P24387-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG
60 70 80 90 100
EQPYRRALRC LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV
110 120 130 140 150
SIDCQGGDFL KVFDGWILKG EKFPSSQDHP LPSAERYIDF CESGLSRRSI
160 170 180 190 200
RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL FPCNVISQTP NGKFTLVVPH
210 220 230 240 250
QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI GDFVELLGGT
260 270 280 290 300
GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ
310 320
LEPYELENPN GNSIGEFCLS GL
Length:322
Mass (Da):36,144
Last modified:June 1, 1994 - v2
Checksum:i771A894BE06039BD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHH7D6RHH7_HUMAN
Corticotropin-releasing factor-bind...
CRHBP
238Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279N → D in BAD97177 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58022 mRNA Translation: CAA41086.1 Sequence problems.
S60697 Genomic DNA Translation: AAD13916.1
CR541666 mRNA Translation: CAG46467.1
AK223457 mRNA Translation: BAD97177.1
CH471084 Genomic DNA Translation: EAW95786.1
BC018038 mRNA Translation: AAH18038.1
CCDSiCCDS4034.1
PIRiS13640
RefSeqiNP_001873.2, NM_001882.3
UniGeneiHs.115617

Genome annotation databases

EnsembliENST00000274368; ENSP00000274368; ENSG00000145708
GeneIDi1393
KEGGihsa:1393
UCSCiuc003ker.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58022 mRNA Translation: CAA41086.1 Sequence problems.
S60697 Genomic DNA Translation: AAD13916.1
CR541666 mRNA Translation: CAG46467.1
AK223457 mRNA Translation: BAD97177.1
CH471084 Genomic DNA Translation: EAW95786.1
BC018038 mRNA Translation: AAH18038.1
CCDSiCCDS4034.1
PIRiS13640
RefSeqiNP_001873.2, NM_001882.3
UniGeneiHs.115617

3D structure databases

ProteinModelPortaliP24387
SMRiP24387
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107783, 13 interactors
STRINGi9606.ENSP00000274368

Chemistry databases

BindingDBiP24387
ChEMBLiCHEMBL5930

PTM databases

iPTMnetiP24387
PhosphoSitePlusiP24387

Polymorphism and mutation databases

BioMutaiCRHBP
DMDMi544099

Proteomic databases

PaxDbiP24387
PeptideAtlasiP24387
PRIDEiP24387
ProteomicsDBi54201

Protocols and materials databases

DNASUi1393
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274368; ENSP00000274368; ENSG00000145708
GeneIDi1393
KEGGihsa:1393
UCSCiuc003ker.4 human

Organism-specific databases

CTDi1393
DisGeNETi1393
EuPathDBiHostDB:ENSG00000145708.10
GeneCardsiCRHBP
HGNCiHGNC:2356 CRHBP
HPAiHPA046120
MIMi122559 gene
neXtProtiNX_P24387
OpenTargetsiENSG00000145708
PharmGKBiPA26873
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II3D Eukaryota
ENOG4111JUQ LUCA
GeneTreeiENSGT00390000001362
HOGENOMiHOG000004819
HOVERGENiHBG051117
InParanoidiP24387
OMAiEITMKHY
OrthoDBiEOG091G094Q
PhylomeDBiP24387
TreeFamiTF105383

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)

Miscellaneous databases

GeneWikiiCRHBP
GenomeRNAii1393
PROiPR:P24387
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145708 Expressed in 126 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_CRHBP
ExpressionAtlasiP24387 baseline and differential
GenevisibleiP24387 HS

Family and domain databases

InterProiView protein in InterPro
IPR008435 CRF-bd
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR10278 PTHR10278, 1 hit
PfamiView protein in Pfam
PF05428 CRF-BP, 1 hit
PIRSFiPIRSF009279 CRF_bd, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRHBP_HUMAN
AccessioniPrimary (citable) accession number: P24387
Secondary accession number(s): Q53F32, Q6FHT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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