UniProtKB - P24385 (CCND1_HUMAN)
G1/S-specific cyclin-D1
CCND1
Functioni
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162, PubMed:33854235).
Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162).
Hypophosphorylates RB1 in early G1 phase (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162).
Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:1833066, PubMed:1827756, PubMed:8302605, PubMed:19412162).
Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed:15241418).
Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:9106657).
Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed:16569215, PubMed:18417529).
10 PublicationsGO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
- enzyme binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- proline-rich region binding Source: UniProtKB
- protein-containing complex binding Source: Ensembl
- protein kinase activity Source: Ensembl
- protein kinase binding Source: UniProtKB
- transcription corepressor activity Source: UniProtKB
GO - Biological processi
- cell division Source: UniProtKB-KW
- cellular response to DNA damage stimulus Source: UniProtKB
- endoplasmic reticulum unfolded protein response Source: Ensembl
- fat cell differentiation Source: Ensembl
- G1/S transition of mitotic cell cycle Source: UniProtKB
- lactation Source: Ensembl
- Leydig cell differentiation Source: Ensembl
- liver regeneration Source: Ensembl
- mammary gland alveolus development Source: Ensembl
- mammary gland epithelial cell proliferation Source: Ensembl
- mitotic cell cycle phase transition Source: GO_Central
- mitotic G1 DNA damage checkpoint signaling Source: UniProtKB
- negative regulation of epithelial cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
- positive regulation of G1/S transition of mitotic cell cycle Source: GO_Central
- positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
- positive regulation of mammary gland epithelial cell proliferation Source: Ensembl
- positive regulation of protein phosphorylation Source: BHF-UCL
- re-entry into mitotic cell cycle Source: Ensembl
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- response to calcium ion Source: Ensembl
- response to corticosterone Source: Ensembl
- response to estradiol Source: Ensembl
- response to estrogen Source: Ensembl
- response to ethanol Source: Ensembl
- response to iron ion Source: Ensembl
- response to leptin Source: UniProtKB
- response to magnesium ion Source: Ensembl
- response to organonitrogen compound Source: Ensembl
- response to UV-A Source: BHF-UCL
- response to vitamin E Source: Ensembl
- response to xenobiotic stimulus Source: UniProtKB
- response to X-ray Source: Ensembl
- Wnt signaling pathway Source: Ensembl
Keywordsi
Molecular function | Cyclin, Repressor |
Biological process | Cell cycle, Cell division, DNA damage, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P24385 |
Reactomei | R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-3214858, RMTs methylate histone arginines R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-69231, Cyclin D associated events in G1 R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8849470, PTK6 Regulates Cell Cycle R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-8878166, Transcriptional regulation by RUNX2 R-HSA-8934593, Regulation of RUNX1 Expression and Activity R-HSA-8951430, RUNX3 regulates WNT signaling R-HSA-8951936, RUNX3 regulates p14-ARF R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9661069, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) |
SignaLinki | P24385 |
SIGNORi | P24385 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: G1/S-specific cyclin-D11 PublicationAlternative name(s): B-cell lymphoma 1 protein1 Publication Short name: BCL-11 Publication BCL-1 oncogene1 Publication PRAD1 oncogene1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1582, CCND1 |
MIMi | 168461, gene |
neXtProti | NX_P24385 |
VEuPathDBi | HostDB:ENSG00000110092 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
- Nucleus membrane 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.1 Publication
Cytosol
- cytosol Source: Reactome
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- bicellular tight junction Source: Ensembl
- cyclin D1-CDK4 complex Source: ComplexPortal
- cyclin-dependent protein kinase holoenzyme complex Source: BHF-UCL
- cytoplasm Source: GO_Central
- transcription repressor complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Multiple myeloma (MM)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 286 – 288 | TPT → ATA: Reduced ubiquitination and subsequent degradation by the proteasome. 1 Publication | 3 | |
Mutagenesisi | 286 | T → A: Reduced interaction with the DCX(AMBRA1) complex, and subsequent ubiquitination and degradation by the proteasome. Abolished ubiquitination and subsequent degradation following DNA damage. 4 Publications | 1 | |
Mutagenesisi | 287 | P → A, L or S: Reduced interaction with the DCX(AMBRA1) complex, and subsequent ubiquitination and degradation by the proteasome. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 595 |
MalaCardsi | CCND1 |
MIMi | 254500, phenotype |
OpenTargetsi | ENSG00000110092 |
Orphaneti | 67038, B-cell chronic lymphocytic leukemia 52416, Mantle cell lymphoma 29073, Multiple myeloma |
PharmGKBi | PA75 |
Miscellaneous databases
Pharosi | P24385, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3610 |
DrugBanki | DB00945, Acetylsalicylic acid DB01169, Arsenic trioxide DB11752, Bryostatin 1 DB11718, Encorafenib |
DrugCentrali | P24385 |
Genetic variation databases
BioMutai | CCND1 |
DMDMi | 116152 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080430 | 1 – 295 | G1/S-specific cyclin-D1Add BLAST | 295 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 269 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 286 | PhosphothreonineCombined sources4 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P24385 |
jPOSTi | P24385 |
MassIVEi | P24385 |
PaxDbi | P24385 |
PeptideAtlasi | P24385 |
PRIDEi | P24385 |
ProteomicsDBi | 54198 |
PTM databases
GlyGeni | P24385, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P24385 |
PhosphoSitePlusi | P24385 |
Expressioni
Gene expression databases
Bgeei | ENSG00000110092, Expressed in endometrium epithelium and 230 other tissues |
ExpressionAtlasi | P24385, baseline and differential |
Genevisiblei | P24385, HS |
Organism-specific databases
HPAi | ENSG00000110092, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex (PubMed:8114739, PubMed:19237565). The cyclin subunit imparts substrate specificity to the complex (PubMed:20399237, PubMed:19237565, PubMed:8302605, PubMed:9106657).
Component of the ternary complex CCND1/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity (PubMed:9106657).
Interacts directly with CDKN1B (By similarity). Can form similar complexes with either CDKN1A or CDKN2A (By similarity).
Interacts with FBXO4 (By similarity).
Interacts with UHRF2; the interaction ubiquitinates CCND1 and appears to occur independently of phosphorylation (PubMed:21952639).
Interacts with USP2 (PubMed:19917254).
Interacts (via cyclin N-terminal domain) with INSM1 (via N-terminal region); the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and inhibits CDK4 activity (PubMed:16569215, PubMed:18417529, PubMed:19124461).
Interacts with CDK4; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression (PubMed:19124461).
By similarity10 PublicationsBinary interactionsi
P24385
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- proline-rich region binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107067, 256 interactors |
ComplexPortali | CPX-2010, Cyclin D1-CDK4 complex CPX-2014, Cyclin D1-CDK6 complex |
CORUMi | P24385 |
DIPi | DIP-123N |
IntActi | P24385, 70 interactors |
MINTi | P24385 |
STRINGi | 9606.ENSP00000227507 |
Chemistry databases
BindingDBi | P24385 |
Miscellaneous databases
RNActi | P24385, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P24385 |
SMRi | P24385 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P24385 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 152 | Cyclin N-terminalAdd BLAST | 125 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 262 – 295 | DisorderedSequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0656, Eukaryota |
GeneTreei | ENSGT00940000157816 |
HOGENOMi | CLU_052190_0_0_1 |
InParanoidi | P24385 |
OMAi | SCYRTTH |
OrthoDBi | 1234739at2759 |
PhylomeDBi | P24385 |
TreeFami | TF101004 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
DisProti | DP02226 |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR015451, Cyclin_D IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF67, PTHR10177:SF67, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK
60 70 80 90 100
EVLPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ
110 120 130 140 150
LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW
160 170 180 190 200
NLAAMTPHDF IEHFLSKMPE AEENKQIIRK HAQTFVALCA TDVKFISNPP
210 220 230 240 250
SMVAAGSVVA AVQGLNLRSP NNFLSYYRLT RFLSRVIKCD PDCLRACQEQ
260 270 280 290
IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF5H437 | F5H437_HUMAN | G1/S-specific cyclin-D1 | CCND1 | 67 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 130 | N → G in AAA52136 (PubMed:1827756).Curated | 1 | |
Sequence conflicti | 168 – 169 | MP → IA in M74092 (PubMed:1833066).Curated | 2 | |
Sequence conflicti | 188 | L → S in AAA52136 (PubMed:1827756).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59798 mRNA Translation: CAA42470.1 M74092 mRNA No translation available. M64349 mRNA Translation: AAA52136.1 M73554 mRNA Translation: AAA58392.1 Z23022 mRNA Translation: CAA80558.1 BT019845 mRNA Translation: AAV38648.1 AF511593 Genomic DNA Translation: AAM34300.2 BC000076 mRNA Translation: AAH00076.1 BC001501 mRNA Translation: AAH01501.1 BC014078 mRNA Translation: AAH14078.1 BC023620 mRNA Translation: AAH23620.1 BC025302 mRNA Translation: AAH25302.1 L09054 Genomic DNA Translation: AAA36481.1 |
CCDSi | CCDS8191.1 |
PIRi | A38977 |
RefSeqi | NP_444284.1, NM_053056.2 |
Genome annotation databases
Ensembli | ENST00000227507.3; ENSP00000227507.2; ENSG00000110092.4 |
GeneIDi | 595 |
KEGGi | hsa:595 |
MANE-Selecti | ENST00000227507.3; ENSP00000227507.2; NM_053056.3; NP_444284.1 |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
SHMPD The Singapore human mutation and polymorphism database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59798 mRNA Translation: CAA42470.1 M74092 mRNA No translation available. M64349 mRNA Translation: AAA52136.1 M73554 mRNA Translation: AAA58392.1 Z23022 mRNA Translation: CAA80558.1 BT019845 mRNA Translation: AAV38648.1 AF511593 Genomic DNA Translation: AAM34300.2 BC000076 mRNA Translation: AAH00076.1 BC001501 mRNA Translation: AAH01501.1 BC014078 mRNA Translation: AAH14078.1 BC023620 mRNA Translation: AAH23620.1 BC025302 mRNA Translation: AAH25302.1 L09054 Genomic DNA Translation: AAA36481.1 |
CCDSi | CCDS8191.1 |
PIRi | A38977 |
RefSeqi | NP_444284.1, NM_053056.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2W96 | X-ray | 2.30 | A | 1-271 | [»] | |
2W99 | X-ray | 2.80 | A | 1-271 | [»] | |
2W9F | X-ray | 2.85 | A | 1-271 | [»] | |
2W9Z | X-ray | 2.45 | A | 16-271 | [»] | |
5VZU | X-ray | 2.70 | E/F | 279-295 | [»] | |
6P8E | X-ray | 2.30 | A | 19-267 | [»] | |
6P8F | X-ray | 2.89 | A | 19-267 | [»] | |
6P8G | X-ray | 2.80 | A | 19-267 | [»] | |
6P8H | X-ray | 3.19 | A | 19-267 | [»] | |
AlphaFoldDBi | P24385 | |||||
SMRi | P24385 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107067, 256 interactors |
ComplexPortali | CPX-2010, Cyclin D1-CDK4 complex CPX-2014, Cyclin D1-CDK6 complex |
CORUMi | P24385 |
DIPi | DIP-123N |
IntActi | P24385, 70 interactors |
MINTi | P24385 |
STRINGi | 9606.ENSP00000227507 |
Chemistry databases
BindingDBi | P24385 |
ChEMBLi | CHEMBL3610 |
DrugBanki | DB00945, Acetylsalicylic acid DB01169, Arsenic trioxide DB11752, Bryostatin 1 DB11718, Encorafenib |
DrugCentrali | P24385 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
GlyGeni | P24385, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P24385 |
PhosphoSitePlusi | P24385 |
Genetic variation databases
BioMutai | CCND1 |
DMDMi | 116152 |
Proteomic databases
EPDi | P24385 |
jPOSTi | P24385 |
MassIVEi | P24385 |
PaxDbi | P24385 |
PeptideAtlasi | P24385 |
PRIDEi | P24385 |
ProteomicsDBi | 54198 |
Protocols and materials databases
Antibodypediai | 3660, 2045 antibodies from 53 providers |
CPTCi | P24385, 7 antibodies |
DNASUi | 595 |
Genome annotation databases
Ensembli | ENST00000227507.3; ENSP00000227507.2; ENSG00000110092.4 |
GeneIDi | 595 |
KEGGi | hsa:595 |
MANE-Selecti | ENST00000227507.3; ENSP00000227507.2; NM_053056.3; NP_444284.1 |
Organism-specific databases
CTDi | 595 |
DisGeNETi | 595 |
GeneCardsi | CCND1 |
HGNCi | HGNC:1582, CCND1 |
HPAi | ENSG00000110092, Low tissue specificity |
MalaCardsi | CCND1 |
MIMi | 168461, gene 254500, phenotype |
neXtProti | NX_P24385 |
OpenTargetsi | ENSG00000110092 |
Orphaneti | 67038, B-cell chronic lymphocytic leukemia 52416, Mantle cell lymphoma 29073, Multiple myeloma |
PharmGKBi | PA75 |
VEuPathDBi | HostDB:ENSG00000110092 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0656, Eukaryota |
GeneTreei | ENSGT00940000157816 |
HOGENOMi | CLU_052190_0_0_1 |
InParanoidi | P24385 |
OMAi | SCYRTTH |
OrthoDBi | 1234739at2759 |
PhylomeDBi | P24385 |
TreeFami | TF101004 |
Enzyme and pathway databases
PathwayCommonsi | P24385 |
Reactomei | R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-3214858, RMTs methylate histone arginines R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-69231, Cyclin D associated events in G1 R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8849470, PTK6 Regulates Cell Cycle R-HSA-8853884, Transcriptional Regulation by VENTX R-HSA-8878166, Transcriptional regulation by RUNX2 R-HSA-8934593, Regulation of RUNX1 Expression and Activity R-HSA-8951430, RUNX3 regulates WNT signaling R-HSA-8951936, RUNX3 regulates p14-ARF R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9661069, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) |
SignaLinki | P24385 |
SIGNORi | P24385 |
Miscellaneous databases
BioGRID-ORCSi | 595, 528 hits in 1083 CRISPR screens |
ChiTaRSi | CCND1, human |
EvolutionaryTracei | P24385 |
GeneWikii | Cyclin_D1 |
GenomeRNAii | 595 |
Pharosi | P24385, Tchem |
PROi | PR:P24385 |
RNActi | P24385, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000110092, Expressed in endometrium epithelium and 230 other tissues |
ExpressionAtlasi | P24385, baseline and differential |
Genevisiblei | P24385, HS |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
DisProti | DP02226 |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR015451, Cyclin_D IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF67, PTHR10177:SF67, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCND1_HUMAN | |
Accessioni | P24385Primary (citable) accession number: P24385 Secondary accession number(s): Q6LEF0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 228 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families