UniProtKB - P24385 (CCND1_HUMAN)
G1/S-specific cyclin-D1
CCND1
Functioni
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
- enzyme binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- proline-rich region binding Source: UniProtKB
- protein-containing complex binding Source: Ensembl
- protein kinase activity Source: Ensembl
- protein kinase binding Source: UniProtKB
- transcription corepressor activity Source: UniProtKB
- transcription factor binding Source: UniProtKB
GO - Biological processi
- cell division Source: UniProtKB-KW
- cellular response to DNA damage stimulus Source: UniProtKB
- cytokine-mediated signaling pathway Source: Reactome
- endoplasmic reticulum unfolded protein response Source: Ensembl
- fat cell differentiation Source: Ensembl
- G1/S transition of mitotic cell cycle Source: UniProtKB
- lactation Source: Ensembl
- Leydig cell differentiation Source: Ensembl
- liver regeneration Source: Ensembl
- mammary gland alveolus development Source: Ensembl
- mammary gland epithelial cell proliferation Source: Ensembl
- mitotic cell cycle phase transition Source: GO_Central
- mitotic G1 DNA damage checkpoint Source: UniProtKB
- negative regulation of cell cycle arrest Source: UniProtKB
- negative regulation of epithelial cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of cell cycle Source: Reactome
- positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
- positive regulation of G1/S transition of mitotic cell cycle Source: GO_Central
- positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
- positive regulation of mammary gland epithelial cell proliferation Source: Ensembl
- positive regulation of protein phosphorylation Source: BHF-UCL
- re-entry into mitotic cell cycle Source: Ensembl
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- response to calcium ion Source: Ensembl
- response to corticosterone Source: Ensembl
- response to drug Source: UniProtKB
- response to estradiol Source: Ensembl
- response to estrogen Source: Ensembl
- response to ethanol Source: Ensembl
- response to iron ion Source: Ensembl
- response to leptin Source: UniProtKB
- response to magnesium ion Source: Ensembl
- response to organonitrogen compound Source: Ensembl
- response to UV-A Source: BHF-UCL
- response to vitamin E Source: Ensembl
- response to X-ray Source: Ensembl
- transcription initiation from RNA polymerase II promoter Source: Reactome
- Wnt signaling pathway Source: Ensembl
Keywordsi
Molecular function | Cyclin, Repressor |
Biological process | Cell cycle, Cell division, DNA damage, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-1912408 Pre-NOTCH Transcription and Translation R-HSA-3214858 RMTs methylate histone arginines R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-69231 Cyclin D associated events in G1 R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D R-HSA-8849470 PTK6 Regulates Cell Cycle R-HSA-8878166 Transcriptional regulation by RUNX2 R-HSA-8934593 Regulation of RUNX1 Expression and Activity R-HSA-8951430 RUNX3 regulates WNT signaling R-HSA-8951936 RUNX3 regulates p14-ARF R-HSA-9018519 Estrogen-dependent gene expression R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
SignaLinki | P24385 |
SIGNORi | P24385 |
Names & Taxonomyi
Protein namesi | Recommended name: G1/S-specific cyclin-D1Alternative name(s): B-cell lymphoma 1 protein Short name: BCL-1 BCL-1 oncogene PRAD1 oncogene |
Gene namesi | Name:CCND1 Synonyms:BCL1, PRAD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1582 CCND1 |
MIMi | 168461 gene |
neXtProti | NX_P24385 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
- Nucleus membrane 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.1 Publication
Cytosol
- cytosol Source: Reactome
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- bicellular tight junction Source: Ensembl
- cyclin-dependent protein kinase holoenzyme complex Source: BHF-UCL
- cytoplasm Source: GO_Central
- intracellular Source: LIFEdb
- transcriptional repressor complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Multiple myeloma (MM)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 286 | T → A: Reduces ubiquitination and subsequent degradation by the proteasome; when associated with A-288. Abolishes ubiquitination and subsequent degradation following DNA damage. 2 Publications | 1 | |
Mutagenesisi | 288 | T → A: Reduces ubiquitination and subsequent degradation by the proteasome; when associated with A-286. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 595 |
MalaCardsi | CCND1 |
MIMi | 254500 phenotype |
OpenTargetsi | ENSG00000110092 |
Orphaneti | 67038 B-cell chronic lymphocytic leukemia 52416 Mantle cell lymphoma 29073 Multiple myeloma |
PharmGKBi | PA75 |
Miscellaneous databases
Pharosi | P24385 |
Chemistry databases
ChEMBLi | CHEMBL3610 |
DrugBanki | DB00945 Acetylsalicylic acid DB01169 Arsenic trioxide DB11718 Encorafenib |
DrugCentrali | P24385 |
Polymorphism and mutation databases
BioMutai | CCND1 |
DMDMi | 116152 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080430 | 1 – 295 | G1/S-specific cyclin-D1Add BLAST | 295 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 269 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Modified residuei | 286 | PhosphothreonineCombined sources1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P24385 |
jPOSTi | P24385 |
MassIVEi | P24385 |
PaxDbi | P24385 |
PeptideAtlasi | P24385 |
PRIDEi | P24385 |
ProteomicsDBi | 54198 |
PTM databases
iPTMneti | P24385 |
PhosphoSitePlusi | P24385 |
Expressioni
Gene expression databases
Bgeei | ENSG00000110092 Expressed in 219 organ(s), highest expression level in endometrium epithelium |
ExpressionAtlasi | P24385 baseline and differential |
Genevisiblei | P24385 HS |
Organism-specific databases
HPAi | CAB000024 HPA027802 |
Interactioni
Subunit structurei
Interacts with FBXO4 (By similarity).
Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
Component of the ternary complex CCND1/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity.
Interacts directly with CDKN1B.
Interacts with UHRF2; the interaction ubiquitinates CCND1 and appears to occur independently of phosphorylation. Can form similar complexes with either CDKN1A or CDKN2A.
Interacts with USP2.
Interacts (via cyclin N-terminal domain) with INSM1 (via N-terminal region); the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and inhibits CDK4 activity.
Interacts with CDK4; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression.
By similarity9 PublicationsBinary interactionsi
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
- proline-rich region binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 107067, 108 interactors |
ComplexPortali | CPX-2010 Cyclin D1-CDK4 complex CPX-2014 Cyclin D1-CDK6 complex |
CORUMi | P24385 |
DIPi | DIP-123N |
IntActi | P24385, 68 interactors |
MINTi | P24385 |
STRINGi | 9606.ENSP00000227507 |
Chemistry databases
BindingDBi | P24385 |
Structurei
Secondary structure
3D structure databases
SMRi | P24385 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P24385 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 152 | Cyclin N-terminalAdd BLAST | 125 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 272 – 280 | Poly-Glu | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0656 Eukaryota ENOG410XRKC LUCA |
GeneTreei | ENSGT00940000157816 |
HOGENOMi | HOG000008182 |
InParanoidi | P24385 |
KOi | K04503 |
OMAi | YRTTHFL |
OrthoDBi | 1234739at2759 |
PhylomeDBi | P24385 |
TreeFami | TF101004 |
Family and domain databases
CDDi | cd00043 CYCLIN, 1 hit |
DisProti | DP02226 |
InterProi | View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR015451 Cyclin_D IPR006671 Cyclin_N |
PANTHERi | PTHR10177 PTHR10177, 1 hit PTHR10177:SF67 PTHR10177:SF67, 1 hit |
Pfami | View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit |
PIRSFi | PIRSF001771 Cyclin_A_B_D_E, 1 hit |
SMARTi | View protein in SMART SM00385 CYCLIN, 1 hit SM01332 Cyclin_C, 1 hit |
SUPFAMi | SSF47954 SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292 CYCLINS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK
60 70 80 90 100
EVLPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ
110 120 130 140 150
LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW
160 170 180 190 200
NLAAMTPHDF IEHFLSKMPE AEENKQIIRK HAQTFVALCA TDVKFISNPP
210 220 230 240 250
SMVAAGSVVA AVQGLNLRSP NNFLSYYRLT RFLSRVIKCD PDCLRACQEQ
260 270 280 290
IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF5H437 | F5H437_HUMAN | G1/S-specific cyclin-D1 | CCND1 | 67 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 130 | N → G in AAA52136 (PubMed:1827756).Curated | 1 | |
Sequence conflicti | 168 – 169 | MP → IA in M74092 (PubMed:1833066).Curated | 2 | |
Sequence conflicti | 188 | L → S in AAA52136 (PubMed:1827756).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59798 mRNA Translation: CAA42470.1 M74092 mRNA No translation available. M64349 mRNA Translation: AAA52136.1 M73554 mRNA Translation: AAA58392.1 Z23022 mRNA Translation: CAA80558.1 BT019845 mRNA Translation: AAV38648.1 AF511593 Genomic DNA Translation: AAM34300.2 BC000076 mRNA Translation: AAH00076.1 BC001501 mRNA Translation: AAH01501.1 BC014078 mRNA Translation: AAH14078.1 BC023620 mRNA Translation: AAH23620.1 BC025302 mRNA Translation: AAH25302.1 L09054 Genomic DNA Translation: AAA36481.1 |
CCDSi | CCDS8191.1 |
PIRi | A38977 |
RefSeqi | NP_444284.1, NM_053056.2 |
Genome annotation databases
Ensembli | ENST00000227507; ENSP00000227507; ENSG00000110092 |
GeneIDi | 595 |
KEGGi | hsa:595 |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
SHMPD The Singapore human mutation and polymorphism database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59798 mRNA Translation: CAA42470.1 M74092 mRNA No translation available. M64349 mRNA Translation: AAA52136.1 M73554 mRNA Translation: AAA58392.1 Z23022 mRNA Translation: CAA80558.1 BT019845 mRNA Translation: AAV38648.1 AF511593 Genomic DNA Translation: AAM34300.2 BC000076 mRNA Translation: AAH00076.1 BC001501 mRNA Translation: AAH01501.1 BC014078 mRNA Translation: AAH14078.1 BC023620 mRNA Translation: AAH23620.1 BC025302 mRNA Translation: AAH25302.1 L09054 Genomic DNA Translation: AAA36481.1 |
CCDSi | CCDS8191.1 |
PIRi | A38977 |
RefSeqi | NP_444284.1, NM_053056.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2W96 | X-ray | 2.30 | A | 1-271 | [»] | |
2W99 | X-ray | 2.80 | A | 1-271 | [»] | |
2W9F | X-ray | 2.85 | A | 1-271 | [»] | |
2W9Z | X-ray | 2.45 | A | 16-271 | [»] | |
5VZU | X-ray | 2.70 | E/F | 279-295 | [»] | |
SMRi | P24385 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 107067, 108 interactors |
ComplexPortali | CPX-2010 Cyclin D1-CDK4 complex CPX-2014 Cyclin D1-CDK6 complex |
CORUMi | P24385 |
DIPi | DIP-123N |
IntActi | P24385, 68 interactors |
MINTi | P24385 |
STRINGi | 9606.ENSP00000227507 |
Chemistry databases
BindingDBi | P24385 |
ChEMBLi | CHEMBL3610 |
DrugBanki | DB00945 Acetylsalicylic acid DB01169 Arsenic trioxide DB11718 Encorafenib |
DrugCentrali | P24385 |
PTM databases
iPTMneti | P24385 |
PhosphoSitePlusi | P24385 |
Polymorphism and mutation databases
BioMutai | CCND1 |
DMDMi | 116152 |
Proteomic databases
EPDi | P24385 |
jPOSTi | P24385 |
MassIVEi | P24385 |
PaxDbi | P24385 |
PeptideAtlasi | P24385 |
PRIDEi | P24385 |
ProteomicsDBi | 54198 |
Protocols and materials databases
DNASUi | 595 |
Genome annotation databases
Ensembli | ENST00000227507; ENSP00000227507; ENSG00000110092 |
GeneIDi | 595 |
KEGGi | hsa:595 |
Organism-specific databases
CTDi | 595 |
DisGeNETi | 595 |
GeneCardsi | CCND1 |
HGNCi | HGNC:1582 CCND1 |
HPAi | CAB000024 HPA027802 |
MalaCardsi | CCND1 |
MIMi | 168461 gene 254500 phenotype |
neXtProti | NX_P24385 |
OpenTargetsi | ENSG00000110092 |
Orphaneti | 67038 B-cell chronic lymphocytic leukemia 52416 Mantle cell lymphoma 29073 Multiple myeloma |
PharmGKBi | PA75 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0656 Eukaryota ENOG410XRKC LUCA |
GeneTreei | ENSGT00940000157816 |
HOGENOMi | HOG000008182 |
InParanoidi | P24385 |
KOi | K04503 |
OMAi | YRTTHFL |
OrthoDBi | 1234739at2759 |
PhylomeDBi | P24385 |
TreeFami | TF101004 |
Enzyme and pathway databases
Reactomei | R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-1912408 Pre-NOTCH Transcription and Translation R-HSA-3214858 RMTs methylate histone arginines R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-69231 Cyclin D associated events in G1 R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D R-HSA-8849470 PTK6 Regulates Cell Cycle R-HSA-8878166 Transcriptional regulation by RUNX2 R-HSA-8934593 Regulation of RUNX1 Expression and Activity R-HSA-8951430 RUNX3 regulates WNT signaling R-HSA-8951936 RUNX3 regulates p14-ARF R-HSA-9018519 Estrogen-dependent gene expression R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
SignaLinki | P24385 |
SIGNORi | P24385 |
Miscellaneous databases
ChiTaRSi | CCND1 human |
EvolutionaryTracei | P24385 |
GeneWikii | Cyclin_D1 |
GenomeRNAii | 595 |
Pharosi | P24385 |
PROi | PR:P24385 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000110092 Expressed in 219 organ(s), highest expression level in endometrium epithelium |
ExpressionAtlasi | P24385 baseline and differential |
Genevisiblei | P24385 HS |
Family and domain databases
CDDi | cd00043 CYCLIN, 1 hit |
DisProti | DP02226 |
InterProi | View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR015451 Cyclin_D IPR006671 Cyclin_N |
PANTHERi | PTHR10177 PTHR10177, 1 hit PTHR10177:SF67 PTHR10177:SF67, 1 hit |
Pfami | View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit |
PIRSFi | PIRSF001771 Cyclin_A_B_D_E, 1 hit |
SMARTi | View protein in SMART SM00385 CYCLIN, 1 hit SM01332 Cyclin_C, 1 hit |
SUPFAMi | SSF47954 SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292 CYCLINS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCND1_HUMAN | |
Accessioni | P24385Primary (citable) accession number: P24385 Secondary accession number(s): Q6LEF0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | November 13, 2019 | |
This is version 215 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references