CCND1

Functionⁱ

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G₁/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G₁ phase. Hypophosphorylates RB1 in early G₁ phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.4 Publications

GO - Molecular functionⁱ

cyclin-dependent protein serine/threonine kinase activity
Source: Reactome
Inferred from experimentⁱ
- 9190208
cyclin-dependent protein serine/threonine kinase regulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19412162
histone deacetylase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18417529
proline-rich region binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19124461
protein-containing complex binding Source: Ensembl
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19124461
transcription corepressor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16569215
- 18417529
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16569215
- 19124461

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
cellular response to DNA damage stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 19412162
cytokine-mediated signaling pathway Source: Reactome
endoplasmic reticulum unfolded protein response Source: Ensembl
fat cell differentiation Source: Ensembl
G1/S transition of mitotic cell cycle
Source: UniProtKB
Inferred from direct assayⁱ
- 19412162
lactation Source: Ensembl
Leydig cell differentiation Source: Ensembl
liver regeneration Source: Ensembl
mammary gland alveolus development Source: Ensembl
mammary gland epithelial cell proliferation Source: Ensembl
mitotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mitotic G1 DNA damage checkpoint
Source: UniProtKB
Inferred from direct assayⁱ
- 19412162
negative regulation of cell cycle arrest
Source: UniProtKB
Inferred from direct assayⁱ
- 19124461
negative regulation of epithelial cell differentiation Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 16569215
- 18417529
positive regulation of cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cyclin-dependent protein serine/threonine kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8114739
positive regulation of G1/S transition of mitotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of G2/M transition of mitotic cell cycle
Source: UniProtKB
Inferred from direct assayⁱ
- 19124461
positive regulation of mammary gland epithelial cell proliferation Source: Ensembl
positive regulation of protein phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 8114739
re-entry into mitotic cell cycle Source: Ensembl
regulation of cyclin-dependent protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of mitotic nuclear division
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to calcium ion Source: Ensembl
response to corticosterone Source: Ensembl
response to drug
Source: UniProtKB
Inferred from expression patternⁱ
- 18291362
response to estradiol Source: Ensembl
response to estrogen Source: Ensembl
response to ethanol Source: Ensembl
response to iron ion Source: Ensembl
response to leptin
Source: UniProtKB
Inferred from direct assayⁱ
- 17344214
response to magnesium ion Source: Ensembl
response to organonitrogen compound Source: Ensembl
response to UV-A
Source: BHF-UCL
Inferred from direct assayⁱ
- 18483258
response to vitamin E Source: Ensembl
response to X-ray Source: Ensembl
transcription initiation from RNA polymerase II promoter Source: Reactome
Wnt signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cyclin, Repressor
Biological process	Cell cycle, Cell division, DNA damage, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-1912408 Pre-NOTCH Transcription and Translation R-HSA-3214858 RMTs methylate histone arginines R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1 R-HSA-69231 Cyclin D associated events in G1 R-HSA-8849470 PTK6 Regulates Cell Cycle R-HSA-8878166 Transcriptional regulation by RUNX2 R-HSA-8934593 Regulation of RUNX1 Expression and Activity R-HSA-8951430 RUNX3 regulates WNT signaling R-HSA-8951936 RUNX3 regulates p14-ARF R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkⁱ	P24385
SIGNORⁱ	P24385

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: G1/S-specific cyclin-D1 Alternative name(s): B-cell lymphoma 1 protein Short name: BCL-1 BCL-1 oncogene PRAD1 oncogene
Gene namesⁱ	Name:CCND1 Synonyms:BCL1, PRAD1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000110092.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1582 CCND1
MIMⁱ	168461 gene
neXtProtⁱ	NX_P24385

Keywords - Cellular componentⁱ

Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t(11;14)(q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle.

A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas. Translocation t(11;11)(q13;p15) with the parathyroid hormone (PTH) enhancer.

Multiple myeloma (MM)1 Publication

The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving CCND1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus.

Disease descriptionA malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	286	T → A: Reduces ubiquitination and subsequent degradation by the proteasome; when associated with A-288. Abolishes ubiquitination and subsequent degradation following DNA damage. 2 Publications		1
Mutagenesisⁱ	288	T → A: Reduces ubiquitination and subsequent degradation by the proteasome; when associated with A-286. 1 Publication		1

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	595
MalaCards human disease database More...MalaCardsⁱ	CCND1
MIMⁱ	254500 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000110092
Orphanetⁱ	67038 B-cell chronic lymphocytic leukemia 52416 Mantle cell lymphoma 29073 Multiple myeloma
PharmGKBⁱ	PA75

Chemistry databases

ChEMBLⁱ	CHEMBL3610
Drug and drug target database More...DrugBankⁱ	DB01169 Arsenic trioxide

Polymorphism and mutation databases

BioMutaⁱ	CCND1
DMDMⁱ	116152

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080430	1 – 295	G1/S-specific cyclin-D1Add BLAST		295

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	269	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residueⁱ	286	PhosphothreonineCombined sources1 Publication		1

Post-translational modificationⁱ

Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.2 Publications

Ubiquitinated, primarily as 'Lys-48'-linked polyubiquitination. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex containing FBXO4 and CRYAB. Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. SCF-type ubiquitination is dependent on Thr-286 phosphorylation (By similarity). Ubiquitinated also by UHRF2 apparently in a phosphorylation-independent manner. Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to its stabilization.By similarity2 Publications

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P24385
PaxDbⁱ	P24385
PeptideAtlas More...PeptideAtlasⁱ	P24385
PRIDEⁱ	P24385
ProteomicsDBⁱ	54198

PTM databases

iPTMnetⁱ	P24385
PhosphoSitePlusⁱ	P24385

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000110092 Expressed in 219 organ(s), highest expression level in endometrium epithelium
CleanExⁱ	HS_CCND1
ExpressionAtlasⁱ	P24385 baseline and differential
Genevisibleⁱ	P24385 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000024 HPA027802

HPAⁱ

CAB000024
HPA027802

Interactionⁱ

Subunit structureⁱ

Interacts with FBXO4 (By similarity). Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex CCND1/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Interacts directly with CDKN1B. Interacts with UHRF2; the interaction ubiquitinates CCND1 and appears to occur independently of phosphorylation. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with USP2. Interacts (via cyclin N-terminal domain) with INSM1 (via N-terminal region); the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and inhibits CDK4 activity. Interacts with CDK4; the interaction is prevented with the binding of CCND1 to INSM1 during cell cycle progression.By similarity8 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	Q96TE0	3	EBI-375001,EBI-10201595
AR	P10275	4	EBI-375001,EBI-608057
BRCA1	P38398	3	EBI-375001,EBI-349905
CDC27	P30260	3	EBI-375001,EBI-994813
CDK2	P24941	3	EBI-375001,EBI-375096
CDK4	P11802	29	EBI-375001,EBI-295644
Cdk4	P30285	2	EBI-375001,EBI-847225	From Mus musculus.
CDK6	Q00534	4	EBI-375001,EBI-295663
CDKN1A	P38936	15	EBI-375001,EBI-375077
CDKN1B	P46527	3	EBI-375001,EBI-519280
FBXO31	Q5XUX0	4	EBI-375001,EBI-6162477
HDAC3	O15379	3	EBI-375001,EBI-607682
NRF1	Q16656	2	EBI-375001,EBI-2547810
Ralbp1	Q62796	2	EBI-375001,EBI-3956409	From Rattus norvegicus.
UHRF2	Q96PU4	4	EBI-375001,EBI-625304

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19412162
histone deacetylase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18417529
proline-rich region binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19124461
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19124461
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16569215
- 19124461

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107067, 101 interactors
ComplexPortalⁱ	CPX-2010 Cyclin D1-CDK4 complex CPX-2014 Cyclin D1-CDK6 complex
CORUMⁱ	P24385
Database of interacting proteins More...DIPⁱ	DIP-123N
IntActⁱ	P24385, 63 interactors
Molecular INTeraction database More...MINTⁱ	P24385
STRINGⁱ	9606.ENSP00000227507

Chemistry databases

BindingDBⁱ

P24385

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	9 – 11	Combined sources	3
Helixⁱ	26 – 37	Combined sources	12
Helixⁱ	44 – 47	Combined sources	4
Helixⁱ	54 – 70	Combined sources	17
Helixⁱ	77 – 89	Combined sources	13
Turnⁱ	96 – 98	Combined sources	3
Helixⁱ	99 – 114	Combined sources	16
Helixⁱ	121 – 127	Combined sources	7
Turnⁱ	128 – 130	Combined sources	3
Helixⁱ	134 – 147	Combined sources	14
Turnⁱ	148 – 150	Combined sources	3
Helixⁱ	157 – 166	Combined sources	10
Helixⁱ	172 – 190	Combined sources	19
Helixⁱ	194 – 197	Combined sources	4
Helixⁱ	200 – 218	Combined sources	19
Turnⁱ	220 – 222	Combined sources	3
Helixⁱ	224 – 226	Combined sources	3
Helixⁱ	229 – 237	Combined sources	9
Helixⁱ	241 – 255	Combined sources	15
Turnⁱ	256 – 260	Combined sources	5
Beta strandⁱ	261 – 263	Combined sources	3
Helixⁱ	288 – 290	Combined sources	3
Helixⁱ	292 – 294	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P24385
SMRⁱ	P24385
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P24385

EvolutionaryTraceⁱ

P24385

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 152	Cyclin N-terminalAdd BLAST		125

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	272 – 280	Poly-Glu		9

Sequence similaritiesⁱ

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0656 Eukaryota ENOG410XRKC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150931
HOGENOMⁱ	HOG000008182
HOVERGENⁱ	HBG050837
InParanoidⁱ	P24385
KEGG Orthology (KO) More...KOⁱ	K04503
OMAⁱ	YRTTHFL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0URX
PhylomeDBⁱ	P24385
TreeFamⁱ	TF101004

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR015451 Cyclin_D IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit PTHR10177:SF67 PTHR10177:SF67, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
PIRSFⁱ	PIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 1 hit SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292 CYCLINS, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P24385-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEHQLLCCEV ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK 
        60         70         80         90        100
EVLPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ 
       110        120        130        140        150
LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPEELLQM ELLLVNKLKW 
       160        170        180        190        200
NLAAMTPHDF IEHFLSKMPE AEENKQIIRK HAQTFVALCA TDVKFISNPP 
       210        220        230        240        250
SMVAAGSVVA AVQGLNLRSP NNFLSYYRLT RFLSRVIKCD PDCLRACQEQ 
       260        270        280        290 
IEALLESSLR QAQQNMDPKA AEEEEEEEEE VDLACTPTDV RDVDI

Length:295

Mass (Da):33,729

Last modified:March 1, 1992 - v1

Checksum:ⁱ3CC00C9905F58D3A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F5H437	F5H437_HUMAN		G1/S-specific cyclin-D1 G1/S-specific cyclin-D1	CCND1	67	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	130	N → G in AAA52136 (PubMed:1827756).Curated	1
Sequence conflictⁱ	168 – 169	MP → IA in M74092 (PubMed:1833066).Curated	2
Sequence conflictⁱ	188	L → S in AAA52136 (PubMed:1827756).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X59798 mRNA Translation: CAA42470.1 M74092 mRNA No translation available. M64349 mRNA Translation: AAA52136.1 M73554 mRNA Translation: AAA58392.1 Z23022 mRNA Translation: CAA80558.1 BT019845 mRNA Translation: AAV38648.1 AF511593 Genomic DNA Translation: AAM34300.2 BC000076 mRNA Translation: AAH00076.1 BC001501 mRNA Translation: AAH01501.1 BC014078 mRNA Translation: AAH14078.1 BC023620 mRNA Translation: AAH23620.1 BC025302 mRNA Translation: AAH25302.1 L09054 Genomic DNA Translation: AAA36481.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8191.1
PIRⁱ	A38977
NCBI Reference Sequences More...RefSeqⁱ	NP_444284.1, NM_053056.2
UniGeneⁱ	Hs.523852

Genome annotation databases

Ensemblⁱ	ENST00000227507; ENSP00000227507; ENSG00000110092
GeneIDⁱ	595
KEGGⁱ	hsa:595

Keywords - Coding sequence diversityⁱ

Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24385	CCND1 protein		HUMAN		295	UniRef100_P24385
CCND1 isoform 1		PANTR		295
Uncharacterized protein		GORGO		295
Cyclin D1 (Fragment)		HUMAN		125
UPI000195C28A		HUMAN		271

Protein	Similar proteins		Species	Score	Length	Source
P24385	G1/S-specific cyclin-D1		BOVIN		295	UniRef90_P24385
G1/S-specific cyclin-D1		MOUSE		295
G1/S-specific cyclin-D1		PONAB		295
G1/S-specific cyclin-D1		RAT		295
CCND1 protein		HUMAN		295
+69

Protein	Similar proteins		Species	Score	Length	Source
P24385	G1/S-specific cyclin-D1		PONAB		295	UniRef50_P24385
G1/S-specific cyclin-D1		MOUSE		295
G1/S-specific cyclin-D1		RAT		295
G1/S-specific cyclin-D1		BOVIN		295
G1/S-specific cyclin-D2		XENLA		291
+372

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NIEHS-SNPs

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X59798 mRNA Translation: CAA42470.1 M74092 mRNA No translation available. M64349 mRNA Translation: AAA52136.1 M73554 mRNA Translation: AAA58392.1 Z23022 mRNA Translation: CAA80558.1 BT019845 mRNA Translation: AAV38648.1 AF511593 Genomic DNA Translation: AAM34300.2 BC000076 mRNA Translation: AAH00076.1 BC001501 mRNA Translation: AAH01501.1 BC014078 mRNA Translation: AAH14078.1 BC023620 mRNA Translation: AAH23620.1 BC025302 mRNA Translation: AAH25302.1 L09054 Genomic DNA Translation: AAA36481.1
CCDSⁱ	CCDS8191.1
PIRⁱ	A38977
RefSeqⁱ	NP_444284.1, NM_053056.2
UniGeneⁱ	Hs.523852

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2W96	X-ray	2.30	A	1-271	[»]
	2W99	X-ray	2.80	A	1-271	[»]
	2W9F	X-ray	2.85	A	1-271	[»]
	2W9Z	X-ray	2.45	A	16-271	[»]
	5VZU	X-ray	2.70	E/F	279-295	[»]
ProteinModelPortalⁱ	P24385
SMRⁱ	P24385
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107067, 101 interactors
ComplexPortalⁱ	CPX-2010 Cyclin D1-CDK4 complex CPX-2014 Cyclin D1-CDK6 complex
CORUMⁱ	P24385
DIPⁱ	DIP-123N
IntActⁱ	P24385, 63 interactors
MINTⁱ	P24385
STRINGⁱ	9606.ENSP00000227507

Chemistry databases

BindingDBⁱ	P24385
ChEMBLⁱ	CHEMBL3610
DrugBankⁱ	DB01169 Arsenic trioxide

PTM databases

iPTMnetⁱ	P24385
PhosphoSitePlusⁱ	P24385

Polymorphism and mutation databases

BioMutaⁱ	CCND1
DMDMⁱ	116152

Proteomic databases

EPDⁱ	P24385
PaxDbⁱ	P24385
PeptideAtlasⁱ	P24385
PRIDEⁱ	P24385
ProteomicsDBⁱ	54198

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	595
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000227507; ENSP00000227507; ENSG00000110092
GeneIDⁱ	595
KEGGⁱ	hsa:595

Organism-specific databases

CTDⁱ	595
DisGeNETⁱ	595
EuPathDBⁱ	HostDB:ENSG00000110092.3
GeneCardsⁱ	CCND1
HGNCⁱ	HGNC:1582 CCND1
HPAⁱ	CAB000024 HPA027802
MalaCardsⁱ	CCND1
MIMⁱ	168461 gene 254500 phenotype
neXtProtⁱ	NX_P24385
OpenTargetsⁱ	ENSG00000110092
Orphanetⁱ	67038 B-cell chronic lymphocytic leukemia 52416 Mantle cell lymphoma 29073 Multiple myeloma
PharmGKBⁱ	PA75
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0656 Eukaryota ENOG410XRKC LUCA
GeneTreeⁱ	ENSGT00930000150931
HOGENOMⁱ	HOG000008182
HOVERGENⁱ	HBG050837
InParanoidⁱ	P24385
KOⁱ	K04503
OMAⁱ	YRTTHFL
OrthoDBⁱ	EOG091G0URX
PhylomeDBⁱ	P24385
TreeFamⁱ	TF101004

Enzyme and pathway databases

Reactomeⁱ	R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-1912408 Pre-NOTCH Transcription and Translation R-HSA-3214858 RMTs methylate histone arginines R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1 R-HSA-69231 Cyclin D associated events in G1 R-HSA-8849470 PTK6 Regulates Cell Cycle R-HSA-8878166 Transcriptional regulation by RUNX2 R-HSA-8934593 Regulation of RUNX1 Expression and Activity R-HSA-8951430 RUNX3 regulates WNT signaling R-HSA-8951936 RUNX3 regulates p14-ARF R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkⁱ	P24385
SIGNORⁱ	P24385

Miscellaneous databases

ChiTaRSⁱ	CCND1 human
EvolutionaryTraceⁱ	P24385
GeneWikiⁱ	Cyclin_D1
GenomeRNAiⁱ	595
Protein Ontology More...PROⁱ	PR:P24385
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000110092 Expressed in 219 organ(s), highest expression level in endometrium epithelium
CleanExⁱ	HS_CCND1
ExpressionAtlasⁱ	P24385 baseline and differential
Genevisibleⁱ	P24385 HS

Family and domain databases

CDDⁱ	cd00043 CYCLIN, 1 hit
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR015451 Cyclin_D IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit PTHR10177:SF67 PTHR10177:SF67, 1 hit
Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
PIRSFⁱ	PIRSF001771 Cyclin_A_B_D_E, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 1 hit SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292 CYCLINS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCND1_HUMAN
Accessionⁱ	P24385Primary (citable) accession number: P24385 Secondary accession number(s): Q6LEF0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	March 1, 1992
	Last modified:	November 7, 2018
	This is version 206 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - P24385 (CCND1_HUMAN)

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G1/S-specific cyclin-D1

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ