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Protein

Peptidyl-prolyl cis-trans isomerase B

Gene

Ppib

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.By similarity

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).By similarity

Activity regulationi

Inhibited by cyclosporin A (CsA).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

ReactomeiR-MMU-1650814 Collagen biosynthesis and modifying enzymes

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase B (EC:5.2.1.8By similarity)
Short name:
PPIase B
Alternative name(s):
CYP-S1
Cyclophilin B
Rotamase B
S-cyclophilin
Short name:
SCYLP
Gene namesi
Name:Ppib
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97750 Ppib

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33By similarityAdd BLAST33
ChainiPRO_000002548034 – 216Peptidyl-prolyl cis-trans isomerase BAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84N6-succinyllysineBy similarity1
Modified residuei165N6-acetyllysineBy similarity1
Modified residuei209N6-acetyllysine; alternateCombined sources1
Modified residuei209N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP24369
PaxDbiP24369
PeptideAtlasiP24369
PRIDEiP24369
TopDownProteomicsiP24369

PTM databases

iPTMnetiP24369
PhosphoSitePlusiP24369

Expressioni

Gene expression databases

BgeeiENSMUSG00000032383 Expressed in 293 organ(s), highest expression level in pancreas
CleanExiMM_PPIB
ExpressionAtlasiP24369 baseline and differential
GenevisibleiP24369 MM

Interactioni

Subunit structurei

Interacts with DYM. Interacts with CALR, CANX and CLGN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202328, 3 interactors
CORUMiP24369
IntActiP24369, 9 interactors
MINTiP24369
STRINGi10090.ENSMUSP00000034947

Structurei

3D structure databases

ProteinModelPortaliP24369
SMRiP24369
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 204PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST158

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi213 – 216Prevents secretion from ERBy similarity4

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0880 Eukaryota
ENOG410Z0G4 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000065981
HOVERGENiHBG001065
InParanoidiP24369
KOiK03768
OMAiEPFAVSK
OrthoDBiEOG091G0BGL
PhylomeDBiP24369
TreeFamiTF354259

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24369-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRLSERNMK VLFAAALIVG SVVFLLLPGP SVANDKKKGP KVTVKVYFDL
60 70 80 90 100
QIGDESVGRV VFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF
110 120 130 140 150
MIQGGDFTRG DGTGGKSIYG ERFPDENFKL KHYGPGWVSM ANAGKDTNGS
160 170 180 190 200
QFFITTVKTS WLDGKHVVFG KVLEGMDVVR KVESTKTDSR DKPLKDVIIV
210
DSGKIEVEKP FAIAKE
Length:216
Mass (Da):23,713
Last modified:November 25, 2008 - v2
Checksum:iCE9DAD1544AE72FE
GO

Sequence cautioni

The sequence AAA37498 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA41736 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60456 mRNA Translation: AAA37498.1 Different initiation.
X58990 mRNA Translation: CAA41736.1 Different initiation.
CCDSiCCDS23301.1
RefSeqiNP_035279.2, NM_011149.2
UniGeneiMm.335249

Genome annotation databases

EnsembliENSMUST00000034947; ENSMUSP00000034947; ENSMUSG00000032383
GeneIDi19035
KEGGimmu:19035
UCSCiuc009qei.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60456 mRNA Translation: AAA37498.1 Different initiation.
X58990 mRNA Translation: CAA41736.1 Different initiation.
CCDSiCCDS23301.1
RefSeqiNP_035279.2, NM_011149.2
UniGeneiMm.335249

3D structure databases

ProteinModelPortaliP24369
SMRiP24369
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202328, 3 interactors
CORUMiP24369
IntActiP24369, 9 interactors
MINTiP24369
STRINGi10090.ENSMUSP00000034947

PTM databases

iPTMnetiP24369
PhosphoSitePlusiP24369

Proteomic databases

EPDiP24369
PaxDbiP24369
PeptideAtlasiP24369
PRIDEiP24369
TopDownProteomicsiP24369

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034947; ENSMUSP00000034947; ENSMUSG00000032383
GeneIDi19035
KEGGimmu:19035
UCSCiuc009qei.1 mouse

Organism-specific databases

CTDi5479
MGIiMGI:97750 Ppib

Phylogenomic databases

eggNOGiKOG0880 Eukaryota
ENOG410Z0G4 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000065981
HOVERGENiHBG001065
InParanoidiP24369
KOiK03768
OMAiEPFAVSK
OrthoDBiEOG091G0BGL
PhylomeDBiP24369
TreeFamiTF354259

Enzyme and pathway databases

ReactomeiR-MMU-1650814 Collagen biosynthesis and modifying enzymes

Miscellaneous databases

PROiPR:P24369
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032383 Expressed in 293 organ(s), highest expression level in pancreas
CleanExiMM_PPIB
ExpressionAtlasiP24369 baseline and differential
GenevisibleiP24369 MM

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPIB_MOUSE
AccessioniPrimary (citable) accession number: P24369
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 25, 2008
Last modified: September 12, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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