Ppib

Functionⁱ

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.By similarity

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Catalytic activityⁱ

Peptidylproline (omega=180) = peptidylproline (omega=0).By similarity

Activity regulationⁱ

Inhibited by cyclosporin A (CsA).By similarity

GO - Molecular functionⁱ

cyclosporin A binding Source: UniProtKB
peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB
protein-containing complex binding Source: UniProtKB
RNA polymerase binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bone development Source: MGI
chaperone-mediated protein folding Source: UniProtKB
positive regulation by host of viral genome replication Source: MGI
positive regulation by host of viral process Source: MGI
positive regulation of multicellular organism growth Source: MGI
protein peptidyl-prolyl isomerization Source: UniProtKB
protein stabilization Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase, Rotamase

Molecular function

Isomerase, Rotamase

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1650814 Collagen biosynthesis and modifying enzymes

Reactomeⁱ

R-MMU-1650814 Collagen biosynthesis and modifying enzymes

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peptidyl-prolyl cis-trans isomerase B (EC:5.2.1.8By similarity) Short name: PPIase B Alternative name(s): CYP-S1 Cyclophilin B Rotamase B S-cyclophilin Short name: SCYLP
Gene namesⁱ	Name:Ppib
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:97750 Ppib

Keywords - Cellular componentⁱ

Endoplasmic reticulum

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 33	By similarityAdd BLAST		33
ChainⁱPRO_0000025480	34 – 216	Peptidyl-prolyl cis-trans isomerase BAdd BLAST		183

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	84	N6-succinyllysineBy similarity	1
Modified residueⁱ	165	N6-acetyllysineBy similarity	1
Modified residueⁱ	209	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	209	N6-succinyllysine; alternateCombined sources	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P24369
PaxDbⁱ	P24369
PeptideAtlas More...PeptideAtlasⁱ	P24369
PRIDEⁱ	P24369
TopDownProteomicsⁱ	P24369

PTM databases

iPTMnetⁱ	P24369
PhosphoSitePlusⁱ	P24369

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000032383 Expressed in 293 organ(s), highest expression level in pancreas
CleanExⁱ	MM_PPIB
ExpressionAtlasⁱ	P24369 baseline and differential
Genevisibleⁱ	P24369 MM

Interactionⁱ

Subunit structureⁱ

Interacts with DYM. Interacts with CALR, CANX and CLGN (By similarity).By similarity

GO - Molecular functionⁱ

RNA polymerase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	202328, 3 interactors
CORUMⁱ	P24369
IntActⁱ	P24369, 9 interactors
Molecular INTeraction database More...MINTⁱ	P24369
STRINGⁱ	10090.ENSMUSP00000034947

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P24369
SMRⁱ	P24369
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	47 – 204	PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST		158

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	213 – 216	Prevents secretion from ERBy similarity		4

Sequence similaritiesⁱ

Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG0880 Eukaryota ENOG410Z0G4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119072
HOGENOMⁱ	HOG000065981
HOVERGENⁱ	HBG001065
InParanoidⁱ	P24369
KEGG Orthology (KO) More...KOⁱ	K03768
OMAⁱ	EPFAVSK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BGL
PhylomeDBⁱ	P24369
TreeFamⁱ	TF354259

Family and domain databases

Gene3Dⁱ	2.40.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR029000 Cyclophilin-like_dom_sf IPR024936 Cyclophilin-type_PPIase IPR020892 Cyclophilin-type_PPIase_CS IPR002130 Cyclophilin-type_PPIase_dom
PANTHERⁱ	PTHR11071 PTHR11071, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00160 Pro_isomerase, 1 hit
PIRSFⁱ	PIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSⁱ	PR00153 CSAPPISMRASE
SUPFAMⁱ	SSF50891 SSF50891, 1 hit
PROSITEⁱ	View protein in PROSITE PS00170 CSA_PPIASE_1, 1 hit PS50072 CSA_PPIASE_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P24369-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLRLSERNMK VLFAAALIVG SVVFLLLPGP SVANDKKKGP KVTVKVYFDL 
        60         70         80         90        100
QIGDESVGRV VFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF 
       110        120        130        140        150
MIQGGDFTRG DGTGGKSIYG ERFPDENFKL KHYGPGWVSM ANAGKDTNGS 
       160        170        180        190        200
QFFITTVKTS WLDGKHVVFG KVLEGMDVVR KVESTKTDSR DKPLKDVIIV 
       210 
DSGKIEVEKP FAIAKE

Length:216

Mass (Da):23,713

Last modified:November 25, 2008 - v2

Checksum:ⁱCE9DAD1544AE72FE

GO

Sequence cautionⁱ

The sequence AAA37498 differs from that shown. Reason: Erroneous initiation.Curated

The sequence CAA41736 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M60456 mRNA Translation: AAA37498.1 Different initiation. X58990 mRNA Translation: CAA41736.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23301.1
NCBI Reference Sequences More...RefSeqⁱ	NP_035279.2, NM_011149.2
UniGeneⁱ	Mm.335249

Genome annotation databases

Ensemblⁱ	ENSMUST00000034947; ENSMUSP00000034947; ENSMUSG00000032383
GeneIDⁱ	19035
KEGGⁱ	mmu:19035
UCSC genome browser More...UCSCⁱ	uc009qei.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24369	Peptidyl-prolyl cis-trans isomerase		Daphnia magna		216	UniRef100_P24369
Peptidyl-prolyl cis-trans isomerase		MOUSE		216

Protein	Similar proteins		Species	Score	Length	Source
P24369	Peptidyl-prolyl cis-trans isomerase B		RAT		216	UniRef90_P24368
Peptidyl-prolyl cis-trans isomerase		Daphnia magna		216
Peptidyl-prolyl cis-trans isomerase		MOUSE		216
Peptidyl-prolyl cis-trans isomerase		ERIEU		216
Peptidyl-prolyl cis-trans isomerase		OTOGA		216
+16

Protein	Similar proteins		Species	Score	Length	Source
P24369	Peptidyl-prolyl cis-trans isomerase B		RAT		216	UniRef50_P24368
Peptidyl-prolyl cis-trans isomerase B		ASPOR		192
Peptidyl-prolyl cis-trans isomerase		MESAU		216
Peptidyl-prolyl cis-trans isomerase		Daphnia magna		216
Peptidyl-prolyl cis-trans isomerase		MOUSE		216
+236

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M60456 mRNA Translation: AAA37498.1 Different initiation. X58990 mRNA Translation: CAA41736.1 Different initiation.
CCDSⁱ	CCDS23301.1
RefSeqⁱ	NP_035279.2, NM_011149.2
UniGeneⁱ	Mm.335249

3D structure databases

ProteinModelPortalⁱ	P24369
SMRⁱ	P24369
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	202328, 3 interactors
CORUMⁱ	P24369
IntActⁱ	P24369, 9 interactors
MINTⁱ	P24369
STRINGⁱ	10090.ENSMUSP00000034947

PTM databases

iPTMnetⁱ	P24369
PhosphoSitePlusⁱ	P24369

Proteomic databases

EPDⁱ	P24369
PaxDbⁱ	P24369
PeptideAtlasⁱ	P24369
PRIDEⁱ	P24369
TopDownProteomicsⁱ	P24369

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000034947; ENSMUSP00000034947; ENSMUSG00000032383
GeneIDⁱ	19035
KEGGⁱ	mmu:19035
UCSCⁱ	uc009qei.1 mouse

Organism-specific databases

CTDⁱ	5479
MGIⁱ	MGI:97750 Ppib

Phylogenomic databases

eggNOGⁱ	KOG0880 Eukaryota ENOG410Z0G4 LUCA
GeneTreeⁱ	ENSGT00760000119072
HOGENOMⁱ	HOG000065981
HOVERGENⁱ	HBG001065
InParanoidⁱ	P24369
KOⁱ	K03768
OMAⁱ	EPFAVSK
OrthoDBⁱ	EOG091G0BGL
PhylomeDBⁱ	P24369
TreeFamⁱ	TF354259

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1650814 Collagen biosynthesis and modifying enzymes

Reactomeⁱ

R-MMU-1650814 Collagen biosynthesis and modifying enzymes

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P24369
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000032383 Expressed in 293 organ(s), highest expression level in pancreas
CleanExⁱ	MM_PPIB
ExpressionAtlasⁱ	P24369 baseline and differential
Genevisibleⁱ	P24369 MM

Family and domain databases

Gene3Dⁱ	2.40.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR029000 Cyclophilin-like_dom_sf IPR024936 Cyclophilin-type_PPIase IPR020892 Cyclophilin-type_PPIase_CS IPR002130 Cyclophilin-type_PPIase_dom
PANTHERⁱ	PTHR11071 PTHR11071, 1 hit
Pfamⁱ	View protein in Pfam PF00160 Pro_isomerase, 1 hit
PIRSFⁱ	PIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSⁱ	PR00153 CSAPPISMRASE
SUPFAMⁱ	SSF50891 SSF50891, 1 hit
PROSITEⁱ	View protein in PROSITE PS00170 CSA_PPIASE_1, 1 hit PS50072 CSA_PPIASE_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPIB_MOUSE
Accessionⁱ	P24369Primary (citable) accession number: P24369
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	November 25, 2008
	Last modified:	September 12, 2018
	This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P24369 (PPIB_MOUSE)

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Peptidyl-prolyl cis-trans isomerase B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ