UniProtKB - P24369 (PPIB_MOUSE)
Protein
Peptidyl-prolyl cis-trans isomerase B
Gene
Ppib
Organism
Mus musculus (Mouse)
Status
Functioni
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.By similarity
Caution
It is uncertain whether Met-1 or Met-9 is the initiator.Curated
Catalytic activityi
- EC:5.2.1.8By similarity
Activity regulationi
Inhibited by cyclosporin A (CsA).By similarity
GO - Molecular functioni
- cyclosporin A binding Source: UniProtKB
- peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB
- RNA polymerase binding Source: MGI
GO - Biological processi
- bone development Source: MGI
- chaperone-mediated protein folding Source: UniProtKB
- neutrophil chemotaxis Source: MGI
- positive regulation by host of viral genome replication Source: MGI
- positive regulation by host of viral process Source: MGI
- positive regulation of multicellular organism growth Source: MGI
- protein folding Source: GO_Central
- protein peptidyl-prolyl isomerization Source: UniProtKB
- protein stabilization Source: MGI
Keywordsi
Molecular function | Isomerase, Rotamase |
Enzyme and pathway databases
Reactomei | R-MMU-1650814, Collagen biosynthesis and modifying enzymes |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidyl-prolyl cis-trans isomerase B (EC:5.2.1.8By similarity)Short name: PPIase B Alternative name(s): CYP-S1 Cyclophilin B Rotamase B S-cyclophilin Short name: SCYLP |
Gene namesi | Name:Ppib |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97750, Ppib |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen By similarity
Other locations
- Melanosome By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum chaperone complex Source: ParkinsonsUK-UCL
- endoplasmic reticulum lumen Source: UniProtKB-SubCell
- smooth endoplasmic reticulum Source: MGI
Nucleus
- nucleoplasm Source: MGI
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
- melanosome Source: UniProtKB-SubCell
- perinuclear region of cytoplasm Source: MGI
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Endoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | By similarityAdd BLAST | 33 | |
ChainiPRO_0000025480 | 34 – 216 | Peptidyl-prolyl cis-trans isomerase BAdd BLAST | 183 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 84 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 165 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 209 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 209 | N6-succinyllysine; alternateCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P24369 |
jPOSTi | P24369 |
PaxDbi | P24369 |
PeptideAtlasi | P24369 |
PRIDEi | P24369 |
TopDownProteomicsi | P24369 |
PTM databases
iPTMneti | P24369 |
PhosphoSitePlusi | P24369 |
Expressioni
Tissue specificityi
Expressed in the kidney thick ascending limb (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000032383, Expressed in pancreas and 309 other tissues |
ExpressionAtlasi | P24369, baseline and differential |
Genevisiblei | P24369, MM |
Interactioni
Subunit structurei
Interacts with DYM.
Interacts with CALR, CLGN and CANX.
Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
By similarityGO - Molecular functioni
- RNA polymerase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202328, 17 interactors |
CORUMi | P24369 |
IntActi | P24369, 9 interactors |
MINTi | P24369 |
STRINGi | 10090.ENSMUSP00000034947 |
Miscellaneous databases
RNActi | P24369, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 204 | PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST | 158 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 213 – 216 | Prevents secretion from ERBy similarity | 4 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG0880, Eukaryota |
GeneTreei | ENSGT00940000158007 |
HOGENOMi | CLU_012062_4_2_1 |
InParanoidi | P24369 |
OMAi | DVTIHDC |
OrthoDBi | 1403619at2759 |
PhylomeDBi | P24369 |
TreeFami | TF354259 |
Family and domain databases
Gene3Di | 2.40.100.10, 1 hit |
InterProi | View protein in InterPro IPR029000, Cyclophilin-like_dom_sf IPR020892, Cyclophilin-type_PPIase_CS IPR002130, Cyclophilin-type_PPIase_dom |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SUPFAMi | SSF50891, SSF50891, 1 hit |
PROSITEi | View protein in PROSITE PS00170, CSA_PPIASE_1, 1 hit PS50072, CSA_PPIASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P24369-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRLSERNMK VLFAAALIVG SVVFLLLPGP SVANDKKKGP KVTVKVYFDL
60 70 80 90 100
QIGDESVGRV VFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF
110 120 130 140 150
MIQGGDFTRG DGTGGKSIYG ERFPDENFKL KHYGPGWVSM ANAGKDTNGS
160 170 180 190 200
QFFITTVKTS WLDGKHVVFG KVLEGMDVVR KVESTKTDSR DKPLKDVIIV
210
DSGKIEVEKP FAIAKE
Sequence cautioni
The sequence AAA37498 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA41736 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60456 mRNA Translation: AAA37498.1 Different initiation. X58990 mRNA Translation: CAA41736.1 Different initiation. |
CCDSi | CCDS23301.1 |
RefSeqi | NP_035279.2, NM_011149.2 |
Genome annotation databases
Ensembli | ENSMUST00000034947; ENSMUSP00000034947; ENSMUSG00000032383 |
GeneIDi | 19035 |
KEGGi | mmu:19035 |
UCSCi | uc009qei.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60456 mRNA Translation: AAA37498.1 Different initiation. X58990 mRNA Translation: CAA41736.1 Different initiation. |
CCDSi | CCDS23301.1 |
RefSeqi | NP_035279.2, NM_011149.2 |
3D structure databases
SMRi | P24369 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 202328, 17 interactors |
CORUMi | P24369 |
IntActi | P24369, 9 interactors |
MINTi | P24369 |
STRINGi | 10090.ENSMUSP00000034947 |
PTM databases
iPTMneti | P24369 |
PhosphoSitePlusi | P24369 |
Proteomic databases
EPDi | P24369 |
jPOSTi | P24369 |
PaxDbi | P24369 |
PeptideAtlasi | P24369 |
PRIDEi | P24369 |
TopDownProteomicsi | P24369 |
Protocols and materials databases
Antibodypediai | 2584, 473 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034947; ENSMUSP00000034947; ENSMUSG00000032383 |
GeneIDi | 19035 |
KEGGi | mmu:19035 |
UCSCi | uc009qei.1, mouse |
Organism-specific databases
CTDi | 5479 |
MGIi | MGI:97750, Ppib |
Phylogenomic databases
eggNOGi | KOG0880, Eukaryota |
GeneTreei | ENSGT00940000158007 |
HOGENOMi | CLU_012062_4_2_1 |
InParanoidi | P24369 |
OMAi | DVTIHDC |
OrthoDBi | 1403619at2759 |
PhylomeDBi | P24369 |
TreeFami | TF354259 |
Enzyme and pathway databases
Reactomei | R-MMU-1650814, Collagen biosynthesis and modifying enzymes |
Miscellaneous databases
BioGRID-ORCSi | 19035, 2 hits in 18 CRISPR screens |
ChiTaRSi | Ppib, mouse |
PROi | PR:P24369 |
RNActi | P24369, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032383, Expressed in pancreas and 309 other tissues |
ExpressionAtlasi | P24369, baseline and differential |
Genevisiblei | P24369, MM |
Family and domain databases
Gene3Di | 2.40.100.10, 1 hit |
InterProi | View protein in InterPro IPR029000, Cyclophilin-like_dom_sf IPR020892, Cyclophilin-type_PPIase_CS IPR002130, Cyclophilin-type_PPIase_dom |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SUPFAMi | SSF50891, SSF50891, 1 hit |
PROSITEi | View protein in PROSITE PS00170, CSA_PPIASE_1, 1 hit PS50072, CSA_PPIASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPIB_MOUSE | |
Accessioni | P24369Primary (citable) accession number: P24369 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | November 25, 2008 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families