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Protein

Stromelysin-3

Gene

MMP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in the progression of epithelial malignancies.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Zinc 2; in inhibited formBy similarity1
Metal bindingi166Zinc 1By similarity1
Metal bindingi171CalciumBy similarity1
Metal bindingi172Calcium; via carbonyl oxygenBy similarity1
Metal bindingi174Calcium; via carbonyl oxygenBy similarity1
Metal bindingi176Calcium; via carbonyl oxygenBy similarity1
Metal bindingi179Zinc 1By similarity1
Metal bindingi192Zinc 1By similarity1
Metal bindingi215Zinc 2; catalyticBy similarity1
Active sitei216PROSITE-ProRule annotation1
Metal bindingi219Zinc 2; catalyticBy similarity1
Metal bindingi225Zinc 2; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processCollagen degradation
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.B3 2681
ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases

Protein family/group databases

MEROPSiM10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Stromelysin-3 (EC:3.4.24.-)
Short name:
SL-3
Short name:
ST3
Alternative name(s):
Matrix metalloproteinase-11
Short name:
MMP-11
Gene namesi
Name:MMP11
Synonyms:STMY3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000099953.9
HGNCiHGNC:7157 MMP11
MIMi185261 gene
neXtProtiNX_P24347

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4320
OpenTargetsiENSG00000099953
PharmGKBiPA30869

Chemistry databases

ChEMBLiCHEMBL2867
DrugBankiDB04318 1-Benzyloxycarbonylamino-2-Phenyl-Ethyl)-{2-[1-Carbamoyl-2-(1h-Indol-3-Yl)-Ethylcarbamoyl]-5-Phenyl-Pentyl}-Phosphinic Acid
DB00786 Marimastat
GuidetoPHARMACOLOGYi1635

Polymorphism and mutation databases

BioMutaiMMP11
DMDMi317373418

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
PropeptideiPRO_000002877032 – 97Activation peptideBy similarityAdd BLAST66
ChainiPRO_000002877198 – 488Stromelysin-3Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi294 ↔ 480By similarity

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Zymogen

Proteomic databases

PaxDbiP24347
PeptideAtlasiP24347
PRIDEiP24347
ProteomicsDBi54197

PTM databases

iPTMnetiP24347
PhosphoSitePlusiP24347

Expressioni

Tissue specificityi

Specifically expressed in stromal cells of breast carcinomas.

Gene expression databases

BgeeiENSG00000099953 Expressed in 124 organ(s), highest expression level in chorionic villus
CleanExiHS_MMP11
ExpressionAtlasiP24347 baseline and differential
GenevisibleiP24347 HS

Organism-specific databases

HPAiCAB002593
HPA068864

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000215743

Chemistry databases

BindingDBiP24347

Structurei

3D structure databases

ProteinModelPortaliP24347
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati291 – 339Hemopexin 1Add BLAST49
Repeati340 – 382Hemopexin 2Add BLAST43
Repeati384 – 432Hemopexin 3Add BLAST49
Repeati433 – 480Hemopexin 4Add BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi78 – 85Cysteine switchBy similarity8

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00760000118870
HOGENOMiHOG000217927
HOVERGENiHBG052484
InParanoidiP24347
KOiK07993
OMAiHIWFFQG
OrthoDBiEOG091G03DP
PhylomeDBiP24347
TreeFamiTF315428

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR028705 Stromelysin-3
PANTHERiPTHR10201:SF20 PTHR10201:SF20, 1 hit
PfamiView protein in Pfam
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits
PS00142 ZINC_PROTEASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P24347-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPAAWLRSA AARALLPPML LLLLQPPPLL ARALPPDAHH LHAERRGPQP
60 70 80 90 100
WHAALPSSPA PAPATQEAPR PASSLRPPRC GVPDPSDGLS ARNRQKRFVL
110 120 130 140 150
SGGRWEKTDL TYRILRFPWQ LVQEQVRQTM AEALKVWSDV TPLTFTEVHE
160 170 180 190 200
GRADIMIDFA RYWHGDDLPF DGPGGILAHA FFPKTHREGD VHFDYDETWT
210 220 230 240 250
IGDDQGTDLL QVAAHEFGHV LGLQHTTAAK ALMSAFYTFR YPLSLSPDDC
260 270 280 290 300
RGVQHLYGQP WPTVTSRTPA LGPQAGIDTN EIAPLEPDAP PDACEASFDA
310 320 330 340 350
VSTIRGELFF FKAGFVWRLR GGQLQPGYPA LASRHWQGLP SPVDAAFEDA
360 370 380 390 400
QGHIWFFQGA QYWVYDGEKP VLGPAPLTEL GLVRFPVHAA LVWGPEKNKI
410 420 430 440 450
YFFRGRDYWR FHPSTRRVDS PVPRRATDWR GVPSEIDAAF QDADGYAYFL
460 470 480
RGRLYWKFDP VKVKALEGFP RLVGPDFFGC AEPANTFL
Length:488
Mass (Da):54,590
Last modified:January 11, 2011 - v3
Checksum:iF03C537EE76706A9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PED7E9PED7_HUMAN
Matrix metalloproteinase
MMP11
354Annotation score:
F8WDI7F8WDI7_HUMAN
Matrix metalloproteinase
MMP11
113Annotation score:
H7C3I7H7C3I7_HUMAN
Matrix metalloproteinase
MMP11
170Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02218138A → V2 PublicationsCorresponds to variant dbSNP:rs738792Ensembl.1
Natural variantiVAR_02218244E → K1 PublicationCorresponds to variant dbSNP:rs28363646Ensembl.1
Natural variantiVAR_02218361P → L1 PublicationCorresponds to variant dbSNP:rs28363647Ensembl.1
Natural variantiVAR_02218486S → P1 PublicationCorresponds to variant dbSNP:rs28363648Ensembl.1
Natural variantiVAR_036140166D → N in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_029659182F → S1 PublicationCorresponds to variant dbSNP:rs17854940Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57766 mRNA Translation: CAA40918.1
AY899208 Genomic DNA Translation: AAW65373.1
AP000349 Genomic DNA No translation available.
BC057788 mRNA Translation: AAH57788.1
X84664 Genomic DNA Translation: CAA59150.1
CCDSiCCDS13816.1
PIRiS13423
RefSeqiNP_005931.2, NM_005940.4
UniGeneiHs.143751

Genome annotation databases

EnsembliENST00000215743; ENSP00000215743; ENSG00000099953
ENST00000612388; ENSP00000483349; ENSG00000275365
GeneIDi4320
KEGGihsa:4320
UCSCiuc002zxx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57766 mRNA Translation: CAA40918.1
AY899208 Genomic DNA Translation: AAW65373.1
AP000349 Genomic DNA No translation available.
BC057788 mRNA Translation: AAH57788.1
X84664 Genomic DNA Translation: CAA59150.1
CCDSiCCDS13816.1
PIRiS13423
RefSeqiNP_005931.2, NM_005940.4
UniGeneiHs.143751

3D structure databases

ProteinModelPortaliP24347
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000215743

Chemistry databases

BindingDBiP24347
ChEMBLiCHEMBL2867
DrugBankiDB04318 1-Benzyloxycarbonylamino-2-Phenyl-Ethyl)-{2-[1-Carbamoyl-2-(1h-Indol-3-Yl)-Ethylcarbamoyl]-5-Phenyl-Pentyl}-Phosphinic Acid
DB00786 Marimastat
GuidetoPHARMACOLOGYi1635

Protein family/group databases

MEROPSiM10.007

PTM databases

iPTMnetiP24347
PhosphoSitePlusiP24347

Polymorphism and mutation databases

BioMutaiMMP11
DMDMi317373418

Proteomic databases

PaxDbiP24347
PeptideAtlasiP24347
PRIDEiP24347
ProteomicsDBi54197

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215743; ENSP00000215743; ENSG00000099953
ENST00000612388; ENSP00000483349; ENSG00000275365
GeneIDi4320
KEGGihsa:4320
UCSCiuc002zxx.4 human

Organism-specific databases

CTDi4320
DisGeNETi4320
EuPathDBiHostDB:ENSG00000099953.9
GeneCardsiMMP11
H-InvDBiHIX0203187
HGNCiHGNC:7157 MMP11
HPAiCAB002593
HPA068864
MIMi185261 gene
neXtProtiNX_P24347
OpenTargetsiENSG00000099953
PharmGKBiPA30869
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00760000118870
HOGENOMiHOG000217927
HOVERGENiHBG052484
InParanoidiP24347
KOiK07993
OMAiHIWFFQG
OrthoDBiEOG091G03DP
PhylomeDBiP24347
TreeFamiTF315428

Enzyme and pathway databases

BRENDAi3.4.24.B3 2681
ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases

Miscellaneous databases

ChiTaRSiMMP11 human
GeneWikiiMMP11
GenomeRNAii4320
PROiPR:P24347
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099953 Expressed in 124 organ(s), highest expression level in chorionic villus
CleanExiHS_MMP11
ExpressionAtlasiP24347 baseline and differential
GenevisibleiP24347 HS

Family and domain databases

CDDicd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR028705 Stromelysin-3
PANTHERiPTHR10201:SF20 PTHR10201:SF20, 1 hit
PfamiView protein in Pfam
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF50923 SSF50923, 1 hit
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits
PS00142 ZINC_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMMP11_HUMAN
AccessioniPrimary (citable) accession number: P24347
Secondary accession number(s): Q5FX24, Q6PEZ6, Q9UC26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 11, 2011
Last modified: September 12, 2018
This is version 183 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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