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Protein

Putative ATP-dependent RNA helicase an3

Gene

an3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative ATP-dependent RNA helicase. Required for Wnt signaling involved in anteroposterior neural patterning (PubMed:23413191).Curated1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi241 – 248ATPPROSITE-ProRule annotation8
Nucleotide bindingi265 – 272ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKiP24346

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase an3 (EC:3.6.4.13)
Gene namesi
Name:an3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-17330554 ddx3x

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550151 – 697Putative ATP-dependent RNA helicase an3Add BLAST697

Proteomic databases

PRIDEiP24346

Interactioni

Protein-protein interaction databases

DIPiDIP-59067N
IntActiP24346, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP24346
SMRiP24346
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini252 – 444Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST193
Domaini455 – 616Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi221 – 249Q motifAdd BLAST29
Motifi388 – 391DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi623 – 697Gly/Ser-richAdd BLAST75

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG015893
KOiK11594

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

P24346-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHVAVENVL NLDQQFAGLD LNSADAESGV AGTKGRYIPP HLRNKEASRN
60 70 80 90 100
DSNWDSGRGG NGYINGMQDD RDGRMNGYDR GGYGSRGTGR SDRGFYDREN
110 120 130 140 150
SGWNSGRDKD AYSSFGSRGD RGKGSLFNER GSGSRRTDDR RQDGFDGMGN
160 170 180 190 200
RSDKSGFGRF DRGNSRWSDD RNDEDDWSKP LAPNDRVEQE LFSGSNTGIN
210 220 230 240 250
FEKYDDIPVE ATGSNCPPHI ESFHDVTMGE IIMGNIQLTR YTRPTPVQKH
260 270 280 290 300
AIPIIIEKRD LMACAQTGSG KTAAFLLPIL SQIYADGPGD AMKHLQENGR
310 320 330 340 350
YGRRKQFPLS LVLAPTRELA VQIYEEARKF AYRSRVRPCV VYGGADIGQQ
360 370 380 390 400
IRDLERGCHL LVATPGRLVD MMERGKIGLD FCKYLVLDEA DRMLDMGFEP
410 420 430 440 450
QIRRIVEQDT MPPKGVRQTM MFSATFPKEI QILARDFLDE YIFLAVGRVG
460 470 480 490 500
STSENITQKV VWVEEMDKRS FLLDLLNATG KDSLTLVFVE TKKGADALED
510 520 530 540 550
FLYHEGYACT SIHGDRSQRD REEALHQFRS GKSPILVATA VAARGLDISN
560 570 580 590 600
VKHVINFDLP SDIEEYVHRI GRTGRVGNLG LATSFFNEKN INITKDLLDL
610 620 630 640 650
LVEAKQEVPS WLENMAYEQH HKSSSRGRSK SRFSGGFGAK DYRQSSGAGS
660 670 680 690
SFGSSRGGRS SGHGGSRGFG GGYGGFYNSD GYGGNYGGSS QVDWWGN
Length:697
Mass (Da):77,303
Last modified:March 1, 1992 - v1
Checksum:iF3DD23EB60B2E2EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57328 mRNA Translation: CAA40605.1
PIRiS13654
RefSeqiNP_001095245.1, NM_001101775.1
UniGeneiXl.21985

Genome annotation databases

GeneIDi397935
KEGGixla:397935

Similar proteinsi

Entry informationi

Entry nameiDDX3_XENLA
AccessioniPrimary (citable) accession number: P24346
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 22, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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