Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kinesin-like protein cut7

Gene

cut7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be a spindle pole body motor. On transition from G2 to M phase of the cell cycle, the spindle pole body duplicates; the daughter pole bodies seed microtubules which interdigitate to form a short spindle that elongates to span the nucleus at metaphase. Mutations at cut7 block spindle formation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi159 – 166ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: PomBase
  • microtubule binding Source: InterPro

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • microtubule-based movement Source: GO_Central
  • microtubule plus-end directed mitotic chromosome migration Source: PomBase
  • mitotic spindle midzone assembly Source: PomBase
  • mitotic spindle pole body separation Source: PomBase

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein cut7
Alternative name(s):
Cell untimely torn protein 7
Gene namesi
Name:cut7
ORF Names:SPAC25G10.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC25G10.07c
PomBaseiSPAC25G10.07c cut7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253701 – 1085Kinesin-like protein cut7Add BLAST1085

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1011Phosphothreonine; by CDC2By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP24339
PaxDbiP24339
PRIDEiP24339

PTM databases

iPTMnetiP24339

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
mad1P871693EBI-16168992,EBI-16079828

GO - Molecular functioni

Protein-protein interaction databases

BioGridi279182, 22 interactors
DIPiDIP-61701N
IntActiP24339, 1 interactor
STRINGi4896.SPAC25G10.07c.1

Structurei

3D structure databases

ProteinModelPortaliP24339
SMRiP24339
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 421Kinesin motorPROSITE-ProRule annotationAdd BLAST350
Repeati987 – 998Add BLAST12
Repeati999 – 1010Add BLAST12

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili436 – 604Sequence analysisAdd BLAST169
Coiled coili715 – 740Sequence analysisAdd BLAST26
Coiled coili897 – 955Sequence analysisAdd BLAST59

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

InParanoidiP24339
KOiK10398
OMAiHTHEESQ
OrthoDBiEOG092C2D4G
PhylomeDBiP24339

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P24339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRVAPGGS QQFLGKQGLK AKNPVSTPNS HFRSASNPRK RREPPTIDTG
60 70 80 90 100
YPDRSDTNSP TDHALHDENE TNINVVVRVR GRTDQEVRDN SSLAVSTSGA
110 120 130 140 150
MGAELAIQSD PSSMLVTKTY AFDKVFGPEA DQLMLFENSV APMLEQVLNG
160 170 180 190 200
YNCTIFAYGQ TGTGKTYTMS GDLSDSDGIL SEGAGLIPRA LYQLFSSLDN
210 220 230 240 250
SNQEYAVKCS YYELYNEEIR DLLVSEELRK PARVFEDTSR RGNVVITGIE
260 270 280 290 300
ESYIKNAGDG LRLLREGSHR RQVAATKCND LSSRSHSIFT ITLHRKVSSG
310 320 330 340 350
MTDETNSLTI NNNSDDLLRA SKLHMVDLAG SENIGRSGAE NKRARETGMI
360 370 380 390 400
NQSLLTLGRV INALVEKAHH IPYRESKLTR LLQDSLGGKT KTSMIVTVSS
410 420 430 440 450
TNTNLEETIS TLEYAARAKS IRNKPQNNQL VFRKVLIKDL VLDIERLKND
460 470 480 490 500
LNATRKKNGV YLAESTYKEL MDRVQNKDLL CQEQARKLEV LDLNVKSSRE
510 520 530 540 550
QLQYVSKSNQ EHKKEVEALQ LQLVNSSTEL ESVKSENEKL KNELVLEIEK
560 570 580 590 600
RKKYETNEAK ITTVATDLSQ YYRESKEYIA SLYEKLDRTE RNNKENENNF
610 620 630 640 650
WNLKFNLLTM LRSFHGSFTD ETNGYFTLLN DFNASMEELL NTHSNQLLIS
660 670 680 690 700
MTKITEHFQS LDEALQSARS SCAVPNSSLD LIVSELKDSK NSLLDALEHS
710 720 730 740 750
LQDISMSSQK LGNGISSELI ELQKDMKESY RQLVQELRSL YNLQHTHEES
760 770 780 790 800
QKELMYGVRN DIDALVKTCT TSLNDADIIL SDYISDQKSK FESKQQDLIA
810 820 830 840 850
NIGKIVSNFL QEQNESLYTK ADILHSHLND TNSNIRKANE IMNNRSEEFL
860 870 880 890 900
RNAASQAEIV GANKERIQKT VENGSQLLDS KSKAIHSNSR SMYDHCLALA
910 920 930 940 950
ESQKQGVNLE VQTLDRLLQK VKEHSEDNTK EKHQQLLDLL ESLVGNNDNL
960 970 980 990 1000
IDSIKTPHTE LQKITDHVLK GTTSLANHTN ELLGLGDESL CNLETTIEDT
1010 1020 1030 1040 1050
SLVKLETTGD TPSKRELPAT PSWTRDSSLI KETTNLNLDS DKKFVRETYT
1060 1070 1080
SSNQTNEPDV YDKPSNSSRT SLLRSSRSAY SKMKR
Length:1,085
Mass (Da):122,133
Last modified:October 1, 1996 - v3
Checksum:i5669277875559D58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34 – 61SASNP…TNSPT → LRAILGNDVSLLLLTL in CAA40738 (PubMed:2145514).CuratedAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57513 Genomic DNA Translation: CAA40738.1
CU329670 Genomic DNA Translation: CAA94636.1
PIRiS14032
T38378
RefSeqiNP_594527.1, NM_001019956.2

Genome annotation databases

EnsemblFungiiSPAC25G10.07c.1; SPAC25G10.07c.1:pep; SPAC25G10.07c
GeneIDi2542732
KEGGispo:SPAC25G10.07c

Similar proteinsi

Entry informationi

Entry nameiCUT7_SCHPO
AccessioniPrimary (citable) accession number: P24339
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health