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Protein

Amphiregulin

Gene

Areg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • epidermal growth factor receptor binding Source: RGD
  • growth factor activity Source: RGD

GO - Biological processi

  • central nervous system development Source: RGD
  • dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis Source: Ensembl
  • epidermal growth factor receptor signaling pathway Source: RGD
  • epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
  • glial cell proliferation Source: RGD
  • G-protein coupled receptor signaling pathway Source: Ensembl
  • mammary gland alveolus development Source: Ensembl
  • mammary gland branching involved in thelarche Source: Ensembl
  • negative regulation of osteoblast differentiation Source: RGD
  • neuron projection development Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  • positive regulation of phosphorylation Source: RGD
  • response to cAMP Source: RGD
  • response to estradiol Source: Ensembl
  • response to glucocorticoid Source: RGD
  • response to hydrogen peroxide Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-RNO-204005 COPII-mediated vesicle transport
R-RNO-5694530 Cargo concentration in the ER

Names & Taxonomyi

Protein namesi
Recommended name:
Amphiregulin
Short name:
AR
Alternative name(s):
Schwannoma-derived growth factor
Short name:
SDGF
Gene namesi
Name:Areg
Synonyms:Sdgf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi2149 Areg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei190 – 213HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000000747825 – 96Add BLAST72
ChainiPRO_000000747997 – 243AmphiregulinAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi137 ↔ 150PROSITE-ProRule annotation
Disulfide bondi145 ↔ 161PROSITE-ProRule annotation
Disulfide bondi163 ↔ 172PROSITE-ProRule annotation
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP24338
PRIDEiP24338

Expressioni

Gene expression databases

BgeeiENSRNOG00000002754
GenevisibleiP24338 RN

Interactioni

Subunit structurei

The immature precursor interacts with CNIH.By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • epidermal growth factor receptor binding Source: RGD
  • growth factor activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003703

Structurei

3D structure databases

ProteinModelPortaliP24338
SMRiP24338
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 173EGF-likePROSITE-ProRule annotationAdd BLAST41

Sequence similaritiesi

Belongs to the amphiregulin family.Curated

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXZG Eukaryota
ENOG4112CXY LUCA
GeneTreeiENSGT00530000063708
HOGENOMiHOG000034038
HOVERGENiHBG060279
InParanoidiP24338
KOiK09782
OMAiCKCHQDY
OrthoDBiEOG091G0XMN
PhylomeDBiP24338
TreeFamiTF332773

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR015497 EGF_rcpt_ligand
PANTHERiPTHR10740 PTHR10740, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTPSLSLAL SVLSLLVLGS GHYAAGLELN GTSSGKGEPS SGDHSAGGLV
60 70 80 90 100
VSEVSTISEM PSGSELSTGD YDYSEEYDNE PQISGYIVDD SVRVEQVIKP
110 120 130 140 150
KENKTEGEKS SEKPKRKKKG GKGGKGRRNR KKKKNPCAAK FQNFCIHGEC
160 170 180 190 200
RYIENLEVVT CHCHQDYFGE RCGEKTMKTQ KKDDSDLSKI ALAAIIVFVS
210 220 230 240
AVSVAAIGII TAVLLRKRFF REYEEAEERR RLRQENGTAH AIA
Length:243
Mass (Da):26,633
Last modified:March 1, 1992 - v1
Checksum:iF59A8173D4921599
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55183 mRNA Translation: CAA38967.1
PIRiS13296
RefSeqiNP_058819.1, NM_017123.1
UniGeneiRn.10568

Genome annotation databases

EnsembliENSRNOT00000003703; ENSRNOP00000003703; ENSRNOG00000002754
GeneIDi29183
KEGGirno:29183
UCSCiRGD:2149 rat

Similar proteinsi

Entry informationi

Entry nameiAREG_RAT
AccessioniPrimary (citable) accession number: P24338
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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