The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P24306 (HEMA_CDVO)
Protein
Hemagglutinin glycoprotein
Gene
H
Organism
Canine distemper virus (strain Onderstepoort) (CDV)
Status
Functioni
Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. The cellular receptor might be SLAM, and may explain the lymphotropism of the virus.
Caution
Morbiliviruses hemagglutinins have no neuraminidase activity.Curated
GO - Molecular functioni
- host cell surface receptor binding Source: InterPro
GO - Biological processi
- viral entry into host cell Source: UniProtKB-KW
- virion attachment to host cell Source: UniProtKB-KW
Keywordsi
Molecular function | Hemagglutinin |
Biological process | Host-virus interaction, Viral attachment to host cell, Virus entry into host cell |
Names & Taxonomyi
Protein namesi | Recommended name: Hemagglutinin glycoprotein |
Gene namesi | Name:H |
Organismi | Canine distemper virus (strain Onderstepoort) (CDV) |
Taxonomic identifieri | 11233 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Negarnaviricota › Haploviricotina › Monjiviricetes › Mononegavirales › Paramyxoviridae › Orthoparamyxovirinae › Morbillivirus › |
Virus hosti | Ailuropoda melanoleuca (Giant panda) [TaxID: 9646] Ailurus fulgens (Lesser panda) (Red panda) [TaxID: 9649] Canis lupus familiaris (Dog) (Canis familiaris) [TaxID: 9615] Mustela [TaxID: 9665] Panthera leo (Lion) [TaxID: 9689] Procyon lotor (Raccoon) [TaxID: 9654] Zalophus californianus (California sealion) [TaxID: 9704] |
Subcellular locationi
- Virion membrane Curated; Single-pass type II membrane protein Curated
- Host cell membrane By similarity; Single-pass type II membrane protein By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 37 | IntravirionSequence analysisAdd BLAST | 37 | |
Transmembranei | 38 – 58 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 59 – 604 | Virion surfaceSequence analysisAdd BLAST | 546 |
Keywords - Cellular componenti
Host cell membrane, Host membrane, Membrane, Viral envelope protein, VirionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 483 | P → S: No effect on fusion activity. 1 Publication | 1 | |
Mutagenesisi | 488 | G → A: No effect on fusion activity. 1 Publication | 1 | |
Mutagenesisi | 489 | N → A: No effect on fusion activity. 1 Publication | 1 | |
Mutagenesisi | 491 | Y → A: Loss of fusion activity. 1 Publication | 1 | |
Mutagenesisi | 493 | P → S: Complete loss of fusion activity. 1 Publication | 1 | |
Mutagenesisi | 525 | Y → A: Complete loss of fusion activity. 1 Publication | 1 | |
Mutagenesisi | 526 | D → A: No effect on fusion activity. 1 Publication | 1 | |
Mutagenesisi | 527 | I → A: Partial loss of fusion activity. 1 Publication | 1 | |
Mutagenesisi | 528 | S → A: Partial loss of fusion activity. 1 Publication | 1 | |
Mutagenesisi | 529 | R → A: Partial loss of fusion activity. 1 Publication | 1 | |
Mutagenesisi | 530 | S → A: No effect on fusion activity. 1 Publication | 1 | |
Mutagenesisi | 532 | H → A: No effect on fusion activity. 1 Publication | 1 | |
Mutagenesisi | 533 | A → S: No effect on fusion activity. 1 Publication | 1 | |
Mutagenesisi | 543 | R → A: No effect on fusion activity. 1 Publication | 1 | |
Mutagenesisi | 545 | I → S: No effect on fusion activity. 1 Publication | 1 | |
Mutagenesisi | 547 | Y → A: No effect on fusion activity. 1 Publication | 1 | |
Mutagenesisi | 548 | T → A: No effect on fusion activity. 1 Publication | 1 | |
Mutagenesisi | 549 | H → A: No effect on fusion activity. 1 Publication | 1 | |
Mutagenesisi | 550 | P → S: No effect on fusion activity. 1 Publication | 1 | |
Mutagenesisi | 551 | F → S: Complete loss of fusion activity. 1 Publication | 1 | |
Mutagenesisi | 552 | R → A: Partial loss of fusion activity. 1 Publication | 1 | |
Mutagenesisi | 553 | L → S: Complete loss of fusion activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000142597 | 1 – 604 | Hemagglutinin glycoproteinAdd BLAST | 604 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 149 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 422 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 587 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PRIDEi | P24306 |
Interactioni
Subunit structurei
Binds canine SLAMF1 at the cell surface.
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixFamily and domain databases
InterProi | View protein in InterPro IPR000665, Hemagglutn/HN IPR036278, Sialidase_sf |
Pfami | View protein in Pfam PF00423, HN, 1 hit |
SUPFAMi | SSF50939, SSF50939, 1 hit |
i Sequence
Sequence statusi: Complete.
P24306-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPYQDKVGA FYKDNARANS TKLSLVTEGH GGRRPPYLLF VLLILLVGIL
60 70 80 90 100
ALLAITGVRF HQVSTSNMEF SRLLKEDMEK SEAVHHQVID VLTPLFKIIG
110 120 130 140 150
DEIGLRLPQK LNEIKQFILQ KTNFFNPNRE FDFRDLHWCI NPPSTVKVNF
160 170 180 190 200
TNYCESIGIR KAIASAANPI LLSALSGGRG DIFPPHRCSG ATTSVGKVFP
210 220 230 240 250
LSVSLSMSLI SRTSEVINML TAISDGVYGK TYLLVPDDIE REFDTREIRV
260 270 280 290 300
FEIGFIKRWL NDMPLLQTTN YMVLPKNSKA KVCTIAVGEL TLASLCVEES
310 320 330 340 350
TVLLYHDSSG SQDGILVVTL GIFWATPMDH IEEVIPVAHP SMKKIHITNH
360 370 380 390 400
RGFIKDSIAT WMVPALASEK QEEQKGCLES ACQRKTYPMC NQASWEPFGG
410 420 430 440 450
RQLPSYGRLT LPLDASVDLQ LNISFTYGPV ILNGDGMDYY ESPLLNSGWL
460 470 480 490 500
TIPPKDGTIS GLINKAGRGD QFTVLPHVLT FAPRESSGNC YLPIQTSQIR
510 520 530 540 550
DRDVLIESNI VVLPTQSIRY VIATYDISRS DHAIVYYVYD PIRTISYTHP
560 570 580 590 600
FRLTTKGRPD FLRIECFVWD DNLWCHQFYR FEADIANSTT SVENLVRIRF
SCNR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D00758 Genomic RNA Translation: BAA00654.1 |
PIRi | A38480, HMNZCD |
RefSeqi | NP_047206.1, NC_001921.1 |
Genome annotation databases
GeneIDi | 1489792 |
KEGGi | vg:1489792 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D00758 Genomic RNA Translation: BAA00654.1 |
PIRi | A38480, HMNZCD |
RefSeqi | NP_047206.1, NC_001921.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7CJQ | X-ray | 2.70 | C/F | 543-551 | [»] | |
SMRi | P24306 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PRIDEi | P24306 |
Genome annotation databases
GeneIDi | 1489792 |
KEGGi | vg:1489792 |
Family and domain databases
InterProi | View protein in InterPro IPR000665, Hemagglutn/HN IPR036278, Sialidase_sf |
Pfami | View protein in Pfam PF00423, HN, 1 hit |
SUPFAMi | SSF50939, SSF50939, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HEMA_CDVO | |
Accessioni | P24306Primary (citable) accession number: P24306 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families