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UniProtKB - P24306 (HEMA_CDVO)

Entry version 94 (07 Apr 2021)
Sequence version 1 (01 Mar 1992)
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Protein

Hemagglutinin glycoprotein

Gene

H

Organism
Canine distemper virus (strain Onderstepoort) (CDV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. The cellular receptor might be SLAM, and may explain the lymphotropism of the virus.

Caution

Morbiliviruses hemagglutinins have no neuraminidase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHemagglutinin
Biological processHost-virus interaction, Viral attachment to host cell, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hemagglutinin glycoprotein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:H
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanine distemper virus (strain Onderstepoort) (CDV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11233 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Negarnaviricota › Haploviricotina › Monjiviricetes › Mononegavirales › Paramyxoviridae › Orthoparamyxovirinae › Morbillivirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiAiluropoda melanoleuca (Giant panda) [TaxID: 9646]
Ailurus fulgens (Lesser panda) (Red panda) [TaxID: 9649]
Canis lupus familiaris (Dog) (Canis familiaris) [TaxID: 9615]
Mustela [TaxID: 9665]
Panthera leo (Lion) [TaxID: 9689]
Procyon lotor (Raccoon) [TaxID: 9654]
Zalophus californianus (California sealion) [TaxID: 9704]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 37IntravirionSequence analysisAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 604Virion surfaceSequence analysisAdd BLAST546

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi483P → S: No effect on fusion activity. 1 Publication1
Mutagenesisi488G → A: No effect on fusion activity. 1 Publication1
Mutagenesisi489N → A: No effect on fusion activity. 1 Publication1
Mutagenesisi491Y → A: Loss of fusion activity. 1 Publication1
Mutagenesisi493P → S: Complete loss of fusion activity. 1 Publication1
Mutagenesisi525Y → A: Complete loss of fusion activity. 1 Publication1
Mutagenesisi526D → A: No effect on fusion activity. 1 Publication1
Mutagenesisi527I → A: Partial loss of fusion activity. 1 Publication1
Mutagenesisi528S → A: Partial loss of fusion activity. 1 Publication1
Mutagenesisi529R → A: Partial loss of fusion activity. 1 Publication1
Mutagenesisi530S → A: No effect on fusion activity. 1 Publication1
Mutagenesisi532H → A: No effect on fusion activity. 1 Publication1
Mutagenesisi533A → S: No effect on fusion activity. 1 Publication1
Mutagenesisi543R → A: No effect on fusion activity. 1 Publication1
Mutagenesisi545I → S: No effect on fusion activity. 1 Publication1
Mutagenesisi547Y → A: No effect on fusion activity. 1 Publication1
Mutagenesisi548T → A: No effect on fusion activity. 1 Publication1
Mutagenesisi549H → A: No effect on fusion activity. 1 Publication1
Mutagenesisi550P → S: No effect on fusion activity. 1 Publication1
Mutagenesisi551F → S: Complete loss of fusion activity. 1 Publication1
Mutagenesisi552R → A: Partial loss of fusion activity. 1 Publication1
Mutagenesisi553L → S: Complete loss of fusion activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001425971 – 604Hemagglutinin glycoproteinAdd BLAST604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi149N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi422N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi587N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		P24306

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds canine SLAMF1 at the cell surface.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P24306

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family. Non-sialidase subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000665, Hemagglutn/HN
IPR036278, Sialidase_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00423, HN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50939, SSF50939, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P24306-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPYQDKVGA FYKDNARANS TKLSLVTEGH GGRRPPYLLF VLLILLVGIL 
        60         70         80         90        100
ALLAITGVRF HQVSTSNMEF SRLLKEDMEK SEAVHHQVID VLTPLFKIIG 
       110        120        130        140        150
DEIGLRLPQK LNEIKQFILQ KTNFFNPNRE FDFRDLHWCI NPPSTVKVNF 
       160        170        180        190        200
TNYCESIGIR KAIASAANPI LLSALSGGRG DIFPPHRCSG ATTSVGKVFP 
       210        220        230        240        250
LSVSLSMSLI SRTSEVINML TAISDGVYGK TYLLVPDDIE REFDTREIRV 
       260        270        280        290        300
FEIGFIKRWL NDMPLLQTTN YMVLPKNSKA KVCTIAVGEL TLASLCVEES 
       310        320        330        340        350
TVLLYHDSSG SQDGILVVTL GIFWATPMDH IEEVIPVAHP SMKKIHITNH 
       360        370        380        390        400
RGFIKDSIAT WMVPALASEK QEEQKGCLES ACQRKTYPMC NQASWEPFGG 
       410        420        430        440        450
RQLPSYGRLT LPLDASVDLQ LNISFTYGPV ILNGDGMDYY ESPLLNSGWL 
       460        470        480        490        500
TIPPKDGTIS GLINKAGRGD QFTVLPHVLT FAPRESSGNC YLPIQTSQIR 
       510        520        530        540        550
DRDVLIESNI VVLPTQSIRY VIATYDISRS DHAIVYYVYD PIRTISYTHP 
       560        570        580        590        600
FRLTTKGRPD FLRIECFVWD DNLWCHQFYR FEADIANSTT SVENLVRIRF 

SCNR
Length:604
Mass (Da):67,988
Last modified:March 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i552429817EF3D2A8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D00758 Genomic RNA Translation: BAA00654.1

Protein sequence database of the Protein Information Resource

More...PIRi		A38480, HMNZCD

NCBI Reference Sequences

More...RefSeqi		NP_047206.1, NC_001921.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1489792

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:1489792

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00758 Genomic RNA Translation: BAA00654.1
PIRiA38480, HMNZCD
RefSeqiNP_047206.1, NC_001921.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7CJQX-ray2.70C/F543-551[»]
SMRiP24306
ModBaseiSearch...
PDBe-KBiSearch...

Proteomic databases

PRIDEiP24306

Genome annotation databases

GeneIDi1489792
KEGGivg:1489792

Family and domain databases

InterProiView protein in InterPro
IPR000665, Hemagglutn/HN
IPR036278, Sialidase_sf
PfamiView protein in Pfam
PF00423, HN, 1 hit
SUPFAMiSSF50939, SSF50939, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEMA_CDVO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24306
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 7, 2021
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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