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Protein

Zinc finger and BTB domain-containing protein 25

Gene

ZBTB25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri238 – 260C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA-binding transcription factor activity Source: ProtInc
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • gene expression Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Protein family/group databases

MoonDBiP24278 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 25
Alternative name(s):
Zinc finger protein 46
Zinc finger protein KUP
Gene namesi
Name:ZBTB25
Synonyms:C14orf51, KUP, ZNF46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000089775.11
HGNCiHGNC:13112 ZBTB25
MIMi194541 gene
neXtProtiNX_P24278

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000089775
PharmGKBiPA37687

Polymorphism and mutation databases

BioMutaiZBTB25
DMDMi116242849

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477381 – 435Zinc finger and BTB domain-containing protein 25Add BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki204Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki303Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki405Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP24278
MaxQBiP24278
PaxDbiP24278
PeptideAtlasiP24278
PRIDEiP24278
ProteomicsDBi54193

PTM databases

iPTMnetiP24278
PhosphoSitePlusiP24278

Expressioni

Tissue specificityi

Expressed mainly in hematopoietic cells and testis.

Gene expression databases

BgeeiENSG00000089775 Expressed in 128 organ(s), highest expression level in gastrocnemius
CleanExiHS_ZBTB25
ExpressionAtlasiP24278 baseline and differential
GenevisibleiP24278 HS

Organism-specific databases

HPAiHPA054699

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi113422, 29 interactors
IntActiP24278, 39 interactors
MINTiP24278
STRINGi9606.ENSP00000261683

Structurei

3D structure databases

ProteinModelPortaliP24278
SMRiP24278
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 107BTBPROSITE-ProRule annotationAdd BLAST107

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri238 – 260C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00850000132316
HOGENOMiHOG000013138
HOVERGENiHBG095695
InParanoidiP24278
KOiK10504
OMAiECHRLSS
OrthoDBiEOG091G06C9
PhylomeDBiP24278
TreeFamiTF332229

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P24278-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTASHSLVL LQQLNMQREF GFLCDCTVAI GDVYFKAHRA VLAAFSNYFK
60 70 80 90 100
MIFIHQTSEC IKIQPTDIQP DIFSYLLHIM YTGKGPKQIV DHSRLEEGIR
110 120 130 140 150
FLHADYLSHI ATEMNQVFSP ETVQSSNLYG IQISTTQKTV VKQGLEVKEA
160 170 180 190 200
PSSNSGNRAA VQGDHPQLQL SLAIGLDDGT ADQQRACPAT QALEEHQKPP
210 220 230 240 250
VSIKQERCDP ESVISQSHPS PSSEVTGPTF TENSVKIHLC HYCGERFDSR
260 270 280 290 300
SNLRQHLHTH VSGSLPFGVP ASILESNDLG EVHPLNENSE ALECRRLSSF
310 320 330 340 350
IVKENEQQPD HTNRGTTEPL QISQVSLISK DTEPVELNCN FSFSRKRKMS
360 370 380 390 400
CTICGHKFPR KSQLLEHMYT HKGKSYRYNR CQRFGNALAQ RFQPYCDSWS
410 420 430
DVSLKSSRLS QEHLDLPCAL ESELTQENVD TILVE
Length:435
Mass (Da):48,990
Last modified:October 17, 2006 - v2
Checksum:i5994E14B735AA0AE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V351G3V351_HUMAN
Zinc finger and BTB domain containi...
ZBTB25 hCG_41676
94Annotation score:
G3V2K3G3V2K3_HUMAN
Zinc finger and BTB domain-containi...
ZBTB25
86Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165H → L in CAA34595 (PubMed:2027750).Curated1
Sequence conflicti169 – 170Missing in CAA34595 (PubMed:2027750).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16576 mRNA Translation: CAA34595.1
AK098181 mRNA Translation: BAG53588.1
CH471061 Genomic DNA Translation: EAW80861.1
BC035804 mRNA Translation: AAH35804.1
CCDSiCCDS9765.1
PIRiS15647
RefSeqiNP_001291436.1, NM_001304507.1
NP_008908.2, NM_006977.3
XP_006720314.1, XM_006720251.3
XP_006720315.1, XM_006720252.3
XP_011535445.1, XM_011537143.2
XP_016877121.1, XM_017021632.1
XP_016877122.1, XM_017021633.1
XP_016877123.1, XM_017021634.1
XP_016877124.1, XM_017021635.1
UniGeneiHs.654571

Genome annotation databases

EnsembliENST00000394715; ENSP00000378204; ENSG00000089775
ENST00000608382; ENSP00000476746; ENSG00000089775
GeneIDi7597
KEGGihsa:7597
UCSCiuc001xhf.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16576 mRNA Translation: CAA34595.1
AK098181 mRNA Translation: BAG53588.1
CH471061 Genomic DNA Translation: EAW80861.1
BC035804 mRNA Translation: AAH35804.1
CCDSiCCDS9765.1
PIRiS15647
RefSeqiNP_001291436.1, NM_001304507.1
NP_008908.2, NM_006977.3
XP_006720314.1, XM_006720251.3
XP_006720315.1, XM_006720252.3
XP_011535445.1, XM_011537143.2
XP_016877121.1, XM_017021632.1
XP_016877122.1, XM_017021633.1
XP_016877123.1, XM_017021634.1
XP_016877124.1, XM_017021635.1
UniGeneiHs.654571

3D structure databases

ProteinModelPortaliP24278
SMRiP24278
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113422, 29 interactors
IntActiP24278, 39 interactors
MINTiP24278
STRINGi9606.ENSP00000261683

Protein family/group databases

MoonDBiP24278 Predicted

PTM databases

iPTMnetiP24278
PhosphoSitePlusiP24278

Polymorphism and mutation databases

BioMutaiZBTB25
DMDMi116242849

Proteomic databases

EPDiP24278
MaxQBiP24278
PaxDbiP24278
PeptideAtlasiP24278
PRIDEiP24278
ProteomicsDBi54193

Protocols and materials databases

DNASUi7597
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394715; ENSP00000378204; ENSG00000089775
ENST00000608382; ENSP00000476746; ENSG00000089775
GeneIDi7597
KEGGihsa:7597
UCSCiuc001xhf.4 human

Organism-specific databases

CTDi7597
EuPathDBiHostDB:ENSG00000089775.11
GeneCardsiZBTB25
HGNCiHGNC:13112 ZBTB25
HPAiHPA054699
MIMi194541 gene
neXtProtiNX_P24278
OpenTargetsiENSG00000089775
PharmGKBiPA37687
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00850000132316
HOGENOMiHOG000013138
HOVERGENiHBG095695
InParanoidiP24278
KOiK10504
OMAiECHRLSS
OrthoDBiEOG091G06C9
PhylomeDBiP24278
TreeFamiTF332229

Miscellaneous databases

ChiTaRSiZBTB25 human
GenomeRNAii7597
PROiPR:P24278
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089775 Expressed in 128 organ(s), highest expression level in gastrocnemius
CleanExiHS_ZBTB25
ExpressionAtlasiP24278 baseline and differential
GenevisibleiP24278 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT25_HUMAN
AccessioniPrimary (citable) accession number: P24278
Secondary accession number(s): B3KUX6, Q8IYH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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