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Entry version 177 (11 Dec 2019)
Sequence version 1 (01 Mar 1992)
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Protein

Protein SSD1

Gene

SSD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can suppress the lethality due to deletion of SIT4, and partially the defects due to BCY1 disruption. Is implicated in the control of the cell cycle G1 phase.

Miscellaneous

Several alleles of SSD1 exist in different yeast strains.
Present with 1100 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-29856-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein SSD1
Alternative name(s):
Protein SRK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SSD1
Synonyms:CLA1, RLD1, SRK1
Ordered Locus Names:YDR293C
ORF Names:D9819.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YDR293C

Saccharomyces Genome Database

More...
SGDi
S000002701 SSD1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001664242 – 1250Protein SSD1Add BLAST1249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei227PhosphothreonineCombined sources1
Modified residuei286PhosphoserineCombined sources1
Modified residuei322PhosphoserineCombined sources1
Modified residuei491PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1
Modified residuei688PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P24276

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P24276

PRoteomics IDEntifications database

More...
PRIDEi
P24276

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P24276

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
32345, 807 interactors

Database of interacting proteins

More...
DIPi
DIP-6449N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P24276

Protein interaction database and analysis system

More...
IntActi
P24276, 32 interactors

Molecular INTeraction database

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MINTi
P24276

STRING: functional protein association networks

More...
STRINGi
4932.YDR293C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P24276 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P24276

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi60 – 67Poly-Gln8
Compositional biasi71 – 74Poly-Gln4
Compositional biasi135 – 141Poly-Asn7
Compositional biasi214 – 217Poly-Pro4
Compositional biasi527 – 530Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNR ribonuclease family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000207194

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24276

KEGG Orthology (KO)

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KOi
K18748

Identification of Orthologs from Complete Genome Data

More...
OMAi
RVAGQMF

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041505 Dis3_CSD2
IPR041093 Dis3l2_C
IPR012340 NA-bd_OB-fold
IPR001900 RNase_II/R
IPR022966 RNase_II/R_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17877 Dis3l2_C_term, 1 hit
PF17849 OB_Dis3, 1 hit
PF00773 RNB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00955 RNB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249 SSF50249, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01175 RIBONUCLEASE_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P24276-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKNSNVNNN RSQEPNNMFV QTTGGGKNAP KQIHVAHRRS QSELTNLMIE
60 70 80 90 100
QFTLQKQLEQ VQAQQQQLMA QQQQLAQQTG QYLSGNSGSN NHFTPQPPHP
110 120 130 140 150
HYNSNGNSPG MSAGGSRSRT HSRNNSGYYH NSYDNNNNSN NPGSNSHRKT
160 170 180 190 200
SSQSSIYGHS RRHSLGLNEA KKAAAEEQAK RISGGEAGVT VKIDSVQADS
210 220 230 240 250
GSNSTTEQSD FKFPPPPNAH QGHRRATSNL SPPSFKFPPN SHGDNDDEFI
260 270 280 290 300
ATSSTHRRSK TRNNEYSPGI NSNWRNQSQQ PQQQLSPFRH RGSNSRDYNS
310 320 330 340 350
FNTLEPPAIF QQGHKHRASN SSVHSFSSQG NNNGGGRKSL FAPYLPQANI
360 370 380 390 400
PELIQEGRLV AGILRVNKKN RSDAWVSTDG ALDADIYICG SKDRNRALEG
410 420 430 440 450
DLVAVELLVV DDVWESKKEK EEKKRRKDAS MQHDLIPLNS SDDYHNDASV
460 470 480 490 500
TAATSNNFLS SPSSSDSLSK DDLSVRRKRS STINNDSDSL SSPTKSGVRR
510 520 530 540 550
RSSLKQRPTQ KKNDDVEVEG QSLLLVEEEE INDKYKPLYA GHVVAVLDRI
560 570 580 590 600
PGQLFSGTLG LLRPSQQANS DNNKPPQSPK IAWFKPTDKK VPLIAIPTEL
610 620 630 640 650
APKDFVENAD KYSEKLFVAS IKRWPITSLH PFGILVSELG DIHDPDTEID
660 670 680 690 700
SILRDNNFLS NEYLDQKNPQ KEKPSFQPLP LTAESLEYRR NFTDTNEYNI
710 720 730 740 750
FAISELGWVS EFALHVRNNG NGTLELGCHV VDVTSHIEEG SSVDRRARKR
760 770 780 790 800
SSAVFMPQKL VNLLPQSFND ELSLAPGKES ATLSVVYTLD SSTLRIKSTW
810 820 830 840 850
VGESTISPSN ILSLEQLDEK LSTGSPTSYL STVQEIARSF YARRINDPEA
860 870 880 890 900
TLLPTLSLLE SLDDEKVKVD LNILDRTLGF VVINEIKRKV NSTVAEKIYT
910 920 930 940 950
KLGDLALLRR QMQPIATKMA SFRKKIQNFG YNFDTNTADE LIKGVLKIKD
960 970 980 990 1000
DDVRVGIEIL LFKTMPRARY FIAGKVDPDQ YGHYALNLPI YTHFTAPMRR
1010 1020 1030 1040 1050
YADHVVHRQL KAVIHDTPYT EDMEALKITS EYCNFKKDCA YQAQEQAIHL
1060 1070 1080 1090 1100
LLCKTINDMG NTTGQLLTMA TVLQVYESSF DVFIPEFGIE KRVHGDQLPL
1110 1120 1130 1140 1150
IKAEFDGTNR VLELHWQPGV DSATFIPADE KNPKSYRNSI KNKFRSTAAE
1160 1170 1180 1190 1200
IANIELDKEA ESEPLISDPL SKELSDLHLT VPNLRLPSAS DNKQNALEKF
1210 1220 1230 1240 1250
ISTTETRIEN DNYIQEIHEL QKIPILLRAE VGMALPCLTV RALNPFMKRV
Length:1,250
Mass (Da):139,954
Last modified:March 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D50FD6838ECA514
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M60318 Genomic DNA Translation: AAA35047.1
M63004 Genomic DNA Translation: AAA35089.1
U51031 Genomic DNA Translation: AAB64469.1
BK006938 Genomic DNA Translation: DAA12132.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A39578

NCBI Reference Sequences

More...
RefSeqi
NP_010579.1, NM_001180601.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR293C_mRNA; YDR293C; YDR293C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851887

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR293C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60318 Genomic DNA Translation: AAA35047.1
M63004 Genomic DNA Translation: AAA35089.1
U51031 Genomic DNA Translation: AAB64469.1
BK006938 Genomic DNA Translation: DAA12132.1
PIRiA39578
RefSeqiNP_010579.1, NM_001180601.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NCLX-ray3.15D205-214[»]
SMRiP24276
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi32345, 807 interactors
DIPiDIP-6449N
ELMiP24276
IntActiP24276, 32 interactors
MINTiP24276
STRINGi4932.YDR293C

PTM databases

iPTMnetiP24276

Proteomic databases

MaxQBiP24276
PaxDbiP24276
PRIDEiP24276

Genome annotation databases

EnsemblFungiiYDR293C_mRNA; YDR293C; YDR293C
GeneIDi851887
KEGGisce:YDR293C

Organism-specific databases

EuPathDBiFungiDB:YDR293C
SGDiS000002701 SSD1

Phylogenomic databases

HOGENOMiHOG000207194
InParanoidiP24276
KOiK18748
OMAiRVAGQMF

Enzyme and pathway databases

BioCyciYEAST:G3O-29856-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P24276
RNActiP24276 protein

Family and domain databases

InterProiView protein in InterPro
IPR041505 Dis3_CSD2
IPR041093 Dis3l2_C
IPR012340 NA-bd_OB-fold
IPR001900 RNase_II/R
IPR022966 RNase_II/R_CS
PfamiView protein in Pfam
PF17877 Dis3l2_C_term, 1 hit
PF17849 OB_Dis3, 1 hit
PF00773 RNB, 1 hit
SMARTiView protein in SMART
SM00955 RNB, 1 hit
SUPFAMiSSF50249 SSF50249, 2 hits
PROSITEiView protein in PROSITE
PS01175 RIBONUCLEASE_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSSD1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24276
Secondary accession number(s): D6VSS2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: December 11, 2019
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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