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Entry version 163 (07 Oct 2020)
Sequence version 3 (11 Oct 2004)
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Protein

PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component

Gene

ascF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in arbutin, cellobiose, and salicin transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei28Phosphocysteine intermediate; for EIIB activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:ASCF-MONOMER
MetaCyc:ASCF-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
4.A.1.2.3, the pts glucose-glucoside (glc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component
Alternative name(s):
EIIBC-Asc
Short name:
EII-Asc
Including the following 2 domains:
Arbutin-, cellobiose-, and salicin-specific phosphotransferase enzyme IIB component (EC:2.7.1.-)
Alternative name(s):
PTS system arbutin-, cellobiose-, and salicin-specific EIIB component
Arbutin, cellobiose, and salicin permease IIC component
Alternative name(s):
PTS system arbutin-, cellobiose-, and salicin-specific EIIC component
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ascF
Ordered Locus Names:b2715, JW5435
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei102 – 122HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei147 – 167HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei177 – 197HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei207 – 227HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei254 – 274HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei285 – 305HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei330 – 350HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei363 – 383HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei389 – 409HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei433 – 453HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001864981 – 485PTS system arbutin-, cellobiose-, and salicin-specific EIIBC componentAdd BLAST485

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P24241

PRoteomics IDEntifications database

More...
PRIDEi
P24241

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4261308, 9 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2715

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P24241

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 88PTS EIIB type-1PROSITE-ProRule annotationAdd BLAST88
Domaini108 – 470PTS EIIC type-1PROSITE-ProRule annotationAdd BLAST363

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1263, Bacteria
COG1264, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012312_2_0_6

KEGG Orthology (KO)

More...
KOi
K02753

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P24241

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00212, PTS_IIB_glc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1360.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036878, Glu_permease_IIB
IPR018113, PTrfase_EIIB_Cys
IPR003352, PTS_EIIC
IPR013013, PTS_EIIC_1
IPR001996, PTS_IIB_1
IPR004719, PTS_maltose/Glc_sub_IIC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00367, PTS_EIIB, 1 hit
PF02378, PTS_EIIC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55604, SSF55604, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00852, pts-Glc, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51098, PTS_EIIB_TYPE_1, 1 hit
PS01035, PTS_EIIB_TYPE_1_CYS, 1 hit
PS51103, PTS_EIIC_TYPE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P24241-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKNYAALAR SVIAALGGVD NISAVTHCMT RLRFVIKDDA LIDSPTLKTI
60 70 80 90 100
PGVLGVVRSD NQCQVIIGNT VSQAFQEVVS LLPGDMQPAQ PVGKPKLTLR
110 120 130 140 150
RIGAGILDAL IGTMSPLIPA IIGGSMVKLL AMILEMSGVL TKGSPTLTIL
160 170 180 190 200
NVIGDGAFFF LPLMVAASAA IKFKTNMSLA IAIAGVLVHP SFIELMAKAA
210 220 230 240 250
QGEHVEFALI PVTAVKYTYT VIPALVMTWC LSYIERWVDS ITPAVTKNFL
260 270 280 290 300
KPMLIVLIAA PLAILLIGPI GIWIGSAISA LVYTIHGYLG WLSVAIMGAL
310 320 330 340 350
WPLLVMTGMH RVFTPTIIQT IAETGKEGMV MPSEIGANLS LGGSSLAVAW
360 370 380 390 400
KTKNPELRQT ALAAAASAIM AGISEPALYG VAIRLKRPLI ASLISGFICG
410 420 430 440 450
AVAGMAGLAS HSMAAPGLFT SVQFFDPANP MSIVWVFAVM ALAVVLSFIL
460 470 480
TLLLGFEDIP VEEAAAQARK YQSVQPTVAK EVSLN
Length:485
Mass (Da):51,026
Last modified:October 11, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE53627EB31B9523C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti167 – 170ASAA → HLPR in AAA69225 (PubMed:9278503).Curated4
Sequence conflicti167A → Q in AAA16429 (PubMed:1630307).Curated1
Sequence conflicti311R → H in AAA16429 (PubMed:1630307).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M73326 Unassigned DNA Translation: AAA16429.1
U29579 Genomic DNA Translation: AAA69225.1
U00096 Genomic DNA Translation: AAT48150.1
AP009048 Genomic DNA Translation: BAE76792.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G65051

NCBI Reference Sequences

More...
RefSeqi
WP_001107828.1, NZ_LN832404.1
YP_026182.1, NC_000913.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAT48150; AAT48150; b2715
BAE76792; BAE76792; BAE76792

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947154

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5435
eco:b2715

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.4026

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73326 Unassigned DNA Translation: AAA16429.1
U29579 Genomic DNA Translation: AAA69225.1
U00096 Genomic DNA Translation: AAT48150.1
AP009048 Genomic DNA Translation: BAE76792.1
PIRiG65051
RefSeqiWP_001107828.1, NZ_LN832404.1
YP_026182.1, NC_000913.3

3D structure databases

SMRiP24241
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261308, 9 interactors
STRINGi511145.b2715

Protein family/group databases

TCDBi4.A.1.2.3, the pts glucose-glucoside (glc) family

Proteomic databases

PaxDbiP24241
PRIDEiP24241

Genome annotation databases

EnsemblBacteriaiAAT48150; AAT48150; b2715
BAE76792; BAE76792; BAE76792
GeneIDi947154
KEGGiecj:JW5435
eco:b2715
PATRICifig|1411691.4.peg.4026

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0084

Phylogenomic databases

eggNOGiCOG1263, Bacteria
COG1264, Bacteria
HOGENOMiCLU_012312_2_0_6
KOiK02753
PhylomeDBiP24241

Enzyme and pathway databases

BioCyciEcoCyc:ASCF-MONOMER
MetaCyc:ASCF-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P24241

Family and domain databases

CDDicd00212, PTS_IIB_glc, 1 hit
Gene3Di3.30.1360.60, 1 hit
InterProiView protein in InterPro
IPR036878, Glu_permease_IIB
IPR018113, PTrfase_EIIB_Cys
IPR003352, PTS_EIIC
IPR013013, PTS_EIIC_1
IPR001996, PTS_IIB_1
IPR004719, PTS_maltose/Glc_sub_IIC
PfamiView protein in Pfam
PF00367, PTS_EIIB, 1 hit
PF02378, PTS_EIIC, 1 hit
SUPFAMiSSF55604, SSF55604, 1 hit
TIGRFAMsiTIGR00852, pts-Glc, 1 hit
PROSITEiView protein in PROSITE
PS51098, PTS_EIIB_TYPE_1, 1 hit
PS01035, PTS_EIIB_TYPE_1_CYS, 1 hit
PS51103, PTS_EIIC_TYPE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTIBC_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24241
Secondary accession number(s): Q2MAB4, Q46880, Q6BF64
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 11, 2004
Last modified: October 7, 2020
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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