UniProtKB - P24216 (FLID_ECOLI)
Protein
Flagellar hook-associated protein 2
Gene
fliD
Organism
Escherichia coli (strain K12)
Status
Functioni
Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
GO - Biological processi
- bacterial-type flagellum-dependent cell motility Source: EcoCyc
- cell adhesion Source: InterPro
Enzyme and pathway databases
BioCyci | EcoCyc:EG10841-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Flagellar hook-associated protein 2Short name: HAP2 Alternative name(s): Filament cap protein Flagellar cap protein |
Gene namesi | Name:fliD Synonyms:flaV, flbC Ordered Locus Names:b1924, JW1909 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- bacterial-type flagellum filament cap Source: GO_Central
- bacterial-type flagellum hook Source: InterPro
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
Bacterial flagellum, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000177017 | 2 – 468 | Flagellar hook-associated protein 2Add BLAST | 467 |
Proteomic databases
PaxDbi | P24216 |
PRIDEi | P24216 |
2D gel databases
SWISS-2DPAGEi | P24216 |
Interactioni
Subunit structurei
Homopentamer.
CuratedBinary interactionsi
P24216
With | #Exp. | IntAct |
---|---|---|
fliT [P0ABY2] | 4 | EBI-1126352,EBI-1114780 |
Protein-protein interaction databases
BioGRIDi | 4260370, 8 interactors 850785, 1 interactor |
IntActi | P24216, 8 interactors |
STRINGi | 511145.b1924 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P24216 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 411 – 439 | Sequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the FliD family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | COG1345, Bacteria |
InParanoidi | P24216 |
PhylomeDBi | P24216 |
Family and domain databases
InterProi | View protein in InterPro IPR040026, FliD IPR010809, FliD_C IPR003481, FliD_N |
PANTHERi | PTHR30288, PTHR30288, 1 hit |
Pfami | View protein in Pfam PF07195, FliD_C, 1 hit PF02465, FliD_N, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P24216-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASISSLGVG SGLDLSSILD SLTAAQKATL TPISNQQSSF TAKLSAYGTL
60 70 80 90 100
KSALTTFQTA NTALSKADLF SATSTTSSTT AFSATTAGNA IAGKYTISVT
110 120 130 140 150
HLAQAQTLTT RTTRDDTKTA IATSDSKLTI QQGGDKDPIT IDISAANSSL
160 170 180 190 200
SGIRDAINNA KAGVSASIIN VGNGEYRLSV TSNDTGLDNA MTLSVSGDDA
210 220 230 240 250
LQSFMGYDAS ASSNGMEVSV AAQNAQLTVN NVAIENSSNT ISDALENITL
260 270 280 290 300
NLNDVTTGNQ TLTITQDTSK AQTAIKDWVN AYNSLIDTFS SLTKYTAVDA
310 320 330 340 350
GADSQSSSNG ALLGDSTLRT IQTQLKSMLS NTVSSSSYKT LAQIGITTDP
360 370 380 390 400
SDGKLELDAD KLTAALKKDA SGVGALIVGD GKKTGITTTI GSNLTSWLST
410 420 430 440 450
TGIIKAATDG VSKTLNKLTK DYNAASDRID AQVARYKEQF TQLDVLMTSL
460
NSTSSYLTQQ FENNSNSK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 114 | R → T in AAA23790 (PubMed:1527488).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M85240 Genomic DNA Translation: AAA23790.1 U00096 Genomic DNA Translation: AAC74991.1 AP009048 Genomic DNA Translation: BAA15752.1 X17440 Genomic DNA Translation: CAA35487.1 J01607 Genomic DNA Translation: AAA92490.1 |
PIRi | A64956 |
RefSeqi | NP_416434.1, NC_000913.3 WP_000146784.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC74991; AAC74991; b1924 BAA15752; BAA15752; BAA15752 |
GeneIDi | 57731321 946428 |
KEGGi | ecj:JW1909 eco:b1924 |
PATRICi | fig|1411691.4.peg.325 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M85240 Genomic DNA Translation: AAA23790.1 U00096 Genomic DNA Translation: AAC74991.1 AP009048 Genomic DNA Translation: BAA15752.1 X17440 Genomic DNA Translation: CAA35487.1 J01607 Genomic DNA Translation: AAA92490.1 |
PIRi | A64956 |
RefSeqi | NP_416434.1, NC_000913.3 WP_000146784.1, NZ_LN832404.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5H5V | X-ray | 3.00 | A/B/C/D/E/F | 43-416 | [»] | |
5H5W | X-ray | 2.15 | A/B | 71-267 | [»] | |
SMRi | P24216 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260370, 8 interactors 850785, 1 interactor |
IntActi | P24216, 8 interactors |
STRINGi | 511145.b1924 |
2D gel databases
SWISS-2DPAGEi | P24216 |
Proteomic databases
PaxDbi | P24216 |
PRIDEi | P24216 |
Genome annotation databases
EnsemblBacteriai | AAC74991; AAC74991; b1924 BAA15752; BAA15752; BAA15752 |
GeneIDi | 57731321 946428 |
KEGGi | ecj:JW1909 eco:b1924 |
PATRICi | fig|1411691.4.peg.325 |
Organism-specific databases
EchoBASEi | EB0834 |
Phylogenomic databases
eggNOGi | COG1345, Bacteria |
InParanoidi | P24216 |
PhylomeDBi | P24216 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10841-MONOMER |
Miscellaneous databases
PHI-basei | PHI:6733 |
PROi | PR:P24216 |
Family and domain databases
InterProi | View protein in InterPro IPR040026, FliD IPR010809, FliD_C IPR003481, FliD_N |
PANTHERi | PTHR30288, PTHR30288, 1 hit |
Pfami | View protein in Pfam PF07195, FliD_C, 1 hit PF02465, FliD_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FLID_ECOLI | |
Accessioni | P24216Primary (citable) accession number: P24216 Secondary accession number(s): P94745 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 149 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families