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Entry version 154 (13 Nov 2019)
Sequence version 1 (01 Mar 1992)
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Protein

Phenylalanine-specific permease

Gene

pheP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:PHEP-MONOMER
ECOL316407:JW0565-MONOMER
MetaCyc:PHEP-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.1.1 the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phenylalanine-specific permease
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pheP
Ordered Locus Names:b0576, JW0565
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 27CytoplasmicCuratedAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 48Helical; Name=ICuratedAdd BLAST21
Topological domaini49 – 50PeriplasmicCurated2
Transmembranei51 – 71Helical; Name=IICuratedAdd BLAST21
Topological domaini72 – 105CytoplasmicCuratedAdd BLAST34
Transmembranei106 – 126Helical; Name=IIICuratedAdd BLAST21
Topological domaini127 – 132PeriplasmicCurated6
Transmembranei133 – 153Helical; Name=IVCuratedAdd BLAST21
Topological domaini154 – 160CytoplasmicCurated7
Transmembranei161 – 181Helical; Name=VCuratedAdd BLAST21
Topological domaini182 – 196PeriplasmicCuratedAdd BLAST15
Transmembranei197 – 217Helical; Name=VICuratedAdd BLAST21
Topological domaini218 – 250CytoplasmicCuratedAdd BLAST33
Transmembranei251 – 271Helical; Name=VIICuratedAdd BLAST21
Topological domaini272 – 288PeriplasmicCuratedAdd BLAST17
Transmembranei289 – 309Helical; Name=VIIICuratedAdd BLAST21
Topological domaini310 – 341CytoplasmicCuratedAdd BLAST32
Transmembranei342 – 362Helical; Name=IXCuratedAdd BLAST21
Topological domaini363 – 367PeriplasmicCurated5
Transmembranei368 – 388Helical; Name=XCuratedAdd BLAST21
Topological domaini389 – 411CytoplasmicCuratedAdd BLAST23
Transmembranei412 – 432Helical; Name=XICuratedAdd BLAST21
Topological domaini433 – 434PeriplasmicCurated2
Transmembranei435 – 455Helical; Name=XIICuratedAdd BLAST21
Topological domaini456 – 458CytoplasmicCurated3

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000542061 – 458Phenylalanine-specific permeaseAdd BLAST458

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P24207

PRoteomics IDEntifications database

More...
PRIDEi
P24207

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4259879, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-10479N

Protein interaction database and analysis system

More...
IntActi
P24207, 2 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b0576

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C85 Bacteria
COG1113 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261849

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24207

KEGG Orthology (KO)

More...
KOi
K11732

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P24207

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004840 Amoino_acid_permease_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324 AA_permease, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006060 AA_transporter, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P24207-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNASTVSED TASNQEPTLH RGLHNRHIQL IALGGAIGTG LFLGIGPAIQ
60 70 80 90 100
MAGPAVLLGY GVAGIIAFLI MRQLGEMVVE EPVSGSFAHF AYKYWGPFAG
110 120 130 140 150
FLSGWNYWVM FVLVGMAELT AAGIYMQYWF PDVPTWIWAA AFFIIINAVN
160 170 180 190 200
LVNVRLYGET EFWFALIKVL AIIGMIGFGL WLLFSGHGGE KASIDNLWRY
210 220 230 240 250
GGFFATGWNG LILSLAVIMF SFGGLELIGI TAAEARDPEK SIPKAVNQVV
260 270 280 290 300
YRILLFYIGS LVVLLALYPW VEVKSNSSPF VMIFHNLDSN VVASALNFVI
310 320 330 340 350
LVASLSVYNS GVYSNSRMLF GLSVQGNAPK FLTRVSRRGV PINSLMLSGA
360 370 380 390 400
ITSLVVLINY LLPQKAFGLL MALVVATLLL NWIMICLAHL RFRAAMRRQG
410 420 430 440 450
RETQFKALLY PFGNYLCIAF LGMILLLMCT MDDMRLSAIL LPVWIVFLFM

AFKTLRRK
Length:458
Mass (Da):50,677
Last modified:March 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69D865369249A1A8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB40774 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M58000 Genomic DNA Translation: AAA24334.1
U82598 Genomic DNA Translation: AAB40774.1 Different initiation.
U00096 Genomic DNA Translation: AAC73677.1
AP009048 Genomic DNA Translation: BAA35216.1

Protein sequence database of the Protein Information Resource

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PIRi
A39431

NCBI Reference Sequences

More...
RefSeqi
NP_415108.1, NC_000913.3
WP_000786319.1, NZ_SSZK01000024.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73677; AAC73677; b0576
BAA35216; BAA35216; BAA35216

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945199

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0565
eco:b0576

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1698

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58000 Genomic DNA Translation: AAA24334.1
U82598 Genomic DNA Translation: AAB40774.1 Different initiation.
U00096 Genomic DNA Translation: AAC73677.1
AP009048 Genomic DNA Translation: BAA35216.1
PIRiA39431
RefSeqiNP_415108.1, NC_000913.3
WP_000786319.1, NZ_SSZK01000024.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi4259879, 6 interactors
DIPiDIP-10479N
IntActiP24207, 2 interactors
STRINGi511145.b0576

Protein family/group databases

TCDBi2.A.3.1.1 the amino acid-polyamine-organocation (apc) family

Proteomic databases

PaxDbiP24207
PRIDEiP24207

Genome annotation databases

EnsemblBacteriaiAAC73677; AAC73677; b0576
BAA35216; BAA35216; BAA35216
GeneIDi945199
KEGGiecj:JW0565
eco:b0576
PATRICifig|1411691.4.peg.1698

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0702

Phylogenomic databases

eggNOGiENOG4105C85 Bacteria
COG1113 LUCA
HOGENOMiHOG000261849
InParanoidiP24207
KOiK11732
PhylomeDBiP24207

Enzyme and pathway databases

BioCyciEcoCyc:PHEP-MONOMER
ECOL316407:JW0565-MONOMER
MetaCyc:PHEP-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P24207

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHEP_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24207
Secondary accession number(s): P77090
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 13, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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