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Entry version 164 (29 Sep 2021)
Sequence version 1 (01 Mar 1992)
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Protein

Lipid A biosynthesis myristoyltransferase

Gene

lpxM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo2-(lauroyl)-lipid IV(A) to form Kdo2-lipid A. Can probably also catalyze the transfer of myristate to Kdo2-(palmitoleoyl)-lipid IV(A) to form the cold-adapted Kdo2-lipid A. In vitro, can acylate Kdo2-lipid IV(A), but acylation of (KDO)2-(lauroyl)-lipid IV(A) is about 100 times faster. In vitro, can use lauroyl-ACP but displays a slight kinetic preference for myristoyl-ACP.

1 Publication1 Publication

Caution

Was originally thought to be the membrane-bound lytic murein transglycosylase (MLT).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: KDO(2)-lipid A biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A).UniRule annotation1 Publication1 Publication This subpathway is part of the pathway KDO(2)-lipid A biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A), the pathway KDO(2)-lipid A biosynthesis and in Glycolipid biosynthesis.

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation1 Publication1 Publication
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:MYRISTOYLACYLTRAN-MONOMER
MetaCyc:MYRISTOYLACYLTRAN-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.1.243, 2026

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00030
UPA00360;UER00486

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lipid A biosynthesis myristoyltransferaseUniRule annotationCurated (EC:2.3.1.243UniRule annotation1 Publication1 Publication)
Alternative name(s):
Kdo(2)-lauroyl-lipid IV(A) myristoyltransferaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lpxM1 PublicationUniRule annotation
Synonyms:msbB1 Publication
Ordered Locus Names:b1855, JW1844
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei23 – 43HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Makes pentaacylated lipid A rather than the usual hexaacylated lipid A.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002017771 – 323Lipid A biosynthesis myristoyltransferaseAdd BLAST323

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P24205

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P24205

PRoteomics IDEntifications database

More...
PRIDEi
P24205

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4260351, 239 interactors

Database of interacting proteins

More...
DIPi
DIP-10262N

Protein interaction database and analysis system

More...
IntActi
P24205, 21 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b1855

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P24205

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi139 – 144HXXXXD motifUniRule annotationCurated6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily.UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1560, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_049421_1_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24205

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P24205

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07984, LPLAT_LABLAT-like, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01944, Lipid_A_LpxM, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004960, LipA_acyltrans
IPR011921, Lipid_A_MsbB

The PANTHER Classification System

More...
PANTHERi
PTHR30606, PTHR30606, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03279, Lip_A_acyltrans, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF026649, MsbB, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02208, lipid_A_msbB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P24205-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METKKNNSEY IPEFDKSFRH PRYWGAWLGV AAMAGIALTP PKFRDPILAR
60 70 80 90 100
LGRFAGRLGK SSRRRALINL SLCFPERSEA EREAIVDEMF ATAPQAMAMM
110 120 130 140 150
AELAIRGPEK IQPRVDWQGL EIIEEMRRNN EKVIFLVPHG WAVDIPAMLM
160 170 180 190 200
ASQGQKMAAM FHNQGNPVFD YVWNTVRRRF GGRLHARNDG IKPFIQSVRQ
210 220 230 240 250
GYWGYYLPDQ DHGPEHSEFV DFFATYKATL PAIGRLMKVC RARVVPLFPI
260 270 280 290 300
YDGKTHRLTI QVRPPMDDLL EADDHTIARR MNEEVEIFVG PRPEQYTWIL
310 320
KLLKTRKPGE IQPYKRKDLY PIK
Length:323
Mass (Da):37,410
Last modified:March 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94DAF38A757D20CD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M77039 Genomic DNA Translation: AAA24181.1
M87660 Genomic DNA Translation: AAA96706.1
U00096 Genomic DNA Translation: AAC74925.1
AP009048 Genomic DNA Translation: BAA15663.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A42608

NCBI Reference Sequences

More...
RefSeqi
NP_416369.1, NC_000913.3
WP_000448381.1, NZ_STEB01000009.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74925; AAC74925; b1855
BAA15663; BAA15663; BAA15663

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
61754717
945143

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1844
eco:b1855

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.1934

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77039 Genomic DNA Translation: AAA24181.1
M87660 Genomic DNA Translation: AAA96706.1
U00096 Genomic DNA Translation: AAC74925.1
AP009048 Genomic DNA Translation: BAA15663.1
PIRiA42608
RefSeqiNP_416369.1, NC_000913.3
WP_000448381.1, NZ_STEB01000009.1

3D structure databases

SMRiP24205
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4260351, 239 interactors
DIPiDIP-10262N
IntActiP24205, 21 interactors
STRINGi511145.b1855

Proteomic databases

jPOSTiP24205
PaxDbiP24205
PRIDEiP24205

Genome annotation databases

EnsemblBacteriaiAAC74925; AAC74925; b1855
BAA15663; BAA15663; BAA15663
GeneIDi61754717
945143
KEGGiecj:JW1844
eco:b1855
PATRICifig|511145.12.peg.1934

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0609

Phylogenomic databases

eggNOGiCOG1560, Bacteria
HOGENOMiCLU_049421_1_0_6
InParanoidiP24205
PhylomeDBiP24205

Enzyme and pathway databases

UniPathwayiUPA00030
UPA00360;UER00486
BioCyciEcoCyc:MYRISTOYLACYLTRAN-MONOMER
MetaCyc:MYRISTOYLACYLTRAN-MONOMER
BRENDAi2.3.1.243, 2026

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P24205

Family and domain databases

CDDicd07984, LPLAT_LABLAT-like, 1 hit
HAMAPiMF_01944, Lipid_A_LpxM, 1 hit
InterProiView protein in InterPro
IPR004960, LipA_acyltrans
IPR011921, Lipid_A_MsbB
PANTHERiPTHR30606, PTHR30606, 1 hit
PfamiView protein in Pfam
PF03279, Lip_A_acyltrans, 1 hit
PIRSFiPIRSF026649, MsbB, 1 hit
TIGRFAMsiTIGR02208, lipid_A_msbB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPXM_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24205
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 29, 2021
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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