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UniProtKB - P24203 (YJIA_ECOLI)

Entry version 149 (07 Apr 2021)
Sequence version 3 (27 Apr 2001)
Previous versions | rss
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Protein

P-loop guanosine triphosphatase YjiA

Gene

yjiA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds GTP and has low GTPase activity. May have a GTP-dependent regulatory function.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

GTPase activity is inhibited by metal binding. Activity is decreased in the presence of Co(II) or Ni(II), and is completely inhibited in the presence of Zn(II).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.006 sec(-1) for GTP hydrolysis in the absence of metal. kcat is 0.0005 sec(-1) for GTP hydrolysis in the presence of Co(II).1 Publication

      Sites

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi37Zinc 11 Publication1
      Metal bindingi42Zinc 11 Publication1
      Metal bindingi66Zinc 11 Publication1
      Metal bindingi74Zinc 2; shared with dimeric partner1 Publication1
      Metal bindingi114Zinc 2; shared with dimeric partner1 Publication1
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei161GTPBy similarity1
      Metal bindingi167Zinc 31 Publication1
      Metal bindingi167Zinc 4; shared with dimeric partner1 Publication1
      Metal bindingi170Zinc 3; via pros nitrogen1 Publication1
      Metal bindingi170Zinc 4; via pros nitrogen; shared with dimeric partner1 Publication1
      Metal bindingi187Zinc 3; shared with dimeric partner1 Publication1
      Metal bindingi187Zinc 41 Publication1

      Regions

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi11 – 19GTPBy similarity9

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      Complete GO annotation on QuickGO ...

      GO - Biological processi

      Complete GO annotation on QuickGO ...

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionHydrolase
      LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

      Enzyme and pathway databases

      BioCyc Collection of Pathway/Genome Databases

      More...      BioCyci      		EcoCyc:EG10021-MONOMER
      MetaCyc:EG10021-MONOMER

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      P-loop guanosine triphosphatase YjiA1 Publication (EC:3.6.-.-2 Publications)
      Alternative name(s):
      GTP-binding protein YjiACurated
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Name:yjiA
      Ordered Locus Names:b4352, JW5790
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
      • UP000000625 Componenti: Chromosome

      <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001697851 – 318P-loop guanosine triphosphatase YjiASequence analysisAdd BLAST318

      Proteomic databases

      jPOST - Japan Proteome Standard Repository/Database

      More...      jPOSTi      		P24203

      PaxDb, a database of protein abundance averages across all three domains of life

      More...      PaxDbi      		P24203

      PRoteomics IDEntifications database

      More...      PRIDEi      		P24203

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

      Monomer in the apo form. Metal binding induces oligomerization. Forms homodimers and higher oligomers.

      1 Publication

      GO - Molecular functioni

      Complete GO annotation on QuickGO ...

      Protein-protein interaction databases

      The Biological General Repository for Interaction Datasets (BioGRID)

      More...      BioGRIDi      		4262771, 37 interactors
      853160, 1 interactor

      Database of interacting proteins

      More...      DIPi      		DIP-12630N

      Protein interaction database and analysis system

      More...      IntActi      		P24203, 2 interactors

      STRING: functional protein association networks

      More...      STRINGi      		511145.b4352

      <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

      Secondary structure

      1318
      Legend: HelixTurnBeta strandPDB Structure known for this area
      Show more details

      3D structure databases

      SWISS-MODEL Repository - a database of annotated 3D protein structure models

      More...      SMRi      		P24203

      Database of comparative protein structure models

      More...      ModBasei      		Search...

      Protein Data Bank in Europe - Knowledge Base

      More...      PDBe-KBi      		Search...

      Miscellaneous databases

      Relative evolutionary importance of amino acids within a protein sequence

      More...      EvolutionaryTracei      		P24203

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      Domains and Repeats

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini224 – 315CobW C-terminalSequence analysisAdd BLAST92

      <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

      Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.Curated

      Phylogenomic databases

      evolutionary genealogy of genes: Non-supervised Orthologous Groups

      More...      eggNOGi      		COG0523, Bacteria

      The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

      More...      HOGENOMi      		CLU_017452_0_2_6

      InParanoid: Eukaryotic Ortholog Groups

      More...      InParanoidi      		P24203

      Database for complete collections of gene phylogenies

      More...      PhylomeDBi      		P24203

      Family and domain databases

      Gene3D Structural and Functional Annotation of Protein Families

      More...      Gene3Di      		3.30.1220.10, 1 hit

      Integrated resource of protein families, domains and functional sites

      More...      InterProi      		View protein in InterPro
      IPR011629, Cbl_biosynth_CobW-like_C
      IPR036627, CobW-likC_sf
      IPR003495, CobW/HypB/UreG_dom
      IPR027417, P-loop_NTPase

      Pfam protein domain database

      More...      Pfami      		View protein in Pfam
      PF02492, cobW, 1 hit
      PF07683, CobW_C, 1 hit

      Simple Modular Architecture Research Tool; a protein domain database

      More...      SMARTi      		View protein in SMART
      SM00833, CobW_C, 1 hit

      Superfamily database of structural and functional annotation

      More...      SUPFAMi      		SSF52540, SSF52540, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      P24203-1 [UniParc]FASTAAdd to basket
      « Hide
              10         20         30         40         50
      MNPIAVTLLT GFLGAGKTTL LRHILNEQHG YKIAVIENEF GEVSVDDQLI 
              60         70         80         90        100
      GDRATQIKTL TNGCICCSRS NELEDALLDL LDNLDKGNIQ FDRLVIECTG 
             110        120        130        140        150
      MADPGPIIQT FFSHEVLCQR YLLDGVIALV DAVHADEQMN QFTIAQSQVG 
             160        170        180        190        200
      YADRILLTKT DVAGEAEKLH ERLARINARA PVYTVTHGDI DLGLLFNTNG 
             210        220        230        240        250
      FMLEENVVST KPRFHFIADK QNDISSIVVE LDYPVDISEV SRVMENLLLE 
             260        270        280        290        300
      SADKLLRYKG MLWIDGEPNR LLFQGVQRLY SADWDRPWGD EKPHSTMVFI 
             310 
      GIQLPEEEIR AAFAGLRK
      Length:318
      Mass (Da):35,660
      Last modified:April 27, 2001 - v3
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D68463182031C41
      GO

      <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

      The sequence AAA97249 differs from that shown. Reason: Frameshift.Curated

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...      EMBLi

      GenBank nucleotide sequence database

      More...      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...      DDBJi
      Links Updated
      		U14003 Genomic DNA Translation: AAA97249.1 Frameshift.
      U00096 Genomic DNA Translation: AAC77308.2
      AP009048 Genomic DNA Translation: BAE78342.1
      X54198 Genomic DNA Translation: CAA38118.1

      Protein sequence database of the Protein Information Resource

      More...      PIRi      		S56578

      NCBI Reference Sequences

      More...      RefSeqi      		NP_418772.4, NC_000913.3
      WP_001312515.1, NZ_LN832404.1

      Genome annotation databases

      Ensembl bacterial and archaeal genome annotation project

      More...      EnsemblBacteriai      		AAC77308; AAC77308; b4352
      BAE78342; BAE78342; BAE78342

      Database of genes from NCBI RefSeq genomes

      More...      GeneIDi      		948882

      KEGG: Kyoto Encyclopedia of Genes and Genomes

      More...      KEGGi      		ecj:JW5790
      eco:b4352

      Pathosystems Resource Integration Center (PATRIC)

      More...      PATRICi      		fig|1411691.4.peg.2334

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      		U14003 Genomic DNA Translation: AAA97249.1 Frameshift.
      U00096 Genomic DNA Translation: AAC77308.2
      AP009048 Genomic DNA Translation: BAE78342.1
      X54198 Genomic DNA Translation: CAA38118.1
      PIRiS56578
      RefSeqiNP_418772.4, NC_000913.3
      WP_001312515.1, NZ_LN832404.1

      3D structure databases

      Select the link destinations:

      Protein Data Bank Europe

      More...      PDBei

      Protein Data Bank RCSB

      More...      RCSB PDBi

      Protein Data Bank Japan

      More...      PDBji
      Links Updated
      		PDB entryMethodResolution (Å)ChainPositionsPDBsum
      1NIJX-ray2.00A1-318[»]
      4IXMX-ray2.57A/B1-318[»]
      4IXNX-ray2.05A/B1-318[»]
      SMRiP24203
      ModBaseiSearch...
      PDBe-KBiSearch...

      Protein-protein interaction databases

      BioGRIDi4262771, 37 interactors
      853160, 1 interactor
      DIPiDIP-12630N
      IntActiP24203, 2 interactors
      STRINGi511145.b4352

      Proteomic databases

      jPOSTiP24203
      PaxDbiP24203
      PRIDEiP24203

      Genome annotation databases

      EnsemblBacteriaiAAC77308; AAC77308; b4352
      BAE78342; BAE78342; BAE78342
      GeneIDi948882
      KEGGiecj:JW5790
      eco:b4352
      PATRICifig|1411691.4.peg.2334

      Organism-specific databases

      EchoBASE - an integrated post-genomic database for E. coli

      More...      EchoBASEi      		EB0020

      Phylogenomic databases

      eggNOGiCOG0523, Bacteria
      HOGENOMiCLU_017452_0_2_6
      InParanoidiP24203
      PhylomeDBiP24203

      Enzyme and pathway databases

      BioCyciEcoCyc:EG10021-MONOMER
      MetaCyc:EG10021-MONOMER

      Miscellaneous databases

      EvolutionaryTraceiP24203

      Protein Ontology

      More...      PROi      		PR:P24203

      Family and domain databases

      Gene3Di3.30.1220.10, 1 hit
      InterProiView protein in InterPro
      IPR011629, Cbl_biosynth_CobW-like_C
      IPR036627, CobW-likC_sf
      IPR003495, CobW/HypB/UreG_dom
      IPR027417, P-loop_NTPase
      PfamiView protein in Pfam
      PF02492, cobW, 1 hit
      PF07683, CobW_C, 1 hit
      SMARTiView protein in SMART
      SM00833, CobW_C, 1 hit
      SUPFAMiSSF52540, SSF52540, 1 hit

      ProtoNet; Automatic hierarchical classification of proteins

      More...      ProtoNeti      		Search...

      MobiDB: a database of protein disorder and mobility annotations

      More...      MobiDBi      		Search...

      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYJIA_ECOLI
      <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24203
      Secondary accession number(s): Q2M5W4
      <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
      Last sequence update: April 27, 2001
      Last modified: April 7, 2021
      This is version 149 of the entry and version 3 of the sequence. See complete history.
      <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programProkaryotic Protein Annotation Program

      <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      3D-structure, Reference proteome

      Documents

      1. PDB cross-references
        Index of Protein Data Bank (PDB) cross-references
      2. SIMILARITY comments
        Index of protein domains and families
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