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Entry version 131 (02 Jun 2021)
Sequence version 1 (01 Mar 1992)
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Protein

Mrr restriction system protein

Gene

mrr

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the acceptance of foreign DNA which is modified. Restricts both adenine- and cytosine-methylated DNA.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRestriction system

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
EcoCyc:EG10612-MONOMER

Protein family/group databases

Restriction enzymes and methylases database

More...
REBASEi
13381, EcoW3110MrrP
152622, Rsp6212MrrP
152626, Rsp621MrrP
152632, Ret561MrrP
152643, Rsp1341MrrP
152655, Rsp113MrrP
152716, Rsp741MrrP
152738, Rsp871MrrP
203759, Lbr1174ORF1924P
211852, Rsp894MrrP
211890, Rsp894Mrr2P
2906, EcoKMrr
296186, Bve83MrrP
441389, EcoBL21FMrrP

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mrr restriction system protein
Alternative name(s):
EcoKMrr
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mrr
Ordered Locus Names:b4351, JW4314
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000773821 – 304Mrr restriction system proteinAdd BLAST304

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P24202

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P24202

PRoteomics IDEntifications database

More...
PRIDEi
P24202

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
4262770, 58 interactors

Database of interacting proteins

More...
DIPi
DIP-10259N

Protein interaction database and analysis system

More...
IntActi
P24202, 1 interactor

STRING: functional protein association networks

More...
STRINGi
511145.b4351

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni120 – 142DisorderedSequence analysisAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1715, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_063822_2_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24202

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P24202

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025745, Mrr-like_N_dom
IPR011335, Restrct_endonuc-II-like
IPR007560, Restrct_endonuc_IV_Mrr

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04471, Mrr_cat, 1 hit
PF14338, Mrr_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52980, SSF52980, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P24202-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVPTYDKFI EPVLRYLATK PEGAAARDVH EAAADALGLD DSQRAKVITS
60 70 80 90 100
GQLVYKNRAG WAHDRLKRAG LSQSLSRGKW CLTPAGFDWV ASHPQPMTEQ
110 120 130 140 150
ETNHLAFAFV NVKLKSRPDA VDLDPKADSP DHEELAKSSP DDRLDQALKE
160 170 180 190 200
LRDAVADEVL ENLLQVSPSR FEVIVLDVLH RLGYGGHRDD LQRVGGTGDG
210 220 230 240 250
GIDGVISLDK LGLEKVYVQA KRWQNTVGRP ELQAFYGALA GQKAKRGVFI
260 270 280 290 300
TTSGFTSQAR DFAQSVEGMV LVDGERLVHL MIENEVGVSS RLLKVPKLDM

DYFE
Length:304
Mass (Da):33,520
Last modified:March 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6DE16E229E9EC9AE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54198 Genomic DNA Translation: CAA38117.1
U14003 Genomic DNA Translation: AAA97248.1
U00096 Genomic DNA Translation: AAC77307.1
AP009048 Genomic DNA Translation: BAE78341.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A40368

NCBI Reference Sequences

More...
RefSeqi
NP_418771.1, NC_000913.3
WP_000217931.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC77307; AAC77307; b4351
BAE78341; BAE78341; BAE78341

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948898

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW4314
eco:b4351

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.2335

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54198 Genomic DNA Translation: CAA38117.1
U14003 Genomic DNA Translation: AAA97248.1
U00096 Genomic DNA Translation: AAC77307.1
AP009048 Genomic DNA Translation: BAE78341.1
PIRiA40368
RefSeqiNP_418771.1, NC_000913.3
WP_000217931.1, NZ_LN832404.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4262770, 58 interactors
DIPiDIP-10259N
IntActiP24202, 1 interactor
STRINGi511145.b4351

Protein family/group databases

REBASEi13381, EcoW3110MrrP
152622, Rsp6212MrrP
152626, Rsp621MrrP
152632, Ret561MrrP
152643, Rsp1341MrrP
152655, Rsp113MrrP
152716, Rsp741MrrP
152738, Rsp871MrrP
203759, Lbr1174ORF1924P
211852, Rsp894MrrP
211890, Rsp894Mrr2P
2906, EcoKMrr
296186, Bve83MrrP
441389, EcoBL21FMrrP

Proteomic databases

jPOSTiP24202
PaxDbiP24202
PRIDEiP24202

Genome annotation databases

EnsemblBacteriaiAAC77307; AAC77307; b4351
BAE78341; BAE78341; BAE78341
GeneIDi948898
KEGGiecj:JW4314
eco:b4351
PATRICifig|1411691.4.peg.2335

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0607

Phylogenomic databases

eggNOGiCOG1715, Bacteria
HOGENOMiCLU_063822_2_0_6
InParanoidiP24202
PhylomeDBiP24202

Enzyme and pathway databases

BioCyciEcoCyc:EG10612-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P24202

Family and domain databases

InterProiView protein in InterPro
IPR025745, Mrr-like_N_dom
IPR011335, Restrct_endonuc-II-like
IPR007560, Restrct_endonuc_IV_Mrr
PfamiView protein in Pfam
PF04471, Mrr_cat, 1 hit
PF14338, Mrr_N, 1 hit
SUPFAMiSSF52980, SSF52980, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRR_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24202
Secondary accession number(s): Q2M5W5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: June 2, 2021
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome
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