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UniProtKB - P24177 (ACRD_ECOLI)

Protein

Probable aminoglycoside efflux pump

Gene

acrD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • drug:proton antiporter activity Source: EcoCyc
  • drug transmembrane transporter activity Source: EcoCyc
  • efflux transmembrane transporter activity Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:ACRD-MONOMER
MetaCyc:ACRD-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.6.2.7 the resistance-nodulation-cell division (rnd) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable aminoglycoside efflux pump
Alternative name(s):
Acriflavine resistance protein D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:acrD
Synonyms:yffA
Ordered Locus Names:b2470, JW2454
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...EcoGenei		EG10014 acrD

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicBy similarity9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 28Helical; Name=1By similarityAdd BLAST19
Topological domaini29 – 339PeriplasmicBy similarityAdd BLAST311
Transmembranei340 – 359Helical; Name=2By similarityAdd BLAST20
Topological domaini360 – 365CytoplasmicBy similarity6
Transmembranei366 – 385Helical; Name=3By similarityAdd BLAST20
Topological domaini386 – 391PeriplasmicBy similarity6
Transmembranei392 – 413Helical; Name=4By similarityAdd BLAST22
Topological domaini414 – 441CytoplasmicBy similarityAdd BLAST28
Transmembranei442 – 460Helical; Name=5By similarityAdd BLAST19
Topological domaini461 – 473PeriplasmicBy similarityAdd BLAST13
Transmembranei474 – 496Helical; Name=6By similarityAdd BLAST23
Topological domaini497 – 537CytoplasmicBy similarityAdd BLAST41
Transmembranei538 – 556Helical; Name=7By similarityAdd BLAST19
Topological domaini557 – 870PeriplasmicBy similarityAdd BLAST314
Transmembranei871 – 890Helical; Name=8By similarityAdd BLAST20
Topological domaini891 – 896CytoplasmicBy similarity6
Transmembranei897 – 916Helical; Name=9By similarityAdd BLAST20
Topological domaini917 – 922PeriplasmicBy similarity6
Transmembranei923 – 944Helical; Name=10By similarityAdd BLAST22
Topological domaini945 – 971CytoplasmicBy similarityAdd BLAST27
Transmembranei972 – 990Helical; Name=11By similarityAdd BLAST19
Topological domaini991 – 1003PeriplasmicBy similarityAdd BLAST13
Transmembranei1004 – 1026Helical; Name=12By similarityAdd BLAST23
Topological domaini1027 – 1037CytoplasmicBy similarityAdd BLAST11

GO - Cellular componenti

View the complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001618121 – 1037Probable aminoglycoside efflux pumpAdd BLAST1037

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P24177

PRoteomics IDEntifications database

More...PRIDEi		P24177

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		4260927, 488 interactors

Database of interacting proteins

More...DIPi		DIP-9050N

Protein interaction database and analysis system

More...IntActi		P24177, 4 interactors

STRING: functional protein association networks

More...STRINGi		316385.ECDH10B_2635

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P24177

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P24177

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105BZS Bacteria
COG0841 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000158129

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P24177

KEGG Orthology (KO)

More...KOi		K18324

Database for complete collections of gene phylogenies

More...PhylomeDBi		P24177

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.2090.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR004764 HAE1

The PANTHER Classification System

More...PANTHERi		PTHR32063 PTHR32063, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00873 ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00702 ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82714 SSF82714, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00915 2A0602, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P24177-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANFFIDRPI FAWVLAILLC LTGTLAIFSL PVEQYPDLAP PNVRVTANYP 
        60         70         80         90        100
GASAQTLENT VTQVIEQNMT GLDNLMYMSS QSSGTGQASV TLSFKAGTDP 
       110        120        130        140        150
DEAVQQVQNQ LQSAMRKLPQ AVQNQGVTVR KTGDTNILTI AFVSTDGSMD 
       160        170        180        190        200
KQDIADYVAS NIQDPLSRVN GVGDIDAYGS QYSMRIWLDP AKLNSFQMTA 
       210        220        230        240        250
KDVTDAIESQ NAQIAVGQLG GTPSVDKQAL NATINAQSLL QTPEQFRDIT 
       260        270        280        290        300
LRVNQDGSEV RLGDVATVEM GAEKYDYLSR FNGKPASGLG VKLASGANEM 
       310        320        330        340        350
ATAELVLNRL DELAQYFPHG LEYKVAYETT SFVKASIEDV VKTLLEAIAL 
       360        370        380        390        400
VFLVMYLFLQ NFRATLIPTI AVPVVLMGTF SVLYAFGYSV NTLTMFAMVL 
       410        420        430        440        450
AIGLLVDDAI VVVENVERIM SEEGLTPREA TRKSMGQIQG ALVGIAMVLS 
       460        470        480        490        500
AVFVPMAFFG GTTGAIYRQF SITIVAAMVL SVLVAMILTP ALCATLLKPL 
       510        520        530        540        550
KKGEHHGQKG FFAWFNQMFN RNAERYEKGV AKILHRSLRW IVIYVLLLGG 
       560        570        580        590        600
MVFLFLRLPT SFLPLEDRGM FTTSVQLPSG STQQQTLKVV EQIEKYYFTH 
       610        620        630        640        650
EKDNIMSVFA TVGSGPGGNG QNVARMFIRL KDWSERDSKT GTSFAIIERA 
       660        670        680        690        700
TKAFNQIKEA RVIASSPPAI SGLGSSAGFD MELQDHAGAG HDALMAARNQ 
       710        720        730        740        750
LLALAAENPE LTRVRHNGLD DSPQLQIDID QRKAQALGVA IDDINDTLQT 
       760        770        780        790        800
AWGSSYVNDF MDRGRVKKVY VQAAAPYRML PDDINLWYVR NKDGGMVPFS 
       810        820        830        840        850
AFATSRWETG SPRLERYNGY SAVEIVGEAA PGVSTGTAMD IMESLVKQLP 
       860        870        880        890        900
NGFGLEWTAM SYQERLSGAQ APALYAISLL VVFLCLAALY ESWSVPFSVM 
       910        920        930        940        950
LVVPLGVIGA LLATWMRGLE NDVYFQVGLL TVIGLSAKNA ILIVEFANEM 
       960        970        980        990       1000
NQKGHDLFEA TLHACRQRLR PILMTSLAFI FGVLPMATST GAGSGGQHAV 
      1010       1020       1030 
GTGVMGGMIS ATILAIYFVP LFFVLVRRRF PLKPRPE
Length:1,037
Mass (Da):113,047
Last modified:November 1, 1997 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i961611E1D24FD4E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti303A → G in AAA20584 (Ref. 1) Curated1
Sequence conflicti372V → E in AAA20584 (Ref. 1) Curated1
Sequence conflicti385A → D in AAA74741 (Ref. 2) Curated1
Sequence conflicti461G → P in AAA20584 (Ref. 1) Curated1
Sequence conflicti665S → PD in AAA20584 (Ref. 1) Curated1
Sequence conflicti763R → A in AAA20584 (Ref. 1) Curated1
Sequence conflicti775A → G in AAA20584 (Ref. 1) Curated1
Sequence conflicti778R → P in AAA20584 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U12598 Genomic DNA Translation: AAA20584.1
U10436 Genomic DNA Translation: AAA74741.1
U00096 Genomic DNA Translation: AAC75523.1
AP009048 Genomic DNA Translation: BAA16344.1
X57403 Genomic DNA Translation: CAA40663.1

Protein sequence database of the Protein Information Resource

More...PIRi		E65022

NCBI Reference Sequences

More...RefSeqi		NP_416965.1, NC_000913.3
WP_001273151.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC75523; AAC75523; b2470
BAA16344; BAA16344; BAA16344

Database of genes from NCBI RefSeq genomes

More...GeneIDi		945464

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW2454
eco:b2470

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.4270

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12598 Genomic DNA Translation: AAA20584.1
U10436 Genomic DNA Translation: AAA74741.1
U00096 Genomic DNA Translation: AAC75523.1
AP009048 Genomic DNA Translation: BAA16344.1
X57403 Genomic DNA Translation: CAA40663.1
PIRiE65022
RefSeqiNP_416965.1, NC_000913.3
WP_001273151.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP24177
SMRiP24177
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260927, 488 interactors
DIPiDIP-9050N
IntActiP24177, 4 interactors
STRINGi316385.ECDH10B_2635

Protein family/group databases

TCDBi2.A.6.2.7 the resistance-nodulation-cell division (rnd) superfamily

Proteomic databases

PaxDbiP24177
PRIDEiP24177

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75523; AAC75523; b2470
BAA16344; BAA16344; BAA16344
GeneIDi945464
KEGGiecj:JW2454
eco:b2470
PATRICifig|1411691.4.peg.4270

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0014
EcoGeneiEG10014 acrD

Phylogenomic databases

eggNOGiENOG4105BZS Bacteria
COG0841 LUCA
HOGENOMiHOG000158129
InParanoidiP24177
KOiK18324
PhylomeDBiP24177

Enzyme and pathway databases

BioCyciEcoCyc:ACRD-MONOMER
MetaCyc:ACRD-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P24177

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
InterProiView protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR004764 HAE1
PANTHERiPTHR32063 PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873 ACR_tran, 1 hit
PRINTSiPR00702 ACRIFLAVINRP
SUPFAMiSSF82714 SSF82714, 2 hits
TIGRFAMsiTIGR00915 2A0602, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACRD_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24177
Secondary accession number(s): P76971, P77178, Q46715
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1997
Last modified: December 5, 2018
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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