UniProtKB - P24177 (ACRD_ECOLI)
Protein
Probable aminoglycoside efflux pump
Gene
acrD
Organism
Escherichia coli (strain K12)
Status
Functioni
Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances.1 Publication
GO - Molecular functioni
- bile acid transmembrane transporter activity Source: EcoCyc
- efflux transmembrane transporter activity Source: InterPro
GO - Biological processi
- bile acid and bile salt transport Source: EcoCyc
- response to antibiotic Source: EcoCyc
- response to toxic substance Source: EcoCyc
- xenobiotic transport Source: EcoCyc
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:ACRD-MONOMER MetaCyc:ACRD-MONOMER |
Protein family/group databases
TCDBi | 2.A.6.2.7, the resistance-nodulation-cell division (rnd) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Probable aminoglycoside efflux pumpAlternative name(s): Acriflavine resistance protein D |
Gene namesi | Name:acrD Synonyms:yffA Ordered Locus Names:b2470, JW2454 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | CytoplasmicBy similarity | 9 | |
Transmembranei | 10 – 28 | Helical; Name=1By similarityAdd BLAST | 19 | |
Topological domaini | 29 – 339 | PeriplasmicBy similarityAdd BLAST | 311 | |
Transmembranei | 340 – 359 | Helical; Name=2By similarityAdd BLAST | 20 | |
Topological domaini | 360 – 365 | CytoplasmicBy similarity | 6 | |
Transmembranei | 366 – 385 | Helical; Name=3By similarityAdd BLAST | 20 | |
Topological domaini | 386 – 391 | PeriplasmicBy similarity | 6 | |
Transmembranei | 392 – 413 | Helical; Name=4By similarityAdd BLAST | 22 | |
Topological domaini | 414 – 441 | CytoplasmicBy similarityAdd BLAST | 28 | |
Transmembranei | 442 – 460 | Helical; Name=5By similarityAdd BLAST | 19 | |
Topological domaini | 461 – 473 | PeriplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 474 – 496 | Helical; Name=6By similarityAdd BLAST | 23 | |
Topological domaini | 497 – 537 | CytoplasmicBy similarityAdd BLAST | 41 | |
Transmembranei | 538 – 556 | Helical; Name=7By similarityAdd BLAST | 19 | |
Topological domaini | 557 – 870 | PeriplasmicBy similarityAdd BLAST | 314 | |
Transmembranei | 871 – 890 | Helical; Name=8By similarityAdd BLAST | 20 | |
Topological domaini | 891 – 896 | CytoplasmicBy similarity | 6 | |
Transmembranei | 897 – 916 | Helical; Name=9By similarityAdd BLAST | 20 | |
Topological domaini | 917 – 922 | PeriplasmicBy similarity | 6 | |
Transmembranei | 923 – 944 | Helical; Name=10By similarityAdd BLAST | 22 | |
Topological domaini | 945 – 971 | CytoplasmicBy similarityAdd BLAST | 27 | |
Transmembranei | 972 – 990 | Helical; Name=11By similarityAdd BLAST | 19 | |
Topological domaini | 991 – 1003 | PeriplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 1004 – 1026 | Helical; Name=12By similarityAdd BLAST | 23 | |
Topological domaini | 1027 – 1037 | CytoplasmicBy similarityAdd BLAST | 11 |
GO - Cellular componenti
- integral component of plasma membrane Source: EcoCyc
- membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000161812 | 1 – 1037 | Probable aminoglycoside efflux pumpAdd BLAST | 1037 |
Proteomic databases
PaxDbi | P24177 |
PRIDEi | P24177 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260927, 488 interactors |
ComplexPortali | CPX-4264, AcrAD-TolC multidrug efflux transport complex |
DIPi | DIP-9050N |
IntActi | P24177, 4 interactors |
STRINGi | 511145.b2470 |
Family & Domainsi
Sequence similaritiesi
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0841, Bacteria |
HOGENOMi | CLU_002755_0_2_6 |
InParanoidi | P24177 |
PhylomeDBi | P24177 |
Family and domain databases
Gene3Di | 3.30.2090.10, 2 hits |
InterProi | View protein in InterPro IPR027463, AcrB_DN_DC_subdom IPR001036, Acrflvin-R IPR004764, HAE1 |
PANTHERi | PTHR32063, PTHR32063, 1 hit |
Pfami | View protein in Pfam PF00873, ACR_tran, 1 hit |
PRINTSi | PR00702, ACRIFLAVINRP |
SUPFAMi | SSF82714, SSF82714, 2 hits |
TIGRFAMsi | TIGR00915, 2A0602, 1 hit |
i Sequence
Sequence statusi: Complete.
P24177-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANFFIDRPI FAWVLAILLC LTGTLAIFSL PVEQYPDLAP PNVRVTANYP
60 70 80 90 100
GASAQTLENT VTQVIEQNMT GLDNLMYMSS QSSGTGQASV TLSFKAGTDP
110 120 130 140 150
DEAVQQVQNQ LQSAMRKLPQ AVQNQGVTVR KTGDTNILTI AFVSTDGSMD
160 170 180 190 200
KQDIADYVAS NIQDPLSRVN GVGDIDAYGS QYSMRIWLDP AKLNSFQMTA
210 220 230 240 250
KDVTDAIESQ NAQIAVGQLG GTPSVDKQAL NATINAQSLL QTPEQFRDIT
260 270 280 290 300
LRVNQDGSEV RLGDVATVEM GAEKYDYLSR FNGKPASGLG VKLASGANEM
310 320 330 340 350
ATAELVLNRL DELAQYFPHG LEYKVAYETT SFVKASIEDV VKTLLEAIAL
360 370 380 390 400
VFLVMYLFLQ NFRATLIPTI AVPVVLMGTF SVLYAFGYSV NTLTMFAMVL
410 420 430 440 450
AIGLLVDDAI VVVENVERIM SEEGLTPREA TRKSMGQIQG ALVGIAMVLS
460 470 480 490 500
AVFVPMAFFG GTTGAIYRQF SITIVAAMVL SVLVAMILTP ALCATLLKPL
510 520 530 540 550
KKGEHHGQKG FFAWFNQMFN RNAERYEKGV AKILHRSLRW IVIYVLLLGG
560 570 580 590 600
MVFLFLRLPT SFLPLEDRGM FTTSVQLPSG STQQQTLKVV EQIEKYYFTH
610 620 630 640 650
EKDNIMSVFA TVGSGPGGNG QNVARMFIRL KDWSERDSKT GTSFAIIERA
660 670 680 690 700
TKAFNQIKEA RVIASSPPAI SGLGSSAGFD MELQDHAGAG HDALMAARNQ
710 720 730 740 750
LLALAAENPE LTRVRHNGLD DSPQLQIDID QRKAQALGVA IDDINDTLQT
760 770 780 790 800
AWGSSYVNDF MDRGRVKKVY VQAAAPYRML PDDINLWYVR NKDGGMVPFS
810 820 830 840 850
AFATSRWETG SPRLERYNGY SAVEIVGEAA PGVSTGTAMD IMESLVKQLP
860 870 880 890 900
NGFGLEWTAM SYQERLSGAQ APALYAISLL VVFLCLAALY ESWSVPFSVM
910 920 930 940 950
LVVPLGVIGA LLATWMRGLE NDVYFQVGLL TVIGLSAKNA ILIVEFANEM
960 970 980 990 1000
NQKGHDLFEA TLHACRQRLR PILMTSLAFI FGVLPMATST GAGSGGQHAV
1010 1020 1030
GTGVMGGMIS ATILAIYFVP LFFVLVRRRF PLKPRPE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 303 | A → G in AAA20584 (Ref. 1) Curated | 1 | |
Sequence conflicti | 372 | V → E in AAA20584 (Ref. 1) Curated | 1 | |
Sequence conflicti | 385 | A → D in AAA74741 (Ref. 2) Curated | 1 | |
Sequence conflicti | 461 | G → P in AAA20584 (Ref. 1) Curated | 1 | |
Sequence conflicti | 665 | S → PD in AAA20584 (Ref. 1) Curated | 1 | |
Sequence conflicti | 763 | R → A in AAA20584 (Ref. 1) Curated | 1 | |
Sequence conflicti | 775 | A → G in AAA20584 (Ref. 1) Curated | 1 | |
Sequence conflicti | 778 | R → P in AAA20584 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12598 Genomic DNA Translation: AAA20584.1 U10436 Genomic DNA Translation: AAA74741.1 U00096 Genomic DNA Translation: AAC75523.1 AP009048 Genomic DNA Translation: BAA16344.1 X57403 Genomic DNA Translation: CAA40663.1 |
PIRi | E65022 |
RefSeqi | NP_416965.1, NC_000913.3 WP_001273151.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75523; AAC75523; b2470 BAA16344; BAA16344; BAA16344 |
GeneIDi | 945464 |
KEGGi | ecj:JW2454 eco:b2470 |
PATRICi | fig|1411691.4.peg.4270 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12598 Genomic DNA Translation: AAA20584.1 U10436 Genomic DNA Translation: AAA74741.1 U00096 Genomic DNA Translation: AAC75523.1 AP009048 Genomic DNA Translation: BAA16344.1 X57403 Genomic DNA Translation: CAA40663.1 |
PIRi | E65022 |
RefSeqi | NP_416965.1, NC_000913.3 WP_001273151.1, NZ_LN832404.1 |
3D structure databases
SMRi | P24177 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260927, 488 interactors |
ComplexPortali | CPX-4264, AcrAD-TolC multidrug efflux transport complex |
DIPi | DIP-9050N |
IntActi | P24177, 4 interactors |
STRINGi | 511145.b2470 |
Protein family/group databases
TCDBi | 2.A.6.2.7, the resistance-nodulation-cell division (rnd) superfamily |
Proteomic databases
PaxDbi | P24177 |
PRIDEi | P24177 |
Genome annotation databases
EnsemblBacteriai | AAC75523; AAC75523; b2470 BAA16344; BAA16344; BAA16344 |
GeneIDi | 945464 |
KEGGi | ecj:JW2454 eco:b2470 |
PATRICi | fig|1411691.4.peg.4270 |
Organism-specific databases
EchoBASEi | EB0014 |
Phylogenomic databases
eggNOGi | COG0841, Bacteria |
HOGENOMi | CLU_002755_0_2_6 |
InParanoidi | P24177 |
PhylomeDBi | P24177 |
Enzyme and pathway databases
BioCyci | EcoCyc:ACRD-MONOMER MetaCyc:ACRD-MONOMER |
Miscellaneous databases
PROi | PR:P24177 |
Family and domain databases
Gene3Di | 3.30.2090.10, 2 hits |
InterProi | View protein in InterPro IPR027463, AcrB_DN_DC_subdom IPR001036, Acrflvin-R IPR004764, HAE1 |
PANTHERi | PTHR32063, PTHR32063, 1 hit |
Pfami | View protein in Pfam PF00873, ACR_tran, 1 hit |
PRINTSi | PR00702, ACRIFLAVINRP |
SUPFAMi | SSF82714, SSF82714, 2 hits |
TIGRFAMsi | TIGR00915, 2A0602, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACRD_ECOLI | |
Accessioni | P24177Primary (citable) accession number: P24177 Secondary accession number(s): P76971, P77178, Q46715 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 156 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families