manB

Functionⁱ

Involved in the biosynthesis of the capsular polysaccharide colanic acid.

Catalytic activityⁱ

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactorⁱ

Mg²⁺By similarityNote: Binds 1 Mg²⁺ ion per subunit.By similarity

Pathwayⁱ: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

no protein annotated in this organism
Phosphomannomutase (manB)

This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	98	Phosphoserine intermediateBy similarity	1
Metal bindingⁱ	98	Magnesium; via phosphate groupBy similarity	1
Metal bindingⁱ	245	MagnesiumBy similarity	1
Metal bindingⁱ	247	MagnesiumBy similarity	1
Metal bindingⁱ	249	MagnesiumBy similarity	1

GO - Molecular functionⁱ

magnesium ion binding Source: InterPro
phosphomannomutase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
lipopolysaccharide biosynthetic process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Capsule biogenesis/degradation, Lipopolysaccharide biosynthesis
Ligand	Magnesium, Metal-binding

Enzyme and pathway databases

BioCycⁱ	EcoCyc:PHOSMANMUT-MONOMER MetaCyc:PHOSMANMUT-MONOMER
UniPathwayⁱ	UPA00126;UER00424

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphomannomutase (EC:5.4.2.8) Short name: PMM
Gene namesⁱ	Name:manB Synonyms:cpsG, rfbL Ordered Locus Names:b2048, JW2033
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10162 manB

EcoGeneⁱ

EG10162 manB

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000147818	1 – 456	PhosphomannomutaseAdd BLAST		456

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P24175
PRIDEⁱ	P24175

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4263309, 280 interactors
IntActⁱ	P24175, 9 interactors
STRINGⁱ	316385.ECDH10B_2198

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P24175
SMRⁱ	P24175
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4107QKV Bacteria COG1109 LUCA
HOGENOMⁱ	HOG000268679
InParanoidⁱ	P24175
KEGG Orthology (KO) More...KOⁱ	K01840
OMAⁱ	KCSQVMY
PhylomeDBⁱ	P24175

Family and domain databases

InterProⁱ	View protein in InterPro IPR005844 A-D-PHexomutase_a/b/a-I IPR016055 A-D-PHexomutase_a/b/a-I/II/III IPR005845 A-D-PHexomutase_a/b/a-II IPR005846 A-D-PHexomutase_a/b/a-III IPR005843 A-D-PHexomutase_C IPR036900 A-D-PHexomutase_C_sf IPR016066 A-D-PHexomutase_CS IPR005841 Alpha-D-phosphohexomutase_SF
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02878 PGM_PMM_I, 1 hit PF02879 PGM_PMM_II, 1 hit PF02880 PGM_PMM_III, 1 hit PF00408 PGM_PMM_IV, 1 hit
PRINTSⁱ	PR00509 PGMPMM
SUPFAMⁱ	SSF53738 SSF53738, 3 hits SSF55957 SSF55957, 1 hit
PROSITEⁱ	View protein in PROSITE PS00710 PGM_PMM, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P24175-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKKLTCFKAY DIRGKLGEEL NEDIAWRIGR AYGEFLKPKT IVLGGDVRLT 
        60         70         80         90        100
SETLKLALAK GLQDAGVDVL DIGMSGTEEI YFATFHLGVD GGIEVTASHN 
       110        120        130        140        150
PMDYNGMKLV REGARPISGD TGLRDVQRLA EANDFPPVDE TKRGRYQQIN 
       160        170        180        190        200
LRDAYVDHLF GYINVKNLTP LKLVINSGNG AAGPVVDAIE ARFKALGAPV 
       210        220        230        240        250
ELIKVHNTPD GNFPNGIPNP LLPECRDDTR NAVIKHGADM GIAFDGDFDR 
       260        270        280        290        300
CFLFDEKGQF IEGYYIVGLL AEAFLEKNPG AKIIHDPRLS WNTVDVVTAA 
       310        320        330        340        350
GGTPVMSKTG HAFIKERMRK EDAIYGGEMS AHHYFRDFAY CDSGMIPWLL 
       360        370        380        390        400
VAELVCLKDK TLGELVRDRM AAFPASGEIN SKLAQPVEAI NRVEQHFSRE 
       410        420        430        440        450
ALAVDRTDGI SMTFADWRFN LRTSNTEPVV RLNVESRGDV PLMEARTRTL 

LTLLNE

Length:456

Mass (Da):50,463

Last modified:March 1, 1992 - v1

Checksum:ⁱ8A96663D7A60BFD1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M77127 Genomic DNA Translation: AAA02894.1 U38473 Genomic DNA Translation: AAC77847.1 U00096 Genomic DNA Translation: AAC75109.1 AP009048 Genomic DNA Translation: BAA15901.1
PIRⁱ	B55239
NCBI Reference Sequences More...RefSeqⁱ	NP_416552.1, NC_000913.3 WP_001350528.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC75109; AAC75109; b2048 BAA15901; BAA15901; BAA15901
GeneIDⁱ	946574
KEGGⁱ	ecj:JW2033 eco:b2048
PATRICⁱ	fig\|511145.12.peg.2125

Protein	Similar proteins		Species	Score	Length	Source
P24175	Phosphomannomutase CpsG		ECOLX		456	UniRef100_P24175
Phosphoglucomutase/phosphomannomutase, C-terminal domain protein		Escherichia coli 3-373-03_S4_C2		456
UPI0003900212		ECOLX		309

Protein	Similar proteins		Species	Score	Length	Source
P24175	Phosphomannomutase		ECOLX		453	UniRef90_P37742
Phosphomannomutase		ECO57		456
ManB (Fragment)		human gut metagenome		115
Phosphomannomutase		Escherichia coli 907672		456
Phosphomannomutase		Escherichia coli HVH 50 (4-2593475)		456
+2016

Protein	Similar proteins		Species	Score	Length	Source
P24175	Phosphomannomutase		ECOLX		456	UniRef50_P37755
Phosphomannomutase	)	SALTY		456
Phosphomannomutase		SALMO		456
Phosphohexose mutases		XANCB		448
Phosphohexose mutases		XANCP		448
+7647

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M77127 Genomic DNA Translation: AAA02894.1 U38473 Genomic DNA Translation: AAC77847.1 U00096 Genomic DNA Translation: AAC75109.1 AP009048 Genomic DNA Translation: BAA15901.1
PIRⁱ	B55239
RefSeqⁱ	NP_416552.1, NC_000913.3 WP_001350528.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P24175
SMRⁱ	P24175
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4263309, 280 interactors
IntActⁱ	P24175, 9 interactors
STRINGⁱ	316385.ECDH10B_2198

Proteomic databases

PaxDbⁱ	P24175
PRIDEⁱ	P24175

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC75109; AAC75109; b2048 BAA15901; BAA15901; BAA15901
GeneIDⁱ	946574
KEGGⁱ	ecj:JW2033 eco:b2048
PATRICⁱ	fig\|511145.12.peg.2125

Organism-specific databases

EchoBASEⁱ	EB0160
EcoGeneⁱ	EG10162 manB

Phylogenomic databases

eggNOGⁱ	ENOG4107QKV Bacteria COG1109 LUCA
HOGENOMⁱ	HOG000268679
InParanoidⁱ	P24175
KOⁱ	K01840
OMAⁱ	KCSQVMY
PhylomeDBⁱ	P24175

Enzyme and pathway databases

UniPathwayⁱ	UPA00126;UER00424
BioCycⁱ	EcoCyc:PHOSMANMUT-MONOMER MetaCyc:PHOSMANMUT-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P24175

PROⁱ

PR:P24175

Family and domain databases

InterProⁱ	View protein in InterPro IPR005844 A-D-PHexomutase_a/b/a-I IPR016055 A-D-PHexomutase_a/b/a-I/II/III IPR005845 A-D-PHexomutase_a/b/a-II IPR005846 A-D-PHexomutase_a/b/a-III IPR005843 A-D-PHexomutase_C IPR036900 A-D-PHexomutase_C_sf IPR016066 A-D-PHexomutase_CS IPR005841 Alpha-D-phosphohexomutase_SF
Pfamⁱ	View protein in Pfam PF02878 PGM_PMM_I, 1 hit PF02879 PGM_PMM_II, 1 hit PF02880 PGM_PMM_III, 1 hit PF00408 PGM_PMM_IV, 1 hit
PRINTSⁱ	PR00509 PGMPMM
SUPFAMⁱ	SSF53738 SSF53738, 3 hits SSF55957 SSF55957, 1 hit
PROSITEⁱ	View protein in PROSITE PS00710 PGM_PMM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MANB_ECOLI
Accessionⁱ	P24175Primary (citable) accession number: P24175
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	March 1, 1992
	Last modified:	March 28, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P24175 (MANB_ECOLI)

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Phosphomannomutase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: GDP-alpha-D-mannose biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: GDP-alpha-D-mannose biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ