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UniProtKB - P24174 (MANC_ECOLI)

Entry version 155 (11 Dec 2019)
Sequence version 3 (19 Jul 2003)
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Protein

Mannose-1-phosphate guanylyltransferase

Gene

manC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the biosynthesis of the capsular polysaccharide colanic acid.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Mannose-1-phosphate guanylyltransferase (manC)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route), the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • mannose-1-phosphate guanylyltransferase activity Source: EcoCyc
Complete GO annotation on QuickGO ...

GO - Biological processi

  • colanic acid biosynthetic process Source: EcoCyc
  • GDP-mannose biosynthetic process Source: GO_Central
  • hyperosmotic response Source: EcoCyc
  • lipopolysaccharide biosynthetic process Source: UniProtKB-KW
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCapsule biogenesis/degradation, Lipopolysaccharide biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:MANNPGUANYLTRANGDP-MONOMER
ECOL316407:JW2034-MONOMER
MetaCyc:MANNPGUANYLTRANGDP-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00126;UER00930

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mannose-1-phosphate guanylyltransferase (EC:2.7.7.13)
Alternative name(s):
GDP-mannose pyrophosphorylase
Short name:
GMP
Short name:
GMPP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:manC
Synonyms:cpsB, rfbM
Ordered Locus Names:b2049, JW2034
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001942531 – 478Mannose-1-phosphate guanylyltransferaseAdd BLAST478

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P24174

PRoteomics IDEntifications database

More...PRIDEi		P24174

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		4263312, 190 interactors

Protein interaction database and analysis system

More...IntActi		P24174, 5 interactors

STRING: functional protein association networks

More...STRINGi		511145.b2049

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P24174

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mannose-6-phosphate isomerase type 2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105CJT Bacteria
COG0662 LUCA
COG0836 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000153549

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P24174

KEGG Orthology (KO)

More...KOi		K00971

Database for complete collections of gene phylogenies

More...PhylomeDBi		P24174

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.10, 1 hit
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006375 Man1P_GuaTrfase/Man6P_Isoase
IPR001538 Man6P_isomerase-2_C
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01050 MannoseP_isomer, 1 hit
PF00483 NTP_transferase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51182 SSF51182, 1 hit
SSF53448 SSF53448, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01479 GMP_PMI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P24174-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQSKLYPVV MAGGSGSRLW PLSRVLYPKQ FLCLKGDLTM LQTTICRLNG 
        60         70         80         90        100
VECESPVVIC NEQHRFIVAE QLRQLNKLTE NIILEPAGRN TAPAIALAAL 
       110        120        130        140        150
AAKRHSPESD PLMLVLAADH VIADEDAFRA AVRNAMPYAE AGKLVTFGIV 
       160        170        180        190        200
PDLPETGYGY IRRGEVSAGE QDMVAFEVAQ FVEKPNLETA QAYVASGEYY 
       210        220        230        240        250
WNSGMFLFRA GRYLEELKKY RPDILDACEK AMSAVDPDLN FIRVDEEAFL 
       260        270        280        290        300
ACPEESVDYA VMERTADAVV VPMDAGWSDV GSWSSLWEIS AHTAEGNVCH 
       310        320        330        340        350
GDVINHKTEN SYVYAESGLV TTVGVKDLVV VQTKDAVLIA DRNAVQDVKK 
       360        370        380        390        400
VVEQIKADGR HEHRVHREVY RPWGKYDSID AGDRYQVKRI TVKPGEGLSV 
       410        420        430        440        450
QMHHHRAEHW VVVAGTAKVT IDGDIKLLGE NESIYIPLGA THCLENPGKI 
       460        470 
PLDLIEVRSG SYLEEDDVVR FADRYGRV
Length:478
Mass (Da):53,016
Last modified:July 19, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i675C0EEA050B4186
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti325V → L (PubMed:7815923).Curated1
Sequence conflicti325V → L (PubMed:8759852).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U38473 Genomic DNA Translation: AAC77846.1
U00096 Genomic DNA Translation: AAC75110.1
AP009048 Genomic DNA Translation: BAA15905.1
M77127 Genomic DNA Translation: AAA02893.1

Protein sequence database of the Protein Information Resource

More...PIRi		H64970

NCBI Reference Sequences

More...RefSeqi		NP_416553.1, NC_000913.3
WP_000079274.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC75110; AAC75110; b2049
BAA15905; BAA15905; BAA15905

Database of genes from NCBI RefSeq genomes

More...GeneIDi		946580

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW2034
eco:b2049

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.202

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38473 Genomic DNA Translation: AAC77846.1
U00096 Genomic DNA Translation: AAC75110.1
AP009048 Genomic DNA Translation: BAA15905.1
M77127 Genomic DNA Translation: AAA02893.1
PIRiH64970
RefSeqiNP_416553.1, NC_000913.3
WP_000079274.1, NZ_LN832404.1

3D structure databases

SMRiP24174
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4263312, 190 interactors
IntActiP24174, 5 interactors
STRINGi511145.b2049

Proteomic databases

PaxDbiP24174
PRIDEiP24174

Genome annotation databases

EnsemblBacteriaiAAC75110; AAC75110; b2049
BAA15905; BAA15905; BAA15905
GeneIDi946580
KEGGiecj:JW2034
eco:b2049
PATRICifig|1411691.4.peg.202

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0159

Phylogenomic databases

eggNOGiENOG4105CJT Bacteria
COG0662 LUCA
COG0836 LUCA
HOGENOMiHOG000153549
InParanoidiP24174
KOiK00971
PhylomeDBiP24174

Enzyme and pathway databases

UniPathwayiUPA00126;UER00930
BioCyciEcoCyc:MANNPGUANYLTRANGDP-MONOMER
ECOL316407:JW2034-MONOMER
MetaCyc:MANNPGUANYLTRANGDP-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P24174

Family and domain databases

Gene3Di2.60.120.10, 1 hit
3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR006375 Man1P_GuaTrfase/Man6P_Isoase
IPR001538 Man6P_isomerase-2_C
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PfamiView protein in Pfam
PF01050 MannoseP_isomer, 1 hit
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
SSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR01479 GMP_PMI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMANC_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24174
Secondary accession number(s): P78084
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 19, 2003
Last modified: December 11, 2019
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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