UniProtKB - P24173 (RFAC_ECOLI)
Protein
Lipopolysaccharide heptosyltransferase 1
Gene
rfaC
Organism
Escherichia coli (strain K12)
Status
Functioni
Heptose transfer to the lipopolysaccharide core. It transfers the innermost heptose to [4'-P](3-deoxy-D-manno-octulosonic acid)2-IVA.
: LPS core biosynthesis Pathwayi
This protein is involved in the pathway LPS core biosynthesis, which is part of Bacterial outer membrane biogenesis.View all proteins of this organism that are known to be involved in the pathway LPS core biosynthesis and in Bacterial outer membrane biogenesis.
GO - Molecular functioni
- ADP-heptose-lipopolysaccharide heptosyltransferase activity Source: GO_Central
- lipopolysaccharide heptosyltransferase activity Source: CACAO
GO - Biological processi
- lipopolysaccharide core region biosynthetic process Source: EcoCyc
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Lipopolysaccharide biosynthesis |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11189-MONOMER MetaCyc:EG11189-MONOMER |
BRENDAi | 2.4.99.B6, 2026 |
UniPathwayi | UPA00958 |
Protein family/group databases
CAZyi | GT9, Glycosyltransferase Family 9 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:rfaC Synonyms:rfa-2, waaC, yibC Ordered Locus Names:b3621, JW3596 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207260 | 1 – 319 | Lipopolysaccharide heptosyltransferase 1Add BLAST | 319 |
Proteomic databases
jPOSTi | P24173 |
PaxDbi | P24173 |
PRIDEi | P24173 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4263304, 500 interactors |
IntActi | P24173, 17 interactors |
STRINGi | 511145.b3621 |
Chemistry databases
BindingDBi | P24173 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P24173 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P24173 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycosyltransferase 9 family.Curated
Phylogenomic databases
eggNOGi | COG0859, Bacteria |
HOGENOMi | CLU_038371_6_0_6 |
InParanoidi | P24173 |
PhylomeDBi | P24173 |
Family and domain databases
InterProi | View protein in InterPro IPR002201, Glyco_trans_9 IPR011908, LipoPS_heptosylTferase-I |
Pfami | View protein in Pfam PF01075, Glyco_transf_9, 1 hit |
TIGRFAMsi | TIGR02193, heptsyl_trn_I, 1 hit |
i Sequence
Sequence statusi: Complete.
P24173-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRVLIVKTSS MGDVLHTLPA LTDAQQAIPG IKFDWVVEEG FAQIPSWHAA
60 70 80 90 100
VERVIPVAIR RWRKAWFSAP IKAERKAFRE ALQAENYDAV IDAQGLVKSA
110 120 130 140 150
ALVTRLAHGV KHGMDWQTAR EPLASLFYNR KHHIAKQQHA VERTRELFAK
160 170 180 190 200
SLGYSKPQTQ GDYAIAQHFL TNLPTDAGEY AVFLHATTRD DKHWPEEHWR
210 220 230 240 250
ELIGLLADSG IRIKLPWGAP HEEERAKRLA EGFAYVEVLP KMSLEGVARV
260 270 280 290 300
LAGAKFVVSV DTGLSHLTAA LDRPNITVYG PTDPGLIGGY GKNQMVCRAP
310
RENLINLNSQ AVLEKLSSL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M95398 Genomic DNA No translation available. X62530 Genomic DNA Translation: CAA44391.1 U00039 Genomic DNA Translation: AAB18598.1 U00096 Genomic DNA Translation: AAC76645.1 AP009048 Genomic DNA Translation: BAE77671.1 |
PIRi | A40619 |
RefSeqi | NP_418078.1, NC_000913.3 WP_001264584.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC76645; AAC76645; b3621 BAE77671; BAE77671; BAE77671 |
GeneIDi | 948136 |
KEGGi | ecj:JW3596 eco:b3621 |
PATRICi | fig|1411691.4.peg.3085 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M95398 Genomic DNA No translation available. X62530 Genomic DNA Translation: CAA44391.1 U00039 Genomic DNA Translation: AAB18598.1 U00096 Genomic DNA Translation: AAC76645.1 AP009048 Genomic DNA Translation: BAE77671.1 |
PIRi | A40619 |
RefSeqi | NP_418078.1, NC_000913.3 WP_001264584.1, NZ_LN832404.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2H1H | X-ray | 2.40 | A/B | 1-300 | [»] | |
SMRi | P24173 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4263304, 500 interactors |
IntActi | P24173, 17 interactors |
STRINGi | 511145.b3621 |
Chemistry databases
BindingDBi | P24173 |
ChEMBLi | CHEMBL4295576 |
Protein family/group databases
CAZyi | GT9, Glycosyltransferase Family 9 |
Proteomic databases
jPOSTi | P24173 |
PaxDbi | P24173 |
PRIDEi | P24173 |
Genome annotation databases
EnsemblBacteriai | AAC76645; AAC76645; b3621 BAE77671; BAE77671; BAE77671 |
GeneIDi | 948136 |
KEGGi | ecj:JW3596 eco:b3621 |
PATRICi | fig|1411691.4.peg.3085 |
Organism-specific databases
EchoBASEi | EB1175 |
Phylogenomic databases
eggNOGi | COG0859, Bacteria |
HOGENOMi | CLU_038371_6_0_6 |
InParanoidi | P24173 |
PhylomeDBi | P24173 |
Enzyme and pathway databases
UniPathwayi | UPA00958 |
BioCyci | EcoCyc:EG11189-MONOMER MetaCyc:EG11189-MONOMER |
BRENDAi | 2.4.99.B6, 2026 |
Miscellaneous databases
EvolutionaryTracei | P24173 |
PROi | PR:P24173 |
Family and domain databases
InterProi | View protein in InterPro IPR002201, Glyco_trans_9 IPR011908, LipoPS_heptosylTferase-I |
Pfami | View protein in Pfam PF01075, Glyco_transf_9, 1 hit |
TIGRFAMsi | TIGR02193, heptsyl_trn_I, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RFAC_ECOLI | |
Accessioni | P24173Primary (citable) accession number: P24173 Secondary accession number(s): P27376, Q2M7T5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families