UniProtKB - P24169 (DCOS_ECOLI)
Protein
Inducible ornithine decarboxylase
Gene
speF
Organism
Escherichia coli (strain K12)
Status
Functioni
The first enzyme leading to putrescine and thus polyamine synthesis.Curated
Catalytic activityi
- EC:4.1.1.171 Publication
Cofactori
pH dependencei
Optimum pH is 7.0.1 Publication
: putrescine biosynthesis via L-ornithine pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.Proteins known to be involved in this subpathway in this organism are:
- Constitutive ornithine decarboxylase (speC), Inducible ornithine decarboxylase (speF)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.
GO - Molecular functioni
- carboxy-lyase activity Source: GO_Central
- ornithine decarboxylase activity Source: EcoCyc
- pyridoxal phosphate binding Source: EcoCyc
GO - Biological processi
- putrescine biosynthetic process from ornithine Source: UniProtKB-UniPathway
- spermidine biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Decarboxylase, Lyase |
Biological process | Spermidine biosynthesis |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BioCyci | EcoCyc:ORNDECARBOXDEG-MONOMER MetaCyc:ORNDECARBOXDEG-MONOMER |
UniPathwayi | UPA00535;UER00288 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:speF1 Publication Ordered Locus Names:b0693, JW0680 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000201135 | 1 – 732 | Inducible ornithine decarboxylaseAdd BLAST | 732 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 355 | N6-(pyridoxal phosphate)lysineBy similarity | 1 |
Proteomic databases
PaxDbi | P24169 |
PRIDEi | P24169 |
Expressioni
Inductioni
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261018, 16 interactors |
DIPi | DIP-154N |
IntActi | P24169, 4 interactors |
STRINGi | 511145.b0693 |
Family & Domainsi
Sequence similaritiesi
Belongs to the Orn/Lys/Arg decarboxylase class-I family.Curated
Phylogenomic databases
eggNOGi | COG1982, Bacteria |
HOGENOMi | CLU_014292_3_0_6 |
InParanoidi | P24169 |
PhylomeDBi | P24169 |
Family and domain databases
CDDi | cd00615, Orn_deC_like, 1 hit |
Gene3Di | 3.40.50.220, 1 hit 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR011006, CheY-like_superfamily IPR027568, ODC_inducible IPR005308, OKR_de-COase_N IPR011193, Orn/lys/arg_de-COase IPR000310, Orn/Lys/Arg_deCO2ase_major_dom IPR027464, Ornithine_deCO2ase_N IPR008286, Prn/Lys/Arg_de-COase_C IPR036633, Prn/Lys/Arg_de-COase_C_sf IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF01276, OKR_DC_1, 1 hit PF03711, OKR_DC_1_C, 1 hit PF03709, OKR_DC_1_N, 1 hit |
PIRSFi | PIRSF009393, Orn_decarb, 1 hit |
SUPFAMi | SSF52172, SSF52172, 1 hit SSF53383, SSF53383, 1 hit SSF55904, SSF55904, 1 hit |
TIGRFAMsi | TIGR04301, ODC_inducible, 1 hit |
PROSITEi | View protein in PROSITE PS00703, OKR_DC_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P24169-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKLKIAVSD SCPDCFTTQR ECIYINESRN IDVAAIVLSL NDVTCGKLDE
60 70 80 90 100
IDATGYGIPV FIATENQERV PAEYLPRISG VFENCESRRE FYGRQLETAA
110 120 130 140 150
SHYETQLRPP FFRALVDYVN QGNSAFDCPG HQGGEFFRRH PAGNQFVEYF
160 170 180 190 200
GEALFRADLC NADVAMGDLL IHEGAPCIAQ QHAAKVFNAD KTYFVLNGTS
210 220 230 240 250
SSNKVVLNAL LTPGDLVLFD RNNHKSNHHG ALLQAGATPV YLETARNPYG
260 270 280 290 300
FIGGIDAHCF EESYLRELIA EVAPQRAKEA RPFRLAVIQL GTYDGTIYNA
310 320 330 340 350
RQVVDKIGHL CDYILFDSAW VGYEQFIPMM ADCSPLLLDL NENDPGILVT
360 370 380 390 400
QSVHKQQAGF SQTSQIHKKD SHIKGQQRYV PHKRMNNAFM MHASTSPFYP
410 420 430 440 450
LFAALNINAK MHEGVSGRNM WMDCVVNGIN ARKLILDNCQ HIRPFVPELV
460 470 480 490 500
DGKPWQSYET AQIAVDLRFF QFVPGEHWHS FEGYAENQYF VDPCKLLLTT
510 520 530 540 550
PGIDARNGEY EAFGVPATIL ANFLRENGVV PEKCDLNSIL FLLTPAEDMA
560 570 580 590 600
KLQQLVALLV RFEKLLESDA PLAEVLPSIY KQHEERYAGY TLRQLCQEMH
610 620 630 640 650
DLYARHNVKQ LQKEMFRKEH FPRVSMNPQE ANYAYLRGEV ELVRLPDAEG
660 670 680 690 700
RIAAEGALPY PPGVLCVVPG EIWGGAVLRY FSALEEGINL LPGFAPELQG
710 720 730
VYIEEHDGRK QVWCYVIKPR DAQSTLLKGE KL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64495 Genomic DNA Translation: AAA62785.1 U00096 Genomic DNA Translation: AAC73787.1 AP009048 Genomic DNA Translation: BAA35349.1 |
PIRi | A40839 |
RefSeqi | NP_415220.1, NC_000913.3 WP_000040195.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC73787; AAC73787; b0693 BAA35349; BAA35349; BAA35349 |
GeneIDi | 945297 |
KEGGi | ecj:JW0680 eco:b0693 |
PATRICi | fig|1411691.4.peg.1583 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64495 Genomic DNA Translation: AAA62785.1 U00096 Genomic DNA Translation: AAC73787.1 AP009048 Genomic DNA Translation: BAA35349.1 |
PIRi | A40839 |
RefSeqi | NP_415220.1, NC_000913.3 WP_000040195.1, NZ_LN832404.1 |
3D structure databases
SMRi | P24169 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261018, 16 interactors |
DIPi | DIP-154N |
IntActi | P24169, 4 interactors |
STRINGi | 511145.b0693 |
Proteomic databases
PaxDbi | P24169 |
PRIDEi | P24169 |
Genome annotation databases
EnsemblBacteriai | AAC73787; AAC73787; b0693 BAA35349; BAA35349; BAA35349 |
GeneIDi | 945297 |
KEGGi | ecj:JW0680 eco:b0693 |
PATRICi | fig|1411691.4.peg.1583 |
Organism-specific databases
EchoBASEi | EB0957 |
Phylogenomic databases
eggNOGi | COG1982, Bacteria |
HOGENOMi | CLU_014292_3_0_6 |
InParanoidi | P24169 |
PhylomeDBi | P24169 |
Enzyme and pathway databases
UniPathwayi | UPA00535;UER00288 |
BioCyci | EcoCyc:ORNDECARBOXDEG-MONOMER MetaCyc:ORNDECARBOXDEG-MONOMER |
Miscellaneous databases
PROi | PR:P24169 |
Family and domain databases
CDDi | cd00615, Orn_deC_like, 1 hit |
Gene3Di | 3.40.50.220, 1 hit 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR011006, CheY-like_superfamily IPR027568, ODC_inducible IPR005308, OKR_de-COase_N IPR011193, Orn/lys/arg_de-COase IPR000310, Orn/Lys/Arg_deCO2ase_major_dom IPR027464, Ornithine_deCO2ase_N IPR008286, Prn/Lys/Arg_de-COase_C IPR036633, Prn/Lys/Arg_de-COase_C_sf IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF01276, OKR_DC_1, 1 hit PF03711, OKR_DC_1_C, 1 hit PF03709, OKR_DC_1_N, 1 hit |
PIRSFi | PIRSF009393, Orn_decarb, 1 hit |
SUPFAMi | SSF52172, SSF52172, 1 hit SSF53383, SSF53383, 1 hit SSF55904, SSF55904, 1 hit |
TIGRFAMsi | TIGR04301, ODC_inducible, 1 hit |
PROSITEi | View protein in PROSITE PS00703, OKR_DC_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DCOS_ECOLI | |
Accessioni | P24169Primary (citable) accession number: P24169 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families