Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P24169 (DCOS_ECOLI)

Entry version 151 (02 Dec 2020)
Sequence version 1 (01 Mar 1992)
Previous versions | rss
Add a publicationFeedback
Protein

Inducible ornithine decarboxylase

Gene

speF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The first enzyme leading to putrescine and thus polyamine synthesis.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7.0.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Constitutive ornithine decarboxylase (speC), Inducible ornithine decarboxylase (speF)
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processSpermidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:ORNDECARBOXDEG-MONOMER
MetaCyc:ORNDECARBOXDEG-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00535;UER00288

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inducible ornithine decarboxylase (EC:4.1.1.171 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:speF1 Publication
Ordered Locus Names:b0693, JW0680
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002011351 – 732Inducible ornithine decarboxylaseAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei355N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P24169

PRoteomics IDEntifications database

More...PRIDEi		P24169

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced at low environmental pH (at protein level). Part of the speFL-speF-potE operon (PubMed:1939141). Expression induced by ornithine (at protein level) (PubMed:32094585) (Probable).1 Publication2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261018, 16 interactors

Database of interacting proteins

More...DIPi		DIP-154N

Protein interaction database and analysis system

More...IntActi		P24169, 4 interactors

STRING: functional protein association networks

More...STRINGi		511145.b0693

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P24169

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-I family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1982, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014292_3_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P24169

Database for complete collections of gene phylogenies

More...PhylomeDBi		P24169

Family and domain databases

Conserved Domains Database

More...CDDi		cd00615, Orn_deC_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.220, 1 hit
3.40.640.10, 1 hit
3.90.1150.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011006, CheY-like_superfamily
IPR027568, ODC_inducible
IPR005308, OKR_de-COase_N
IPR011193, Orn/lys/arg_de-COase
IPR000310, Orn/Lys/Arg_deCO2ase_major_dom
IPR027464, Ornithine_deCO2ase_N
IPR008286, Prn/Lys/Arg_de-COase_C
IPR036633, Prn/Lys/Arg_de-COase_C_sf
IPR015424, PyrdxlP-dep_Trfase
IPR015422, PyrdxlP-dep_Trfase_dom1
IPR015421, PyrdxlP-dep_Trfase_major

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01276, OKR_DC_1, 1 hit
PF03711, OKR_DC_1_C, 1 hit
PF03709, OKR_DC_1_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF009393, Orn_decarb, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52172, SSF52172, 1 hit
SSF53383, SSF53383, 1 hit
SSF55904, SSF55904, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR04301, ODC_inducible, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00703, OKR_DC_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P24169-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKLKIAVSD SCPDCFTTQR ECIYINESRN IDVAAIVLSL NDVTCGKLDE 
        60         70         80         90        100
IDATGYGIPV FIATENQERV PAEYLPRISG VFENCESRRE FYGRQLETAA 
       110        120        130        140        150
SHYETQLRPP FFRALVDYVN QGNSAFDCPG HQGGEFFRRH PAGNQFVEYF 
       160        170        180        190        200
GEALFRADLC NADVAMGDLL IHEGAPCIAQ QHAAKVFNAD KTYFVLNGTS 
       210        220        230        240        250
SSNKVVLNAL LTPGDLVLFD RNNHKSNHHG ALLQAGATPV YLETARNPYG 
       260        270        280        290        300
FIGGIDAHCF EESYLRELIA EVAPQRAKEA RPFRLAVIQL GTYDGTIYNA 
       310        320        330        340        350
RQVVDKIGHL CDYILFDSAW VGYEQFIPMM ADCSPLLLDL NENDPGILVT 
       360        370        380        390        400
QSVHKQQAGF SQTSQIHKKD SHIKGQQRYV PHKRMNNAFM MHASTSPFYP 
       410        420        430        440        450
LFAALNINAK MHEGVSGRNM WMDCVVNGIN ARKLILDNCQ HIRPFVPELV 
       460        470        480        490        500
DGKPWQSYET AQIAVDLRFF QFVPGEHWHS FEGYAENQYF VDPCKLLLTT 
       510        520        530        540        550
PGIDARNGEY EAFGVPATIL ANFLRENGVV PEKCDLNSIL FLLTPAEDMA 
       560        570        580        590        600
KLQQLVALLV RFEKLLESDA PLAEVLPSIY KQHEERYAGY TLRQLCQEMH 
       610        620        630        640        650
DLYARHNVKQ LQKEMFRKEH FPRVSMNPQE ANYAYLRGEV ELVRLPDAEG 
       660        670        680        690        700
RIAAEGALPY PPGVLCVVPG EIWGGAVLRY FSALEEGINL LPGFAPELQG 
       710        720        730 
VYIEEHDGRK QVWCYVIKPR DAQSTLLKGE KL
Length:732
Mass (Da):82,416
Last modified:March 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2C030BEAB9D23F6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M64495 Genomic DNA Translation: AAA62785.1
U00096 Genomic DNA Translation: AAC73787.1
AP009048 Genomic DNA Translation: BAA35349.1

Protein sequence database of the Protein Information Resource

More...PIRi		A40839

NCBI Reference Sequences

More...RefSeqi		NP_415220.1, NC_000913.3
WP_000040195.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC73787; AAC73787; b0693
BAA35349; BAA35349; BAA35349

Database of genes from NCBI RefSeq genomes

More...GeneIDi		945297

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW0680
eco:b0693

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.1583

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64495 Genomic DNA Translation: AAA62785.1
U00096 Genomic DNA Translation: AAC73787.1
AP009048 Genomic DNA Translation: BAA35349.1
PIRiA40839
RefSeqiNP_415220.1, NC_000913.3
WP_000040195.1, NZ_LN832404.1

3D structure databases

SMRiP24169
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261018, 16 interactors
DIPiDIP-154N
IntActiP24169, 4 interactors
STRINGi511145.b0693

Proteomic databases

PaxDbiP24169
PRIDEiP24169

Genome annotation databases

EnsemblBacteriaiAAC73787; AAC73787; b0693
BAA35349; BAA35349; BAA35349
GeneIDi945297
KEGGiecj:JW0680
eco:b0693
PATRICifig|1411691.4.peg.1583

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0957

Phylogenomic databases

eggNOGiCOG1982, Bacteria
HOGENOMiCLU_014292_3_0_6
InParanoidiP24169
PhylomeDBiP24169

Enzyme and pathway databases

UniPathwayiUPA00535;UER00288
BioCyciEcoCyc:ORNDECARBOXDEG-MONOMER
MetaCyc:ORNDECARBOXDEG-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P24169

Family and domain databases

CDDicd00615, Orn_deC_like, 1 hit
Gene3Di3.40.50.220, 1 hit
3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR011006, CheY-like_superfamily
IPR027568, ODC_inducible
IPR005308, OKR_de-COase_N
IPR011193, Orn/lys/arg_de-COase
IPR000310, Orn/Lys/Arg_deCO2ase_major_dom
IPR027464, Ornithine_deCO2ase_N
IPR008286, Prn/Lys/Arg_de-COase_C
IPR036633, Prn/Lys/Arg_de-COase_C_sf
IPR015424, PyrdxlP-dep_Trfase
IPR015422, PyrdxlP-dep_Trfase_dom1
IPR015421, PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF01276, OKR_DC_1, 1 hit
PF03711, OKR_DC_1_C, 1 hit
PF03709, OKR_DC_1_N, 1 hit
PIRSFiPIRSF009393, Orn_decarb, 1 hit
SUPFAMiSSF52172, SSF52172, 1 hit
SSF53383, SSF53383, 1 hit
SSF55904, SSF55904, 1 hit
TIGRFAMsiTIGR04301, ODC_inducible, 1 hit
PROSITEiView protein in PROSITE
PS00703, OKR_DC_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCOS_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24169
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: December 2, 2020
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again