Cd247

Functionⁱ

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN).By similarity2 Publications

GO - Molecular functionⁱ

identical protein binding Source: MGI
protein homodimerization activity Source: MGI
protein tyrosine kinase binding Source: MGI
transmembrane signaling receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW
cell surface receptor signaling pathway Source: MGI
interleukin-2 production
Source: MGI
Inferred from genetic interactionⁱ
- 15184345
positive regulation of protein localization to cell surface
Source: MGI
Inferred from direct assayⁱ
- 15184345
protein homotetramerization Source: MGI
protein homotrimerization Source: MGI
T cell receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 11435465

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Adaptive immunity, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-202424 Downstream TCR signaling R-MMU-202427 Phosphorylation of CD3 and TCR zeta chains R-MMU-202430 Translocation of ZAP-70 to Immunological synapse R-MMU-202433 Generation of second messenger molecules R-MMU-2029481 FCGR activation R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation R-MMU-2029485 Role of phospholipids in phagocytosis R-MMU-389948 PD-1 signaling

Reactomeⁱ

R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-202424 Downstream TCR signaling
R-MMU-202427 Phosphorylation of CD3 and TCR zeta chains
R-MMU-202430 Translocation of ZAP-70 to Immunological synapse
R-MMU-202433 Generation of second messenger molecules
R-MMU-2029481 FCGR activation
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-2029485 Role of phospholipids in phagocytosis
R-MMU-389948 PD-1 signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-cell surface glycoprotein CD3 zeta chain Alternative name(s): T-cell receptor T3 zeta chain CD_antigen: CD247
Gene namesⁱ	Name:Cd247 Synonyms:Cd3z, Tcrz
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:88334 Cd247

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 30	ExtracellularSequence analysis	9
Transmembraneⁱ	31 – 51	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	52 – 164	CytoplasmicSequence analysisAdd BLAST	113

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

CD3Z deletion causes severely defective thymocyte differentiation (PubMed:8223495). Absence of CD3Z also leads to altered dendritic structure and motility in developing retina (PubMed:20188655).2 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Add BLAST		21
ChainⁱPRO_0000016494	22 – 164	T-cell surface glycoprotein CD3 zeta chainAdd BLAST		143

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	22	Blocked amino end (Gln)	1
Modified residueⁱ	58	PhosphoserineBy similarity	1
Modified residueⁱ	72	PhosphotyrosinePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	83	PhosphotyrosinePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	111	PhosphotyrosinePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	123	PhosphotyrosinePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	142	PhosphotyrosinePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	153	PhosphotyrosinePROSITE-ProRule annotationBy similarity	1

Post-translational modificationⁱ

Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P24161
PRIDEⁱ	P24161

PTM databases

iPTMnetⁱ	P24161
PhosphoSitePlusⁱ	P24161

Expressionⁱ

Tissue specificityⁱ

CD3Z is expressed in normal lymphoid tissue and in peripheral blood mononuclear cells (PBMCs). Expressed also in retinal ganglion cells (PubMed:20188655).Curated1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000005763 Expressed in 91 organ(s), highest expression level in thymus
CleanExⁱ	MM_CD247
ExpressionAtlasⁱ	P24161 baseline and differential
Genevisibleⁱ	P24161 MM

Interactionⁱ

Subunit structureⁱ

The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta. Interacts with SLA (PubMed:10662792). Interacts with SLA2 (PubMed:11891219). Interacts with TRAT1. Interacts with DOCK2. Interacts with SHB. Interacts with ZAP70. Interacts (tyrosine phosphorylated) with SHC1 (via SH2 domain). Interacts with PTPRC (By similarity). Interacts with CRK; this interaction regulates CD3Z phosphorylation (By similarity).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Ptpn4	Q9WU22	3	EBI-7803400,EBI-7249866
Zap70	P43404	4	EBI-7803400,EBI-3862932

GO - Molecular functionⁱ

identical protein binding Source: MGI
protein homodimerization activity Source: MGI
protein tyrosine kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198598, 5 interactors
CORUMⁱ	P24161
ELMⁱ	P24161
IntActⁱ	P24161, 7 interactors
Molecular INTeraction database More...MINTⁱ	P24161
STRINGⁱ	10090.ENSMUSP00000027849

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P24161
SMRⁱ	P24161
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	61 – 89	ITAM 1PROSITE-ProRule annotationAdd BLAST	29
Domainⁱ	100 – 128	ITAM 2PROSITE-ProRule annotationAdd BLAST	29
Domainⁱ	131 – 159	ITAM 3PROSITE-ProRule annotationAdd BLAST	29

Domainⁱ

The ITAM domains mediate interaction with SHB.By similarity

Sequence similaritiesⁱ

Belongs to the CD3Z/FCER1G family.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J0ID Eukaryota ENOG411241T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018208
HOGENOMⁱ	HOG000234398
HOVERGENⁱ	HBG005280
KEGG Orthology (KO) More...KOⁱ	K06453
OMAⁱ	LHMQTLP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QJC

Family and domain databases

InterProⁱ	View protein in InterPro IPR021663 CD3_zeta/IgE_Fc_rcpt_gamma IPR003110 Phos_immunorcpt_sig_ITAM IPR024128 T-cell_CD3_zeta
PANTHERⁱ	PTHR10035 PTHR10035, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02189 ITAM, 3 hits PF11628 TCR_zetazeta, 1 hit
SMARTⁱ	View protein in SMART SM00077 ITAM, 3 hits
PROSITEⁱ	View protein in PROSITE PS51055 ITAM_1, 3 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform CD-3-zeta (identifier: P24161-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKWKVSVLAC ILHVRFPGAE AQSFGLLDPK LCYLLDGILF IYGVIITALY 
        60         70         80         90        100
LRAKFSRSAE TAANLQDPNQ LYNELNLGRR EEYDVLEKKR ARDPEMGGKQ 
       110        120        130        140        150
QRRRNPQEGV YNALQKDKMA EAYSEIGTKG ERRRGKGHDG LYQGLSTATK 
       160 
DTYDALHMQT LAPR

Length:164

Mass (Da):18,637

Last modified:March 1, 1992 - v1

Checksum:ⁱ1B8022035A312831

GO

Isoform CD-3-eta (identifier: P24161-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
144-164: GLSTATKDTYDALHMQTLAPR → DSHFQAVQFG...PWPPSSSSQL

« Hide

        10         20         30         40         50
MKWKVSVLAC ILHVRFPGAE AQSFGLLDPK LCYLLDGILF IYGVIITALY 
        60         70         80         90        100
LRAKFSRSAE TAANLQDPNQ LYNELNLGRR EEYDVLEKKR ARDPEMGGKQ 
       110        120        130        140        150
QRRRNPQEGV YNALQKDKMA EAYSEIGTKG ERRRGKGHDG LYQDSHFQAV 
       160        170        180        190        200
QFGNRREREG SELTRTLGLR ARPKGESTQQ SSQSCASVFS IPTLWSPWPP 

SSSSQL

Show »

Length:206

Mass (Da):23,339

Checksum:ⁱ829256A2CF44E444

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q3UU54	Q3UU54_MOUSE	T-cell surface glycoprotein CD3 zet... T-cell surface glycoprotein CD3 zeta chain	Cd247 Cd3z	177	Annotation score:
A2MZG6	A2MZG6_MOUSE	CD3 theta CD3 theta (T-cell surface glycoprotein CD3 zeta chain)	Cd247	188	Annotation score:
J3QMU3	J3QMU3_MOUSE	T-cell surface glycoprotein CD3 zet... T-cell surface glycoprotein CD3 zeta chain	Cd247	189	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	153	Y → C in BAB30997 (PubMed:16141072).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_058346	144 – 164	GLSTA…TLAPR → DSHFQAVQFGNRREREGSEL TRTLGLRARPKGESTQQSSQ SCASVFSIPTLWSPWPPSSS SQL in isoform CD-3-eta. Add BLAST		21

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M19729 Genomic DNA Translation: AAA40171.1 J04967 mRNA Translation: AAA50301.1 M33158 mRNA Translation: AAA37398.1 AK017904 mRNA Translation: BAB30997.1 BC052824 mRNA Translation: AAH52824.1 M76711 Genomic DNA Translation: AAA40403.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15443.1 [P24161-2] CCDS48427.1 [P24161-1]
PIRⁱ	A35900 A40104
NCBI Reference Sequences More...RefSeqⁱ	NP_001106862.1, NM_001113391.2 [P24161-1] NP_112439.1, NM_031162.4 [P24161-2] XP_011237047.1, XM_011238745.2 [P24161-1] XP_017168774.1, XM_017313285.1 [P24161-1]
UniGeneⁱ	Mm.217308 Mm.245261 Mm.475205

Genome annotation databases

Ensemblⁱ	ENSMUST00000005907; ENSMUSP00000005907; ENSMUSG00000005763 [P24161-1] ENSMUST00000027849; ENSMUSP00000027849; ENSMUSG00000005763 [P24161-2] ENSMUST00000086002; ENSMUSP00000083165; ENSMUSG00000005763 [P24161-2] ENSMUST00000187313; ENSMUSP00000140926; ENSMUSG00000005763 [P24161-2]
GeneIDⁱ	12503
KEGGⁱ	mmu:12503
UCSC genome browser More...UCSCⁱ	uc007djn.2 mouse [P24161-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24161	CD3 antigen, zeta polypeptide, isoform CRA_b		RAT		164	UniRef90_P24161
UPI000A30A086		MUSPA		164
UPI000A31A079		MUSCR		164
UPI0003D77D7F		MOUSE		163
UPI0003D09B48		RAT		163
P24161-2	T-cell surface glycoprotein CD3 zeta chain		MOUSE		189	UniRef90_P24161-2
UPI000A31362F		MUSPA		203
CD3 theta		MOUSE		188

Protein	Similar proteins		Species	Score	Length	Source
P24161	T-cell surface glycoprotein CD3 zeta chain		SHEEP		166	UniRef50_P24161
T-cell surface glycoprotein CD3 zeta chain		RABIT		165
CD3 antigen, zeta polypeptide, isoform CRA_b		RAT		164
CD247 antigen		CASCN		164
T-cell surface glycoprotein CD3 zeta chain		MOUSE		177
+115
P24161-2	T-cell surface glycoprotein CD3 zeta chain		MOUSE		189	UniRef50_P24161-2
Uncharacterized protein		CAVPO		164
CD3 eta chain (Fragment)		PIG		216
T-cell surface glycoprotein CD3 zeta chain		MYOBR		208
T-cell surface glycoprotein CD3 zeta chain isoform X1		DIPOR		210
+10

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M19729 Genomic DNA Translation: AAA40171.1 J04967 mRNA Translation: AAA50301.1 M33158 mRNA Translation: AAA37398.1 AK017904 mRNA Translation: BAB30997.1 BC052824 mRNA Translation: AAH52824.1 M76711 Genomic DNA Translation: AAA40403.1
CCDSⁱ	CCDS15443.1 [P24161-2] CCDS48427.1 [P24161-1]
PIRⁱ	A35900 A40104
RefSeqⁱ	NP_001106862.1, NM_001113391.2 [P24161-1] NP_112439.1, NM_031162.4 [P24161-2] XP_011237047.1, XM_011238745.2 [P24161-1] XP_017168774.1, XM_017313285.1 [P24161-1]
UniGeneⁱ	Mm.217308 Mm.245261 Mm.475205

3D structure databases

ProteinModelPortalⁱ	P24161
SMRⁱ	P24161
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198598, 5 interactors
CORUMⁱ	P24161
ELMⁱ	P24161
IntActⁱ	P24161, 7 interactors
MINTⁱ	P24161
STRINGⁱ	10090.ENSMUSP00000027849

PTM databases

iPTMnetⁱ	P24161
PhosphoSitePlusⁱ	P24161

Proteomic databases

EPDⁱ	P24161
PRIDEⁱ	P24161

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	12503
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000005907; ENSMUSP00000005907; ENSMUSG00000005763 [P24161-1] ENSMUST00000027849; ENSMUSP00000027849; ENSMUSG00000005763 [P24161-2] ENSMUST00000086002; ENSMUSP00000083165; ENSMUSG00000005763 [P24161-2] ENSMUST00000187313; ENSMUSP00000140926; ENSMUSG00000005763 [P24161-2]
GeneIDⁱ	12503
KEGGⁱ	mmu:12503
UCSCⁱ	uc007djn.2 mouse [P24161-1]

Organism-specific databases

CTDⁱ	919
MGIⁱ	MGI:88334 Cd247

Phylogenomic databases

eggNOGⁱ	ENOG410J0ID Eukaryota ENOG411241T LUCA
GeneTreeⁱ	ENSGT00390000018208
HOGENOMⁱ	HOG000234398
HOVERGENⁱ	HBG005280
KOⁱ	K06453
OMAⁱ	LHMQTLP
OrthoDBⁱ	EOG091G0QJC

Enzyme and pathway databases

Reactomeⁱ	R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-202424 Downstream TCR signaling R-MMU-202427 Phosphorylation of CD3 and TCR zeta chains R-MMU-202430 Translocation of ZAP-70 to Immunological synapse R-MMU-202433 Generation of second messenger molecules R-MMU-2029481 FCGR activation R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation R-MMU-2029485 Role of phospholipids in phagocytosis R-MMU-389948 PD-1 signaling

Reactomeⁱ

R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-202424 Downstream TCR signaling
R-MMU-202427 Phosphorylation of CD3 and TCR zeta chains
R-MMU-202430 Translocation of ZAP-70 to Immunological synapse
R-MMU-202433 Generation of second messenger molecules
R-MMU-2029481 FCGR activation
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-2029485 Role of phospholipids in phagocytosis
R-MMU-389948 PD-1 signaling

Miscellaneous databases

ChiTaRSⁱ	Cd247 mouse
Protein Ontology More...PROⁱ	PR:P24161
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005763 Expressed in 91 organ(s), highest expression level in thymus
CleanExⁱ	MM_CD247
ExpressionAtlasⁱ	P24161 baseline and differential
Genevisibleⁱ	P24161 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR021663 CD3_zeta/IgE_Fc_rcpt_gamma IPR003110 Phos_immunorcpt_sig_ITAM IPR024128 T-cell_CD3_zeta
PANTHERⁱ	PTHR10035 PTHR10035, 1 hit
Pfamⁱ	View protein in Pfam PF02189 ITAM, 3 hits PF11628 TCR_zetazeta, 1 hit
SMARTⁱ	View protein in SMART SM00077 ITAM, 3 hits
PROSITEⁱ	View protein in PROSITE PS51055 ITAM_1, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD3Z_MOUSE
Accessionⁱ	P24161Primary (citable) accession number: P24161 Secondary accession number(s): P29020, Q9D3G3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	March 1, 1992
	Last modified:	October 10, 2018
	This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniRef

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Supporting data

UniProtKB - P24161 (CD3Z_MOUSE)

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T-cell surface glycoprotein CD3 zeta chain

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ