PRTN3

Functionⁱ

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).5 Publications

Catalytic activityⁱ

Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-.6 Publications

Activity regulationⁱ

Inhibited by phenylmethanesulfonyl fluoride (PMSF) and diisopropyl fluorophosphate (DFP).1 Publication

pH dependenceⁱ

Optimum pH is 7.4.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	71	Charge relay systemPROSITE-ProRule annotation	1
Active siteⁱ	118	Charge relay systemPROSITE-ProRule annotation	1
Active siteⁱ	203	Charge relay systemPROSITE-ProRule annotation	1

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17712045
serine-type endopeptidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 28240246
serine-type peptidase activity
Source: ProtInc
Traceable author statementⁱ
- 2679910
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17244676

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antimicrobial humoral response Source: Reactome
blood coagulation Source: Reactome
cell-cell junction maintenance
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23202369
collagen catabolic process Source: UniProtKB-KW
cytokine-mediated signaling pathway Source: Reactome
mature conventional dendritic cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 16478888
membrane protein ectodomain proteolysis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23202369
negative regulation of phagocytosis
Source: UniProtKB
Inferred from direct assayⁱ
- 17712045
neutrophil degranulation Source: Reactome
neutrophil extravasation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22266279
positive regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 2598267
positive regulation of GTPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23202369
proteolysis
Source: UniProtKB
Inferred from direct assayⁱ
- 28240246

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Serine protease
Biological process	Collagen degradation

Enzyme and pathway databases

BRENDAⁱ	3.4.21.76 2681
Reactomeⁱ	R-HSA-140875 Common Pathway of Fibrin Clot Formation R-HSA-449836 Other interleukin signaling R-HSA-6798695 Neutrophil degranulation R-HSA-6803157 Antimicrobial peptides
SABIO-RKⁱ	P24158

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.134

MEROPSⁱ

S01.134

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myeloblastin (EC:3.4.21.766 Publications) Alternative name(s): AGP7 C-ANCA antigen Leukocyte proteinase 3 Short name: PR-3 Short name: PR3 Neutrophil proteinase 4 Short name: NP-4 P29 Wegener autoantigen
Gene namesⁱ	Name:PRTN3 Synonyms:MBN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196415.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9495 PRTN3
MIMⁱ	177020 gene
neXtProtⁱ	NX_P24158

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Is the major autoantigen in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (Wegener's granulomatosis) (PubMed:2377228, PubMed:2679910). This complex, systemic disease is characterized by granulomatous inflammation with necrotizing lesions in the respiratory tract, glomerulonephritis, vasculitis, and anti-neutrophil cytoplasmatic autoantibodies detected in patient sera (PubMed:2377228, PubMed:2679910). PRTN3 causes emphysema when administered by tracheal insufflation to hamsters (PubMed:3198760).2 Publications1 Publication

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5657
MalaCards human disease database More...MalaCardsⁱ	PRTN3
Open Targets More...OpenTargetsⁱ	ENSG00000196415
Orphanetⁱ	900 Granulomatosis with polyangiitis
PharmGKBⁱ	PA33842

Chemistry databases

ChEMBLⁱ	CHEMBL3900
Drug and drug target database More...DrugBankⁱ	DB05161 Elafin
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2401

Polymorphism and mutation databases

BioMutaⁱ	PRTN3
DMDMⁱ	6174926

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 25	Add BLAST	25
PropeptideⁱPRO_0000027707	26 – 27		2
ChainⁱPRO_0000027708	28 – 248	Myeloblastin4 PublicationsAdd BLAST	221
PropeptideⁱPRO_0000027709	249 – 256		8

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	56 ↔ 72	Combined sources1 Publication
Glycosylationⁱ	129	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	152 ↔ 209	Combined sources1 Publication
Glycosylationⁱ	174	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1
Disulfide bondⁱ	182 ↔ 188	Combined sources1 Publication
Disulfide bondⁱ	199 ↔ 224	Combined sources1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDⁱ	P24158
PaxDbⁱ	P24158
PeptideAtlas More...PeptideAtlasⁱ	P24158
PRIDEⁱ	P24158
ProteomicsDBⁱ	54192

PTM databases

GlyConnectⁱ	1529

GlyConnectⁱ

1529

Expressionⁱ

Tissue specificityⁱ

Expressed in polymorphonuclear leukocytes (at protein level) (PubMed:2033050, PubMed:7897245, PubMed:3198760). Expressed in neutrophils (at protein level) (PubMed:28240246, PubMed:18462208, PubMed:21193407, PubMed:22266279, PubMed:17244676). Expressed in differentiating neutrophils (PubMed:18462208).8 Publications

Inductionⁱ

Induced during CSF3/G-CSF-mediated neutrophil differentiation.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000196415 Expressed in 71 organ(s), highest expression level in trabecular bone tissue
CleanExⁱ	HS_PRTN3
ExpressionAtlasⁱ	P24158 baseline and differential
Genevisibleⁱ	P24158 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB017558 HPA005938

HPAⁱ

CAB017558
HPA005938

Interactionⁱ

Subunit structureⁱ

May form dimers (PubMed:28240246). Interacts with CD177; the interaction tethers PRTN3 to the cell surface; the interaction is direct (PubMed:17244676, PubMed:28240246).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IL32	P24001-4	3	EBI-465028,EBI-15570379

With

Entry

#Exp.

IntAct

Notes

IL32

P24001-4

3

EBI-465028,EBI-15570379

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17712045
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17244676

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111638, 15 interactors
Database of interacting proteins More...DIPⁱ	DIP-31107N
IntActⁱ	P24158, 3 interactors
Molecular INTeraction database More...MINTⁱ	P24158
STRINGⁱ	9606.ENSP00000234347

Chemistry databases

BindingDBⁱ

P24158

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	42 – 47	Combined sources	6
Beta strandⁱ	56 – 62	Combined sources	7
Beta strandⁱ	65 – 68	Combined sources	4
Helixⁱ	70 – 73	Combined sources	4
Beta strandⁱ	74 – 76	Combined sources	3
Helixⁱ	78 – 80	Combined sources	3
Beta strandⁱ	81 – 86	Combined sources	6
Beta strandⁱ	98 – 107	Combined sources	10
Turnⁱ	112 – 115	Combined sources	4
Beta strandⁱ	120 – 126	Combined sources	7
Beta strandⁱ	151 – 160	Combined sources	10
Beta strandⁱ	162 – 164	Combined sources	3
Beta strandⁱ	171 – 178	Combined sources	8
Beta strandⁱ	186 – 190	Combined sources	5
Beta strandⁱ	192 – 195	Combined sources	4
Beta strandⁱ	206 – 209	Combined sources	4
Beta strandⁱ	212 – 219	Combined sources	8
Beta strandⁱ	221 – 223	Combined sources	3
Beta strandⁱ	227 – 229	Combined sources	3
Beta strandⁱ	231 – 235	Combined sources	5
Helixⁱ	236 – 239	Combined sources	4
Helixⁱ	240 – 247	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P24158
SMRⁱ	P24158
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P24158

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 248	Peptidase S1PROSITE-ProRule annotationAdd BLAST		221

Sequence similaritiesⁱ

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3627 Eukaryota COG5640 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144219
HOVERGENⁱ	HBG013304
InParanoidⁱ	P24158
KEGG Orthology (KO) More...KOⁱ	K01350
OMAⁱ	PGSHFCG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DF7
PhylomeDBⁱ	P24158
TreeFamⁱ	TF335284

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00190 Tryp_SPc, 1 hit
InterProⁱ	View protein in InterPro IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00089 Trypsin, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit
PROSITEⁱ	View protein in PROSITE PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P24158-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAHRPPSPAL ASVLLALLLS GAARAAEIVG GHEAQPHSRP YMASLQMRGN 
        60         70         80         90        100
PGSHFCGGTL IHPSFVLTAA HCLRDIPQRL VNVVLGAHNV RTQEPTQQHF 
       110        120        130        140        150
SVAQVFLNNY DAENKLNDVL LIQLSSPANL SASVATVQLP QQDQPVPHGT 
       160        170        180        190        200
QCLAMGWGRV GAHDPPAQVL QELNVTVVTF FCRPHNICTF VPRRKAGICF 
       210        220        230        240        250
GDSGGPLICD GIIQGIDSFV IWGCATRLFP DFFTRVALYV DWIRSTLRRV 

EAKGRP

Length:256

Mass (Da):27,807

Last modified:December 15, 1998 - v3

Checksum:ⁱCBECA36D8C4B2A40

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	U3KPS2	U3KPS2_HUMAN		Myeloblastin Myeloblastin	PRTN3	215	Annotation score:

Sequence cautionⁱ

The sequence AAA36342 differs from that shown. Reason: Frameshift at positions 34 and 39.Curated

The sequence CAA39598 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	2	A → R in CAA39203 (PubMed:2258701).Curated	1
Sequence conflictⁱ	38	S → I AA sequence (PubMed:1688612).Curated	1
Sequence conflictⁱ	40	P → PI AA sequence (PubMed:1688612).Curated	1
Sequence conflictⁱ	46	Q → E AA sequence (PubMed:2404977).Curated	1
Sequence conflictⁱ	46	Q → E AA sequence (PubMed:2501794).Curated	1
Sequence conflictⁱ	48	R → A AA sequence (PubMed:2121162).Curated	1
Sequence conflictⁱ	64	S → D AA sequence (PubMed:2033050).Curated	1
Sequence conflictⁱ	70	A → P in AAA59558 (PubMed:1681549).Curated	1
Sequence conflictⁱ	255	Missing in CAA39203 (PubMed:2258701).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_011691	119	V → I7 PublicationsCorresponds to variant dbSNP:rs351111Ensembl.	1
Natural variantⁱVAR_011713	135	A → T4 PublicationsCorresponds to variant dbSNP:rs1042281Ensembl.	1
Natural variantⁱVAR_011714	136	T → S4 PublicationsCorresponds to variant dbSNP:rs1042282Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M75154 mRNA Translation: AAA59558.1 AC004799 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69591.1 BC096183 mRNA Translation: AAH96183.1 BC096184 mRNA Translation: AAH96184.1 BC096185 mRNA Translation: AAH96185.1 BC096186 mRNA Translation: AAH96186.1 M96628 Genomic DNA Translation: AAB59364.1 AH005293 Genomic DNA Translation: AAB59493.1 M97911 Genomic DNA No translation available. AH007523 Genomic DNA Translation: AAD21524.1 X56606 mRNA Translation: CAA39943.1 X55668 mRNA Translation: CAA39203.1 M29142 mRNA Translation: AAA36342.1 Frameshift. X56132 mRNA Translation: CAA39597.1 X56132 mRNA Translation: CAA39598.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32860.1
PIRⁱ	A45080 PRHU3
NCBI Reference Sequences More...RefSeqⁱ	NP_002768.3, NM_002777.3
UniGeneⁱ	Hs.928

Genome annotation databases

Ensemblⁱ	ENST00000234347; ENSP00000234347; ENSG00000196415 ENST00000612112; ENSP00000478977; ENSG00000277804
GeneIDⁱ	5657
KEGGⁱ	hsa:5657
UCSC genome browser More...UCSCⁱ	uc002lqa.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P24158	Myeloblastin		HUMAN		215	UniRef100_P24158
UPI0005D02339		HUMAN		206

Protein	Similar proteins		Species	Score	Length	Source
P24158	Myeloblastin		HUMAN		215	UniRef90_P24158
Uncharacterized protein		PANTR		256
Uncharacterized protein		PANPA		133
Proteinase 3		GORGO		256
PRTN3 isoform 2 (Fragment)		PANTR		123
+4

Protein	Similar proteins		Species	Score	Length	Source
P24158	Neutrophil elastase	)	HUMAN		267	UniRef50_P08246
Myeloblastin		MOUSE		254
ELANE isoform 1		PONAB		267
Uncharacterized protein		PANTR		267
Uncharacterized protein		PANPA		145
+177

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Proteinase 3 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M75154 mRNA Translation: AAA59558.1 AC004799 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69591.1 BC096183 mRNA Translation: AAH96183.1 BC096184 mRNA Translation: AAH96184.1 BC096185 mRNA Translation: AAH96185.1 BC096186 mRNA Translation: AAH96186.1 M96628 Genomic DNA Translation: AAB59364.1 AH005293 Genomic DNA Translation: AAB59493.1 M97911 Genomic DNA No translation available. AH007523 Genomic DNA Translation: AAD21524.1 X56606 mRNA Translation: CAA39943.1 X55668 mRNA Translation: CAA39203.1 M29142 mRNA Translation: AAA36342.1 Frameshift. X56132 mRNA Translation: CAA39597.1 X56132 mRNA Translation: CAA39598.1 Different initiation.
CCDSⁱ	CCDS32860.1
PIRⁱ	A45080 PRHU3
RefSeqⁱ	NP_002768.3, NM_002777.3
UniGeneⁱ	Hs.928

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1FUJ	X-ray	2.20	A/B/C/D	28-248	[»]
ProteinModelPortalⁱ	P24158
SMRⁱ	P24158
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111638, 15 interactors
DIPⁱ	DIP-31107N
IntActⁱ	P24158, 3 interactors
MINTⁱ	P24158
STRINGⁱ	9606.ENSP00000234347

Chemistry databases

BindingDBⁱ	P24158
ChEMBLⁱ	CHEMBL3900
DrugBankⁱ	DB05161 Elafin
GuidetoPHARMACOLOGYⁱ	2401

Protein family/group databases

MEROPSⁱ	S01.134

MEROPSⁱ

S01.134

PTM databases

GlyConnectⁱ	1529

GlyConnectⁱ

1529

Polymorphism and mutation databases

BioMutaⁱ	PRTN3
DMDMⁱ	6174926

Proteomic databases

EPDⁱ	P24158
PaxDbⁱ	P24158
PeptideAtlasⁱ	P24158
PRIDEⁱ	P24158
ProteomicsDBⁱ	54192

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5657
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000234347; ENSP00000234347; ENSG00000196415 ENST00000612112; ENSP00000478977; ENSG00000277804
GeneIDⁱ	5657
KEGGⁱ	hsa:5657
UCSCⁱ	uc002lqa.2 human

Organism-specific databases

CTDⁱ	5657
DisGeNETⁱ	5657
EuPathDBⁱ	HostDB:ENSG00000196415.9
GeneCardsⁱ	PRTN3
HGNCⁱ	HGNC:9495 PRTN3
HPAⁱ	CAB017558 HPA005938
MalaCardsⁱ	PRTN3
MIMⁱ	177020 gene
neXtProtⁱ	NX_P24158
OpenTargetsⁱ	ENSG00000196415
Orphanetⁱ	900 Granulomatosis with polyangiitis
PharmGKBⁱ	PA33842
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3627 Eukaryota COG5640 LUCA
GeneTreeⁱ	ENSGT00910000144219
HOVERGENⁱ	HBG013304
InParanoidⁱ	P24158
KOⁱ	K01350
OMAⁱ	PGSHFCG
OrthoDBⁱ	EOG091G0DF7
PhylomeDBⁱ	P24158
TreeFamⁱ	TF335284

Enzyme and pathway databases

BRENDAⁱ	3.4.21.76 2681
Reactomeⁱ	R-HSA-140875 Common Pathway of Fibrin Clot Formation R-HSA-449836 Other interleukin signaling R-HSA-6798695 Neutrophil degranulation R-HSA-6803157 Antimicrobial peptides
SABIO-RKⁱ	P24158

Miscellaneous databases

EvolutionaryTraceⁱ	P24158
GeneWikiⁱ	Proteinase_3
GenomeRNAiⁱ	5657
Protein Ontology More...PROⁱ	PR:P24158
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196415 Expressed in 71 organ(s), highest expression level in trabecular bone tissue
CleanExⁱ	HS_PRTN3
ExpressionAtlasⁱ	P24158 baseline and differential
Genevisibleⁱ	P24158 HS

Family and domain databases

CDDⁱ	cd00190 Tryp_SPc, 1 hit
InterProⁱ	View protein in InterPro IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
Pfamⁱ	View protein in Pfam PF00089 Trypsin, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit
PROSITEⁱ	View protein in PROSITE PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRTN3_HUMAN
Accessionⁱ	P24158Primary (citable) accession number: P24158 Secondary accession number(s): P15637 Q9UQD8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	December 15, 1998
	Last modified:	October 10, 2018
	This is version 200 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Peptidase families
Classification of peptidase families and list of entries
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P24158 (PRTN3_HUMAN)

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Myeloblastin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Other locations

Cytosol

Extracellular region or secreted

Lysosome

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

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Functionⁱ

pH dependenceⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ