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UniProtKB - P24158 (PRTN3_HUMAN)

Entry version 223 (25 May 2022)
Sequence version 3 (15 Dec 1998)
Previous versions | rss
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Protein

Myeloblastin

Gene

PRTN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246).

By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369).

May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).

5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by phenylmethanesulfonyl fluoride (PMSF) and diisopropyl fluorophosphate (DFP).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7.4.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei71Charge relay systemPROSITE-ProRule annotation1
Active sitei118Charge relay systemPROSITE-ProRule annotation1
Active sitei203Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processCollagen degradation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.21.76, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P24158

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-140875, Common Pathway of Fibrin Clot Formation
R-HSA-449836, Other interleukin signaling
R-HSA-6798695, Neutrophil degranulation
R-HSA-6803157, Antimicrobial peptides

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P24158

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P24158

SIGNOR Signaling Network Open Resource

More...SIGNORi		P24158

Protein family/group databases

MEROPS protease database

More...MEROPSi		S01.134

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myeloblastin (EC:3.4.21.766 Publications)
Alternative name(s):
AGP7
C-ANCA antigen
Leukocyte proteinase 3
Short name:
PR-3
Short name:
PR3
Neutrophil proteinase 4
Short name:
NP-4
P29
Wegener autoantigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRTN3
Synonyms:MBN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9495, PRTN3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		177020, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P24158

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196415

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Is the major autoantigen in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (Wegener's granulomatosis) (PubMed:2377228, PubMed:2679910). This complex, systemic disease is characterized by granulomatous inflammation with necrotizing lesions in the respiratory tract, glomerulonephritis, vasculitis, and anti-neutrophil cytoplasmatic autoantibodies detected in patient sera (PubMed:2377228, PubMed:2679910). PRTN3 causes emphysema when administered by tracheal insufflation to hamsters (PubMed:3198760).2 Publications1 Publication

Organism-specific databases

DisGeNET

More...DisGeNETi		5657

MalaCards human disease database

More...MalaCardsi		PRTN3

Open Targets

More...OpenTargetsi		ENSG00000196415

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		900, Granulomatosis with polyangiitis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33842

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P24158, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3900

Drug and drug target database

More...DrugBanki		DB05161, Elafin

DrugCentral

More...DrugCentrali		P24158

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2401

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRTN3

Domain mapping of disease mutations (DMDM)

More...DMDMi		6174926

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Add BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002770726 – 272
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002770828 – 248Myeloblastin4 PublicationsAdd BLAST221
PropeptideiPRO_0000027709249 – 2568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi56 ↔ 72Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 209Combined sources1 Publication
Glycosylationi174N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi182 ↔ 188Combined sources1 Publication
Disulfide bondi199 ↔ 224Combined sources1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-1142

Encyclopedia of Proteome Dynamics

More...EPDi		P24158

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P24158

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P24158

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P24158

PeptideAtlas

More...PeptideAtlasi		P24158

PRoteomics IDEntifications database

More...PRIDEi		P24158

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54192

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1529, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P24158, 3 sites, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P24158

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in polymorphonuclear leukocytes (at protein level) (PubMed:2033050, PubMed:7897245, PubMed:3198760). Expressed in neutrophils (at protein level) (PubMed:28240246, PubMed:18462208, PubMed:21193407, PubMed:22266279, PubMed:17244676). Expressed in differentiating neutrophils (PubMed:18462208).8 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced during CSF3/G-CSF-mediated neutrophil differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196415, Expressed in bone marrow and 91 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P24158, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P24158, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196415, Tissue enriched (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form dimers (PubMed:28240246).

Interacts with CD177; the interaction tethers PRTN3 to the cell surface; the interaction is direct (PubMed:17244676, PubMed:28240246).

Interacts with SERPINB1 (PubMed:30692621).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111638, 107 interactors

Database of interacting proteins

More...DIPi		DIP-31107N

Protein interaction database and analysis system

More...IntActi		P24158, 7 interactors

Molecular INTeraction database

More...MINTi		P24158

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000234347

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P24158

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P24158, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P24158

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P24158

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P24158

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 248Peptidase S1PROSITE-ProRule annotationAdd BLAST221

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3627, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234528

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006842_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P24158

Identification of Orthologs from Complete Genome Data

More...OMAi		IQLNRPA

Database of Orthologous Groups

More...OrthoDBi		1314811at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P24158

TreeFam database of animal gene trees

More...TreeFami		TF335284

Family and domain databases

Conserved Domains Database

More...CDDi		cd00190, Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00089, Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00722, CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00020, Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494, SSF50494, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P24158-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHRPPSPAL ASVLLALLLS GAARAAEIVG GHEAQPHSRP YMASLQMRGN 
        60         70         80         90        100
PGSHFCGGTL IHPSFVLTAA HCLRDIPQRL VNVVLGAHNV RTQEPTQQHF 
       110        120        130        140        150
SVAQVFLNNY DAENKLNDVL LIQLSSPANL SASVATVQLP QQDQPVPHGT 
       160        170        180        190        200
QCLAMGWGRV GAHDPPAQVL QELNVTVVTF FCRPHNICTF VPRRKAGICF 
       210        220        230        240        250
GDSGGPLICD GIIQGIDSFV IWGCATRLFP DFFTRVALYV DWIRSTLRRV 

EAKGRP
Length:256
Mass (Da):27,807
Last modified:December 15, 1998 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCBECA36D8C4B2A40
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KPS2U3KPS2_HUMAN
Myeloblastin
PRTN3
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36342 differs from that shown. Reason: Frameshift.Curated
The sequence CAA39598 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2A → R in CAA39203 (PubMed:2258701).Curated1
Sequence conflicti38S → I AA sequence (PubMed:1688612).Curated1
Sequence conflicti40P → PI AA sequence (PubMed:1688612).Curated1
Sequence conflicti46Q → E AA sequence (PubMed:2404977).Curated1
Sequence conflicti46Q → E AA sequence (PubMed:2501794).Curated1
Sequence conflicti48R → A AA sequence (PubMed:2121162).Curated1
Sequence conflicti64S → D AA sequence (PubMed:2033050).Curated1
Sequence conflicti70A → P in AAA59558 (PubMed:1681549).Curated1
Sequence conflicti255Missing in CAA39203 (PubMed:2258701).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011691119V → I7 PublicationsCorresponds to variant dbSNP:rs351111Ensembl.1
Natural variantiVAR_011713135A → T4 PublicationsCorresponds to variant dbSNP:rs1042281Ensembl.1
Natural variantiVAR_011714136T → S4 PublicationsCorresponds to variant dbSNP:rs1042282Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M75154 mRNA Translation: AAA59558.1
AC004799 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69591.1
BC096183 mRNA Translation: AAH96183.1
BC096184 mRNA Translation: AAH96184.1
BC096185 mRNA Translation: AAH96185.1
BC096186 mRNA Translation: AAH96186.1
M96628 Genomic DNA Translation: AAB59364.1
AH005293 Genomic DNA Translation: AAB59493.1
M97911 Genomic DNA No translation available.
AH007523 Genomic DNA Translation: AAD21524.1
X56606 mRNA Translation: CAA39943.1
X55668 mRNA Translation: CAA39203.1
M29142 mRNA Translation: AAA36342.1 Frameshift.
X56132 mRNA Translation: CAA39597.1
X56132 mRNA Translation: CAA39598.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32860.1

Protein sequence database of the Protein Information Resource

More...PIRi		A45080, PRHU3

NCBI Reference Sequences

More...RefSeqi		NP_002768.3, NM_002777.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000234347.10; ENSP00000234347.3; ENSG00000196415.10
ENST00000612112.4; ENSP00000478977.1; ENSG00000277804.4

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5657

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5657

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000234347.10; ENSP00000234347.3; NM_002777.4; NP_002768.3

UCSC genome browser

More...UCSCi		uc002lqa.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Proteinase 3 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75154 mRNA Translation: AAA59558.1
AC004799 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69591.1
BC096183 mRNA Translation: AAH96183.1
BC096184 mRNA Translation: AAH96184.1
BC096185 mRNA Translation: AAH96185.1
BC096186 mRNA Translation: AAH96186.1
M96628 Genomic DNA Translation: AAB59364.1
AH005293 Genomic DNA Translation: AAB59493.1
M97911 Genomic DNA No translation available.
AH007523 Genomic DNA Translation: AAD21524.1
X56606 mRNA Translation: CAA39943.1
X55668 mRNA Translation: CAA39203.1
M29142 mRNA Translation: AAA36342.1 Frameshift.
X56132 mRNA Translation: CAA39597.1
X56132 mRNA Translation: CAA39598.1 Different initiation.
CCDSiCCDS32860.1
PIRiA45080, PRHU3
RefSeqiNP_002768.3, NM_002777.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FUJX-ray2.20A/B/C/D28-248[»]
AlphaFoldDBiP24158
SMRiP24158
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111638, 107 interactors
DIPiDIP-31107N
IntActiP24158, 7 interactors
MINTiP24158
STRINGi9606.ENSP00000234347

Chemistry databases

BindingDBiP24158
ChEMBLiCHEMBL3900
DrugBankiDB05161, Elafin
DrugCentraliP24158
GuidetoPHARMACOLOGYi2401

Protein family/group databases

MEROPSiS01.134

PTM databases

GlyConnecti1529, 2 N-Linked glycans (1 site)
GlyGeniP24158, 3 sites, 1 N-linked glycan (1 site)
iPTMnetiP24158

Genetic variation databases

BioMutaiPRTN3
DMDMi6174926

Proteomic databases

CPTACinon-CPTAC-1142
EPDiP24158
jPOSTiP24158
MassIVEiP24158
PaxDbiP24158
PeptideAtlasiP24158
PRIDEiP24158
ProteomicsDBi54192

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P24158, 4 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1069, 524 antibodies from 39 providers

The DNASU plasmid repository

More...DNASUi		5657

Genome annotation databases

EnsembliENST00000234347.10; ENSP00000234347.3; ENSG00000196415.10
ENST00000612112.4; ENSP00000478977.1; ENSG00000277804.4
GeneIDi5657
KEGGihsa:5657
MANE-SelectiENST00000234347.10; ENSP00000234347.3; NM_002777.4; NP_002768.3
UCSCiuc002lqa.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5657
DisGeNETi5657

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRTN3
HGNCiHGNC:9495, PRTN3
HPAiENSG00000196415, Tissue enriched (bone)
MalaCardsiPRTN3
MIMi177020, gene
neXtProtiNX_P24158
OpenTargetsiENSG00000196415
Orphaneti900, Granulomatosis with polyangiitis
PharmGKBiPA33842
VEuPathDBiHostDB:ENSG00000196415

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3627, Eukaryota
GeneTreeiENSGT01030000234528
HOGENOMiCLU_006842_1_0_1
InParanoidiP24158
OMAiIQLNRPA
OrthoDBi1314811at2759
PhylomeDBiP24158
TreeFamiTF335284

Enzyme and pathway databases

BRENDAi3.4.21.76, 2681
PathwayCommonsiP24158
ReactomeiR-HSA-140875, Common Pathway of Fibrin Clot Formation
R-HSA-449836, Other interleukin signaling
R-HSA-6798695, Neutrophil degranulation
R-HSA-6803157, Antimicrobial peptides
SABIO-RKiP24158
SignaLinkiP24158
SIGNORiP24158

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5657, 11 hits in 1069 CRISPR screens
EvolutionaryTraceiP24158

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Proteinase_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5657
PharosiP24158, Tchem

Protein Ontology

More...PROi		PR:P24158
RNActiP24158, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196415, Expressed in bone marrow and 91 other tissues
ExpressionAtlasiP24158, baseline and differential
GenevisibleiP24158, HS

Family and domain databases

CDDicd00190, Tryp_SPc, 1 hit
Gene3Di2.40.10.10, 2 hits
InterProiView protein in InterPro
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER
PfamiView protein in Pfam
PF00089, Trypsin, 1 hit
PRINTSiPR00722, CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020, Tryp_SPc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRTN3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24158
Secondary accession number(s): P15637
, P18078, Q4VB08, Q4VB09, Q6LBM7, Q6LBN2, Q9UD25, Q9UQD8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 15, 1998
Last modified: May 25, 2022
This is version 223 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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