UniProtKB - P24156 (L2CC_DROME)
Protein
Protein l(2)37Cc
Gene
l(2)37Cc
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Required for larval metabolism or for the progression of the larva into a pupa.1 Publication
GO - Biological processi
- cellular response to hypoxia Source: FlyBase
- multicellular organism development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
Reactomei | R-DME-8949664, Processing of SMDT1 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein l(2)37Cc |
Gene namesi | Name:l(2)37Cc ORF Names:CG10691 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0002031, l(2)37Cc |
Subcellular locationi
Mitochondrion
- mitochondrion Source: FlyBase
Other locations
- membrane Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213881 | 1 – 276 | Protein l(2)37CcAdd BLAST | 276 |
Proteomic databases
PaxDbi | P24156 |
PRIDEi | P24156 |
Expressioni
Developmental stagei
Expressed in early embryos, late embryos, late third instar larvae and adults.1 Publication
Gene expression databases
Bgeei | FBgn0002031, Expressed in embryonic/larval hemocyte (Drosophila) and 50 other tissues |
ExpressionAtlasi | P24156, baseline and differential |
Genevisiblei | P24156, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 72039, 22 interactors |
IntActi | P24156, 18 interactors |
MINTi | P24156 |
STRINGi | 7227.FBpp0080707 |
Family & Domainsi
Sequence similaritiesi
Belongs to the prohibitin family.Curated
Phylogenomic databases
eggNOGi | KOG3083, Eukaryota |
GeneTreei | ENSGT00950000183070 |
HOGENOMi | CLU_047969_0_0_1 |
InParanoidi | P24156 |
OMAi | RTRIRDN |
OrthoDBi | 1089994at2759 |
PhylomeDBi | P24156 |
Family and domain databases
CDDi | cd03401, SPFH_prohibitin, 1 hit |
InterProi | View protein in InterPro IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR000163, Prohibitin |
PANTHERi | PTHR23222, PTHR23222, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit |
PRINTSi | PR00679, PROHIBITIN |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P24156-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAQFFNRIG QMGLGVAVLG GVVNSALYNV EGGHRAVIFD RFTGIKENVV
60 70 80 90 100
GEGTHFFIPW VQRPIIFDIR SQPRNVPVIT GSKDLQNVNI TLRILYRPIP
110 120 130 140 150
DQLPKIYTIL GQDYDERVLP SIAPEVLKAV VAQFDAGELI TQREMVSQRV
160 170 180 190 200
SQELTVRAKQ FGFILDDISL THLTFGREFT LAVEMKQVAQ QEAEKARFVV
210 220 230 240 250
EKAEQQKLAS IISAEGDAEA AGLLAKSFGE AGDGLVELRR IEAAEDIAYQ
260 270
LSRSRGVAYL PSGQSTLLNL PSTIAQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A023GQA5 | A0A023GQA5_DROME | Prohibitin | l(2)37Cc Cc, Dmel\CG10691, fs(2)HH32, l (2) 37Cc, l(2)Cc | 276 | Annotation score: |
Sequence cautioni
The sequence CAA27807 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 78 | V → E in CAA27807 (PubMed:3092183).Curated | 1 | |
Sequence conflicti | 78 | V → E in CAA27810 (PubMed:3092183).Curated | 1 | |
Sequence conflicti | 125 – 143 | Missing in CAA27807 (PubMed:3092183).CuratedAdd BLAST | 19 | |
Sequence conflicti | 125 – 143 | Missing in CAA27810 (PubMed:3092183).CuratedAdd BLAST | 19 | |
Sequence conflicti | 220 – 252 | AAGLL…AYQLS → RACVGQVIARPETVWWSLRL IDRPRYRLTSYP in CAA27807 (PubMed:3092183).CuratedAdd BLAST | 33 | |
Sequence conflicti | 220 – 252 | AAGLL…AYQLS → RACVGQVIARPETVWWSLRL IDRPRYRLTSYP in CAA27810 (PubMed:3092183).CuratedAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04228 mRNA Translation: CAA27810.1 Frameshift. X04227 Genomic DNA Translation: CAA27807.1 Frameshift. AE014134 Genomic DNA Translation: AAN11026.1 AY122111 mRNA Translation: AAM52623.1 |
PIRi | C25511 |
RefSeqi | NP_001163012.2, NM_001169541.2 NP_476607.2, NM_057259.6 NP_724165.1, NM_165281.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0081164; FBpp0080707; FBgn0002031 FBtr0081165; FBpp0080708; FBgn0002031 FBtr0346428; FBpp0312093; FBgn0002031 |
GeneIDi | 49168 |
KEGGi | dme:Dmel_CG10691 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04228 mRNA Translation: CAA27810.1 Frameshift. X04227 Genomic DNA Translation: CAA27807.1 Frameshift. AE014134 Genomic DNA Translation: AAN11026.1 AY122111 mRNA Translation: AAM52623.1 |
PIRi | C25511 |
RefSeqi | NP_001163012.2, NM_001169541.2 NP_476607.2, NM_057259.6 NP_724165.1, NM_165281.2 |
3D structure databases
SMRi | P24156 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 72039, 22 interactors |
IntActi | P24156, 18 interactors |
MINTi | P24156 |
STRINGi | 7227.FBpp0080707 |
Proteomic databases
PaxDbi | P24156 |
PRIDEi | P24156 |
Genome annotation databases
EnsemblMetazoai | FBtr0081164; FBpp0080707; FBgn0002031 FBtr0081165; FBpp0080708; FBgn0002031 FBtr0346428; FBpp0312093; FBgn0002031 |
GeneIDi | 49168 |
KEGGi | dme:Dmel_CG10691 |
Organism-specific databases
FlyBasei | FBgn0002031, l(2)37Cc |
Phylogenomic databases
eggNOGi | KOG3083, Eukaryota |
GeneTreei | ENSGT00950000183070 |
HOGENOMi | CLU_047969_0_0_1 |
InParanoidi | P24156 |
OMAi | RTRIRDN |
OrthoDBi | 1089994at2759 |
PhylomeDBi | P24156 |
Enzyme and pathway databases
Reactomei | R-DME-8949664, Processing of SMDT1 |
Miscellaneous databases
BioGRID-ORCSi | 49168, 0 hits in 1 CRISPR screen |
ChiTaRSi | l(2)37Cc, fly |
GenomeRNAii | 49168 |
PROi | PR:P24156 |
Gene expression databases
Bgeei | FBgn0002031, Expressed in embryonic/larval hemocyte (Drosophila) and 50 other tissues |
ExpressionAtlasi | P24156, baseline and differential |
Genevisiblei | P24156, DM |
Family and domain databases
CDDi | cd03401, SPFH_prohibitin, 1 hit |
InterProi | View protein in InterPro IPR001107, Band_7 IPR036013, Band_7/SPFH_dom_sf IPR000163, Prohibitin |
PANTHERi | PTHR23222, PTHR23222, 1 hit |
Pfami | View protein in Pfam PF01145, Band_7, 1 hit |
PRINTSi | PR00679, PROHIBITIN |
SMARTi | View protein in SMART SM00244, PHB, 1 hit |
SUPFAMi | SSF117892, SSF117892, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | L2CC_DROME | |
Accessioni | P24156Primary (citable) accession number: P24156 Secondary accession number(s): Q0E8P3, Q9VIZ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | August 30, 2005 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families